Identification of 1,400 metabolites as mediators of obesity in 473 gut microbiota taxa: a mediation Mendelian randomization study by Xiaomin Li, Qike Wu, Shan-peng Liu

“…Bidirectional and two-sample Mendelian randomization (MR) were used to explore causal relationships. …”
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Causal effects of brain subregion gene expression on inflammatory bowel diseases revealed by Mendelian randomization and single cell analysis by Yuan Li, Yao Wang, Simeng Chen, Lijia Liu

“…However, correlation analysis revealed that eQTL sample sizes significantly influence the detection of significant associations (r = 0.53–0.90), indicating that direct quantitative comparisons between tissues should be interpreted cautiously. …”
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Unraveling the causal relationship and underlying mechanisms between cathepsins on liver cancer: findings from mendelian randomization and bioinformatics analysis by Xiaoxue Wang, Zexin Zhu

“…Therefore, we conducted a two-sample Mendelian randomization (MR) study to evaluate the causal relationship between cathepsins and PLC. …”
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Exploring the Association Between Human Blood Metabolites and Autism Spectrum Disorder Risk: A Bidirectional Mendelian Randomization Study by Wenhua Li, Suya Ma, Yunong Tian

“…This study aimed to investigate the causal association between these factors using two‐sample Mendelian randomization (TSMR). Methods We conducted a TSMR analysis to assess the relationship between blood metabolites and ASD using summarized GWAS data. …”
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Interannual changes of carbon storage in mangrove forests in Futian based on WorldView-3 remote sensing images by HU Liuliu1, TAN Min2, LUO Qin2, HUANG Zijian2, XIANG Xuelian2, LI Buhang2, YU Shixiao2, WU Zefeng1, YANG Qiong1, HU Ping1*

“…However, the dynamic changes of their carbon storage are rarely reported. Based on ground sample points and WorldView-3 high-resolution remote sensing images obtained in 2017, we identified the canopy of dominant mangrove communities in Futian mangrove utilizing random forest algorithm and object-oriented classification methods, and inverted and calculated the area of each dominant community. …”
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Causal relationship between gastroesophageal reflux disease and the risk of chronic suppurative otitis media: a mendelian randomization analysis by Qianyou Zheng, Ce Wu, Yaru Li, Jing Wu, Wenrui Tang, Qiuyang Zhu, Shaokang Ren, Xiaowen Zhang, Shenling Li, Tao Fu

“…This research sought to elucidate the causative link between GERD and CSOM. Methods: A two-sample bidirectional Mendelian randomization (MR) study was conducted using genetic data to assess the causal relationship between GERD and CSOM. …”
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The Impact of Telemonitoring and Telehealth Coaching on General Nutrition Knowledge in Overweight and Obese Individuals: A Pilot Randomized Controlled Trial by Noura M. S. Eid, Ebtisam A. Al-Ofi, Sumia Enani, Rana H. Mosli, Raneem R. Saqr, Karimah M. Qutah, Sara M. S. Eid

“…All participants enrolled in a randomized controlled trial (RCT) and received a hypocaloric-tailored diet and three online nutrition education sessions over 6 months. …”
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Investigating the causal effects of childhood and adulthood adiposity on later life mental health outcome: a Mendelian randomization study by Sweta Pathak, Tom G. Richardson, Eleanor Sanderson, Bjørn Olav Åsvold, Laxmi Bhatta, Ben M. Brumpton

“…However, there is lack of causal understanding if childhood body size has a direct effect on mental health or has an indirect effect after accounting for adulthood body size. Methods Two-sample Mendelian randomization (MR) was performed to estimate the total effect and direct effect (accounting for adulthood body size) of childhood body size on anxiety and depression. …”
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Effects of Functional Partial Body Weight Support Treadmill Training on Mobility in Children with Ataxia: A Randomized Controlled Trial by Alexandra Lepoura, Sofia Lampropoulou, Antonis Galanos, Marianna Papadopoulou, Georgios Gkrimas, Magda Tziomaki, Vasiliki Sakellari

“…<b>Methods:</b> Through a stratified randomized control trial, a sample of 18 children with progressive and non-progressive ataxia and GMFCS II-IV (mean age: 14 years; standard deviation: 2.5) was assessed prior to the intervention, post-intervention, and 2 months after its end. …”
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A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children by Anna Nikula, Stefan Lundeberg, Malin Ryd Rinder, Mitja Lääperi, Katri Sandholm, Maaret Castrén, Lisa Kurland

“…Patients were randomized to receive 2.0 mcg/kg intranasal dexmedetomidine or 1.0 mg/kg intranasal esketamine. …”
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The role of three-dimensional printing models in medical education: a systematic review and meta-analysis of randomized controlled trials by Guanli Xie, Tao Wang, Han Fu, Duo Liu, Li Deng, Xia Zheng, Lvyu Li, Jianglong Liao

“…Nevertheless, caution must be exercised in interpreting the current findings due to variations in model types, low quality of included studies, and the limited number of studies with small sample sizes.…”
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The impact of expressive writing of deep feelings about labor experiences on postpartum depression: a randomized clinical controlled trial by Sara Mohammadi, Fatemeh Hadizadeh Talasaz, Fatemeh Mohammadzadeh, Jahanshir Tavakolizadeh, Narjes Bahri

“…More clinical trials with larger sample sizes are needed to draw better conclusions. …”
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The hidden pathway: biological aging as a mediator between diabetes and breast cancer risk: a Mendelian randomized study by Yipang Zhao, Jingzhi Zhang, Dong Chen, Sixuan Xing, Shuhan Zhang, Qing Zhang

“…Abstract Objective To explore the relationship between type 2 diabetes mellitus and the risk of developing breast cancer and its subtypes, and the mediating role of biological aging in it. Methods A two-sample Mendelian randomized analyses were performed to assess the effect of type 2 diabetes mellitus on breast cancer and its subtypes, and the mediating effect of biological aging between type 2 diabetes mellitus with breast cancer and its subtypes was explored by mediation analysis. …”
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Novel Insights into Causal Effects of Lipid and Lipid-Lowering Targets with Autoimmune Thyroid Disease: A Mendelian Randomization Study by Su C, Tian J, He X, Chang X, Wang G, Liu J

“…This study aims to evaluate the effects of lipid-lowering drugs on AITD and explore their potential mechanisms.Methods: Two-sample and two-step Mendelian randomization (MR) studies were performed to assess the causal relationships between circulating lipids (LDL-C, TC, TG, and ApoB) and seven lipid-lowering drug targets (ApoB, CETP, HMGCR, LDLR, NPC1L1, PCSK9, and PPARα) with AITD. …”
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Association of 25-hydroxyvitamin D with Parkinson’s disease based on the results from the NHANES 2007 to 2018 and Mendelian randomization analysis by Yan Xu, Jie Peng, Xiguo Zhou, Yuexin Huang, Guanzhen Zhong, Zhiwei Xia

“…Demographic characteristics and multivariable-adjusted logistic regression were conducted to assess the relationship between the serum 25(OH)D levels and risk of PD prevalence by utilizing NHANES database. Besides, a two-sample MR analysis was applied to evaluate the causal association between serum 25(OH)D levels and PD risk. …”
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Investigating the effect of mindfulness-based art therapy on self-efficacy of multiparous and nulliparous women: A randomized controlled trial by Ashraf Beirami, Zahra Rahemi

“…The statistical population of the study included pregnant women (multiparous and nulliparous groups) referring to health centers (public and private) in Bandar Abbas city for prenatal care. A total sample size of 90 participants was determined, with 30 individuals randomly assigned to each group using a block randomization method. …”
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Biological effects of add-on eicosapentaenoic acid supplementation in diabetes mellitus and co-morbid depression: a randomized controlled trial. by Roel J T Mocking, Johanna Assies, Mariska Bot, Eugene H J M Jansen, Aart H Schene, François Pouwer

“…<h4>Conclusion</h4>Overall, add-on EPA-supplementation had limited effects on biological risk factors for adverse outcome in this sample of DM-patients with comorbid MDD. Besides increases in concentrations of supplemented α-tocopherol and EPA, AA decreased, and inconclusive effects on HPA-axis (re)activity and lipoprotein concentrations were observed. …”
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Influence of Spiritual Support Program on Quality‐of‐Life of Stroke Survivors Post Substance Overdose: A Randomized Controlled Trial by Leyla Alilu, Mansour Arad, Rasoul Goli, Amireh Hassanpour, Navid Faraji, Sorena Nazarbaghi

“…Participants were randomly assigned to an intervention group (n = 50) receiving a four‐session spiritual support program or a control group (n = 50). …”
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Mendelian randomization study revealed a gut microbiota-immune system-kidney junction axis in chronic kidney disease by Junjie Tan, Zhile Xiong, Shengyou Yu, Wei Lu, Li Yu

“…Using genome-wide association studies (GWAS) data for CKD, estimated glomerular filtration rate (eGFR) and UACR (urinary albumin to creatinine) from the CKDGen consortium, microbiome data from the MiBioGen consortium and the Dutch Microbiome Project (DMP), 41 cytokine and 731 immune cell traits were identified from large-scale GWAS summary data. We performed two-sample Mendelian randomization (MR) analysis to analyses the causal relationships between gut microbiome, circulating cytokines, immune cells and CKD, eGFR and UACR. …”
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Study protocol for a randomized single-center cross-over study: Dapagliflozin treatment in recurring kidney stone patients. by Haris Omić, Michael Eder, Harald Herkner, Christian Seitz, Željko Kikić, Tarek Arno Schrag

“…This data will inform the calculation of the study sample size (ranging from 17 to 104 participants) to include high-risk calcium oxalate kidney stone formers in a randomized controlled crossover study design. …”
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