The role of mitochondrial DNA copy number in female infertility: a bidirectional two-sample Mendelian randomization study by XiaoJu Wan, XiaoBao Lai, MeiZhen Huang, Min Yu, Tao Ding, ZhiHui Huang, ZhiQin Zhang, XingWu Wu, Jun Tan

Subjects: “…Two-sample Mendelian randomization…”
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Causal relationship of liposomes and circulating metabolomes to schizophrenia： a two-step， two-sample Mendelian randomization study by Lei Mengyun, Du Yanhong, Gao Yao, Deng Huaili, Wang Binhong, Ren Zhiyong, Liu Sha

“…However， available studies have mainly focused on a few liposomes and circulating metabolites， failing to systematically reveal the mediating role of circulating metabolomes in the causal relationship between liposomes and schizophrenia.ObjectiveTo uncover mediating role of circulating metabolomes in the causal relationship between liposomes and schizophrenia， thereby providing biomarkers and potential therapeutic targets for the prevention and treatment of schizophrenia.MethodsData from Genome-Wide Association Studies （GWAS） were analyzed， taking data on 179 liposomes as exposure variables， data on 123 circulating metabolites as intermediate variables， and data on schizophrenia as outcome variable. A two-step， two-sample Mendelian randomization analysis was conducted using the inverse-variance weighted （IVW）， MR- Egger， Weighted median， and Weighted mode methods to study the causal relationship of liposomes with schizophrenia and the mediating role of circulating metabolomes in the relationship.ResultsIVW model identified 8 lipids associated with schizophrenia without reverse causality. …”
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Anatomic subtype-specific causal effects of endometriosis on ovarian cancer: a two-sample Mendelian randomization study by Xu Zhang, Li Wang, Xingxing Ruan, Jie Ding, Jing Wan, Chengfang Xu, Xiaomao Li

“…Abstract While epidemiological studies have associated endometriosis with ovarian cancer risk, the causal relationships across anatomic subtypes and histotypes remain undefined. Using two-sample Mendelian randomization with 84 genetic instruments (F-statistic = 30.01–228.09), we analyzed genome-wide data from 20,190 endometriosis cases and 25,509 ovarian cancer patients. …”
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Impact of gut microbiota on metabolic syndrome and its comprising traits: a two-sample mendelian randomization study by Yaodong Zhang, Jinhai Fan

“…Methods Using Inver Variance Weighted (IVW) as primary analysis method, we performed two-sample Mendelian Randomization (MR) analyses to explore the causal relationship between gut microbiota and metabolic syndrome with its comprising traits. …”
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Association between gut microbiota and central retinal artery occlusion: A two-sample Mendelian randomization study by Jin Chen, Xinghua Wang, Junjie Yang, Jiahui Huang, Meng Xie, Zixuan Su, Fagang Jiang

“…Purpose: The gut microbiota might be closely related to central retinal artery occlusion (CRAO), but the causality has not been well defined. Two-sample Mendelian randomization (MR) study was used to reveal the potential causal effect between the gut microbiota and CRAO. …”
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Causal relationship between immune cells and acute myeloid leukemia: a two-sample Mendelian randomization study by Fanhua Yu, Hao Jiang, Yena Gu

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Causal Relationship Between Emotional Disorders and Thyroid Disorders: A Bidirectional Two‐Sample Mendelian Randomization Study by Jiaying Fan, Kai Zhou, Cuiwen Yu

“…We conducted a bidirectional two‐sample Mendelian randomization (MR) analysis to explore the genetic causal association between emotional disorders and thyroid disorders. …”
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Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study by Xinru Xiao, Ziqi Ding, Yujia Shi, Qian Zhang

“…In this study, we employed a two-sample Mendelian randomization (MR) analysis, utilizing the genome-wide association study database, to investigate the causal association between 731 immune-cell signatures and the susceptibility to COPD from a host genetics perspective. …”
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Potential Causal Relationship Between Plasma and Cerebrospinal Fluid Metabolites and Meningioma: Two-Sample Mendelian Randomization Study by Du G, Xu D, Zhao H, Yan Z, Wang J

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Assessing the influence of plasma metabolites on chronic skin ulcer risk: a two-sample Mendelian randomization study by Zheng Ye, Deqing Hong, Jiaqi Yuan, Peng Xu, Wenbin Liu

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Causal Associations Between Nitrogen Dioxide Exposure and Thyroid Nodules: a Two-Sample Mendelian Randomization Analysis by Chengxiang Liu, Sainan Li, Chen Zhu, Shan Chen, Juan Zhou, Hong Chen

“…In this investigation, we applied two-sample Mendelian randomization (TSMR) to evaluate the causal relationship between NO₂ concentrations and the risk of thyroid nodules Methods Using publicly available aggregated data from genome-wide association studies (GWAS) within the IEU Open GWAS database, we conducted a TSMR analysis. …”
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Causality between insulin use and malignant tumors of the digestive system: a two-sample mendelian randomized study by DengZhuo Chen, YongLi Ma, JingHui Li, Liang Wen, GuoSheng Zhang, ChengZhi Huang, XueQing Yao

“…Abstract Background Existing cohort studies show no association between insulin use and cancers of the digestive system, while numerous meta-analyses suggest that insulin use increases the risk of digestive system tumours. This study uses two-sample Mendelian randomization (MR) to further investigate the causal relationship between the two. …”
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Causal Relationship Between Colorectal Cancer and Common Psychiatric Disorders: A Two-sample Mendelian Randomization Study by Yuan YAO, Mingze YANG, Chen LI, Haibo CHENG

“…ObjectiveTo elucidate the causal relationships between colorectal cancer (CRC) and prevalent psychiatric disorders through a two-sample Mendelian randomization approach. MethodsUtilizing publicly available genome-wide association study data, we explored the connections between CRC and various psychiatric disorders, including depression, anxiety, bipolar disorder, and schizophrenia. …”
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Inflammatory bowel disease and risk of ophthalmic inflammation-related diseases: a two-sample Mendelian randomization study by Shao-Jie Ren, Ting Liu, Man-Hong Xu, Wei Shi, Xiao-Rong Li

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Causal association between plasma phosphatidylethanolamine and risk of colorectal adenocarcinoma: a two-sample Mendelian randomization study by XU Ling, HUANGFU Yuchan, SHEN Lisong, MA Yanhui

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Association between bone mineral density and scoliosis: a two-sample mendelian randomization study in european populations by Fangjun Yang, Jiantao Wen

“…The aim of this study is to investigate whether there is a causal association between BMD at different body positions and scoliosis by two-sample Mendelian randomization (MR). Methods Genetic variants (SNPS) strongly associated with BMD (total body BMD (TB-BMD), lumbar spine BMD (LS-BMD), femoral neck BMD (FN-BMD), heel BMD (HE-BMD), and forearm BMD (FA-BMD)) were extracted from GEFOS and genome-wide association analysis (GWAS) databases SNPs) were used as instrumental variables (IVs). …”
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Inflammatory cytokines and oral cancer risk: an integrated study combining two-sample Mendelian randomization with experimental validation by Yinhua Xia, Guanqun Wan, Simin Li, Shaonan Hu, Guohui Wu

“…Abstract Objective This study aimed to investigate the causal relationship between inflammatory cytokines and oral cavity cancer risk using Mendelian randomization analysis and experimental validation. Methods Two-sample Mendelian randomization was conducted using summary-level genome-wide association study data on 41 inflammatory cytokines and oral cavity cancer risk in Europeans. …”
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The association between serum albumin levels and metabolic syndrome based on the NHANES and two sample Mendelian randomization study by Yile Tang, Yong Fan, Jin Su, Zisen Yang, Zaoling Liu

“…The association of serum albumin levels with metabolic syndrome and its components was estimated using weighted multivariable logistic regression, with its nonlinearity being examined by restricted cubic spline (RCS) regression. Bidirectional two-sample Mendelian randomization (MR) analysis was performed using Genome-Wide Association Study (GWAS) data on serum albumin and MetS to assess the causal relationship between serum albumin levels and MetS and its components. …”
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Bidirectional causal relationship between obesity and osteoarthritis: Insights from a two-sample Mendelian randomization study by Anne Kamps, Jos Runhaar, Katerina Trajanoska, William D. Thompson, Weiya Zhang, Bahar Sedaghati-khayat, Joyce B.J. van Meurs, Sita M.A. Bierma-Zeinstra

“…Method: This study employed a two-sample Mendelian randomization (MR) approach to investigate the bidirectional causal relationship between obesity, using body mass index (BMI) as its proxy, and OA of the knee, hip, and hand. …”
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Causal relationship between immune cells and venous thromboembolism: a bidirectional two-sample Mendelian randomization study by Wen Xiao, Danfeng Gu, Mingqi Zhang, Jiansu Liao, Tao Xu, Hailin Lu, Yang Zhao

“…Methods To systematically assess the causal relationships between 731 immune phenotypic traits and VTE, PE, and DVT, this study employed a bidirectional, two-sample Mendelian randomization (MR) approach. In the forward MR analysis, immune cell characteristics were treated as the exposure, while VTE, DVT, and PE were the outcomes. …”
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