Lipids, Apolipoproteins, Lipid‐Lowering Drugs, and the Risk of Cerebral Small Vessel Disease: A Mendelian Randomization Study by Yi Xie, Shuai Liu, Xinyue Wang, Hao Huang, Minghuan Wang, Wensheng Qu, Zhiyuan Yu, Wei Wang, Xiang Luo

“…Methods and Results Data on genetic instruments of lipids/apolipoproteins, as well as characteristic cerebral small vessel disease manifestations, including small vessel stroke (SVS) and white matter hyperintensity (WMH), were obtained from publicly genome‐wide association studies. Through 2‐sample Mendelian randomization analyses, it was found that decreased levels of high‐density lipoprotein cholesterol (odds ratio [OR], 0.85, P=0.007) and apolipoprotein A‐I (OR, 0.83, P=0.005), as well as increased level of triglycerides (OR, 1.16, P=0.025) were associated with a higher risk of SVS. …”
Get full text

Exploring the genetic causal inference between plasma lipidome and lung carcinoma: a bidirectional mendelian randomization study by Hongyu Pan, Jinyu Hu, Shanshan Gong, Yuchang Fei

“…Methods A bivariate two-sample Mendelian randomization (MR) study was conducted using data from public genome-wide association studies (GWAS). …”
Get full text

Exploring the causal relationship between CX3CL1 and prostate cancer prognosis using Mendelian randomization by Weisheng Li, Baoguo Xia, Weixin Chu, Likui Lu, Xuedong Liu

“…Finally, the impact of CX3CL1 on PCa was further explored using gene expression data, immune cell infiltration profiles, survival analysis, and single-cell sequencing. Results Two-sample Mendelian randomization analysis indicated that CX3CL1 was inversely associated with PCa risk. …”
Get full text

Assessing the Causal Relationship Between Various Immune Cells and Attention Deficit Hyperactivity Disorder: Mendelian Randomization Study by Qian Ge, Zhongyan Li, Weijing Meng, Chen Cai, Mengdi Qiu, Yafei Liu, Haibo Zhu

“…Methods In this study, 731 immune cells and the risk of ADHD were examined using publicly accessible genetic data and a two‐sample MR analysis. Included were four different types of immunological profiles: determinate cells (DC), proportional cells (PC), median brightness level (MBL), and morphological characteristics (MA). …”
Get full text

Effect of aloe vera and coconut in the management of xerostomia in patients with Sjogren’s syndrome: a crossover randomized clinical trial by Alaa Mahmoud, Basma Elsaadany, Mervat Eissa, Wesam Abd Elmoneim, Sherifa Tarek, Mai Zakaria

“…Aim: This study aimed to evaluate the efficacy of carboxymethyl cellulose (CMC)-based natural mixture of aloe vera gel and coconut oil as a salivary substitute in comparison to the conventional CMC for the management of xerostomia in a sample of patients with Sjogren’s syndrome (SS). Methods: This crossover randomized clinical trial included 24 patients diagnosed with SS. …”
Get full text

Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999–2004 and Mendelian Randomization by Jia C, Li H, Yang S, Liu Y, Liu L, Ma A, Zhang L

“…Genetic causality was investigated via two-sample Mendelian randomization (MR) using genome-wide association study (GWAS) data.Results: 20% of total participants reported migraines. …”
Get full text

The association of gut microbiota, immunocyte dynamics, and protein–protein ratios with tuberculosis susceptibility: a Mendelian randomization analysis by Hanxin Wu, Weijie Ma, Liangyu Zhu, Li Peng, Xun Huang, Lei Zhong, Rui Yang, Bingxue Li, Weijiang Ma, Li Gao, Xinya Wu, Jieqin Song, Suyi Luo, Fukai Bao, Aihua Liu

“…Given the unclear causal relationship between gut microbiota and tuberculosis and the scarcity of research on relevant plasma protein ratios in tuberculosis, Mendelian randomization analysis (MR) was employed for in-depth exploration. …”
Get full text

The causal relationship between immune cell phenotypes and esophageal cancer development: a bidirectional Mendelian randomization study by Xun Zhang, Hailang Zhou, Qianqian Meng, Weiyi Wang, Lu Zhou, Ying Xu, Haiqin Zhang, Zixu Zhang, Jinnian Cheng, Xiaopeng Zhan, Ji Li, Changping Hu, Fengli Zhou, Daming Yang, Luowei Wang, Yimin Chu, Haixia Peng

“…This study aimed to explore the potential causal associations between immune cell traits and EC risk using Mendelian randomization (MR) analysis. Methods A bidirectional two-sample MR analysis was conducted using genome-wide association study data from European populations. …”
Get full text

The Efficacy of Oral Dexamethasone in the Management of Symptomatic Irreversible Pulpitis Without Pulpotomy: A Non-Randomized Clinical Trial by Sara Chehab, Roula Abiad, Lara Nasr, Hala Sacre, Pascale Salameh, Reem Chamseddine, Romy Zouein, Louis Hardan, Naji Kharouf, Rim Bourgi, Roula El Hachem

Get full text

Effectiveness of individualized breastfeeding counseling during the dyad’s stay in rooming-in: a randomized, multicenter, open and parallel study by Mariana Torreglosa Ruiz, Elisa da Conceição Rodrigues, Marialda Moreira Christoffel, Cynthya Viana de Resende, Michele Curcino Cavalcanti, Marianne Guterres Ferreira, Jéssica Aparecida da Silva, Karine Emanuelle Peixoto Oliveira da Silva, Monika Wernet, Ana Letícia Monteiro Gomes, Maria Beatriz Guimarães Raponi, Jacqueline Faria de Oliveira, Divanice Contim, Ana Maria Linares

“…This study aims to evaluate the effectiveness of individualized counseling during the dyad’s rooming-in period and its role in maintaining exclusive breastfeeding until the sixth month of life, compared to standard care. Methods This randomized, multicenter, parallel, and open clinical trial was conducted at two Brazilian university hospitals. …”
Get full text

Screening and Validation of Potential Biomarkers of Immune Cells in Childhood Asthma Patients via Mendelian Randomization and Machine Learning by Zhang Y, Hai Y, Song B, Xu J, Cao L, Yasen R, Xu W, Zhang J, Hu J

“…Therefore, a deeper investigation of the correlation between immune cells and childhood asthma could lead to a better understanding of asthma’s origin, the identification of potential treatment targets, and the development of personalized treatment strategies.Patients and Methods: We used a two-sample Mendelian randomization (MR) analysis to investigate the possible causal relationship between childhood asthma and a total of 731 immune cells, including B cell (190), Maturation stages of T cell (79), Monocyte (43), Myeloid cell (64), TBNK (124), Treg (167), and CDC (64). …”
Get full text

Effects of Cashew Nut (Anacardium occidentale L.) Seed Flour in Moderately Malnourished Children: Randomized Clinical Trial by Ana Cristina Pereira de Jesus Costa, Mércia Kelly dos Santos Silva, Samae Batista de Oliveira, Luana Leite Silva, Alessandra Cruz Silva, Raidanes Barros Barroso, José de Ribamar Macedo Costa, Virlane Kelly Lima Hunaldo, Marcelino Santos Neto, Lívia Maia Pascoal, Márcia Caroline Nascimento Sá Ewerton Martins, Floriacy Stabnow Santos, Leonardo Hunaldo dos Santos, Gledson Weslley Pereira Santos, Maria Aparecida Alves de Oliveira Serra, Ariadne Siqueira de Araújo Gordon, Thiago Moura de Araújo, Márcio Flávio Moura de Araújo

“…The sample comprised 30 children born at term, aged between 2 and 5 years, and newly diagnosed with malnutrition (60 days or less), randomized into experimental and control groups. …”
Get full text

Mendelian randomization and multiomics comprehensively reveal the causal relationship and potential mechanism between atrial fibrillation and gastric cancer by Zhao Sicheng, Zhao Sicheng, Zhang Jingcheng, Zhang Jingcheng, Zhang Shuo, Zhang Shuo, Lou Jiaheng, Lou Jiaheng, Cai Yan, Cai Yan, Bai Xing, Bai Xing, Jiang Tao, Jiang Tao, Jiang Tao, Zhang Guangji, Zhang Guangji, Zhang Guangji

“…ObjectiveGastric cancer is a harmful disease, the comorbidity mechanism and causality relationship between this disease and other diseases are worth studying.MethodsUsing a two-sample Mendelian Randomization method, this study revealed the potential causal effect of atrial fibrillation (AF) on gastric cancer (GC) risk by constructing a genetic instrument containing 136 AF associated SNPs. …”
Get full text

Virtual Coach–Guided Online Acceptance and Commitment Therapy for Chronic Pain: Pilot Feasibility Randomized Controlled Trial by Erin D Reilly, Megan M Kelly, Hannah L Grigorian, Molly E Waring, Karen S Quigley, Timothy P Hogan, Alicia A Heapy, Charles E Drebing, Matias Volonte, Ummul-Kiram Kathawalla, Hannah E Robins, Katarina Bernice, Timothy Bickmore

“…We used Wilcoxon signed rank tests with the intention-to-treat sample to describe changes in secondary outcomes from pre- to postintervention within each group. …”
Get full text

Crowdsourcing integrated into a digital mental health platform for anxiety and depression: A pilot randomized controlled trial by Benjamin Kaveladze, Jane Shkel, Stacey Le, Veronique Marcotte, Kevin Rushton, Theresa Nguyen, Stephen M. Schueller

“…Optimizing intervention engagement and obtaining the large sample sizes needed for appropriate statistical power will be key challenges for similar studies.NCT: 04226742…”
Get full text

Shared decision-making for pediatric acute otitis media in the United States: a randomized emergency department trial by Jana L. Anderson, Lucas Oliveira J. E. Silva, Erik P. Hess, Derek E. Vanmeter, Aidan Mullan, Juan P. Brito, Ian G. Hargraves, Fernanda Bellolio

“…Although no significant reduction in antibiotic prescribing was observed, this may be due to the study’s limited sample size, which increases the risk of Type II error. …”
Get full text

Missing Value Estimation and Analysis in Neutrosophic RBD by Masum Raj, S. C. Malik, Rahul Thakur

“…Further, simulation study is conducted to evaluate the performance of various parameters across different sample sizes. The analysis demonstrates the efficacy of Neutrosophic Randomized Block Design in preserving the statistical properties of the dataset and ensures more accurate and reliable experimental conclusions. …”
Get full text

SREBF1, a target gene of multiple sclerosis and coronary heart disease: based on mendelian randomization study by Linqin Du, Yangyang Cui, Yang Zhou, Ofe Eugene Kwaku, Xuefeng Ding, Lang Zeng, Shikang Li, Lijuan Xiong, Yonghong Zhang, Peng Zhou, Kun Wang, Rongchuan Yue

“…Methods We conducted various methods, including two-sample MR. method, reverse, and multivariable MR analyses, to examine the causal relationship between MS and CHD. …”
Get full text

Acupuncture effects of post-stroke thalamic pain: a systematic review and meta-analysis of randomized controlled trials by Tianwei Zhang, Tianwei Zhang, Junying Zhai, Junying Zhai, Ling Cheng, Ling Cheng, Kaixin Jiang, Kaixin Jiang, Dayang Wang, Huawei Shi, Bin Wang, Xing Chen, Xinglu Dong, Li Zhou

“…In the future, more large-sample, high-quality RCTs are needed to provide primarily high-level evidence in evidence-based medicine regarding the safety and sustained effects of acupuncture treatment for PS-TP.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42024498698, identifier CRD42024498698.…”
Get full text

Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study. by Daniel B Rosoff, George Davey Smith, Nehal Mehta, Toni-Kim Clarke, Falk W Lohoff

“…<h4>Methods and findings</h4>Using large publicly available genome-wide association studies (GWASs) (results from more than 1.2 million combined study participants) of predominantly European ancestry, we conducted 2-sample single-variable Mendelian randomization (SVMR) and multivariable Mendelian randomization (MVMR) to simultaneously assess the independent impact of alcohol consumption and smoking on a wide range of CVD risk factors and outcomes. …”
Get full text