Assessing the Causal Relationship between Chronic Obstructive Pulmonary Disease and Tuberculosis: A Mendelian Randomization Study by Wang Z, Zhao S, Zhou Y, He Y

“…However, their causal relationship remains unclear.Methods: We utilized genome-wide association study (GWAS) datasets to conduct bidirectional two-sample Mendelian randomization and multivariable Mendelian randomization analyses. …”
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Causal associations between air pollution and breast cancer risk and survival: a Mendelian randomization study by Wenhuan Li, Yonggang Yang, Rong Xie, Xinyu Su, Pengfei Shi, Lin Chen, Bo Hu

“…Methods This study employed a two-sample Mendelian Randomization (MR) design to investigate the causal effects of PM2.5, PM10, NO₂, and NOx on breast cancer risk and survival. …”
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Serum uric acid levels as a causal factor in hypertension: Insights from Mendelian randomization analysis by Jiayue Xu, Jiajing Zhao, Jiaming Gu, Wenjian Wang, Jingxian Chen

“…MR, a genetic epidemiology technique, uses genetic variations as proxies to mimic a randomized controlled trial and minimizing biases from confounding and reverse causation. …”
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The use of sequential multiple assignment randomized trials (SMARTs) in physical activity interventions: a systematic review by Aoife Whiston, K. M. Kidwell, S. O’Reilly, C. Walsh, J. C. Walsh, L. Glynn, K. Robinson, S. Hayes

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Causal Relationship Between Circulating Inflammatory Cytokines and the Risk of Trigeminal Neuralgia: A Mendelian Randomization Study by Hui Shang, Xianqiang Liu, Mengying Bai, Xiao Li, Yuhang Lan, Bingbing Bai, Shuyun Yang, Xianlin Wu, Guocai Li

“…Methods This study aimed to assess the causal relationship between 41 inflammatory cytokines and TN using Mendelian randomization (MR) analysis. A two‐sample MR approach was utilized, employing genetic variation data on TN from a large publicly available genome‐wide association study (GWAS) comprising 1777 cases of European ancestry and 360,538 controls. …”
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Immune cells mediate the effect of plasma lipidomes on IgA nephropathy: a Mendelian randomization study by Quanxin Li, Ye Chen, Yahan Zhu, Xiaoyang Cui, Jichen Pan, Xiao Li, Xiaolin Liu

“…This study employs Mendelian randomization (MR) to investigate the causal relationship between plasma lipidomes and IgAN, with a focus on the potential mediating role of immune cells.Methods We analyzed the 179 genetically predicted plasma lipidomes and the IgAN gene using two-sample Mendelian randomization (TSMR) and multivariable MR based on summary-level data from a genome-wide association study, and the results were validated by liquid chromatography-mass spectrometry. …”
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Glucagon-like peptide-1 receptor agonists, inflammation, and kidney diseases: evidence from Mendelian randomization by Yu-Xuan Yao, Chen Tang, Feng-Lei Si, Ji-Cheng Lv, Su-Fang Shi, Xu-Jie Zhou, Li-Jun Liu, Hong Zhang

“…However, it remains unknown whether GLP1R agonists could provide similar protection against other kidney diseases.Methods We performed two-sample Mendelian randomization (MR) analyses to determine the causal effects of GLP1R agonists on multiple kidney diseases. …”
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A single-blind randomized controlled trial of celiac plexus block for analgesia after whipple surgery by Minpu Li, Lili Fang, Taotao Xing, Chenyang Wang, Shuyi Chen, Shui Yu, Jiali Zhu

“…Further studies with larger sample sizes are warranted to confirm these findings and explore long-term outcomes. …”
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Identification of EPHB4 as a potential causal gene and therapeutic target for endometriosis using Mendelian randomization by Shaohua Ling, Delong Xie, Lifang Huang, Siqi Huang, Chun Tian, Liying Huang, Rong Chen, Li Qin, Xiao Qin

“…However, this preliminary study is limited by sample size and population diversity, requiring further validation to confirm the reliability of these findings.…”
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The impact of lipidome on intervertebral disk degeneration, low back pain, and sciatica: a Mendelian randomization study by Ze-Yu Pang, Yi-Bo Zhu, Jun-Xian Hu, Xiao-Xiao Li, Yong-Jian Gao, Yi-Yang Wang, Qiang Zhou, Pei Li

“…To establish causality, we employed two-sample Mendelian randomization, supplemented by Bayesian model averaging for verification. …”
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3-Hydroxybutyrate, a metabolite in sustaining neuronal cell vitality: a mendelian randomization and in vitro experimentation by Xiaoling Hu, Yu Lin, Kaiwen Huang, HuiLin Xu, Changmei Huang Fu, Jiayin Ou, Xiude Fan, Zhe Li, Jiansong Fang, Shuhuan Fang

“…Methods Employing a two-sample and a mediation Mendelian randomization (MR) analysis of the IEU OpenGWAS database, involving 383,476 participants from a genome-wide association study (GWAS) and an exome-wide association study (ExWAS), we identified intermediary metabolites linking mtDNA-CN and Tau.Meanwhile, the effects of mediating metabolites on HT22 cell viability and its mitochondrial morphology were also assessed in conjunction with in vitro experiments. …”
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Bidirectional Mendelian randomization analysis of causal relationships between immune cell traits and recurrent aphthous ulceration by XIE Xuejie, XU Jun, LIU Yuan, CHEN Yue, TANG Li, GULINUER Awuti

“…Objective To explore the bidirectional causal relationship between 731 immune cell phenotypes and recurrent aphthous ulcers (RAU) using Mendelian randomization (MR). Methods A two-sample bidirectional MR study was conducted using publicly available genome-wide association study (GWAS) summary statistics for 731 immune cell phenotypes and the RAU GWAS summary data from the FinnGen consortium. …”
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A multi-omics Mendelian randomization identifies putatively causal genes and DNA methylation sites for asthma by Jia Wang, MD, Jinxin Hu, MS, Dan Qin, MD, Dan Han, MD, Jiapeng Hu, MD

“…Employing Summary Data-based Mendelian Randomization (SMR) and Two-Sample Mendelian Randomization (TSMR), we pinpointed asthma causal genes, causal DNA methylation sites, and methylation sites affecting gene expression, cross validated with at least 2 large-scale GWAS from each source. …”
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Non‐alcoholic fatty liver disease and heart failure: A comprehensive bioinformatics and Mendelian randomization analysis by Yayun Zhang, Lu Feng, Xin Guan, Zixiong Zhu, Yubin He, Xuewen Li

“…The GSE24807 dataset comprised 12 NASH samples and 5 healthy controls. The GSE57338 dataset included 313 cardiac muscle samples [177 HF patients (95 ischaemic heart disease patients and 82 idiopathic dilated cardiomyopathy patients) and 136 healthy controls]. …”
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Causal relationships between gut microbiota and polycystic ovarian syndrome: A bidirectional Mendelian randomization study by Ruo‐Lin Mao, Xiang‐Fei Wang, Jue‐Pu Zhou, Meng Wang, Rui Long, Lei Jin, Li‐Xia Zhu

“…Material and Methods We performed a bidirectional two‐sample Mendelian randomization (MR) analysis. Datasets were from the largest published meta‐analysis on gut microbiota composition and the FinnGen cohort of the IEU Open Genome‐Wide Association Study Project database. …”
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Effect of Gamification on Improved Adherence to Inhaled Medications in Chronic Obstructive Pulmonary Disease: Randomized Controlled Trial by Xiting Huang, Zhili Jiang, Yifan Dai, Yang Liu, Ziying Dai, Jing Wang, Liping Chen, Zhiqian Wang, Wenxiao Wu, Lihua Huang

“…Participants were randomly assigned to either the control group (51/102, 50%) or the experimental group (51/102, 50%). …”
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Associations between insomnia and pregnancy and perinatal outcomes: Evidence from mendelian randomization and multivariable regression analyses. by Qian Yang, Maria Carolina Borges, Eleanor Sanderson, Maria C Magnus, Fanny Kilpi, Paul J Collings, Ana Luiza Soares, Jane West, Per Magnus, John Wright, Siri E Håberg, Kate Tilling, Deborah A Lawlor

“…<h4>Methods and findings</h4>We used 2-sample mendelian randomization (MR) with 81 single-nucleotide polymorphisms (SNPs) instrumenting for a lifelong predisposition to insomnia. …”
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Causal Effects of Inflammatory Cytokines and Immune Cell Phenotypes on Spontaneous Abortion: Evidence From Mendelian Randomization by Lin S, Tian X, Kong S, Zhang B, Wang S, Zhu K, Liu X, Yeung WSB, Cao D, Yao Y

“…Shaochong Lin,1– 3,&ast; Xiangming Tian,4,&ast; Sijia Kong,5 Bolun Zhang,1– 3 Sidong Wang,2,6 Kongfu Zhu,2 Xiaomin Liu,7,8 William S B Yeung,2,6 Dandan Cao,2 Yuanqing Yao1– 3 1School of Medicine, Nankai University, Tianjin, People’s Republic of China; 2Shenzhen Key Laboratory of Fertility Regulation, Reproductive Medicine Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People’s Republic of China; 3Department of Obstetrics and Gynecology, The First Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 4Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 5Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, People’s Republic of China; 6Department of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China; 7Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, Shenzhen, People’s Republic of China; 8College of Life Sciences, University of Chinese Academy of Sciences, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yuanqing Yao, Shenzhen Key Laboratory of Fertility Regulation, Reproductive Medicine Center, The University of Hong Kong-Shenzhen Hospital, No. 1 haiyuan 1st Road, Futian District, Shenzhen, People’s Republic of China, Email yaoyq_hkuszh@126.com Dandan Cao, Shenzhen Key Laboratory of Fertility Regulation, Reproductive Medicine Center, The University of Hong Kong-Shenzhen Hospital, No. 1 haiyuan 1st Road, Futian District, Shenzhen, People’s Republic of China, Email caodd@hku-szh.orgPurpose: This study aims to investigate the causal relationship between inflammatory cytokines, immune cells and spontaneous abortion (SA).Methods: A bidirectional two-sample Mendelian randomization (MR) analyses was conducted based on the genetic data of 91 inflammatory cytokines (n=14,824), 731 immune traits (n=3757) and SA (18,680 cases and 162,987 controls) cohorts. …”
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Effects of YouTube Health Videos on Mental Health Literacy in Adolescents and Teachers: Randomized Controlled Trial by Rebekka Schröder, Tim Hamer, Victoria Kruzewitz, Ellen Busch, Ralf Suhr, Lars König

“…Participants of each sample were allocated to an experimental group (176 adolescents and 254 teachers) and a control group (176 adolescents and 248 teachers) through randomization. …”
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Inferring the Timing of Antiretroviral Therapy by Zero-Inflated Random Change Point Models Using Longitudinal Data Subject to Left-Censoring by Hongbin Zhang, McKaylee Robertson, Sarah L. Braunstein, David B. Hanna, Uriel R. Felsen, Levi Waldron, Denis Nash

“…We propose a new random change point model that utilizes routinely recorded individual-level HIV viral load data to estimate the timing of antiretroviral therapy (ART) initiation in people living with HIV. …”
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