Causal Associations of Sleep Apnea With Alzheimer Disease and Cardiovascular Disease: A Bidirectional Mendelian Randomization Analysis by Clémence Cavaillès, Shea J. Andrews, Yue Leng, Aadrita Chatterjee, Iyas Daghlas, Kristine Yaffe

“…We sought to examine the bidirectional causal relationships between SA, Alzheimer disease (AD), coronary artery disease (CAD), and ischemic stroke using Mendelian randomization. Methods and Results Using summary statistics from 4 recent, large genome‐wide association studies of SA (n=523 366), AD (n=94 437), CAD (n=1 165 690), and stroke (n=1 308 460), we conducted bidirectional 2‐sample Mendelian randomization analyses. …”
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Genetic prediction of the casual relationship between micronutrients and ER+ breast cancer: a Mendelian randomized study by Wei-Da Fu, Jin-Qiu Wang, Jin Luo, Ming-Ze Wei, Yong-Ping Dai, He-He Wang

“…Following the selection of appropriate IVs, we conducted a two-sample MR analysis. This analytical framework incorporated comprehensive sensitivity analyses to evaluate potential heterogeneity and horizontal pleiotropy, with the inverse variance weighted (IVW) method established as the principal analytical approach.ResultsThe findings of our study revealed a significant causal relationship between vitamin B6 and ER+ breast cancer. …”
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Association between chronic kidney disease and colorectal cancer: evidence from meta-analysis and Mendelian randomization by Shuyi Qian, Yuting Gong, Ying Chen

“…This research utilized a meta-analysis of cohort studies along with two-sample Mendelian randomization (MR) approaches to explore the causal impact of CKD on CRC. …”
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Bidirectional Mendelian randomization study of the relationship between brain imaging-derived phenotypes and obstructive sleep apnea by ZHANG Huihua, GAN Jing, HOU Miaomiao, LU Na

“…Objective·To elucidate the causal relationship between obstructive sleep apnea (OSA) and imaging-derived phenotypes (IDPs) through two-sample Mendelian randomization (MR) studies.Methods·The genetic data related to OSA were obtained from the genome-wide association study (GWAS) (ncase group=50 200, ncontrol group=401 484) in the FinnGen Biobank R11. …”
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Causal relationship between inflammatory cytokines and polycystic ovary syndrome: a bidirectional mendelian randomization study by Danling Tian, Jinfeng Chen, Liang Liu

“…We underwent dual-sample MR analysis with inverse variance weights (IVW) as the predominant MR methodology with multiple validity and heterogeneity analyses. …”
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Digital vertigo therapy: study protocol for a confirmatory randomized controlled trial in patients with vestibular vertigo by Markus Wirth, Jannik Pieper, Ulrike Heller, Michael Bulitta, Daniel Schmitz, Barbara Wollenberg, Hubert Löwenheim, Stephan Wolpert

“…Patients will be randomly assigned to one of two treatment groups and the endpoints examined in a pre-determined order. …”
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Causal relationship between type I diabetes mellitus and atrial fibrillation: A Mendelian randomization study by Yongkai Li, Shasha Liu, Yiming Dong, Jianzhong Yang, Yingping Tian

“…We employed inverse variance-weighted, weighted median, MR-Egger regression, simple mode, and weighted mode methods within a two-sample Mendelian randomization framework to assess the causal relationship between type 1 diabetes mellitus and atrial fibrillation. …”
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Does Tai Chi relieve fatigue? A systematic review and meta-analysis of randomized controlled trials. by Yu Xiang, Liming Lu, Xiankun Chen, Zehuai Wen

“…Further multi-center RCTs with large sample sizes and high methodological quality, especially carefully blinded design, should be conducted in future research.…”
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No causal effects of serum urate levels on the risk of chronic kidney disease: A Mendelian randomization study. by Daniel M Jordan, Hyon K Choi, Marie Verbanck, Ruth Topless, Hong-Hee Won, Girish Nadkarni, Tony R Merriman, Ron Do

“…<h4>Methods and findings</h4>We used Mendelian randomization (MR) methods to evaluate the presence of a causal effect. …”
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Unveiling Novel Protein Biomarkers for Psoriasis Through Integrated Analysis of Human Plasma Proteomics and Mendelian Randomization by Mao R, Zhang T, Yang Z, Li J

“…This was complemented by two-sample Mendelian randomization (TSMR), Summary-data-based Mendelian Randomization (SMR), and coloc colocalization studies to identify genetic correlations with protein targets linked to psoriasis. …”
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Transforming Health and Reducing Perinatal Anxiety Through Virtual Engagement: Protocol for a Randomized Controlled Trial by Carolyn Ponting, Rebecca J Baer, Kacie Blackman, Bridgette Blebu, Jennifer N Felder, Scott Oltman, Karen M Tabb, Laura Jelliffe Pawlowski

“…ObjectiveWe propose a randomized controlled trial of a dCBT (Daylight app, Big Health, Ltd) in a sample of low-income pregnant people oversampled for racial, ethnic, sexual, and gender minority identity. …”
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A Bidirectional Mendelian Randomization Study of Causal Relationships Between Migraine and White-Matter Structural Connectivity by Tong D, Zhang X, Xiao Z, Taothong S, Teeravarunyou P, Wu W, Wu S, Chen N, Tao S, Zhou J, Song Q, Liang F, Li Z

“…Dan Tong,1,2,&amp;ast; Xinyue Zhang,1,2,&amp;ast; Zhiyong Xiao,1,3,&amp;ast; Supattra Taothong,1,2 Prapawee Teeravarunyou,1,2 Wanxia Wu,1,2 Sai Wu,1,2 Nuo Chen,1,2 Siyuan Tao,1,2 Jun Zhou,1,2 Qian Song,4 Fanrong Liang,1,2 Zhengjie Li1,2,4 On behalf of International Headache Genetics Consortium (IHGC)1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Key Laboratory of Acupuncture for Senile Disease (Chengdu University of TCM), Ministry of Education, Chengdu, Sichuan, People’s Republic of China; 3Sichuan Jinxin Xinan Women’s &amp; Children’s Hospital (Bisheng), Chengdu, People’s Republic of China; 4National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, Tianjin, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Zhengjie Li, Email lzjbenjamin@163.comObjective: This study aims to investigate the potential causal relationship between migraine and white matter (WM) structural connectivity using genetic data and the Mendelian randomization (MR) analyses method.Methods: Genome-wide association study (GWAS) summary statistics for migraine (48,975 cases/540,381 controls) and 206 WM structural connectivity related imaging-derived phenotypes (IDPs) (26,333 samples) were collected. …”
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Neoadjuvant or concurrent atezolizumab with chemoradiation for locally advanced cervical cancer: a randomized phase I trial by Jyoti Mayadev, Dmitriy Zamarin, Wei Deng, Heather A. Lankes, Giulio Pesci, Hayeon Kim, Junzo P. Chino, Barbara Banbury, Ned Sherry, Elad Sharon, Sharad A. Ghamande, Catherine Ferguson, Loren Mell, Laura Holman, Cara Mathews, David O’Malley, Alexander Olawaiye, Elizabeth Hopp, Charles Leath, Larry Copeland, Robert Mannel, Roisin O’Cearbhaill, Carol Aghajanian, Russell J. Schilder

“…Forty patients were randomized, 36 received treatment, and 25 were evaluable for the primary endpoint. …”
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Gait physiotherapy with motor imagery in people with Parkinson’s disease: a protocol for randomized control GAITimagery trial by Constanza San Martín Valenzuela, Constanza San Martín Valenzuela, Constanza San Martín Valenzuela, Esperanza Ramírez Murcia, Estela Aznar-Requena, Dalia García Sotolongo, Rebeca Rosas-Martín, M. Luz Sánchez-Sánchez, M. Luz Sánchez-Sánchez

“…This study aims to determine if gait training combined with MI has a greater effect on the gait of people with PD than just gait training.MethodsThe GAITimagery is designed as a double-blind, randomized control trial, including a convenience sample in 2 parallel groups (1:1) with two interventions of 2 sessions per week during 6-week and 8-week follow-up. …”
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Exploring the Causal Relationship Between Gut Microbiota and Pulmonary Artery Hypertension: Insights From Mendelian Randomization by Lihuang Su, Xinghong Wang, Ya Lin, Yiying Zhang, Dan Yao, Tongtong Pan, Xiaoying Huang

“…Methods and Results We examined the association between gut microbiota taxa and PAH using inverse variance weighted 2‐sample Mendelian randomization analysis, Mendelian randomization–Egger, weighted median, and weighted mode methods. …”
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Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian Randomization by Yuyang Liu, Hui Feng, Hengchao Ma, Jing Li, Yang Yu, Hua Zhao, Xiaoguang Wang, Yun Li, Jun Zhang, Qi Liu

“…Objective This study aims to investigate the causal effects of various genetically predicted risk factors on sporadic vestibular schwannoma utilizing a Two-Sample Mendelian Randomization (MR) approach to enhance understanding of its etiology and inform prevention strategies. …”
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Associations between the gut microbiota, immune cells, and different subtypes of epilepsy: A Mendelian randomization study by Xu Zhang, Zhenlin Yang, Jingjing Guo, Yuanxin Wei, Jinzi Li

“…Methods We performed a two‐sample Mendelian randomization (MR) study focused on the relationships between different epilepsy subtypes associated with the GM and the mediating role of immune cells between different epilepsy subtypes and the GM. …”
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Mendelian Randomization Study Supports Genetic Liability to Obsessive–Compulsive Disorder Associated With the Risk of Alzheimer's Disease by Si Cao, Han Su, Xiaoyi Zhang, Chao Fang, Nayiyuan Wu, Youjie Zeng, Minghua Chen

“…This study aimed to assess the causal effect of OCD on AD risk by performing a two‐sample Mendelian randomization (MR) analysis. Methods Genome‐wide association summary statistics were obtained for OCD, comprising 2688 cases and 7037 controls, as well as for AD, including 21,982 cases and 41,944 controls from Kunkle et al.’s study, and 39,918 cases and 358,140 controls from Wightman et al.’s study. …”
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Causal Effect of Obstructive Sleep Apnea on Sick Sinus Syndrome: A Bidirectional Mendelian Randomization Study by Chen W, Pan W, Ling L, Jiang B, Zhang Y, Su X, Jiang T, Lin J

“…This study aims to investigate the potential causal relationship between OSA and the development of SSS.Methods: To evaluate the association between OSA and SSS, we utilized a bidirectional two-sample Mendelian randomization (MR) method. Genetic variant OSA association data were sourced from FinnGens genome-wide association studies, comprising 410,385 individuals, while SSS association data were obtained from deCODE genetics, involving a dataset of 1, 000,187 individuals. …”
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Dissecting Causal Relationships Between Gut Microbiota, Immunocyte Phenotype, and Migraine: A Mendelian Randomization Study by Yupei Lai, Yike Liu, Jiahao Chen, Yu Cao, Xiangsheng Zhang, Lu Li, Pengyu Zhou, Peng Sun, Jun Zhou

“…Methods We employed a two‐sample, two‐step Mendelian Randomization approach to examine the mediating effects of immunocyte phenotypes on the relationship between gut microbiota and migraine outcomes, including migraine with aura and migraine without aura. …”
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