The Causal Relationship Between Dietary Factors and the Risk of Intracranial Aneurysms: A Mendelian Randomization Analysis by Longyuan Li, Jiaxuan Li, Mei Chang, Xin Wu, Ziqian Yin, Zhouqing Chen, Zhong Wang

“…This study aimed to investigate whether dietary factors and habits are associated with intracranial aneurysms using Mendelian randomization (MR) analysis. <b>Methods:</b> A two-sample MR study was conducted to evaluate the association of dietary factors with IAs. …”
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Surgical managements for rhegmatogenous retinal detachment: A network meta-analysis of randomized controlled trial. by Xinyu Yan, Meng Xu, Fengjun Su

“…Frequentist network meta-analyses with the random-effects model was used to synthesize data. …”
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Identification of biomarkers for chronic lymphocytic leukemia risk: a proteome-wide Mendelian randomization study by Changyu Jin, Zehong Lu, Yuzhan Chen, Huijie Hu, Miao Zhou, Yanli Zhang, Guifang Ouyang, Tongyu Li, Lixia Sheng

“…This study used Mendelian randomization (MR) to investigate the causal relationship between 7156 plasma proteins and CLL risk. …”
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Exploring the causal relationship between inflammatory cytokines and intrahepatic cholangiocarcinoma: a Mendelian randomization study by Yue Tang, Jialu Chen, Delong Qin, Zonglong Li, Xinjian Xu, Zhaohui Tang

“…Methods The study used Mendelian two-sample randomization, drawing on inflammatory cytokine data from a genome-wide association study (GWAS) involving 8,293 healthy participants and cases of ICC. …”
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Causal role of immune cells in varicose veins: insights from a Mendelian randomization study by Qi-Feng Zhang, Qi-Li Liu

“…In this study, we utilized summary statistics from a genome-wide association study (GWAS) and employed bidirectional two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between immune cell phenotypes and varicose veins. …”
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Unveiling the immunological terrain of pancreatic ductal adenocarcinoma: strategies to prompt immunotherapy from Mendelian randomization by Peizan Ni, Lilin Li, KunPeng Du, Pengkhun Nov, Duanyu Wang, Changqian Wang, Qianzi Kou, Ying Li, Yangfeng Zhang, Chongyang Zheng, Wen Fu, Jiqiang Li

“…Methods Using Mendelian randomization, we studied causal relationships between PDAC and an array of immune cell traits, bacterial traits, inflammatory factors, and blood metabolites. …”
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Causal effect of potential risk factors on obstructive sleep apnea: a Mendelian randomization study by Jia Chen, Weixing Liu, Pei Li, Yue Liu, Zhiyuan Wang, Hui Liu, Jin Ye

“…We aimed to investigate the causal relationship between potential risk factors and OSA risk.Methods A two-sample Mendelian randomization approach was used to evaluate the causal association of 42 risk factors with OSA risk. …”
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Gut microbiota and protein-to-protein ratios in NAFLD: insights from Mendelian randomization and murine studies by Langhuan Lei, Wei Shi, Xing Yang, Jiali Lin, Qiuyu Liang, Xiaozhi Huang, Liuxian Pan, Wei Li

“…This study integrates Mendelian randomization (MR) analysis and experimental validation to identify microbial and molecular contributors to NAFLD and explore potential therapeutic targets.MethodsTwo-sample MR analysis was performed to assess the causal effects of gut microbiota and protein-to-protein ratios on NAFLD using inverse variance-weighted, maximum likelihood, MR-Egger, weighted median, weighted mode, and Wald ratio methods. …”
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Analysis of causal effects on metabolic syndrome and inflammatory bowel disease: a Mendelian randomization study by Danyang Zhang, Haitao Shi, Chongcao Wei, Fenrong Chen, Pan Zhang, Xin Gao, Yan Wang

“…Results Univariate two-sample MR (TSMR) revealed that WC was significantly linked to the risk of Crohn’s disease (CD) (OR = 1.659; 95% CI: 1.144–2.405; p = 0.008) and IBD (OR = 1.383; 95% CI: 1.050–1.822; p = 0.021). …”
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Gut microbiota and breast cancer risk: a Mendelian randomization study stratified by ER status by Jian Yue, Lei Gu, Sheng Chen, Fang Wen, Guoxing Huang

“…Method We conducted a two-sample Mendelian randomization (MR) analysis to examine genetically predicted causal associations between 473 GM features (abundance in stool) and BC, including overall BC (Ncase = 24,270, Ncontrol = 222,078), ER+ BC (Ncase = 14,540, Ncontrol = 221,705) and ER– BC (Ncase = 9,724, Ncontrol = 221,705). …”
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Causal relationship between immune cells and Guillain-Barré syndrome: a Mendelian randomization study by Huaiquan Liu, Shuoshuo Shao, Bo Chen, Shili Yang, Xinyan Zhang

“…ObjectiveThe aim of this study was to investigate the causal effect of immune cell phenotype on GBS using two-sample Mendelian randomization (MR) approach.MethodsThis study used MR to investigate the causal relationship between 731 immune cell phenotypes and GBS. …”
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Online Peer Support for Long-Term Conditions: Protocol for a Feasibility Randomized Controlled Trial by Grace Lavelle, Hannah Grace Jones, Ewan Carr, Elly Aylwin-Foster, Vanessa Lawrence, Alan Simpson, Matthew Hotopf

“…ObjectiveThis feasibility randomized controlled trial will investigate whether the CommonGround platform is usable and acceptable for people with long-term physical health conditions experiencing mild depressive symptoms and whether conducting a future, larger confirmatory randomized controlled trial is feasible. …”
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Unraveling the causal pathway between phosphatidylinositol, metabolites, and metabolic syndrome: a Mendelian randomization study by YueGuang Yang, YanLing Ma, Ming Li, YuBo Han, Li Liu

“…This study seeks to clarify the causal link between PI and MetS while investigating the role of mediating metabolites. Methods A two-sample Mendelian randomization (MR) analysis was performed to examine the association between PI and MetS, utilizing aggregated data from genome-wide association studies (GWAS). …”
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Liver enzyme and risk of vascular dementia: A univariable and multivariable Mendelian randomization of European descent by Jieyu Chen, Jianzhun Chen, Chunyu Liang, Chenxi Liu, Liu Jie, Bin Liu, Xinglong Yang

“…Abstract Background Observational studies have indicated a link between liver enzymes and dementia, but the causal relationship remains uncertain. We conducted a two‐sample Mendelian randomization (MR) study to investigate potential causal links between liver function markers (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], and γ‐glutamyltransferase [GGT]) and various forms of dementia (all‐cause dementia, Alzheimer's disease [AD], vascular dementia [VaD], and frontotemporal dementia [FTD]). …”
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Mendelian randomization study of lipid metabolites reveals causal associations with age-related macular degeneration by Miao Shui, Guoke Yang, Jiang Jiang, Sibo Wang, Rongfeng Liao

“…This study aims to elucidate the causal relationship between lipid metabolites and AMD using Mendelian randomization (MR) methodology. Methods: A two-sample MR analysis was conducted to explore the associations between specific lipid metabolites (such as bile acids, fatty acids, sphingolipids, and steroid hormones) and the incidence of AMD, as well as the potential causal effect of AMD on these lipid metabolites. …”
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Association between gynecological cancers and female infertility: insights from bidirectional Mendelian randomization analysis by Jifeng Li, Yifei Zeng, Dongxiao Zhang

“…This study aims to explore the causal relationship between FI and GC using bidirectional two-sample Mendelian randomization (MR) analyses, thereby informing future strategies for FI and GC prevention. …”
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The Relationship Between Serum Uric Acid and Gynecologic Cancer Risk: A Mendelian Randomization Study by Cai L, Yang C

“…This study uses Mendelian randomization (MR) to explore the potential association between serum UA levels and various gynecological cancers.Methods: In this two-sample MR study, summary statistical data of the genome-wide association studies (GWASs) on serum UA levels were extracted from the UK Biobank (UKB), and those on gynecological cancers were obtained from the FinnGen consortium, the Epidemiology of Endometrial Cancer Consortium (E2C2), and the Ovarian Cancer Association Consortium (OCAC). …”
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Evaluating the association between lipidome and female reproductive diseases through comprehensive Mendelian randomization analyses by Ye Ma, Fang Wu, Zeming Yu, Lu Yang

“…The two-sample MR (TSMR) approach was employed to investigate the causal relationships, with further validation using false discovery rate (FDR) and multivariable MR (MVMR) methods. …”
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Circulating mediators linking cardiometabolic diseases to HFpEF: a mediation Mendelian randomization analysis by Mingzhi Lin, Jiuqi Guo, Hongqian Tao, Zhilin Gu, Wenyi Tang, Fuliang Zhou, Yanling Jiang, Ruyi Zhang, Dalin Jia, Yingxian Sun, Pengyu Jia

“…Objectives This study aimed to identify cardiometabolic risk factors specifically driving HFpEF and to determine their underlying circulating mediators. Methods We used two-sample Mendelian Randomization (MR) to analyze the effects of obesity, Type 2 diabetes, hypertension, chronic kidney disease (CKD), and dyslipidemia on HFpEF and heart failure with reduced ejection fraction (HFrEF) in large European-ancestry GWAS datasets. …”
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Mendelian randomization identifies genetically predicted calorie dietary preference as causal risk factors for cancer by Kaiyuan Zhang, Jiaheng Lou, Jianbo Huang, Xiaochen Ni, Chuhang Wang, Jianing Guo, Wei Fan, Yuanlin Lv, Guangji Zhang, Tao Jiang

“…Methods In this study, data on dietary calorie preference were sourced from a large-scale genome-wide association study (GWAS) database of food liking, while information on 18 cancer types was obtained from Finger R9 database. Two-sample Mendelian randomization (MR) analysis was conducted to assess the causal effects of Calorie Dietary Liking on 18 types of cancers. …”
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