A Mendelian randomization study of type 2 diabetes and cancer risk in East Asians by Ling Li, Fangxuan Li, Zhanyu Pan

“…In an East Asian population, we leverage two-sample Mendelian Randomization to investigate the complex association between Type 2 Diabetes (T2D) and cancer susceptibility. …”
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Mendelian randomization analysis of causal relationship between celiac disease and autoimmune thyroid disease by YAN Junhao, GUO Xiaolei, LUO Zhaofeng, TANG Jian, WANG Zheng

“…Objective·To investigate the bidirectional causal relationships between celiac disease (CeD) and Hashimoto thyroiditis (HT) as well as Graves disease (GD), using a two-sample Mendelian randomization (MR) approach.Methods·Single nucleotide polymorphisms (SNPs) related to CeD, HT and GD were extracted from publicly available Genome-Wide Association Studies (GWAS) databases and used as instrumental variables. …”
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Exploring potential therapeutic targets for asthma: a proteome-wide Mendelian randomization analysis by Yuhan Jiang, Yifan Wang, Ju Guo, Zixuan Wang, Xuelin Wang, Xueming Yao, Hongxi Yang, Yingxue Zou

“…Methods This study employs summary-data-based Mendelian randomization (MR) and two-sample MR methods to investigate the association between 2940 plasma proteins from the UK Biobank study and asthma. …”
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Causal role of immune cells in primary liver cancer: a mendelian randomization study by Jia Liu, Tongyuan Zhang, Yang Gao, Dong Ji, Lijian Chen

“…Thus, this study aimed to explore the potential causal association between immune cells and primary liver cancer, encompassing hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Methods A two-sample mendelian randomization (MR) analysis was performed using summary statistics from genome-wide association studies (GWAS) of the 731 immune traits and primary liver cancer. …”
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Causal association between Parkinson’s disease and cancer: a bidirectional Mendelian randomization study by Chunyan Tang, Ping Fu, Liangqing Lin, Hui Zhou, Yunjun Huang, Yang Li, Sijun Zhao

“…Thus, we utilized Mendelian randomization (MR) analysis to explore the potential causal link between PD and various cancers.MethodsWe conducted a bidirectional two-sample Mendelian randomization (TSMR) of genetic variants associated with PD and 14 types of cancers. …”
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Free triiodothyronine and risk of gestational diabetes mellitus: an observational study and Mendelian randomization analysis by Yanan Li, Shuai Yang, Zixuan Huang, Yong Zhang, Haixia Guan, Jianxia Fan

“…Additionally, genome-wide association study (GWAS) summary statistics of FT3 and GDM were used to perform a bidirectional two-sample Mendelian randomization (MR) analysis to test for causal associations. …”
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Association of antihypertensive drug target genes with alzheimer’s disease: a mendelian randomization study by He Zheng, Chaolei Chen, Yingqing Feng

“…Exposure was derived from existing eQTL data in blood from the eQTLGen consortium and in the brain from the PsychENCODE and subsequently replicated in GTEx V8 and BrainMeta V2. We performed two-sample Mendelian randomization (MR) to estimate the potential effect of different antihypertensive drug classes on AD using summary statistics from a meta-analysis (111,326 cases and 677,663 controls) and further replicated in FinnGen cohorts (9301 cases and 367,976 controls). …”
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Identification of novel biomarkers and prognostic model for neuroblastoma using Mendelian randomization and transcriptomic analysis by Yongcheng Fu, Nan Zhang, Jian Cheng, Xiaohan Qin, Xing Zhou, Xiaoran Du, Yuanyuan Wang, Jingyue Wang, Da Zhang

“…This study aims to identify novel biomarkers for NB and develop a prognostic model using comprehensive analytical methods, including Mendelian randomization (MR) analysis. Methods Utilizing bioinformatics and Mendelian randomization methods, we explored biomarkers associated with neuroblastoma at the mRNA level. …”
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Effectiveness of an antioxidant-rich diet on childhood asthma outcomes: A randomized controlled trial by Theerapan Songnuy, Putrada Ninla-aesong, Piyada Thairach, Janjira Thok-Ngaen

“…The results suggest that for further investigation, a larger sample size and long-term multi-center trial are warranted. …”
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A Novel Sparse Polynomial Expansion Method for Interval and Random Response Analysis of Uncertain Vibro-Acoustic System by Shengwen Yin, Xiaohan Zhu, Xiang Liu

“…This study presents a novel interval and random polynomial expansion method, called Sparse Grids’ Sequential Sampling-based Interval and Random Arbitrary Polynomial Chaos (SGS-IRAPC) method, to obtain the response of a vibro-acoustic system with interval and random uncertainties. …”
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Association between gout and kidney stone: results from mendelian randomization and the NHANES study by Shengkai Jin, Shengkai Jin, Haochen Geng, Haochen Geng, Yichen Lu, Yichen Lu, Yuhua Zhou, Yuhua Zhou, Jing Lv, Jing Lv, Chaowei Fu, Chaowei Fu, Yuwei Zhang, Yuwei Zhang, Menglu Li, Ninghan Feng, Ninghan Feng, Ninghan Feng

“…This finding requires further large-sample studies and adequate follow-up.…”
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Serum metabolites and risk of sudden sensorineural hearing loss: A Mendelian randomization study by Wenhui Yuan, Yong Liu, Chao Liu, Yuanzheng Qiu

“…Here we performed a two-sample Mendelian Randomization (MR) analysis to systematically assess the causation between blood metabolites and SSNHL. …”
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Genetically supported causal genes for rheumatoid arthritis: Mendelian randomization and co‐localization analyses by Yuanyuan Niu, Fan Su, Simin Chen, Jingnan Wang, Shuoyang Zhang, Ruiru Li, Yu Kuang, Liuqin Liang, Youjun Xiao, Hanshi Xu

“…To explore the potential genes that may cause RA, we conducted a comprehensive Mendelian randomization analysis and co‐localization based on data from large sample size genome‐wide association studies. …”
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Leukocyte telomere length and lung function: a mendelian randomization study in European population by Shenyu Zhu, Shenyu Zhu, Wenlong Zheng, Dingyu Rao, Dingyu Rao, Zhixian Tang, Zhixian Tang, Xinhui Liao

“…However, the existence of a associated between leukocyte telomere length (LTL) and lung function remains uncertain.MethodsA two-sample Mendelian randomization (MR) analysis was used. …”
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The gut microbiota and diabetic nephropathy: an observational study review and bidirectional Mendelian randomization study by Yi Zhen Han, Yang Zhi Yuan Wang, Xing Yu Zhu, Bo Xuan Du, Yao Xian Wang, Xue Qin Zhang, Jia Meng Jia, Wei Jing Liu, Hui Juan Zheng

“…The European Bioinformatics Institute data included 1032 DN patients and 451,248 controls, while the FinnGen consortium data consisted of 3283 DN patients and 210,463 controls. Two-sample Mendelian randomization (TSMR) was utilized to determine the link between the GM and DN. …”
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Preliminary Study of Air Pollution and Adverse Pregnancy Outcomes: A Mendelian Randomization Study by Chunhan Shan, Liwen Chen, Huayan Mo, Xin Chen, Chen Han, Fangbiao Tao, Hui Gao

“…The chief aim of this research is to investigate the causality of air pollutants and adverse pregnancy outcomes. Two-sample Mendelian randomization was conducted, employing genetic variants connected with air pollution as instrumental variables. …”
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The causal relationships between mitochondria and six types of cancer: a Mendelian randomization study by Jincheng Tang, Jingting Zhang, Renyi Yang, Hongyao Chen, Xiaopeng Yu, Wei Peng, Puhua Zeng

“…This study aimed to evaluate the potential causal effects of 82 mitochondrial-related exposures on six major cancers—hepatic, colorectal, lung, esophageal, thyroid, and breast—using Mendelian randomization (MR). Methods Two-sample MR analysis was performed using the inverse variance weighted (IVW) method, with MR-Egger regression and weighted median as complementary approaches. …”
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Dietary intake and five types of mental disorders: a bidirectional Mendelian randomization study by Yichun Zhang, Mingzhu Zhang, Qihua Guan, Pengcheng Liu, Wangxin Zhang, Song Yang, Hualei Dong, Haifeng Hou

“…The study aimed to estimate the causal relationship between dietary macronutrient intake and mental disorders using a bidirectional two-sample Mendelian randomization (MR) analysis. Methods The causal relationships between dietary macronutrient intake (i.e., carbohydrate, fat, protein and sugar) and mental disorders (i.e., anxiety, bipolar disorder, depression, neuroticism and schizophrenia) were explored on the basis of UK Biobank and 5 datasets. …”
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Non-Randomized Comparative Study of Olfaction in post-COVID-19 Children. Intermediary Results by Leyla S. Namazova-Baranova, Georgiy A. Karkashadze, Irina V. Zelenkova, Alexander A. Baranov, Elena A. Vishneva, Elena V. Kaytukova, Dina S. Rusinova, Natalia S. Sergienko, Yuliya V. Nesterova, Svetlana G. Gubanova, Viktor A. Gankovskiy, Tinatin Yu. Gogberashvili, Tatiana A. Konstantinidi, Daria A. Bushueva, Anastasiya I. Rykunova, Olga B. Gordeeva, Ekaterina V. Shirdanina, Anastasiya D. Lamasova, Elizaveta V. Leonova, Alina R. Pankova, Ekaterina Yu. Dubonosova

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The Resilience of Attitude Toward Vaccination: Web-Based Randomized Controlled Trial on the Processing of Misinformation by Benoît Béchard, Julie A Gramaccia, Dominique Gagnon, Elhadji Anassour Laouan-Sidi, Ève Dubé, Mathieu Ouimet, Delphine de Hemptinne, Sébastien Tremblay

“…ResultsThe survey included 537 participants, with 12 excluded for not meeting the task completion time. The final sample comprised 525 participants distributed about equally across the 4 news article versions. …”
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