The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: a randomized controlled trial. by Brooke M Winzer, Jennifer D Paratz, Jonathan P Whitehead, David C Whiteman, Marina M Reeves

“…<h4>Results</h4>Recruitment was difficult in this population with a total of 33 participants recruited (target sample size: n = 80); 97% retention at 24-weeks. Adherence to the exercise protocol was moderate. …”
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Integrating single-cell with transcriptome-proteome Mendelian randomization reveals colorectal cancer targets by Song Wang, Xin Yao, Shenshen Li, Shanshan Wang, Xuyu Huang, Jing Zhou, Xiao Li, Jieying Wen, Weixuan Lan, Yunsi Huang, Hao Li, Yunlong Sun, Xiaoqian Zhao, Qiaoling Chen, Xuedong Han, Ziming Zhu, Xinyue Zhang, Tao Zhang

“…Subsequent batch Two-sample Mendelian randomization and further SMR analysis aimed to identify key genes in the pathogenesis of colorectal cancer. …”
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Bidirectional Mendelian Randomization analysis of iron status and uremia: no evidence of a causal relationship by Jianwei Chen, Hu Zhao, Yang He, Chen Lin, Yu Wang

“…Utilizing summary data from genome-wide association studies (GWAS) of iron status and uremia, a two-sample Mendelian Randomization (MR) design was employed. …”
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Immune Cell Proteins and Parkinson's Disease: A Mendelian Randomization Analysis of Causal Associations by Haining Li, Jianhang He, Tingting Xuan, Shue Gu, Xiaoyan Niu, Yazhou Ren, Xiuping Zhan, Jiang Cheng

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Circulating inflammatory cytokines and the risk of myasthenia gravis: a bidirectional Mendelian randomization study by Boyang Su, Zhengqing He, Luyao Shi, Mao Li, Xusheng Huang

“…In this study, a two-sample Mendelian randomization (TSMR) analysis was performed to explore the causal relationship between 91 circulating inflammatory cytokines and MG. …”
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Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study. by Despoina Manousaki, Adil Harroud, Ruth E Mitchell, Stephanie Ross, Vince Forgetta, Nicholas J Timpson, George Davey Smith, Constantin Polychronakos, J Brent Richards

“…<h4>Background</h4>Vitamin D deficiency has been associated with type 1 diabetes in observational studies, but evidence from randomized controlled trials (RCTs) is lacking. The aim of this study was to test whether genetically decreased vitamin D levels are causally associated with type 1 diabetes using Mendelian randomization (MR).…”
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Glucokinase activator, circulating metabolites, and cardio-cerebrovascular diseases: a Mendelian randomization study by Xiaohan Wang, Weimeng Cheng, Tingting Xu, Ping He, Tianyue Li, Ying Zhang, Zhonghai Wei

“…Data on 168 circulating metabolites measured by nuclear magnetic resonance spectroscopy, along with information on atrial fibrillation (AF), heart failure (HF), coronary artery disease (CAD), myocardial infarction (MI), and stroke, were retrieved from large-scale datasets. Using two-sample Mendelian randomization analysis, we investigated the causal associations between GKA and CVDs. …”
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An oropharyngeal device for airway management of conscious and semiconscious patients: A randomized clinical trial by Kalev Freeman, Zachary D. Miller, Robert Ramsey Herrington, Nathan T. Dreyfus, Philip Buttaravoli, Adam Burgess, Joshua P. Nickerson, Nirav Daphtary, Jason H. T. Bates

“…Of these, a convenience sample of 5 individuals was selected for MRI; the remaining individuals (n = 14) were randomized for the cross‐over study. …”
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Preventing respiratory illness in cerebral palsy: Results of a pilot randomized controlled trial. by Ryan J Coller, Kristina Singh-Verdeflor, Jens Eickhoff, Paul J Chung, Heidi M Kloster, Christopher C Cushing, Danielle M Gerber, Barbara J Katz, Siem Ia, Teresa Wagner, Roxana Delgado-Martinez, Gemma Warner, Lorena Porras-Javier, Thomas S Klitzner, Carlos F Lerner

“…These data inform the sample and design characteristics needed for efficacy testing of RE-PACT's ability to prevent severe respiratory illness.…”
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Causal Effects of Inflammatory Arthritis Subtypes on Fibromyalgia: A Comprehensive Mendelian Randomization Study by Wang F, Jiang D, Zhang Z, Hu Z, Liang Y

“…While observational studies suggest a higher prevalence of FM among IA patients, the causal relationship between IA and FM remains uncertain due to potential confounding factors and the possibility of reverse causation.Patients and Methods: We employed a two-sample Mendelian randomization (TSMR) approach to evaluate the causal effect of nine IA subtypes on FM, utilizing genetic summary data from large-scale genome-wide association studies (GWAS) encompassing up to 201,581 participants (exposure: IA phenotypes) and 168,378 participants (outcome: FM). …”
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Interprofessional homebased reablement intervention for older adults in Sweden: a randomized controlled trial by Lena-Karin Gustafsson, M. Söderman, C. Johansson, M. L. Elfström

“…This paper aims to report the measured effects of reablement among the older adults in terms of bio-psycho-social health that emerged in the randomized controlled trial (RCT). Methods A sample of older adults (65+) was studied, consisting of those who applied for homecare in the municipal home service (n = 237), those who received intensive home reablement (IHR) carried out by an interprofessional team, and a control group who received home-based care as usual. …”
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Mendelian Randomization Study Investigating the Causal Relationship Between Thyroid Dysfunction and Cerebral Infarction by Letai Li, Jiajie Leng, Haibing Xiong, Zishan Deng, Meng Ye, Haiyan Wang, Xin Guo, Shi Zeng, Haofeng Xiong, Jianhong Huo

“…ABSTRACT BACKGROUND There is an association between thyroid dysfunction and cerebral infarction (CI), but the causality cannot be determined. A two‐sample two‐way Mendelian randomization (MR) study was conducted to assess the causal relationship between thyroid function and CI. …”
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Association between human blood metabolome and risk of myocarditis: a mendelian randomization study by Ziyi Wang, Haonan Tian, Jun Wang

“…To identify potential biometabolic markers associated with myocarditis, we conducted a two-sample Mendelian randomization (MR) study. We performed preliminary MR analysis using the inverse variance weighted (IVW) method, supplemented by MR-Egger, weighted median, and weighted mode methods to adjust for false discovery rate (FDR). …”
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Exploring causal correlations between immune cells and diabetic neuropathy: a Mendelian randomization by Lingfen Ji, Puyu Li, Nana Duan, Jinjin Xu, Yijuan Song, Bohui Shu, Lijun Liang, Fuli Zhao

“…In this study, we conducted bidirectional two-sample MR to address this problem. Methods We used freely available genome-wide association study summary statistics. …”
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Exploring the Impact of Neuroticism on Lung Cancer Risk: Insights From Mediated Mendelian Randomization by Jie Zhang, Xiao Ma, Zhiyu Liu, He Wang, Binbin Lu, Zhaoxia Wang

“…The objective was to identify single nucleotide polymorphisms (SNPs) significantly associated with neuroticism and utilize them as instrumental variables in a two‐sample Mendelian randomization framework to evaluate the gender‐specific causal link between neuroticism and lung cancer risk. …”
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Exploring the relationship between cathepsin and age-related macular degeneration using Mendelian randomization by Qiuyuan Wang, Qiuyuan Wang, Shanjun Cai

“…The association between nine cathepsins and the two classifications of AMD were analyzed using multivariable Mendelian randomization (MVMR). Sensitivity analysis included Cochran’s Q-test and the MR-Egger intercept test.ResultsTwo-sample MR analysis showed that higher levels of cathepsin L2 were associated with a delay in the development of atrophic AMD (IVW: p = 0.017; OR = 0.885; 95% CI = 0.799–0.979). …”
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Bidirectional mendelian randomization assessment of causality between lactate levels and multiple autoimmune diseases by Hua Fan, Hongna Song, Qizhi Fu, Ganqin Du, Yongjie Bai, Canfei Zhang, Xiaofei Shi

“…Abstract Bidirectional two-sample Mendelian randomization (MR) was performed to provide genetic evidence for the causal association between multiple sclerosis (MS), type 1 diabetes(T1D), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), Crohn’s disease (CD), systemic lupus erythematosus (SLE), ulcerative colitis (UC) and lactate levels. …”
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Improving appendix cancer prediction with SHAP-based feature engineering for machine learning models: a prediction study by Ji Yoon Kim

“…Preprocessing involved label encoding, SMOTE (synthetic minority over-sampling technique) to address class imbalance, and an 80:20 train-test split. …”
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Unveiling the influence of lipidomes on inflammatory bowel disease: a bidirectional mendelian randomization study by Hang Lei, Yuhong Jiang, Zhe Chen, Jiaqi Yao, Wenjun Ma, Yiqi Huang, Pengcheng Zhang, Zhijun Xie, Lv Zhu, Wenfu Tang

“…Methods We obtained genome-wide association study (GWAS) summary statistics of lipidomes and IBD (including UC and CD) from published studies to perform two-sample Mendelian randomization (MR) analyses. Outliers were removed using radial MR, followed by the application of the inverse-variance weighted (IVW) method to assess causal relationships. …”
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Causal roles of immune cells and metabolites in chronic pancreatitis: a mendelian randomization study by Chao Zhang, Tao Yang, Yuan Yu, Qian Jia, Wan-Meng Xiao, Sha Liu, Ze-Hui Yu, Cheng-Li Wen, Yan Wei, Hao Li, Mu-Han Lü

“…Methods This study utilized publicly available genome-wide association study (GWAS) databases and conducted a two-sample Mendelian randomization (MR) analysis to examine the causal relationships (CRs) among 731 immune cells, 1,400 metabolites, and CP. …”
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