Exploring the causal relationship between immune factors and chondrosarcoma: a Mendelian randomization study by Taichuan Xu, Wentao Xiao, Wenjie Li, Xianfa Xu, Haiwen Zhang, Xian Zhang

“…However, the causal relationship is unknown. Methods A two-sample Mendelian randomization (MR) was used to explore potential correlations between 731 immunocyte phenotypes, 91 inflammatory proteins, and CHS. …”
Get full text

Novel therapeutic targets for metabolism-related diseases: proteomic Mendelian randomization and colocalization analyses by Yue-Yang Zhang, Bin-Lu Wang, Bing-Xue Chen, Qin Wan

“…We employed two-sample MR within this framework to assess the associations between 1001 plasma proteins and 5 metabolism-related diseases. …”
Get full text

Sex-specific Mendelian randomization phenome-wide association study of basal metabolic rate by Jack C. M. Ng, C. Mary Schooling

“…In this Mendelian randomization (MR) phenome-wide association study, using two-sample MR methods, we systematically and comprehensively investigated the health effects of genetically predicted BMR across the phenome sex-specifically. …”
Get full text

Dietary-related characteristics and cataract risk: evidence from a mendelian randomization study by Chen Li, Yicheng Lu, Mingxuan Chen, Qing Zhang, Zhe Zhang, Wenqun Xi, Weihua Yang

“…We conducted a two-sample MR analysis using data from the open GWAS database, focusing on individuals of European descent. …”
Get full text

Mendelian randomization analysis of immune cell populations, serum metabolites and hepatocellular carcinoma risk by Wei Shen, Yuanying Zeng

“…Methods A two-sample Mendelian randomization (2SMR) design was employed, based on large-scale genome-wide association studies (GWAS) databases, selecting single nucleotide polymorphisms (SNPs) strongly associated with immune cell features and plasma metabolites as genetic instrumental variables. …”
Get full text

Rhomboid Intercostal Block for Postoperative Analgesia in Mastectomy: A Prospective, Randomized Controlled Trial by Paulus Gunawan, I Gusti Ngurah Mahaalit Aribawa, Made Septyana Parama Adi

“…The sample size was based on prior data demonstrating opioid reduction with RIB undergoing mastectomy. …”
Get full text

Ultrasound guided pediatric caudal dose: a two-center randomized controlled trial by Kartik Syal, Ankita Chandel, Manjit Singh Kanwar

Get full text

The association between immune cells and acute kidney injury: insights from Mendelian randomization by Xianzhen Yang, XiaoLei Zhang, Denglu Zhang, Shengtian Zhao

“…Subsequently, we performed two-sample Mendelian randomization (MR) using inverse variance weights to explore the causal relationship between 731 immune cell characteristics and ARF and rapid kidney function declineas at the gene level. …”
Get full text

Causal relationship between circulating cytokines and myelodysplastic syndrome: a Mendelian randomization study by Xia Wang, Ye Zhang, Xueqing Xu, Xuntao Liu, Bin Zhang

“…This study used Mendelian randomization (MR) to examine the causal relationship between circulating cytokines and Myelodysplastic syndrome (MDS) onset. …”
Get full text

The association between breast cancer and lung cancer: a bidirectional Mendelian randomization study by Xiaoqian Li, Junjie Liu, Jingyi Zhang, Yidi Wang, Jianjun He, Huimin Zhang

“…This study explored the association between these two cancers through Mendelian randomization (MR) analysis. A bidirectional two-sample MR analysis was conducted with BC genome-wide association study (GWAS) data from the Breast Cancer Association Consortium (BCAC) included 228,951 individuals and the GWAS summary statistics from the Transdisciplinary Research in Cancer of the Lung (TRICL) of LC included 112,781 individuals. …”
Get full text

The effect of coagulation traits on the risk of retinal vein occlusion: a mendelian randomization study by Chaoyi Yuan, Chao He, Ling Zuo, Baoxing Liu, Hui Qi

“…This study aims to investigate the potential causal relationship between coagulation traits and the risk of RVO by analyzing publicly available genome-wide association study (GWAS) summary statistics. A two-sample Mendelian randomization (MR) analysis framework was employed to investigate the causal relationship between coagulation traits and the risk of RVO. …”
Get full text

From meta-analysis to Mendelian randomization: Unidirectional perspectives on the association of glaucoma with depression and anxiety. by Jie Deng, YuHui Qin

“…It employed R's 'meta' package to assess the association between glaucoma and depression or anxiety prevalence. The Mendelian Randomization (MR) analysis was conducted using R's 'TwoSampleMR' package, based on data from the IEU database data to explore the impact of glaucoma on depression and anxiety.…”
Get full text

ENERGY expenditure of COmmuting to school (ENERGYCO): protocol for a cluster randomized controlled trial by Pablo Campos-Garzón, Pablo Campos-Garzón, Víctor Manuel Valle-Muñoz, José Manuel Segura-Díaz, Manuel Ávila-García, Manuel Ávila-García, Romina Gisele Saucedo-Araujo, Romina Gisele Saucedo-Araujo, Ana Ruiz-Alarcón, Francisco David López-Centeno, Unai A. Pérez De Arrilucea Le Floc’h, Juan M. A. Alcantara, Juan M. A. Alcantara, Juan M. A. Alcantara, Luis Miguel Medel-Carbonell, David Rodriguez-Sanchez, Ana Ramírez-Osuna, Marina Castillo-Barragán, Estela Águila-Lara, Francisco Javier Huertas-Delgado, Manuel Herrador-Colmenero, Sandra Mandic, Sandra Mandic, Palma Chillón, Yaira Barranco-Ruiz, Emilio Villa-González

“…Regarding phase II, a total of 300 adolescents from different schools in three Spanish cities will participate in this cluster randomized controlled trial. As many schools as necessary to meet the target sample will be included. …”
Get full text

Effects of iranian guidelines on primiparous women’s childbirth experience: A randomized controlled trial by Mojgan Mirghafourvand, Shahla Meedya, Sakineh Mohammad-Alizadeh-Charandabi, Zahra Fardiazar, Eesa Mohammadi, Mohammad Asghari Jafarabadi, Mansour Rezaei, Solmaz Ghanbari homaie

“…Women’s birth experience was evaluated 24 hours postpartum using the Childbirth Experience Questionnaire (CEQ 2.0). An independent sample t-test was employed to compare the average scores between the groups. …”
Get full text

The Effects of Palmar Cooling on Repeated Sprinting Ability: A Randomized Controlled Clinical Trial by Michael Brown, Jacob Daniels, Marli Crabtree, Kenneth Thompson, Joshua Murphy, William Pannell, Ryan McGlawn

“…Fifteen graduate students were randomly assigned to either a palmar cooling intervention or placebo group (males: n = 8, females: n = 7; Avg. age: 24.06 yrs.) …”
Get full text

Mendelian randomization study reveals causal association between skin microbiome and skin cancers by Yong He, Liming Li, Yuancheng Li, Xiaoke Wang, Leqi Qian, Jiajia Yang, Mingjun Jiang

“…This study aimed to investigate the causal relationship between genetically predicted skin microbiome and skin cancer, including basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (CSCC), cutaneous melanoma (CM), and actinic keratosis (AK). A two-sample Mendelian randomization (MR) analysis was conducted using summary datasets of public genome-wide association study (GWAS) statistics. …”
Get full text

Serum Matrix Metalloproteinases and Risk of Urologic Cancers: A Bidirectional Mendelian Randomization Study by BoWen Yang, XiaoYu Zeng, HanYu Wang, JiuHuan Feng, ShuFang Hou

“…Using data from large-scale genome-wide association studies (GWAS), we employed two-sample Mendelian randomization (MR) methods to assess the causal relationship between serum MMPs and urologic cancers. …”
Get full text

Use of caffeine in 19,660 randomly selected U.S. adults: the role of overweight and obesity by Larry A. Tucker, Frank Beltran

“…The specific objective was to determine whether adults with higher BMIs or larger waist circumferences consume more or less caffeine than their counterparts.MethodsA sample of 19,660 randomly selected women and men, 20–75 years old, representing the U.S. adult population, was studied using a cross-sectional design. …”
Get full text

Causal impact of air pollution on head and neck cancer: a Mendelian randomization study by Dong-ling Huang, Bing-shuang Zhao, Hao Wu, Shu-zheng Wang, Hao-sheng Ni

“…Methods To investigate this relationship, we employed two-sample Mendelian randomization (TSMR), MRlap, and multivariable Mendelian randomization (MVMR) analyses using publicly available genome-wide association study (GWAS) datasets. …”
Get full text

Individual Characteristics in the Comprehension of Pandemic Video Communication: Randomized Controlled Between-Subjects Design by Daniel Adrian Lungu, Jo Røislien, Ionica Smeets, Siri Wiig, Kolbjørn Kallesten Brønnick

Get full text