The effects of coagulation factors on the risk of lung cancer: a Mendelian randomization study by Heran Zhou, Xinye Mao, Junhua Guo, Xuefei Yang, Ting Huang

“…To address this, a Mendelian randomization (MR) analysis was undertaken to explore the connections between coagulation factors and LC. …”
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A Mendelian randomization study on the causal association of circulating cytokines with diabetic nephropathy by Yiming Xu, Tian Xiao, Junqing Yang, Jiali Wang, Bingting Wang, Chen Qiao

“…This study aimed to investigate the causal relationship between DN and circulating cytokines with genetic data in the frame of Mendelian Randomization (MR). Methods We performed a two‐sample MR analysis to investigate the causal relationship in individuals of European ancestry, utilizing publicly available genome‐wide association study (GWAS) statistics. …”
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Causal relationship between mental disorders and hypercholesterolemia： a Mendelian randomization analysis by Zou Qian, Tang Ni, Liu Huanhui, Zhang Hanjing, Ma Xiaojie

“…As an important component of MetS， the relationship between hypercholesterolemia and mental disorder has been extensively reported， whereas few genome-wide association studies （GWAS） have been conducted to identify the causal role of mental disorders in hypercholesterolemia.ObjectiveTo explore the potential causal relationship between mental disorders and hypercholesterolemia by two-sample Mendelian randomization （MR） method.MethodsSummary data from GWAS were analyzed. …”
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A Mendelian randomized study of circulating antioxidants in the diet and risk of cardiovascular disease by Ruonan Yang, Mingyue Lv, Xiujuan Yang, Siwei Zhai

“…This study investigates the causal effects of five circulatory antioxidants on various cardiovascular diseases using Mendelian randomization (MR) to mitigate confounding biases.We conducted a two-sample Mendelian Randomization (MR) analysis utilizing summary-level genome-wide association study (GWAS) data from both the UK Biobank and FinnGen. …”
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The role of preeclampsia in breast cancer risk: insights from Mendelian randomization study by Chenfei Qian, Ganwei Xiong, Shihao Hong, Linzhe Miao, Yitao Guo

“…A two-sample Mendelian randomization (TSMR) approach was applied, primarily using inverse variance weighting (IVW) to assess the causal impact of preeclampsia on breast cancer risk. …”
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Genetic correlation and mendelian randomization reveal the impact of sleep traits on urolithiasis risk by Mo Yan, Zhe-xin Zhang, Jia-xin Hu, Kai-bin Wang, Cheng-yi Liu

“…We used publicly available genome-wide association study (GWAS) summary data from the UK Biobank and FinnGen to perform a two-sample Mendelian randomization (MR) analysis and genetic correlation analysis, evaluating the causal relationship and genetic correlation between sleep traits (chronotype, getting up in the morning, sleep duration, nap during the day, and insomnia) and urolithiasis (calculus of the kidney and ureter, and calculus of the lower urinary tract). …”
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Metformin reduces the risk of frailty: evidence from a Mendelian randomization study by Tong Chen, Yan-Lan Liu, Hui-Na Qiu, Chen-Ying Lin, Fan Wu, Jing-Bo Li, Jing-Na Lin

“…This study aimed to explore the genetically predicted causal relationship between metformin targets and FI. Methods A two-sample Mendelian randomization (MR) analysis was conducted. …”
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Immune Cells and Intracerebral Hemorrhage: A Causal Investigation Through Mendelian Randomization by Liumei Mo, Wei Pan, Wenjing Cao, Kui Wang, Li'an Huang

“…The principal analytical tool utilized in our study was the inverse‐variance weighted (IVW) method, incorporated as a key component of a two‐sample MR approach. To mitigate potential biases and verify the stability of the conclusions drawn from the primary analytical methods, a series of sensitivity analyses were performed. …”
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Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for stroke by Xueling Zhao, Menghao He, Desheng Zhou, Zhong Li, Lijuan Liu, Renyi Yang, Xinhua Zhu, Cuilan Gong, Siyang Yan

“…Abstract Background Stroke is a leading cause of death and disability worldwide, yet its treatment still faces significant challenges. Mendelian randomization (MR) has been widely used to discover new biomarkers and therapeutic targets. …”
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Mendelian randomization analysis reveals the causal relationship between immune cells and leukemia by Yaobin Lin, Shenghong Shi, Jianyuan Song, Shan Liu

“…Abstract Background Increasing evidence indicates certain types of immune cells are linked to leukemia, but whether this link is causal has remained unclear. Methods A two-sample Mendelian randomization (MR) analysis was conducted to examine the causal relationship (CR) among 731 immune cell traits and leukemia. …”
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Moxibustion for prehypertension and stage I hypertension: a pilot randomized controlled trial by Kyung-Min Shin, Ji-Eun Park, Tae-Han Yook, Jong-Uk Kim, Ojin Kwon, Sun-Mi Choi

“…Conclusion: In conclusion, the results of this study show that moxibustion (3 sessions/week for 4 weeks) might lower blood pressure in patients with prehypertension or stage I hypertension and treatment frequency might affect effectiveness of moxibustion in BP regulation. Further randomized controlled trials with a large sample size on prehypertension and hypertension should be conducted. …”
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Mendelian randomization analysis reveals causal relationship between allergic diseases and influenza by Hui Li, BSc, Yanping Zong, BSc, Lei He, BSc, Yujie Sun, BSc, Weibing Shi, MD, Jinchen Guo, MD

“…Observational studies have established a correlation between these 2 conditions; however, the precise direction of the causal relationship remains unclear. This Mendelian randomization (MR) study aims to evaluate the causal relationship between allergic diseases and influenza. …”
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Optimizing ERAS protocols in robotic nephron-sparing surgery: a randomized trial by Yiqiang Wang, Mangmang He, Lulu Lou

“…Methods A total of 240 patients undergoing Da Vinci robot-assisted partial nephrectomy were randomized (1:1) to ERAS (n = 120) or conventional care (n = 120) groups using a stratified block randomization method. …”
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Exploring the bidirectional causality between neuroticism and frailty: a Mendelian randomization analysis by Yuhang Xing, Rui Pu, Mengdie Fu, Zhikang Wang, Zhen Wang, Xiaopeng Shang, Guoli Yang, Zhiwei Jiang

“…This study employed a bi-directional two-sample Mendelian randomization (MR) approach to investigate the causal relationship between neuroticism and frailty. …”
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Procedure‐specific simulation for vaginal surgery training: A randomized controlled trial by Roxana Geoffrion, Nicole A. Koenig, Geoffrey W. Cundiff, Catherine Flood, Momoe T. Hyakutake, Jane Schulz, Erin A. Brennand, Terry Lee, Joel Singer, Nicole J. Todd

“…NCT05887570. Results We randomized 83 residents to intervention or control and 55 completed the trial (2011–23). …”
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Exploring lipidome mediated inflammatory pathways in acute pancreatitis using mendelian randomization by Wenbin Liu, Song Yang, Yuhan Li, Dava Tenzing, Ruizi Shi, Yang Jiang, Hao Deng, Enqiang Mao, Ying Chen, Yihui Wang

“…The investigation employed a two-sample, bidirectional Mendelian randomization method to investigate potential causal relationship between lipidome profiles, inflammatory mediators, and AP. …”
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Impairment of kidney function and kidney cancer: A bidirectional Mendelian randomization study by Yifei Lin, Yong Yang, Tingting Fu, Ling Lin, Xingming Zhang, Qiong Guo, Zhenglong Chen, Banghua Liao, Jin Huang

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Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysis by Fan Jiang, Junhao Tu, Wenqi Luo, Yizhen Jia, Qing Luo, Jing Ye

“…Methods: Utilizing data from the Genome-Wide Association Studies (GWAS) database, employing two-sample MR analysis to investigate the potential causal relationship between 233 circulating metabolites with the occurrence of CRS. …”
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Endometriosis Severity and Risk of Preeclampsia: A Combined Mendelian Randomization and Observational Study by Zu Y, Xie Y, Zhang H, Chen L, Yan S, Wang Z, Fang Z, Lin S, Yan J

“…This study aimed to further explore the potential association between endometriosis and PE/eclampsia through Mendelian randomization (MR) and confirm these findings in a retrospective cohort study.Methods: A two-sample MR study was performed using genetic variants associated with endometriosis from the Finnish database, with outcome data for PE and eclampsia from the UK Biobank. …”
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Genetic Influence of the Brain on Muscle Structure: A Mendelian Randomization Study of Sarcopenia by Ting Lei, Zichao Jiang, Jiahao Wang, Jiangyu Nan, Long Hua, Zewu Zhu, Yihe Hu

“…The inverse variance weighted (IVW), MR Egger, weighted median, weighted mode and Wald ratio methods were used for a two‐sample Mendelian randomization (MR) analysis between brain structures and sarcopenia‐related traits. …”
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