Associations and mediators between vitiligo and cardiovascular diseases: a Mendelian randomization study by Xiaoyan Zhang, Lei Pu, Cheng Pu, Qian He

“…Using summary statistics from genome-wide association study (GWAS), we conducted a bidirectional two-sample Mendelian randomization (MR) analysis and mediation analysis to investigate the causal association between vitiligo and 13 CVD outcomes and potential mediators. …”
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Association between venous thromboembolism and atrial fibrillation: a Mendelian randomization study by Caijing Dang, Wenkai Liao, Lin Xu, Wenshu Zhao, Yuxia Lu

“…Methods and results This two-sample bidirectional Mendelian randomization (MR) analysis was performed to investigate the causal relationship between VTE and AF. …”
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A comprehensive analysis through Mendelian randomization of immunological markers and sphingolipid metabolism by Dunpeng Yang, Wentian Zhang, Qibin Wang

“…Methods We conducted a two-sample MR analysis of 731 immunological features and 1,400 metabolites using inverse-variance weighted methodology. …”
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English Jazz Dance in menopause: protocol study for a randomized clinical trial by Julia Beatriz Bocchi Martins, Danielly Yani Fausto, Juliana da Silveira, Leonessa Boing, Thuane Huyer da Roza, Adriana Coutinho de Azevedo Guimarães

“…Method: This study is a protocol for a randomized clinical trial with menopausal women with two arms: Control Group and Jazz Intervention Group. …”
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Investigating potential drug targets for the treatment of glioblastoma: a Mendelian randomization study by Hongwei Zhang, Zixuan Wang, Xiaolong Qiao, Jiaxing Wu, Chuandong Cheng

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Causal association between dietary factors and telomere length revealed by mendelian randomization by Xinghai Yue, Hongfei Liu, Wenzhao Guo, Yuhang Gao, Shaoshun Shi

“…The stability of the effect of significant results is assessed using multivariable Mendelian randomization (MVMR) and MR-lap. Two-sample MR analysis revealed a statistically significant association between dried fruit intake and telomere length (β = 0.223, 95% CI 0.091 to 0.356, P IVW =9.089 × 10^-4). …”
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Association between autoimmune diseases and myelodysplastic syndrome:a Mendelian randomization study by Zhengyang Miao, Wenwei Zhu, Yongming Zhou, Hailin Chen

“…A two-sample MR analysis was performed using summary-level statistics sourced from GWAS datasets. …”
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The statistical fragility of vertebroplasty outcomes: A systematic review of randomized controlled trials by Alexander Yu, Kareem S. Mohamed, Mark Kurapatti, Junho Song, Jonathan J. Huang, Prabhjot Singh, Yazan Alasadi, Abhijeet Grewal, Avanish Yendluri, Nikan Namiri, John Corvi, Jun S. Kim, Samuel K. Cho

“…Randomized clinical trials (RCTs) on vertebroplasty are crucial for guiding the treatment of vertebral compression fractures, but their overlooked statistical fragility can undermine clinical reliability. …”
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Unraveling the role of blood cell perturbation responses in lung cancer by Mendelian randomization by Yichao Huang, Xinjing Lou, Ziqing Han, Linyu Wu, Chen Gao

“…Methods This study employs two-sample mendelian randomization, incorporating lung cancer data from the IEU OpenGWAS project, as well as hematopoietic perturbation response data, to investigate the causal relationships between hematopoietic perturbation responses and lung cancer. …”
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The relationship between smoking and recurrent aphthous stomatitis: A Mendelian randomization study by Yujiao Hu, Cheng Chen, Fei Yu, Jin Zhang, Hui Zeng

“…We employed Mendelian randomization (MR) to clarify the potential causal association between smoking and the risk of developing RAS. …”
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Characteristics of randomized trials published in Latin America and the Caribbean according to funding source. by Ludovic Reveiz, Stephanie Sangalang, Demian Glujovsky, Carlos E Pinzon, Claudia Asenjo Lobos, Marcela Cortes, Martin Cañón, Ariel Bardach, Xavier Bonfill

“…As a comparison, aesthetic and sport related interventions account for 4.6% of all trials. A random sample of RCTs (n = 358) was assessed for funding source: exclusively public (33.8%); private (e.g. pharmaceutical company) (15.3%); other (e.g. mixed, NGO) (15.1%); no funding (35.8%). …”
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Carnitine is causally associated with susceptibility and severity of sepsis: a Mendelian randomization study by Qingju Zhang, Xilong Liu, Qi Shen, Xingfang Wang, Jiaojiao Pang, Yuguo Chen

“…Therefore, we aimed to explore whether there is a causal relationship between carnitine levels and sepsis. Methods. Two-sample Mendelian randomization (MR) analysis was performed. …”
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Protective role of gout against colorectal cancer: a Mendelian randomization study by Xia Pan, Yong’an Liu, Xiaoming Zhang, Yan Meng

“…Methods A two-sample MR analysis was conducted using genetic instruments for gout derived from genome-wide association studies (GWAS) in both discovery and replication cohorts. …”
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The Causal Relationship Between Neurotrophic Factors and Delirium: A Mendelian Randomization Study by Han Wu, Ruilai Jiang, Xiaocheng Huang, Xiaogang Hu

“…Herein, we performed a two‐sample Mendelian randomization (MR) analysis to investigate the causal relationship between these factors and delirium. …”
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Systemic Inflammatory Factors and Neuropsychiatric Disorders: A Bidirectional Mendelian Randomization Study by Hao Wang, Ziji Cheng, Zixuan Xu, Min Wang, Xingyang Sun, Wen Liu, Jingtian Wang, Qian Yang, Tuo Zhang, Jie Song, Yanjun Du, Xiaoming Zhang

“…Discussion The methodology utilized involved the standard inverse variance weighting method within a two‐sample, two‐way Mendelian randomization framework and integrated statistics from genome‐wide association studies. …”
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Lung function and nonalcoholic fatty liver disease: a Mendelian randomization study by Jiran Shen, Yue Wang, Sijing Zhou, Min Tang, Min Li, Rui Han, Ran Wang

“…We aimed to evaluate the causal effect of pulmonary function on NAFLD using the Mendelian randomization (MR) method. Material and methods We performed univariate MR, multivariate MR, and bidirectional two-sample MR analyses to jointly assess the causal relationship between pulmonary function and NAFLD. …”
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Identification of potential drug targets for diabetic polyneuropathy through Mendelian randomization analysis by Xiaokun Chen, Guohua Jiang, Tianjing Zhao, Nian Sun, Shanshan Liu, Hao Guo, Canjun Zeng, Yijun Liu

“…This study employed two-sample MR using MR-Egger and inverse-variance weighted methods to evaluate the causal relationship between plasma proteins and DPN risk, with Cochran’s Q test, and I2 statistics, among other methods, used to validate the robustness of the results. …”
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Exploring the association between systemic lupus erythematosus and osteonecrosis by Mendelian randomization analysis by Baochuang Qi, Jinglin Zhao, Chen Meng, Pengfei Bu, Lu Qiao Pu, Wanqiu Zhao, Chuan Li, Yongqing Xu

“…The Cochrane Q-test, MR-Egger interception, MR-multidirectional residual and outlier methods, entrance/exit analysis and funnel plot were applied for sensitivity analysis. Two-sample Mendelian randomization analysis of the 19 SNPs obtained from screening showed no significant causal effect of SLE and osteonecrosis, and IVW and MR-Egger heterogeneity analyses showed no significant heterogeneity between the instrumental variables (P > 0.05). …”
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Gut microbiota, allergic rhinitis, vasomotor rhinitis, Mendelian randomization, causal association by Xitan Lin, Xiaoyan Hu, Jing Zhang, Jing Luo, Gang Qin, Liang Jiang

“…Methods: We conducted a two-sample Mendelian Randomization (MR) study to investigate the genetic causal relationship between gut microbiota and allergic rhinitis and vasomotor rhinitis. …”
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Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study. by Irene Pichler, Fabiola Del Greco M, Martin Gögele, Christina M Lill, Lars Bertram, Chuong B Do, Nicholas Eriksson, Tatiana Foroud, Richard H Myers, PD GWAS Consortium, Michael Nalls, Margaux F Keller, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium 2, Beben Benyamin, John B Whitfield, Genetics of Iron Status Consortium, Peter P Pramstaller, Andrew A Hicks, John R Thompson, Cosetta Minelli

“…Epidemiological studies suffer from problems of confounding and reverse causation, and mendelian randomization (MR) represents an alternative approach to provide unconfounded estimates of the effects of biomarkers on disease. …”
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