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941
Mediators of the association between education and periodontitis: Mendelian randomization study
Published 2025-04-01“…Methods The biggest genome-wide association studies (GWAS) were used to conduct two-sample univariable Mendelian randomization (MR) analyses to evaluate the direct and combined effects of body mass index (BMI), smoking, household income, alcohol drinking, major depression, and EA on chronic periodontitis. …”
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942
RETRACTED: Mendelian randomization based on immune cells in diabetic nephropathy
Published 2024-08-01“…Sensitivity analysis ensured robustness, heterogeneity checks, and FDR correction minimized false positives.ResultsOur study explored the causal link between diabetic nephropathy (DKD) and immunophenotypes using two-sample Mendelian Randomization (MR) with IVW. Nine immunophenotypes were significantly associated with DKD at p<0.05 after FDR correction. …”
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943
Dietary factors and risk for endometriosis: a Mendelian randomization analysis
Published 2025-07-01“…The study aimed to investigate the potential causal association between dietary factors and endometriosis using Mendelian randomization (MR). Methods We performed a two-sample MR analysis to investigate the effects of 18 diet-related exposure factors (alcoholic drinks per week, alcohol intake frequency, processed meat intake, poultry intake, beef intake, non-oily fish intake, oily fish intake, pork intake, lamb/mutton intake, bread intake, cheese intake, cooked vegetable intake, tea intake, fresh fruit intake, cereal intake, salad/raw vegetable intake, coffee intake, dried fruit intake) on the risk of endometriosis using summary statistics from the genome-wide association study (GWAS). …”
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944
Breast Cancer and Meningioma Risk: A Mendelian Randomization Study
Published 2025-03-01“…ABSTRACT Background The exact nature of the link between breast cancer and meningiomas is unknown, although observational studies have shown a correlation between the two. Using a two‐sample Mendelian randomization (MR) strategy, we aimed to investigate the effect of breast cancer on meningiomas. …”
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945
Systemic lupus erythematosus and epilepsy: A Mendelian randomization study
Published 2024-12-01“…This study aimed to investigate the causal role of SLE in epilepsy or any of its subtypes using a two‐sample Mendelian randomization (MR) analysis. Methods Single nucleotide polymorphisms (SNPs) linked to SLE were utilized as instrumental variables in MR analysis to assess their causal impact on epilepsy. …”
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946
Mendelian randomization analysis to identify potential drug targets for osteoarthritis.
Published 2025-01-01“…<h4>Method</h4>Causal associations between 1553 circulating proteins and five OA-related traits were assessed in large-scale two-sample MR analyses using Wald ratio or inverse variance weighting, and the results were corrected for Bonferroni. …”
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947
Insomnia and sleep duration for kidney function: Mendelian randomization study
Published 2024-12-01“…This study aims to estimate this relationship using Mendelian randomization (MR).Methods Independent genetic variants strongly associated with insomnia (N = 462,341) and sleep duration (N = 460,099) were selected as instrumental variables from corresponding genome-wide association studies (GWAS). …”
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948
Micronutrients and skin cancer risk: a Mendelian randomization study
Published 2025-05-01“…This study systematically investigated the causal effects of 15 micronutrients on non-melanoma skin cancer (NMSC) and malignant melanoma (MM) using Mendelian Randomization (MR). Methods Genetically predicted levels of 15 micronutrients served as instrumental variables in a two-sample MR analysis, utilizing data from the Finnish FinnGen database (version R10). …”
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Characterization of medical device randomized controlled trials with adaptive designs
Published 2024-12-01“…Aim: Adaptive designs are frequently used in drug randomized controlled trials (RCTs). However, their use in medical device RCTs remains unclear. …”
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Mendelian Randomized Study of Protective Effect of Statins on Breast Cancer
Published 2025-02-01“…Instrumental variables for total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C) were derived from a previous human genome-wide association study and restricted to be chromosomally located within 100 kb of the above cholesterol regulatory genes; the instrumental variables could predict TC, LDL-C, or non-HDL-C levels under the regulation of the abovementioned cholesterol-associated genes which were used as exposure factors. Two-sample Mendelian randomization (IVW, MR-PRESSO, and MR-Egger) was used to explore the genetic effects of exposure factors on the risk of all breast cancers, ER+ breast cancer, and ER− breast cancer. …”
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951
Mendelian randomization study of sleep traits and risk of colorectal cancer
Published 2025-04-01“…Here we investigated whether genetically predicted chronotype, insomnia and sleep duration are associated with CRC risk in males, females and overall and according to CRC anatomical subsites using Mendelian randomization (MR). The two-sample inverse variance weighted (IVW) method was applied using summary-level data in up to 58,221 CRC cases and 67,694 controls and genome-wide association data of genetic variants for self-reported sleep traits. …”
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952
Estimating a Finite Population Mean Using Transformed Data in Presence of Random Nonresponse
Published 2020-01-01“…Developing finite population estimators of parameters such as mean, variance, and asymptotic mean squared error has been one of the core objectives of sample survey theory and practice. Sample survey practitioners need to assess the properties of these estimators so that better ones can be adopted. …”
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953
History-Dependent Patterns in Randomly Perturbed Nematic Liquid Crystals
Published 2013-01-01“…We focus on the impact of the samples history on the universal behavior. The obtained results are of interest for every randomly perturbed system exhibiting a continuous symmetry-breaking phase transition. …”
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954
Comparative Study of ASE-ASE and ASE-Laser Based Quantum Random Number Generators
Published 2024-01-01“…Quantum random number generators (QRNG) based on amplified spontaneous emission (ASE) are known to achieve multi-gigabit-per-second rates through high-speed sampling of intensity and phase fluctuations. …”
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Generalized Class of Finite Population Variance in the Presence of Random Nonresponse Using Simulation Approach
Published 2023-01-01“…In this article, we estimate the finite population variance in random nonresponse using simple random sampling, which may be helpful for data analysis in applied and environmental sciences. …”
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Improved Test for High-Dimensional Mean Vectors and Covariance Matrices Using Random Projection
Published 2025-06-01“…This paper proposes an improved random projection-based method for testing high-dimensional two-sample mean vectors and covariance matrices. …”
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The Risk Priority Number Evaluation of FMEA Analysis Based on Random Uncertainty and Fuzzy Uncertainty
Published 2021-01-01“…Accordingly, increasing studies have ignored the important impact of the random sampling uncertainty in the FMEA assessment. …”
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960
Reliability Analysis on Random Meshing Efficiency of Helical Gear based on Monte Carlo Method
Published 2021-06-01“…Five parameters that have a greater impact on the meshing efficiency are selected as random parameters. Through the normal distribution sampling of the random parameters,the reliability effects of each random parameter on the meshing efficiency are obtained. …”
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