Effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Menstrual Cycle Abnormalities, Hormonal Profile, and IGF-1 System in Polycystic Ovary Syndrome Pa... by Sally Kadoura, Marwan Alhalabi, Abdul Hakim Nattouf

“…Study Design. This is a randomized, placebo-controlled clinical trial. Setting. …”
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Evaluation of Pharmacokinetics and Safety of the Biosimilar (B01711) and Insulin Degludec/Insulin Aspart (IDegAsp, Ryzodeg) in Healthy Chinese Adults in a Randomized, Open-Label, S... by Liu H, Cao H, Li T, Chen X, Yu H, Sun J, Yu Y

“…All participants completed the study without any dropouts. Blood samples were collected at pre-defined intervals for PK analysis.Results: The primary PK parameters included the area under the curve (AUC) of insulin degludec (IDeg) from 0 to 24 hours (AUCIDeg, 0– 24 h), AUC of insulin aspart (IAsp) from 0 to the time of the last measurable value (AUCIAsp, 0-t), and the peak concentration of IAsp (CIAsp, max). …”
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On the effectiveness of the new estimators obtained from the Bayes estimator by Amani Alahmadi, Abdelkader Benkhaled, Waleed Almutiry

“…Estimating the mean parameters in random variables, particularly within multivariate normal distributions, is a critical issue in statistics. …”
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Prediction of Vanadium Contamination Distribution Pattern Through Remote Sensing Image Fusion and Machine Learning by Zipeng Zhao, Yuman Sun, Weiwei Jia, Jinyan Yang, Fan Wang

“…This study targets a vanadium-contaminated area in Panzhihua City, Sichuan Province. Soil sampling and spectral measurements occurred in the laboratory. …”
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Evaluating the feasibility of study methods for a future trial-based economic evaluation of a multistage shared decision-making program for type 2 diabetes mellitus: Protocol for a... by Anna Tichler, Dorijn F L Hertroijs, Ghislaine A P G van Mastrigt, Martijn C G J Brouwers, Dirk Ruwaard, Arianne M J Elissen

“…In this article, we outline its protocol, which focuses on sample recruitment and retention, study management, and feasibility of outcome and cost measurements.…”
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Comparative Study of Machine Learning Techniques for Predicting UCS Values Using Basic Soil Index Parameters in Pavement Construction by Mudhaffer Alqudah, Haitham Saleh, Hakan Yasarer, Ahmed Al-Ostaz, Yacoub Najjar

“…To evaluate the potential effectiveness of UCS for pavement engineering applications, a dataset of 152 laboratory-tested soil samples was compiled to develop predictive models. …”
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Exploring the Molecular Mechanism and Role of Glutathione S-Transferase P in Prostate Cancer by Shan Huang, Hang Yin

“…<b>Method</b>: Transcriptomic datasets from the Gene Expression Omnibus (GEO) database were analyzed to identify differentially expressed genes (DEGs) and enriched pathways in prostate cancer versus normal tissues. Two-sample bidirectional Mendelian randomization (MR) was employed to assess causal relationships between Glutathione metabolic enzymes (exposure) and prostate cancer risk (outcome). …”
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A Randomized, Placebo-Controlled, Single-Center, Crossover Study to Evaluate the Effects of Pre-Meal Whey Protein Microgel on Post-Prandial Glucometabolic and Amino Acid Response i... by Ian J Neeland, Luiz H de Gregório, Roberto Zagury, Bo Ahrén, Joel Neutel, Christian Darimont, John Corthesy, Yohan Grzywinski, Emilie Perrin, Maximilian von Eynatten, Odd Erik Johansen

“…Effects on PPG (primary endpoint), insulin, GLP-1, and branched-chain amino acids (BCAAs) were evaluated with frequent blood sampling. Changes in incremental areas under the concentration curve (iAUC) were compared using a mixed model. …”
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Do randomised clinical trials on dental caries adopt Open Science practices? by Carolina de Picoli Acosta, Jaisson Cenci, Bruna Brondani, Rokaia Ahmed Elagami, Tatiana Pereira-Cenci, Maximiliano Sergio Cenci, Marie-Charlotte D. N. J. M. Huysmans, Daniela Prócida Raggio, Mariana Minatel Braga, Fausto Medeiros Mendes

“…Two independent researchers assessed a random sample of these articles to evaluate their eligibility until reaching the minimum sample size. …”
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Adaptive Design for Phase II/III Platform Trial of Lassa Fever Therapeutics by Josephine Bourner, Michel Vaillant, Alex Paddy Abdel Salam, Marie Jaspard, Camille Fritzell, Shevin T. Jacob, Tom E. Fletcher, Michael Ramharter, Nnennaya Ajayi, Sylvanus Okogbenin, Cyril Erameh, Donald Grant, Robert Samuels, Oladele Oluwafemi Ayodeji, Armand Sprecher, Bronner P. Gonçalves, Tansy Edwards, Piero Olliaro

“…We propose an adaptive phase II/III multicenter randomized controlled platform trial that uses a superiority framework with an equal allocation ratio and accounts for challenges selecting the primary end point and estimating the target sample size by using an interim analysis. …”
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Assessing the replicability of RCTs in RWE emulations by Jeanette Köppe, Charlotte Micheloud, Stella Erdmann, Rachel Heyard, Leonhard Held

“…Results The sceptical p-value depends not only on the two p-values, but also on sample size and effect size of the two studies. It can be calibrated to have the same Type-I error rate as the two-trials rule, but has larger power to detect an existing effect. …”
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SMART: Structured Missingness Analysis and Reconstruction Technique for credit scoring by Seongil Han, Haemin Jung, Paul D. Yoo

“…Traditional approaches to addressing missing data, such as sample deletion or mean imputation, are widely used; however, they often prove insufficient for accurate prediction. …”
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The efficacy of parasacral transcutaneous electrical nerve stimulation for the treatment of overactive bladder in children: a systematic review and meta-analysis by Zhuoqi Cheng, Yumeng Chai, Zhongbao Zhou, Yong Zhang

“…However, it is important to note that the findings of this study are limited by the small sample size and imperfect outcomes. Further high-quality RCTs are needed to establish the most effective treatment protocol.…”
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MR analysis reveals no causal association between mitochondrial DNA copy number and osteoporosis by Misu Xiao, Cheng Guo, Quanjun Yang

“…This study aimed to elucidate the causal association between mtDNA-CN and osteoporosis using a two-sample Mendelian randomization (MR) approach. Genome-wide association studies (GWAS) summary data were utilized. …”
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Genetic evidence for a protective role of Omega-3 fatty acids in nummular dermatitis by Yi Chen, Zhimin Wu, Lucy Yue Lau, Boyang Li, Yipeng Pan, Alice Yang, Yuanyuan Zhang, Chao Shu, Yifei Ma, Hongyi Zhang, Wenjia Guo

“…Background: The causal relationship between Omega-3 fatty acids and nummular dermatitis remains unclear.Methods: We performed a two-sample Mendelian randomization analysis using six independent SNPs associated with circulating Omega-3 levels. …”
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Causal Links Between Bone Diseases and Temporomandibular Disorders by Ling Zhang, Qinghua Zhang, Dong Zhao

“…This study aims to investigate the causal relationship between bone joint-related diseases and TMD using Mendelian randomization (MR). Methods: We utilized a two-sample MR design, applying pooled genome-wide association study (GWAS) data from six subtypes of bone and joint diseases and TMD. …”
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Investigating the genetic association of mitochondrial DNA copy number with neurodegenerative diseases by Huan Xia, Zi-Hao Wang, Xiao-Bei Wang, Mei-Rong Gao, Sen Jiang, Xin-Yu Du, Xin-Ling Yang

“…Methods We conducted a bidirectional two-sample Mendelian randomization (MR) analysis using data from genome-wide association studies (GWAS) as instrumental variables (IVs). …”
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Bridging the gap: clinical translation of adipose-derived stem cells - a scoping review of clinical trials by Hankun Su, Hoksan Chau, Qilin Li, Fen Xiao, Yuanyuan Sun, Jingjing Chen, Yayi He, Jinyao Ning, Qin Hu, Yujie Xiao, Caiwen Li, Bixia Huang, Jing Zhao, Yanping Li, Hui Li

“…Spain (21.95%) and China (18.29%) and the USA (15.85%) led trial numbers, but 97% were single-country studies with a median sample size of 40. Primary endpoints trends from safety to efficacy. …”
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Causal association analysis between blood metabolomes and osteopenia and therapeutic target prediction for mechanomedicine by Ruobing Liu, Yaru Huang, Maogang Jiang, Fei Xu, Qilin Pei, Jiajun Ma, Youru Li, Siqi Shen, Bo Zhang, Xiangyang Guo, Jing Cai, Wenwen Wang

“…Utilizing genome-wide association study summary statistics, we analyzed 1091 metabolites and 309 metabolite ratios from 8299 individuals, correlating them with total body bone mineral density (BMD) from 56,284 individuals in the IEU GWAS database and osteopenia data from 408,961 European populations. Through two-sample Mendelian randomization, we investigated the association between blood metabolomes and skeletal characteristics. …”
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Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications by Chunxiao Cheng, Yuanjiao Liu, Lingyun Sun, Jiayao Fan, Xiaohui Sun, Ju-Sheng Zheng, Lin Zheng, Yimin Zhu, Dan Zhou

“…A metabolome-wide genome-wide association study (GWAS) in ZMSC, followed by two-sample Mendelian randomization (MR) analyses, was conducted to explore potential causal metabolite-T2D associations. …”
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