Effectiveness of a clinical decision support algorithm (ePOCT+) in improving quality of care for sick children in primary health facilities in Tanzania (DYNAMIC project): results f... by Dr Caroline Enos, Godfrey A. Kavishe, Alexandra V. Kulinkina, Sabine Renggli, Chacha D. Mangu, Lameck Luwanda, Peter Agrea, Humphrey Mhagama, Margaret Joram, Ibrahim Mtebene, Geofrey Isdory Ashery, Marie-Annick Le Pogam, Honorati Masanja, Nyanda E. Ntinginya, Valérie D'Acremont, Rainer Tan

“…Methods: 18 health facilities (9 intervention and 9 control, randomized 1:1) were sampled from the main cluster randomized trial. …”
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Comparative efficacy and safety of adalimumab biosimilar (BCD-057) and innovator in patients with psoriasis vulgaris. Results of the BCD-057-2/CALYPSO phase III international, mult... by Т. V. Korotaeva, A. V. Samtsov, A. L. Bakulev, M. M. Kokhan, I. K. Minullin, O. A. Vylegzhanina, V. V. Dubensky, B. V. Khalilov, A. A. Khotko, O. S. Zykova, I. V. Chumachenko, A. M. Lukyanov, A. V. Artemyeva, S. I. Derbin, E. Yu. Stukalina, E. V. Chernyaeva, R. A. Ivanov

“…After screening, the patients were randomized in a 1:1 ratio into BCD-057 or Humira® groups. …”
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Evaluating the effectiveness of six exercise interventions for low back pain: a systematic review and meta-analysis by Mei Cheng, Yu Tian, Qi Ye, Jun Li, Lin Xie, Fan Ding

“…Random effects models were employed to test for overall effects, heterogeneity, and bias. …”
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The effects of moxibustion in chronic heart failure patients: a systematic review and meta-analysis by Guancheng Chen, Wenxin Song, Weiwei Wu, Xuan Li, Jinyan Chen, Qiao Yang, Huili Liao

“…A meta-analysis of randomized controlled trials was utilized to aggregate the pooled metrics in patients with chronic heart failure (CHF) and to compare the clinical efficacy rate, N-terminal pro-B-type natriuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF), 6 min walk test (6MWT), and cardiac output (CO) variations between standard CHF treatment and standard treatment combined with moxibustion for CHF.ResultsThe study encompassed 22 randomized controlled trials (RCTs) involving 2,039 participants, with 1,021 in the experimental group and 1,018 in the control group. …”
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Causal relationships between inflammatory mediators, sleep traits, and cardiac magnetic resonance imaging-derived cardiac phenotypes by Shuhui Cao, Hongjie Xu, Yangfeng Tang, Zhiyun Xu, Shangyi Yu

“…Abstract This study investigated the causal relationships between cytokines, chemokines, neutrophil-related factors, sleep traits, and CMR-derived cardiovascular phenotypes using two-sample Mendelian randomization (MR) analysis. The primary method employed was inverse variance weighted (IVW) analysis, supplemented with MR-Egger and weighted median analyses. …”
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Efficacy of Submucosal versus Pterygomandibular Dexamethasone Injection in Surgical Extraction of the Impacted Lower Third Molar by Shaheen Ahmed, Usman Ashraf, Abdul Hafeez Shaikh, Soofia Jamil, Syed Jaffar Abbas Zaidi, Qaiser Ali Baig

“…Methodology: The study sample consisted of 72 patients who reported surgical extraction of their lower wisdom teeth and consented to participate in this study. …”
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Exploring Effects of Age at the Onset of Myopia on Multiple Diseases Using Electronic Health Records by Xiayin Zhang, PhD, Shan Wang, MD, Yu Huang, PhD, Yanjie Xie, PhD, Ishith Seth, MD, Gabriella Bulloch, MD, Chunran Lai, MD, Yijun Hu, PhD, Xianwen Shang, PhD, Mingguang He, PhD, Zhuoting Zhu, PhD, Honghua Yu, PhD

“…Cox proportional hazards analysis and 2-sample Mendelian randomization (MR) further confirmed associations between PRS and diseases passing Bonferroni correction. …”
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The Replication Crisis and Psychotherapy Efficacy Studies by Kutlu Kağan Türkarslan

“…Randomized controlled trials have problems and biases such as low sample size, allegiance bias, selective outcome reporting, strictness of inclusion or exclusion criteria, using wait-list as a control group, problems of randomization and blinding, exclusion of drop-out subjects from the analyses, and ignoring psychotherapists effects. …”
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Patients’ perceptions on non‐specific effects of acupuncture: Qualitative comparison between responders and non‐responders by Robin S.T. Ho, Fai Fai Ho, Jon Adams, Holger Cramer, Brenda Leung, Lesley Ward, Yan Zhang, Vincent C.H. Chung

“…We aimed to compare their experiences in a nested qualitative study embedded in an acupuncture randomized trial on functional dyspepsia. Methods: Purposive sampling was used to capture experience of responders (n=15) and non-responders (n=15) to acupuncture via individual in-depth interviews. …”
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Potential cerebrospinal fluid metabolomic biomarkers and early prediction model for Parkinson’s disease by Yifan Zhang, Yifan Zhang, Yuexin Yan, Xiangxu Kong, Haijun Zhang, Shengyuan Su

“…An XGBoost-based early prediction model was developed to assess the distinction between PD, prodromal PD, and HC. A two-sample bidirectional Mendelian randomization analysis was performed to examine the association between differential metabolites and Parkinson’s disease.ResultsSixty-four metabolites were significantly altered in PD patients compared to HC, with 58 elevated and 6 reduced. …”
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Genetic predisposition to digital device use and the risk of five psychiatric disorders by Qi Liu, Zhen Zhang

“…We aimed to uncover the causal links between digital device use and five psychiatric disorders risk utilizing the two-sample Mendelian Randomization method.MethodsWe obtained genetic variants related to digital device use from the UK Biobank’s genome-wide association study and psychiatric disorders data from the Psychiatric Genomics Consortium. …”
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Assessment of quality of presentation of clinical trial results in Russia in accordance with CONSORT standards by A. R. Kasimova, N. M. Guseinova

“…The authors paid the least attention to such details of the methodology when publishing a description of the sample calculation (2 out of 5 publications), the type of randomization (2 out of 5 publications), the mechanism of blinding participants (3 out of 5 publications), and implementation and masking (1 out of 5 publications). …”
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Exploring the role of EBV ZEBRA antibody levels in papillary thyroid cancer risk and drug resistance by Jiaqin Deng, Yeqian Lai, Ming Yu, Yihua Gu, Lihong Qiu, Yuedong Wang

“…To rigorously evaluate the causal relationship between EBV ZEBRA antibody levels and PTC risk, we conducted a two-sample bidirectional Mendelian randomization (MR) analysis leveraging large-scale genome-wide association study (GWAS) data. …”
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Safety and efficacy of omaveloxolone v/s placebo for the treatment of Friedreich's ataxia in patients aged more than 16 years: a systematic review by Ankita Umrao, Monika Pahuja, Nabendu Sekhar Chatterjee

“…However, the short duration, small sample size, and missing data, including the values of different measures of mFARS scores in patients, limit the generalizability of the results. …”
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Dynamics of mitochondrial DNA copy number regulation in relation to gastric cancer survival by Qizhou Yang, Tian Zhao, Yuying Han, Zhengguo Ji, Haihong Ye

“…Methods We performed two-sample mendelian randomization (MR) analyses to evaluate the causal relationship between mtDNA-CN in peripheral blood and overall survival period of different cancer types. …”
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Genetically predicted inflammatory protein mediate the association between lipidome and colon cancer by Sun Jiawei, Jiang Yixin, Shen Ting, Guan Yining

“…Methods We used a two-sample Mendelian Randomization (MR) strategy to assess the link between lipidomes and colon cancer risk. …”
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Exploring effects of Souvenaid on cerebral glucose metabolism in Alzheimer's disease by Nienke M.E. Scheltens, Casper T. Briels, Maqsood Yaqub, Frederik Barkhof, Ronald Boellaard, Wiesje M. van derFlier, Lothar A. Schwarte, Charlotte E. Teunissen, Amos Attali, Laus M. Broersen, Bart N.M. vanBerckel, Philip Scheltens

“…Methods We conducted an exploratory double‐blind randomized controlled single‐center trial. Fifty patients with mild cognitive impairment or mild dementia with evidence of amyloid pathology (cerebrospinal fluid or PET) were stratified for MMSE (20–24 and 25–30) and randomly 1:1 allocated to 24‐week daily administration of 125 mL Souvenaid (n = 25) or placebo (n = 25). …”
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Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study by Jiandong Zhao, Liwei Chen, Bing Han, Siyang Li, Yongxia Zhang, Ge Gao, Jinjing Liu

“…Abstract Background This Mendelian randomization (MR) study aimed to investigate bidirectional causal relationships between genetically predicted iron homeostasis, mitochondrial function, and the risk of laryngeal and hypopharyngeal cancers. …”
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CD9 expression rivals IDH mutation as a prognostic marker in glioma: a novel nomogram approach by Yue Peng, Qiang Ji, Qiang Ji, Xiangyu Guo, Weichunbai Zhang, Zixuan Yang, Wenbin Li, Wenbin Li

“…Two-sample Mendelian randomization (MR) assessed the causal link between CD9 expression and glioma risk using IVW, MR-Egger, and WM methods. …”
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Genetic Prediction of the Phosphate‐to‐Glucose Ratio Mediates the Association Between CXCL5 and Vascular Dementia by Guifeng Zhuo, Wei Chen, Yanan Hu, Jinzhi Zhang, Xiaomin Zhu, Mingyang Su, Yulan Fu, Wu Lin

“…Methods Using summary‐level data from genome‐wide association studies (GWAS), we conducted a two‐sample MR analysis to investigate the genetic prediction of CXCL5 and VaD. …”
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