A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 8-Week Pilot Study of Tuna-Byproduct-Derived Novel Supplements for Managing Cellular Senescence and Cognitive Declin... by Jintanaporn Wattanathorn, Wipawee Thukham-mee, Terdthai Tong-un, Weerapon Sangartit, Woraluck Somboonporn, Pongsatorn Paholpak

“…An 8-week, three-arm, randomized, double-blind, placebo-controlled parallel study was performed. …”
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Evaluation of a Maternal Behavior Change Communication (MBCC) dental public health intervention on pregnant women to prevent early childhood caries in their infants: a study protoc... by Arun M. Xavier, Balagopal Varma R, Radhamany K, Chandrashekar Janakiram, Nigel King, Sherene Alexander, Kavita Rai

“…Pregnant women (n = 450) aged 20–35 years in the 12th -20th week of gestation will be the sampling frame for the study, which will be extended to a 2-year postnatal period. …”
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Effect of Theme-Based Nursing Education on Disease Awareness, Serum Uric Acid Control, Quality of Life, and Acute Attacks in Patients with Gout: A Randomized Controlled Study at a... by Gao Z, Meng J

“…The innovative introduction of theme-based nursing education aims to enhance patients’ disease awareness, reduce acute attacks, and improve quality of life.Methods: This study is a randomized controlled trial, A total of 72 patients with gout admitted to Beijing Chaoyang Hospital between 1 January 2023 and 31 November 2023 were randomly divided into the intervention group and the traditional nursing health education group. …”
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Impact of a 3-Month Recall Using High-Fidelity Simulation or Screen-Based Simulation on Learning Retention During Neonatal Resuscitation Training for Residents in Anesthesia and In... by Anne-Claire Louvel, Cécile Dopff, Gauthier Loron, Daphne Michelet

“…The study outcomes justify the need for further studies with larger sample sizes to confirm the promising role of serious games in educational programs for medical students.…”
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An Integrated Cognitive Remediation and Recovery-Oriented Program for Individuals with Bipolar Disorder Using a Virtual Reality-Based Intervention: 6- and 12-Month Cognitive Outcom... by Alessandra Perra, Mauro Giovanni Carta, Diego Primavera, Giulia Cossu, Aurora Locci, Rosanna Zaccheddu, Federica Piludu, Alessia Galetti, Antonio Preti, Valerio De Lorenzo, Lorenzo Di Natale, Sergio Machado, Antonio Egidio Nardi, Federica Sancassiani

“…Further follow-up studies with control groups and larger sample sizes are needed to validate these findings.…”
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Efficacy and safety of risankizumab versus methotrexate in patients with moderate-to-severe plaque psoriasis: results from IMMbrace, a randomized, double-blind, phase 3 study with... by Tania F. Cestari, Cacilda da Silva Souza, Luna Azulay-Abulafia, Ricardo Romiti, André V.E. Carvalho, Caio César Silva de Castro, Sílvio Alencar Marques, João Roberto Antonio, Lincoln Fabrício, Ahmed M. Soliman, Tianshuang Wu, Ranjeeta Sinvhal, Vassilis Stakias, Alexandra P. Song, Jasmina Kalabic, Naomi Martin, Luiza Keiko Matsuka Oyafuso

“…Methods: IMMbrace was a phase 3, multicenter, randomized, double-blind, double-dummy, active-controlled study. …”
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The effect of co-administration of vitamin E and C supplements on plasma oxidative stress biomarkers and antioxidant capacity: a GRADE-assessed systematic review and meta-analysis... by Mahdi Moabedi, Mahdi Moabedi, Alireza Milajerdi

“…We conducted this meta-analysis to gain a clearer view of this area.MethodsWe performed a systematic search in online databases using the relevant keyword combination. Randomized controlled trials that investigated the effect of vitamins E and C simultaneously, compared with control, on oxidative stress and antioxidant status biomarkers were included in the analyses.ResultsA total of 17 trials were included in the meta-analysis, building a total sample size of 965. …”
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The safety and efficacy of spray cryotherapy after endoscopic sinus surgery in chronic rhinosinusitis: A systematic review of randomized controlled trials [version 2; peer review:... by Adham A. Aljariri, Ibrahim T. Abuawwad, Mohammad T. Abuawwad, Ayham R. Sara, Mohammad J. J. Taha, Obaida Falah, Abdulqadir J. Nashwan, Majed Akili, Ahmad J. Taha, Abdullah A. Elhakim

“…However, further research with longer follow-ups, a larger sample size, and subjective assessment is needed to assess any possible long-term side effects.…”
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Pre-intervention characteristics of the mosquito species in Benin in preparation for a randomized controlled trial assessing the efficacy of dual active-ingredient long-lasting ins... by Boulais Yovogan, Arthur Sovi, Gil G Padonou, Constantin J Adoha, Bruno Akinro, Saïd Chitou, Manfred Accrombessi, Edouard Dangbénon, Hilaire Akpovi, Louisa A Messenger, Razaki Ossè, Aurore Ogouyemi Hounto, Jackie Cook, Immo Kleinschmidt, Corine Ngufor, Mark Rowland, Natacha Protopopoff, Martin C Akogbéto

“…After morphological identification, a sub-sample of Anopheles gambiae s.l. were dissected for parity, analyzed by PCR for species and presence of L1014F kdr mutation and by ELISA-CSP to identify Plasmodium falciparum sporozoite infection. …”
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The Effect of Fungal Nutraceutical Supplementation on Postoperative Complications, Inflammatory Factors and Fecal Microbiota in Patients Undergoing Colorectal Cancer Surgery with C... by Cristina Regueiro, Astrid Irene Diez Martín, Sonia Pérez, Carlos Daviña-Núñez, Sara Zarraquiños, David Remedios, Cristina Alejandra Sánchez Gómez, Sara Alonso Lorenzo, Romina Fernández Poceiro, María Luisa de Castro Parga, Vicent Hernández Ramírez, Arturo Rodríguez-Blanco, Esteban Sinde, Catalina Fernández-de-Ana, Joaquín Cubiella

“…<b>Limitations:</b> The trial did not reach the calculated sample size.…”
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One-month evaluation of safety and immunogenicity of a Vi-DT typhoid conjugate vaccine (Bio-TCV®) in Indonesian subjects 6 months to 45 years: A phase III randomized clinical trial... by Bernie Endyarni Medise, I. Gusti Ayu Trisna Windiani, Dominicus Husada, Rini Sekartini, Hartono Gunardi, Angga Wirahmadi, Dwiyanti Puspitasari, Leny Kartina, I. Gusti Agung Ngurah Sugitha Adnyana, I. Gusti Lanang Sidiartha, I. Made Dwi Lingga Utama, I. Ketut Agus Somia, Iris Rengganis, Sukamto Koesnoe, Hindra Irawan Satari, Soedjatmiko Soedjatmiko, Sri Rezeki Hadinegoro, Ismoedijanto Ismoedijanto, Parwati Setiono Basuki, Gatot Soegiarto, Soetjiningsih Soetjiningsih, Rini Mulia Sari, Mita Puspita, Aria Kekalih, Sreshta Mukhi, Vianca Samara Andhary, Novilia Sjafri Bachtiar, Sushant Sahastrabuddhe

“…Methods: This is a randomized, observer blinded phase III trial using Vi-DT typhoid conjugate vaccine and an already WHO licensed prequalified (PQed) typhoid conjugate vaccine (Typbar TCV) as control. …”
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Variants of the Sliding Mode Control in Presence of External Disturbance for Quadrotor by Irfan Ahmad, Muwaida Liaquat, Fahad Mumtaz Malik, Hameed Ullah, Usman Ali

“…Secondly, kinodynamic Rapidly Exploring Random Tree with Fixed Node (RRT&#x002A;FN) which is an incremental sampling-based optimal algorithm has been implemented for online navigation and flight control of the quadrotor system. …”
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Evaluation of GLOCK 9 mm Firing Pin Aperture Shear Mark Individuality Based on 3,156 Different Pistols (Manufactured Over a 30 Year Period in Two Countries) Using Additional Patter... by James E. Hamby, Eric Warren, Stephen Norris, Nicholas D.K. Petraco

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Towards an Integrated <i>Orobanche</i> Management: Understanding Farmers’ Decision-Making Processes Using a Discrete Choice Experiment by Ahmed Yangui, Taheni Mlayeh, Zouhaier Abbes, Mohamed Kharrat

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Longitudinal Analysis of Risk Factors for Pulmonary Function Decline in Chronic Lung Diseases Over Five Years by Li L, Meng J, Chen J

“…A latent class growth model (LCGM) was established using CLDs as the baseline sample. This model stratified the patients based on the extent of the decline in Δpeak expiratory flow (ΔPEF), which served as the target variable. …”
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A Double-Blinded Randomized Study Investigating a Possible Anti-Inflammatory Effect of Saxagliptin versus Placebo as Add-On Therapy in Patients with Both Type 2 Diabetes And Stable... by Ida Unhammer Njerve, Sissel Åkra, Thomas W. Weiss, Svein Solheim, Reidun Øvstebø, Hans Christian D. Aass, Rune Byrkjeland, Harald Arnesen, Ingebjørg Seljeflot

“…Samples were taken at baseline and end of study in fasting state prior to intake of medications. …”
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CC Genotype at TCF7L2 Diabetes Risk Locus rs7903146 Directs a Coordinated Fatty Acid Response to a Mediterranean Diet Intervention: A Randomized Controlled Trial by Laurence D. Parnell, Chao-Qiang Lai, Christina Holzapfel, Jacob J. Christensen, José M. Ordovás

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Comparison of 3-Day and 7-Day Gonadotropin-Releasing Hormone Antagonist Treatment for the Prevention of Ovarian Hyperstimulation Syndrome in Women Undergoing Assisted Reproductive... by Vajiheh Hazari, Aida Najafian, Hamid Salehiniya

“…Data were analyzed using SPSS version 22, with independent samples t-test and Chi-square test conducted at a significance level of <0.05. …”
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Associations between serum uric acid and risk of depressive symptoms in East Asian populations by Menghui Yao, Xinxin Han, Yue Yin, Shuolin Wang, Yingdong Han, He Zhao, Hong Di, Juan Wu, Yun Zhang, Xuejun Zeng

“…Furthermore, we performed two-sample Mendelian randomization analyses to explore the potential causal relationships between them. …”
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Tislelizumab plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy for elderly patients with inoperable locally advanced esophageal squamous cell carcinoma: a multi... by Ke Zhang, Qifeng Wang, Jianzhong Cao, Chengcheng Fan, Wenbin Shen, Qin Xiao, Xiaolin Ge, Tian Zhang, Xiao Liu, Xi Chen, Jie Dong, Zewei Li, Zhunhao Zheng, Cihui Yan, Ping Wang, Qingsong Pang, Wencheng Zhang

“…Fresh or archival tumor tissues and peripheral blood samples will be used in exploratory studies. Discussion This study is the first “programmed death-1 (PD-1) inhibitor combined with concurrent chemoradiotherapy” for elderly patients with inoperable locally advanced ESCC (NCT06061146). …”
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