Protein Drug Targets for Abdominal Aortic Aneurysm and Proteomic Associations Between Modifiable Risk Factors and Abdominal Aortic Aneurysm by Yao Qi, Han Jiang, Yu Lun, Qingwei Gang, Shikai Shen, Han Zhang, Mingyu Liu, Yixian Wang, Jian Zhang

“…Methods Causal inferences between plasma proteins and AAA were drawn using 2‐sample Mendelian randomization, followed by comprehensive sensitivity testing, colocalization, and replication efforts. …”
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Efficacy and safety of hydroxychloroquine for treatment of mild SARS‐CoV‐2 infection and prevention of COVID‐19 severity in pregnant and postpartum women: A randomized, double‐blin... by Raquel González, Anna Goncé, Mª. del Mar Gil, Edurne Mazarico, Elena Ferriols‐Pérez, Paloma Toro, Elisa Llurba, Elisa Saéz, Miguel Ángel Rodríguez‐Zambrano, Laura García‐Otero, Marta López, Belén Santacruz, Mª. Ángeles Román, Antoni Payà, Sofia Alonso, Mónica Cruz‐Lemini, Clara Pons‐Duran, Luis Bernardo Herrera, Haily Chen, Azucena Bardají, Llorenç Quintó, Clara Menendez, the COVID‐Preg research group

“…Enrollment was stopped before reaching the target sample due to low recruitment rate. Trial registration EudraCT #: 2020‐001587‐29, on April 2, 2020. …”
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Machine learning-based coalbed methane well production prediction and fracturing parameter optimization by HU Qiujia, LIU Chunchun, ZHANG Jianguo, CUI Xinrui, WANG Qian, WANG Qi, LI Jun, HE Shan

“…A deep convolutional autoencoder-decoder was applied to unstructured data (e.g., well logs), and the integration of random forest with multi-task learning strategies effectively addressed limited sample sizes and poor generalization, ensuring high prediction accuracy under small-data conditions. …”
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Association between 25(OH) vitamin D and schizophrenia: shared genetic correlation, pleiotropy, and causality by Guo-Wei Rong, Guo-Wei Rong, Xiao-Min Li, Xiao-Min Li, Xiao-Min Li, Hui-Min Lu, Ming-Zhu Su, Ming-Zhu Su, Yi Jin, Yi Jin, Yi Jin

“…It leverages extensive sample data derived from Genome-Wide Association Studies (GWAS) to uncover genetic correlations.MethodsEmploying Linkage Disequilibrium Score Regression (LDSC) and S-LDSC, this study investigates genetic connections between 25OHD and SCZ. …”
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A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthma by Yuan Zhang, Xiaochen Du, Yujuan Yang, Yaqiong Ren, Lijun Zhou, Jun Hua, Hongying Wang

“…Methods A genome-wide screening of over 19,000 human genes was performed to identify cis-eQTL-regulated genes associated with childhood asthma. Two-sample MR was conducted to assess causality, followed by Summary-based Mendelian Randomization (SMR) to validate findings in independent datasets. …”
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Genetically predicted plasma metabolites mediate the causal relationship between gut microbiota and osteosarcoma by Xiuyu Qin, Zhuming Fan, Shaopeng Qiao, Jian Li, Jia Lv

“…The two-sample and two-step MR methods were used for the current analysis: (1) genetic causality between GM and plasma metabolites on OS; (2) mediation effects of plasma metabolites. …”
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Air Pollution and Oral Health: An Overall Insight From Genetic Causality by Ziyang Zheng, Mingzhang Xu, Yifei Wang, Lan Wang, Yang Zhou, Yunyi Deng, Ke Yu

“…Methods: This study utilized a two-sample Mendelian randomization approach to assess the causal relationship between air pollution and oral diseases. …”
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Observational and genetic evidence highlight the association of modifiable risk factors with the incidence and severity of neuroimmunological disorders by Jiang-wei Xia, Jia-jian Li, Yu Qian, Jinmin Han, Ming Lin, Ming-yang Wang, Teng Chen, Guo-liang Chai, Yi-nan Zhao, Jun-wei Hao

“…Additionally, we applied two-sample Mendelian Randomization (MR) analyses using genetic variants as instrumental variables to investigate the causal relationships of 32 modifiable lifestyle factors with 8 outcomes, representing risk and severity across three neuroimmunological diseases. …”
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Efficacy and safety of Tanshinone capsule in Acne vulgaris: a systematic review and meta-analysis by Yutong Deng, Ruli Feng, Bo Hu, Xuewen Ren, Fengchuan Zhang, Huishang Feng, Huishang Feng, Xuewan Wang, Yatong Li, Tangyunni Liu, Lingling Cai, Yuanwen Li

“…However, due to the limitations of this study, more multi-center and large-sample studies are needed to confirm these conclusions.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?…”
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Exploring the Association Between Immune Cell Phenotypes and Osteoporosis Mediated by Inflammatory Cytokines: Insights from GWAS and Single-Cell Transcriptomics by Kuang S, Ma X, Sun L, Wang C, Li Y, Wang G, Sun J, Zhou F, Zhang C

“…Despite established links between immune cell phenotypes and inflammatory cytokines and osteoporosis, the exact mechanism involved remains unclear, and further understanding is needed for effective prevention and treatment.Methods: Here, we performed a two-sample Mendelian randomization (MR) study to estimate the causal effects between 731 immune cell types, 91 and 41 inflammatory factors (which may have some overlap), and 5 types of osteoporosis. …”
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Secondary school randomized controlled interventions with a minimum dual approach to health and the links to BMI in pupils: A systematic review and meta-analysis within the project... by Derrick R. Tanous, Gerhard Ruedl, Mohamad Motevalli, Katharina C. Wirnitzer

“…The databases searched (12/2021) included PubMed, Education Source, and EMBASE. Only school-based randomized controlled trial interventions on PA and/or diet published in English or German were included. …”
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Identification of protein targets for dyslipidaemia and cardiovascular diseases among people with South Asian ancestry: a mendelian randomisation studyResearch in context by Siwei Wu, Devendra Meena, Alexander Smith, Jingxian Huang, Georg W. Otto, Yi-Hsuan Ko, James Yarmolinsky, Dipender Gill, Anand Rohatgi, Abbas Dehghan, Ioanna Tzoulaki

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Efficacy and Safety of Dulaglutide Biosimilar LY05008 Versus the Reference Product Dulaglutide (Trulicity) in Chinese Adults With Type 2 Diabetes Mellitus: A Randomized, Open‐Label... by Li Liu, Zhifeng Cheng, Lianwei Wang, Lili Zhang, Shunbin Li, Shu Li, Shuguang Pang, Qifu Li, Fang Bian, Junling Gu, Jie Shen, Liujun Fu, Baiping Sun, Yanyan Zhao, Changlin Dou, Zhaoyang Zeng, Lixin Guo

“…A well‐controlled phase 3 study with an adequate sample size was subsequently conducted for safety and efficacy evaluation. …”
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Efficacy and safety of reduning injection for severe pneumonia: a systematic review and meta-analysis by Yan Wang, Yan Wang, Baichuan Xu, Baichuan Xu, Peng Zhang, Peng Zhang, Suyun Li, Suyun Li, Suyun Li, Yang Xie, Yang Xie, Yang Xie

“…Further well-designed and standardized large sample clinical studies are needed for validation.Systematic review registrationPROSPERO, identifier CRD42024540365.…”
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POST‐UK (Adjunctive Intra‐Arterial Urokinase After Successful Endovascular Thrombectomy in Patients With Large‐Vessel Occlusion Stroke): Study Protocol of a Multicenter, Prospectiv... by Chang Liu, Fengli Li, Jiaxing Song, Xu Xu, Jiacheng Huang, Changwei Guo, Weilin Kong, Jie Yang, Xiaolei Shi, Jinfu Ma, Shihai Yang, Zhixi Wang, Shitao Fan, Liu Xiang, Sun Wenzhe, Nizhen Yu, Chengsong Yue, Zhouzhou Peng, Linyu Li, Cheng Huang, Dahong Yang, Duolao Wang, Jeffrey Saver, Thanh N. Nguyen, Raul G. Nogueira, Yangmei Chen, Wenjie Zi

“…The planned sample size is 498. Those eligible patients with anterior circulation large‐vessel occlusion stroke and achieving excellent to complete reperfusion by endovascular thrombectomy are planned to be consecutively randomized in a 1:1 ratio to the experimental group (a single dose of intra‐arterial urokinase) or to standard of care. …”
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A Double-blind Randomized Comparative Phase I Study to Assess Biosimilarity and Immunogenicity of "Trastuzumab" (LLC "Mabscale", Russia) and Herceptin® (F. Hoffmann-La Roche Ltd.,... by M. A. Kolganova, E. E. Beketov, V. V. Pisarev, A. V. Ivanov, S. V. Vasiliev, I. E. Shokhin

“…The study results showed that test and reference drug are biosimilar, and moreover immunogenicity assessment showed no anti-trastuzumab antibodies in any samples of healthy volunteers.…”
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The impact of Limosilactobacillus reuteri in combination with non-surgical periodontal therapy on periodontal clinical parameters and salivary and subgingival microbiota compositio... by Pengcheng Huo, Li Deng, Jiawei Lu, Powen Kan, Rui Jing, Li-jun Luo

“…Saliva and subgingival biofilm samples were collected for 16 S rRNA gene sequencing analysis. …”
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The effect of chitosan supplementation on liver function, hepatic steatosis predictors, and metabolic indicators in adults with non-alcoholic fatty liver disease: a randomized, dou... by Mohammad Ali Mohsenpoor, Karim Parastouei, Maryam Taghdir, Marzieh Akbarzadeh, Sepideh Abbaszadeh, Mohammad Ali Abyazi Heris, Mohammad Reza Mansouri Rad, Mohammad Amin Jafari, Ronak Borzooei

“…Methods Seventy-two adults with NAFLD were randomly assigned to consume either 1.5 g/day chitosan or placebo along with a low-calorie (− 500 kcal/day) diet for 8 weeks in a parallel, randomized, double-blinded, placebo-controlled, clinical trial. …”
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Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomi... by Haotian Zhao, Hongkang Zhu, Hezhang Yun, Jingqi Liu, Ge Song, Jin Teng, Dixin Zou, Naiyan Lu, Chang Liu

“…Muscle strength and muscle endurance measures were assessed, and fasting venous blood samples and morning urine samples were collected to evaluate their oxidative stress levels, inflammatory markers, and protein metabolism status.Results There were no significant differences observed in terms of dietary energy intake and composition between the two assessments conducted within a 24-hour period. …”
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Effect of heat therapy compared with strength training on metabolic profile, heat shock response, inflammation, cardiovascular responses and microbiota in individuals with type 2 d... by Patrícia Martins Bock, Lucas Stahlhöfer Kowalewski, Layane Ramos Ayres, Mariana Kras Borges Russo, Gabriela Tomedi Leites, Andreza Francisco Martins, Álvaro Reischak de Oliveira, Mauricio Krause

“…METHODS: Participants with T2DM will be randomized into control (any intervention), RT, or HT groups. …”
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