Design of a Randomized Sham-Controlled Trial: Strengthening Positive Treatment Expectations Using a Communication Model for Maximized Antiemetic Effects of Acupuncture and Antiemet... by Widgren Ylva MSP, Fransson Per PhD, Englund Erling PhD, Efverman Anna PhD

“…Patients (n = 198 patients according to a sample size calculation) with breast, colorectal, or bladder cancer undergoing neo-/adjuvant moderately to highly emetogenic chemotherapy are being randomized in 2 × 3 factorial design to the following conditions: 1. neutral or 2. positive communication style regarding expected treatment effects, during the antiemetic treatment types: A) standard care only (including antiemetics, no acupuncture), or, in addition to standard care, B) sham acupuncture with telescopic non-penetrating needles, or C) verum, penetrating acupuncture. …”
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A phase I, randomized, double-blind, parallel, single-dose pharmacokinetic study to evaluate the biosimilarity of KM118 (proposed pertuzumab biosimilar) with reference pertuzumab (... by Yan Li, Yu Wang, Caixia Yang, Na Zhao, Xinghe Wang

“…The sample size was 100 cases. The dosage was 420 mg. …”
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Bifidobacterium species serve as key gut microbiome regulators after intervention in gestational diabetes mellitus by Zifeng Cui, Shuxian Wang, Jianhua Niu, Jingmei Ma, Huixia Yang

“…At the same time, 38 normal glucose tolerance (NGT) samples served as controls. Additionally, we employed two-sample Mendelian Randomization (MR) to validate our findings against Genome-Wide Association Study (GWAS) database. …”
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From infection to tumor: genetic evidence of viral antibody immune response’ role in urologic cancer development by Chen Wang, Qifa Zhang, Qiang Li, Yelong Wang, Xin Chen

“…Method This study employs a two-sample bidirectional Mendelian randomization analysis, utilizing genetic data on antibody levels and urologic tumors obtained from GWAS databases. …”
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Effects of Using a Smart Bassinet on the Mental Health of Military-Affiliated Pregnant Women: Protocol for a Randomized Controlled Sleep Health and Mood in Newly Expectant Military... by Michele L Okun, Jennifer L Payne, Lauren M Osborne, Leilani Feliciano, Andrew Lac

“…ObjectiveThis study describes a protocol for a new randomized controlled trial that aims to ameliorate the risk for PMADs through improving infant sleep or maternal sleep during the first 6 postdelivery months in a sample of military-affiliated women. …”
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High mortality among fishermen along the beaches of lake Victoria: secondary analysis of evidence from a randomized control trial to promote HIV testing and services uptake in Siay... by Kawango Agot, Benard O. Ayieko, Lila A. Sheira, Carol S. Camlin, Jayne Kulzer, Harsha Thirumurthy, Phoebe Olugo, Edwin D. Charlebois, Zachary Kwena

“…Results We screened 1,509 registered fishermen, of whom 934 were mapped to close social networks (the intent to treat sample), and 733 were enrolled. At baseline, participants’ median age was 36 years, 78% were married/cohabiting, 68% attained primary education or below, the majority (57%) earned ≤ USD 83 a month, and all were engaged in fishing/fish-related trade. …”
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SGLT2 inhibition mitigates intracerebral hemorrhage risk by modulating inflammation by Mingsheng Huang, Yiheng Liu, Cheng Chen

“…This study analyzed genome-wide association study (GWAS) data from individuals of European ancestry, focusing on the relationship between 92 inflammatory biomarkers and ICH. A two-sample, two-step Mendelian randomization (MR) approach was used to examine the potential connection between SGLT-2 inhibition and ICH, as well as to investigate whether inflammatory biomarkers mediate this relationship. …”
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Statins' protective effects on focal epilepsy are independent of LDL‐C by Zhen Sun, Jing Zhang, Yulong Li, Miao Tuo, Limin Yu, Yun Wang, Yanping Sun

“…It investigates the role of statins through the HMGCR gene and associated low‐density lipoprotein (LDL) cholesterol levels. Methods A two‐sample Mendelian randomization (MR) and summary‐data‐based MR (SMR) approach were employed using genetic instruments from genome‐wide association studies (GWASs) and expression quantitative trait loci (eQTLs). …”
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Role of gut microbiota and immune response in breast cancer progression by Xiaofang Zhang, Na Ma, Conghui Jin, Xiaoli Cao

“…Two-sample MR analyses were conducted to assess potential causal relationships between gut microbiota and breast cancer. …”
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Impact of liraglutide on albumin-to-creatinine ratio in type 2 diabetes mellitus: a meta-analysis by Feng Wang, Guangzhong Xu, Wei Feng, Gengbao Qu, Pengyu Li, Kai Li

“…The data were pooled using fixed- or random-effects models based on the heterogeneity. …”
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Predicting New York Heart Association (NYHA) heart failure classification from medical student notes following simulated patient encounters by Ishan R. Perera, Taylor Daniels, Janella Looney, Kimberly Gittings, Frederic A. Rawlins

“…Abstract Random forest models have demonstrated utility in the determination of New York Heart Association (NYHA) Heart Failure Classifications. …”
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Decoding the epigenetic-immune nexus in hepatocellular carcinoma: a Mendelian randomization study reveals BTN3A2, S100A12 and TRIM27 as white blood cell regulators by Yang Qiu, Haiyan Zhang, Xiao Yu, Jielu Pan, Dinghong Xiao, Hongyu Miao, Ruiqing Wang, Nan Shen, Peimin Pu, Yinling Zhou, Zhidong Liu, Lin He, Lianjun Xing

“…Using these data, we applied a two-sample Mendelian Randomization (MR) framework to systematically investigate the causal effects of HCC-related CpG sites on white blood cell counts. …”
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Effects of an elimination diet and a healthy diet in children with Attention‐Deficit/Hyperactivity Disorder: 1‐Year prospective follow‐up of a two‐arm randomized, controlled study... by Annick Huberts‐Bosch, Margreet Bierens, Julia J. Rucklidge, Verena Ly, Rogier Donders, Gigi H. H. van deLoo‐Neus, Alejandro Arias‐Vasquez, Helen Klip, Jan K. Buitelaar, Saskia W. van denBerg, Nanda N. Rommelse

“…Methods One‐year prospective follow‐up of a sample of 165 children (5–12 years) with ADHD randomized (unblinded; 1:1) to 5 weeks treatment with either ED (N = 84) or HD (N = 81) and a non‐randomized comparator arm including 58 children being treated with Care as Usual (CAU). …”
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Impact of a 10-week multimodal stress management and lifestyle modification program on stress response and immune function in Crohn’s disease: a mixed-methods approach using the Tr... by Özlem Öznur, Sandra Utz, Christoph Schlee, Jost Langhorst

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Empowering breast cancer clients through AI chatbots: transforming knowledge and attitudes for enhanced nursing care by Mostafa Shaban, Yasmine M. Osman, Nermen Abdelfatah Mohamed, Marwa Mamdouh Shaban

“…G*Power analysis determined sample adequacy for between-group comparisons. Results Post-intervention, the intervention group showed significantly higher knowledge (20.3 ± 2.1 vs. 17.9 ± 3.4, p <.001) and more positive attitudes (82.4 ± 7.2 vs. 72.6 ± 8.9, p <.001) compared to controls. …”
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Findings from the Tushirikiane-4-MH (supporting each other for mental health) mobile health–supported virtual reality randomized controlled trial among urban refugee youth in Kampa... by Carmen H. Logie, Moses Okumu, Zerihun Admassu, Frannie MacKenzie, Lesley Gittings, Jean-Luc Kortenaar, Naimul Khan, Robert Hakiza, Daniel Kibuuka Musoke, Aidah Nakitende, Brenda Katisi, Peter Kyambadde, Richard Lester, Lawrence Mbuagbaw

“…We examined the effectiveness of VR in reducing depression with urban refugee youth in Kampala, Uganda. This randomized controlled trial assessed VR alone (Arm 1), VR followed by Group Problem Management Plus (GPM+) (Arm 2) and a control group (Arm 3), with a peer-driven and convenience sample of refugee youth aged 16–25 in Kampala. …”
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Ultra-rapid lispro or fast-acting aspart compared to standard insulin lispro and aspart using closed-loop insulin therapy: a systematic review and meta-analysis of randomized contr... by Mohamed Saad Rakab, Rahma Mogahed Rateb, Basel Hatem Elsalakawi, Bashar M. Al Zoubi, Abubakar Nazir, Mutaz Moath Abu-Laila, Abdelrahman Sherif Ghanem, Alaa Maamoun, Mohab Mattar, Basma Ataallah, Brian T. Layden, Brian T. Layden, Abeer M. Mahmoud, Abeer M. Mahmoud

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Effectiveness of a Mobile Breastfeeding Monitoring Tool Among Mothers in WeChat Groups on Breastfeeding Exclusivity and Self-Efficacy: Intention-to-Treat and Per-Protocol Analyses... by Ni Jia, Jean J Schensul, Meixian Zhang, Lianfang Kong, Qi Yan, Yaohua Dai

“…In the per-protocol analysis sample, the rate of EBF of the app-using group was 57% (16/28), compared to 48% (39/81) in the comparison group (P=.41; odds ratio [OR] 1.44, 95% CI 0.60-3.41; adjusted OR 1.66, 95% CI 0.59-4.68). …”
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Unveiling the role of lipid metabolism in haemorrhagic disorders: genetic insights and therapeutic perspectives by Jiaqi Wei, Zhen Yang, Xiaojin Wu, Nana Zheng, Depei Wu

“…Understanding the metabolic basis of these conditions may improve therapeutic strategies. Methods A two-sample Mendelian randomization (MR) approach was employed to evaluate the causal relationships between the levels of 1,400 metabolites and coagulation defects. …”
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Asynchronous Distance Learning Performance and Knowledge Retention of the National Institutes of Health Stroke Scale Among Health Care Professionals Using Video or e-Learning: Web-... by Avinash Koka, Loric Stuby, Emmanuel Carrera, Ahmed Gabr, Margaret O'Connor, Nathalie Missilier Peruzzo, Olivier Waeterloot, Friedrich Medlin, Fabien Rigolet, Thomas Schmutz, Patrik Michel, Thibaut Desmettre, Mélanie Suppan, Laurent Suppan

“…MethodsA prospective, multicentric, triple-blind, and web-based randomized controlled trial was conducted in 3 Swiss university hospitals, involving HCPs previously trained in NIHSS. …”
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