Decoding the impact of glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist on cardiometabolic health: inflammatory mediators at the focus by Fang Cheng, Xinyu Niu, Yaoling Wang, Fan Yang, Kang Yang, Wei Li

“…Methods Using genetic variants as instrumental variables, we performed a two-sample Mendelian randomization (MR) analysis to investigate causal relationships between genetically proxied GIPR agonist and 23 CMD outcomes, and a two-step mediation analysis to identify mediating inflammatory biomarkers. …”
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Effect of acceptance and commitment therapy for adolescent depression: a meta-analysis by Xin Yu, Bing Zhao, Tongtong Yin, Haiying Qu, Jingxuan Zhang, Xiaojing Cheng, Xu Chen, Xu Chen

“…Intervention forms and sample types should be considered when implementing ACT interventions. …”
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Association between Helicobacter pylori antibodies and otolaryngological diseases by Fang Zhang, Haowei Zhang, Jing Luo, Yixi Xiao, Hai Liu, Jianhui Zhang

“…To elucidate H. pylori role in 12 common otolaryngological diseases, we conducted two-sample Mendelian randomization analysis. Methods: Single-nucleotide polymorphisms associated with 7 H. pylori antibodies (IgG, CagA, Catalase, GroEL, OMP, UREA and Vac A) served as instrumental variables. …”
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Integrating analysis of multi-omics summary data identifies novel plasma protein biomarkers and drug targets for bladder cancer by Jinlong Cao, Siyu Chen, Jirong Wang, Xinpeng Fan, Shanhui Liu, Jiaqi Shan, Xiaoran Li, Li Yang

“…This study aims to address the diagnostic and therapeutic challenges of bladder cancer (BC) by using Mendelian randomization (MR) with a large sample size from multiple centers to identify the plasma proteins which are causally related to the pathogenesis of BC. …”
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Analysis of the accuracy of disease prediction in pediatric ward patients based on the modified early warning score for children: A randomized controlled trialWhat is already known... by Kang Lin, Xiaojun Weng, Bing Du, Ting Tian, Xiaoxiang Quan

“…Design: A single-blind, two-arm randomized controlled trial was conducted using a convenience sampling method. …”
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Geospatial digital mapping of soil organic carbon using machine learning and geostatistical methods in different land uses by Yahya Parvizi, Shahrokh Fatehi

“…This study was conducted to evaluate potential of different simulation models to map the spatial variability of SOC as affected by land use in a study area in Qarasu watershed in Kermanshah province, west of Iran. Map of sampling points was prepared using the Latin hypercube sampling method. …”
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Strong Convergence Rates of the Product-limit Estimator for Left Truncated and Right Censored Data under Association by Amir Hossin Shabani, Hadi Jabbari Nooghabi, Vahid Fakoor

“…It is commonly assumed in such studies that the lifetime variables are a sample of independent and identically distributed random variables from the target population. …”
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Systematic review and meta-analysis on the efficacy and safety of acupuncture for perimenopausal insomnia by ShiWei Song, Hao Chen, HongFang Fu

“…The two groups had no significant differences in regulating serum E2 (MD: 7.70; 95% CI: 2.20–13.19; p = 0.06) and LH levels (MD: −5.42; 95% CI: −9.46– −1.37; p = 0.009).ConclusionAcupuncture treatment is significantly effective for patients with perimenopausal insomnia. However, large-sample, multi-center, long-term follow-up trials should be conducted to obtain more reliable results. …”
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Genetic evidence for the causal effect of clonal hematopoiesis on pulmonary arterial hypertension by Jia-Yong Qiu, Shen-Shen Huang, Chao Liu, Dong Ding, Yan-Hong Xu, Yi-Min Mao, Ya-Dong Yuan

“…This study aims to investigate the causal effect of CH on the risk of PAH using a two-sample Mendelian randomization (MR) approach. Methods We utilized genetic variants associated with CH as instrumental variables, identified from two large genome-wide association studies (GWAS) involving 359,088 participants in the discovery cohort and 184,121 participants in the validation cohort, all of European descent. …”
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Exploring the Causal Relationship Between the Plasma Levels of MMP1 (Matrix Metalloproteinase‐1), MMP3, MMP7, MMP10, and MMP12 and Intervertebral Disc Degeneration: Mendelian Rando... by Lin Sun, Kai‐Qing Yan, Qi Zhang, Ji Ma, Bo Shi, Xi‐Yuan Yang, Li‐Jun Li

“…In this study, Mendelian randomization (MR) was used to analyze the causal relationship between the plasma levels of multiple MMPs and the risk of IDD. …”
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Acupuncture in the Treatment of Infertility due to Luteal Phase Defect: A Meta-Analysis by Yiyi Kong, Jingli Liang, Yanhua Chen, Xin Zeng, Min Xu

“…Well-designed clinical studies with large sample sizes are still required to confirm our results. …”
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Illuminating the intricate role of genetic factors in chronic low back pain: from the molecular basis of onset to the determination of susceptibility and the search for novel thera... by Ding-Qiang Chen, Zhi-Qiang Que, Wen-Bin Xu, Ke-Yi Xiao, Nai-Kun Sun, Jin-Yi Feng, Gang Rui

“…These existing studies are plagued by issues such as small sample sizes and inconsistent inclusion criteria. …”
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Multi-omics analysis reveals the role of the autophagy-related gene AGT in chemotherapy resistance in colorectal cancer and the therapeutic potential of its inhibitors by Wenjiao Cai, Tao Xiang, Xiaoli Liu, Chong Fu

“…AGT expression was significantly higher in tumor samples, especially in the fibroblast C6 subpopulation. …”
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MindRegulation-SEL: randomized controlled trial of the effects of a relaxation and guided imagery intervention with socioemotional learning on the psychological and biophysiologica... by Iolanda Costa Galinha, Joana Leite da Cunha Sampaio de Carvalho, Ana Cristina Pires de Oliveira, Patrícia Arriaga, Augusta D. Gaspar, Hugo P. Silva, Vitória Ortega

“…The RCT includes four data collection times: pretest, intermediate, posttest, and a 6-month follow-up. The sample comprises 259 students, elementary school third and fourth graders, 8–11 years old. …”
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Exploring the role of inflammatory biomarkers in trigeminal neuralgia by Shenglong Lai, Haiyang Li, Yazhou Xing, Du Wu, Lin Wang, Qinghua Liang

“…This study investigates the causal relationship between inflammatory biomarkers, including 41 circulating inflammatory cytokines, C-reactive protein (CRP), and procalcitonin (PCT), and TN using Mendelian randomization (MR) analysis. Methods: A two-sample MR approach was employed using genome-wide association study (GWAS) data from 8293 Finnish individuals for inflammatory cytokines and data from the FinnGen database for TN. …”
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Elevated VRK2 expression promotes the onset and progression of bronchiectasis by Shaochu Zheng, Yuting Huang, Kangkang Hong, Jinling Tang, Xiaopu Wu, Cao Qing, Yun Jiang, Wei Lu, Chongxi Bao, Jing Luo, Jinliang Kong

“…Methods First, we used the cis-expression quantitative trait locus (cis-eQTL) data of druggable genes from blood samples as the exposure factor and the genome-wide association study (GWAS) data of bronchiectasis as the outcome to perform two-sample Mendelian randomization (MR) analysis. …”
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Multiomics insight into the role of glucagon‐like peptide‐1 receptor agonists in heart failure by Yuhang Tao, Qi Liu, Yuxing Wang, Yingchao Gong, Mingying Xu, Ruhong Jiang, Kai Zhang

“…Genetic instruments were selected from the GLP1R gene region, and two‐sample Mendelian randomization (MR) analyses were conducted to assess the causal effects of GLP1Ra on cardiovascular diseases in European and East Asian populations. …”
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From Clusters to Communities: Enhancing Wetland Vegetation Mapping Using Unsupervised and Supervised Synergy by Li Wen, Shawn Ryan, Megan Powell, Joanne E. Ling

“…This study addresses these challenges by developing a scalable vegetation classification framework that integrates cluster-guided sample selection, Random Forest modelling, and multi-source remote-sensing data. …”
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The feasibility of conducting a randomized controlled trial that compares immediate versus optional delayed surgical repair for treatment of acute Anterior cruciate ligament injury... by Feryal Ghafelzadeh Ahwaz, Annemie Smeets, Stijn Bogaerts, Pieter Berger, Koen Peers

“…Of the initial 29 patients, 5 dropped out after randomization. The recruited sample confirmed the typically young and physically active sample of ACL patients. …”
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What drives the profitability of banking sectors in the European Union? The machine learning approach by Bernardelli Michał, Korzeb Zbigniew, Niedziółka Paweł

“…The study’s novelty lies in the reliance on a broad spectrum of explanatory variables assigned to three groups of factors, reference to all EU countries, and decomposition of the sample to identify similarities among the determinants of profitability.…”
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