Exploring the mechanistic link between the oxytocinergic system and mindfulness training in adults with heightened stress: study protocol for a double-blind, randomized, placebo-co... by E. van Weert, HJ. De Vuyst, K. Van der Gucht, E. Debbaut, J. Steyaert, K. Alaerts

“…Exploratory measures include (i) electroencephalography (EEG), electrocardiography (ECG), skin conductance, and respiration, measured during rest, meditation, stress induction, and stress recovery; (ii) intervention-induced changes in biological samples, including hormonal levels of oxytocin and cortisol and DNA methylation of the oxytocin receptor gene (OXTR); and (iii) stress reactivity in daily life, assessed through experience sampling and heart rate/sleep monitoring. …”
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A Randomized Controlled Trial to Test the Effects of Repetitive Peripheral Magnetic Stimulation Versus Neuromuscular Electrical Stimulation in Patients with Spastic Hemiparesis Aft... by Kristin Loreen Pohl, Jens Müller, Katja Wittig-Böttger, Alexander Ritter, Farsin Hamzei

“…Methods: REPMAST is an interventional, randomized controlled single-blinded study. Patients with subacute stroke are randomized to receive rPMS or NMS five days a week for three weeks in addition to standard rehabilitation therapy. …”
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Effectiveness of a resilience, gender equity and mental health group intervention for young people living in informal urban communities in North India: a cluster randomized control... by Varadharajan Srinivasan, Miguel San Sebastián, Samson Rana, Pooja Bhatt, Greg Armstrong, Smita Deshpande, Kaaren Mathias

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Effectiveness of a school-based educational intervention on oral health knowledge, attitudes, practices, and self-efficacy among female secondary school students: a randomized cont... by Akram Mehtari Taheri, Fatemeh Zarei, Alireza Hidarnia, Mahmoud Tavousi

“…The participants were selected via cluster sampling and randomly assigned to either the intervention group (n = 40) or the control group (n = 40). …”
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Comparison of clinic-based assistance versus a centralized call center on patient-reported social needs: findings from a randomized pilot social health integration program by Ammarah Mahmud, Meagan C. Brown, Edwin S. Wong, India J. Ornelas, Robert Wellman, Roy Pardee, Sophia Mun, Ariel Singer, Emily Westbrook, Kathleen Barnes, Heidi Den Haan, Cara C. Lewis

“…This analytic sample consisted of 153 CCC participants and 176 participants under CRS. …”
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Efficacy and safety of YQFM (YiQiFuMai lyophilized injection) on acute ischemic stroke (FAST): rationale and design for a randomized, double-blind, placebo-controlled trial by Yingzhi Xu, Li Sun, Zhaoyou Meng, Xinxing Lai, Dayong Ma, Yuqiu An, Boxuan Du, Qiaosheng Ren, Ying Gao, Kegang Cao

“…Studies have shown that YQFM (YiQiFuMai lyophilized injection) can ameliorate neurological deficits in ischemic stroke.However, all of these studies are all small-sample clinical observations lacking rigorous study design for AIS with inappropriate blood pressure. …”
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The effect of aqueous extract of Iranian oak (Quercus brantii) on lipid profile and liver enzymes in beta-thalassemia patients: a randomized controlled trial, double-blind, placebo... by Mahdi Babamir Satehi, Mahdi Karimi, Mahdi Karimi, Mahdi Karimi, Ataollah Eskandari, Hamid Mahmoodi

“…Further studies with larger sample sizes and extended follow-up are recommended to confirm these benefits.Clinical trial tegistrationhttp://www.irct.ir, identifier IRCT2015101411819N4.…”
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Effectiveness of Low‐Cost, Virtual Sexual Health Education and Educational Leaflets on Reducing Anxiety and Enhancing Sexual Function Among Infertile Women: A Pilot Randomized Cont... by Mahdiyeh Karimi, Fatemeh Heshmatnia, Sara Azima, Marzieh Akbarzadeh, Subash Thapa

“…Methods In this triple‐blind pilot randomized controlled trial, 90 women seeking medical treatment for infertility were randomly divided into three groups: (a) control, (b) educational booklet, and (c) virtual education. …”
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Effects of online mindfulness-based stress reduction training on depression and anxiety symptoms among psychiatric healthcare workers in a randomized controlled trial: the mediatin... by Yuekun Wu, Yue Ban, Guoliang Pan, Mingyang Yao, Li Liu, Ting Chen, Hui Wu

“…The effective sample size that actually completed the intervention was 135 (74 participants in the intervention group and 61 in the control group), and the loss-to-follow-up rate was approximately 18%. …”
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Cluster-randomized trial of the implementation of the Responses to Illness Severity Quantification (RISQ) system in children with acute malnutrition 6 to 59 months of age in Ngouri... by Nancy M. Dale, Youssouf Djidita Hagre, Susan Shepherd, George Tomlinson, Stanley Zlotkin, Masra Ngaradoum, Mahmat Bechir, Marius Madjissem, Charles Tehoua, Christopher Parshuram

“…A 14-month baseline period will precede a 14-month intervention period. With a sample of 20,000 patients in 34 centers (assuming an intraclass correlation coefficient of 0.0005, equal-sized clusters, and 1.5% baseline mortality) provides 80% power to detect a 0.5% absolute decrease in mortality using a one-sided alpha of 0.05. …”
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The effects of diacylglycerol edible oil intervention in patients with chronic metabolic syndrome combined with asymptomatic hyperuricemia: study protocol for a multicenter, prospe... by Gui-yu Li, Cui-feng Zhu, Zhao-qi Huang, Chun-li Piao, Jia-jun Yu, Li Wang, Qiang Zeng, Yu-yu Lei, Yue Li, Xiao-ling Zhu, Zhen-tian Zhang, Tian-hua Huang, Meng-shuang Li, Shu-zhong Lin, Nai-wen Zhang, Fangyingnan Zhang, Yong-hua Wang, Dan-ping Xu

“…Abstract Background The aim of this study is to evaluate the efficacy and safety of diacylglycerol (DAG) edible oil intervention in patients with chronic metabolic syndrome complicated by asymptomatic hyperuricemia through a multicenter, prospective, double-blind, randomized controlled clinical trial. Methods A multicenter, double-blind, and randomized controlled trial involving 176 patients was designed. …”
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Assessing Behavior and Anxiety among 3–9-year-old Children during Local Anesthesia Administration Using Conventional and Camouflaged Syringes: A Randomized Split-mouth Design by Reshma E Rajan, Sowndarya Gunasekaran, Veena Arali, Vijayakumar Mohan, Arya A Vargheese, Yash S Latkar

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Ambulance Commanders’ Reluctance to Enter Road Tunnels in Simulated Incidents and the Effects of a Tunnel-Specific e-Learning Course on Decision-Making: Web-Based Randomized Contro... by Johan Hylander, Lina Gyllencreutz, Michael Haney, Anton Westman

“…There were no significant differences between the groups (P=.59; 2-sample test of proportions) in the second assessment. …”
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Effects of Self-Assisted Manual Therapy Combined with a High-Intensity Walking Program on Musculoskeletal Pain, Functionality, and Posture in Older Adults: A Multicentre Randomized... by Gemma Victoria Espí-López, Laura Fuentes-Aparicio, Rocío Cogollos-de-la-Peña, Lucas Monzani, Elena Marques-Sule, Dagmar Pavlu, Anna Arnal-Gómez

“…Methods: A multicentre, double-blind, randomized trial was conducted on older adults. The sample was divided into two groups: the self-assisted manual therapy plus walking at high-intensity group (MTWG) and the Control Group (CG), with the latter undergoing supervised high-intensity walking only. …”
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A character-strengths based coaching intervention to improve wellbeing of rural community health workers in Madhya Pradesh, India: Protocol for a single-blind randomized controlled... by Ameya P. Bondre, Azaz Khan, Abhishek Singh, Spriha Singh, Ritu Shrivastava, Narendra Verma, Aashish Ranjan, Jyotsna Agrawal, Seema Mehrotra, Rahul Shidhaye, Anant Bhan, John A. Naslund, Steve D. Hollon, Deepak Tugnawat

“…The arms are intervention added to routine ASHA supervision (weekly, by the ASHA supervisor), and routine supervision alone (control arm). The target sample comprises 330 rural ASHAs in Madhya Pradesh, India. …”
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Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias us... by Niels Hendrickx, France Mentré, Alzahra Hamdan, Mats O. Karlsson, Andrew C. Hooker, Andreas Traschütz, Cynthia Gagnon, Rebecca Schüle, Matthis Synofzik, Emmanuelle Comets, ARCA Study Group, EVIDENCE-RND consortium

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Supporting primary care clinicians in caring for patients with alcohol use disorder: study protocol for Records for Alcohol Care Enhancement (RACE), a factorial four-arm randomized... by Kara M. Magane, Richard Saitz, Sarah Fielman, Marc R. LaRochelle, Christopher W. Shanahan, Christine A. Pace, Michael LaValley, Kaley Penington, Skylar Karzhevsky, Emily Hurstak

“…This four-arm factorial design randomized trial will assess whether population health management (PHM) and clinical care management (CCM) support for primary care providers (PCPs) are associated with improved AUD treatment engagement among their patients, beyond electronic health record (EHR) prompting and decision support alone. …”
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An Internet-Based and Mobile Family Management Intervention for Mothers of Very Preterm Infants Hospitalized in the Neonatal Intensive Care Unit (the Preemie Progress Program): Pil... by Ashley Weber, Tamilyn Bakas, Qutaibah Oudat, Nehal A Parikh, Joshua Lambert, Heather L Tubbs-Cooley, Jared Rice, Kristin Voos, Matthew Rota, Heather C Kaplan

“…ConclusionsWe were able to recruit a diverse sample of mothers from a range of socioeconomic backgrounds, including mothers experiencing barriers to bedside presence. …”
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Efficacy of Tripterygium glycosides in immune-mediated kidney diseases as a immunomodulation drug in combination with conventional immunosuppressive agents: a systematic review and... by Yaotan Li, Yaotan Li, Jinyi Hou, Jinyi Hou, Xiaochang Wu, Xiaochang Wu, Chang Liu, Mengqi Zhou, Shijia Lin, Weijing Liu, Weijing Liu, Yaoxian Wang, Yaoxian Wang, Huijuan Zheng, Huijuan Zheng

“…However, treatment course, TG dosage, and sample size are important factors influencing the results.ConclusionOur study suggests that the combination of TG with immunosuppressive agents offers more pronounced efficacy in treating immune mediated kidney diseases, without increasing the incidence of adverse reactions. …”
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Effects of two different dexamethasone dosing regimens on ventilator-free days and long-term mortality in COVID-19 patients with moderate-to-severe ARDS: the REMED randomized clini... by Jan Maláska, Jan Stašek, Jan Máca, Martin Kutěj, František Duška, Petr Kafka, Olga Klementová, Lenka Doubravská, Jan Hruda, Marek Fencl, Tomáš Gabrhelík, Libor Číž, Jan Zatloukal, Jiří Pouska, Pavel Novotný, Martin Balík, Regina Demlová, Jana Kubátová, Jana Vinklerová, Karolína Grodová, Radka Štěpánová, Adam Svobodník, Milan Kratochvíl, Jozef Klučka, Petr Štourač, Mervyn Singer, the REMED Study Group

“…The long-term outcomes were 180- and 360-day mortality and the Barthel index. The planned sample size was 300, with interim analysis after enrollment of 150 patients. …”
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