The Persistent Threat of Chronic Inflammation on the Mortality Among Cervical Cancer Survivors: A Mendelian Randomization and Machine Learning Analysis Using UK Biobank and Chinese... by Wang J, Chen Z, Guan M, Ma Z, Peng L, Chen J, Fiori PL, Carru C, Capobianco G, Coradduzza D, Zhou L

“…Nine ML and logistic regression (LR) integrated prognosis models were developed for 1042 subjects with cervical cancer (random allocation into training and validation cohorts at 6:4 ratio).Results: Three potential causative CIMs for cervical cancer were identified via a two-sample MR. …”
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Scapular dyskinesis-based exercise therapy versus multimodal physical therapy for subacromial impingement syndrome in young overhead athletes with scapular dyskinesis: a randomized... by Meilin Wen, Xuanming Hu, Guiying Bao

“…Outcome assessors were blinded to group allocation. Sample size was determined a priori using G*Power (f = 0.25, α = 0.05, power = 0.80), yielding a required sample of 28; 32 participants were planned to account for potential dropout. …”
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Effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in primary care: a prospective randomized, controlled, open and multicenter study in pr... by Roland von Känel, Stefan Neuner-Jehle, Reto W. Kressig, Idris Guessous, Pierre Alexandre Krayenbühl, Lukas Zimmerli, Anne Angelilo-Scherer, Thomas Keller, Caroline Elzner, Karl Pauls, Neige Morin, Edouard Battegay

“…Thus, cluster randomization was performed, but the analysis to consider this was not feasible.…”
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Get strong to fight childhood cancer - an exercise intervention for children and adolescents undergoing anti-cancer treatment (FORTEe): Rationale and design of a randomized control... by Marie Astrid Neu, Elias Dreismickenbecker, Francesca Lanfranconi, Sandra Stössel, Adriana Balduzzi, Peter Wright, Stan Windsor, Joachim Wiskemann, Inaam El-Rajab, Alejandro Lucia, Carmen Fiuza-Luces, Rodolf Mongondry, Martin Kaj Fridh, Filippo Spreafico, Barbara Konda, Lidija Kitanovski, Barbara Heißerer, Marco Polak, Tobias Baader, Wilhelm Bloch, Miriam Götte, on behalf of Network ActiveOncoKids, Katie Rizvi, on behalf of Youth Cancer Europe, Christian Ruckes, Norbert W. Paul, Joerg Faber, on behalf of the FORTEe Consortium

“…Given that childhood cancer is a rare disease, this sample size is only achievable through a multicenter approach. …”
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Effects of galantamine and galantamine combined with nimodipine on cognitive speed and quality of life in mixed dementia: a 24-week, randomized, placebo-controlled exploratory tria... by Paulo Caramelli, Jerson Laks, André Luis Fernandes Palmini, Ricardo Nitrini, Márcia Lorena Fagundes Chaves, Orestes Vicente Forlenza, Francisco de Assis Carvalho do Vale, Maira Tonidandel Barbosa, Cássio Machado de Campos Bottino, João Carlos Machado, Helenice Charchat-Fichman, Fabio Lorea Lawson

“…The combination GAL/NIM was not advantageous. However, the small sample size precludes any definitive conclusions. …”
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Investigating Irritability as a Potentially Causal Risk Pathway to Depression Using Two Genetically Informed Designs by Amy Shakeshaft, Olakunle Oginni, Joanna Martin, Charlotte A. Dennison, Olga Eyre, Ellen Leibenluft, Sebastian Lundström, Evie Stergiakouli, Henrik Larsson, Paul Lichtenstein, Argyris Stringaris, Lucy Riglin, Mark J. Taylor, Anita Thapar

“…Second, we conducted bidirectional two-sample Mendelian randomization (MR) to examine relationships between genetic liability to self-reported irritability and depression, using published genome-wide association studies. …”
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Study protocol for a non-randomized controlled trial of the effects of internet-based parent training as a booster to the preschool edition of PATHS®: Universal edition of the Pare... by Tina M Olsson, Pia Enebrink, Sabina Kapetanovic, Laura Ferrer-Wreder, Johanna Stålnacke, Lilianne Eninger, Kyle Eichas, Åsa Norman, Lene Lindberg, Ingela Clausén Gull, Hanna Ginner Hau, Mara Westling Allodi, Mina Sedem

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Effect of Direct Cold Compress for Femoral Arterial Sheath Removal on Reduction of Local Vascular Complications in Patients after Percutaneous Coronary Intervention: A Randomized C... by Hussam Malik Al-Bayati, Rajha A. Hamza Al-Kassar

“…A non-probability (homogenous purposive sample) of (90) patients are involved after PCI (45 patients for the experimental group and 45 patients for the control group). …”
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Examining the feasibility and preliminary efficacy of a group-based physical activity intervention integrating strength training among pre- and perimenopausal women: A randomized p... by Beth A. Lewis, Katie J. Schuver, Kaitlyn B. Swinney, Tyler M. Dregney, Jennifer A. Linde

“…Design: This study was a randomized controlled trial lasting 12 weeks. Methods: Low active pre- and perimenopausal women between the ages of 40–50 (n = 39) were randomly assigned to a 12-week physical activity strength intervention or a waitlist control. …”
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The effects of an anti-inflammatory diet alone or in combination with acupuncture on mental health, anthropometric indices, and metabolic status in diabetic patients with depressio... by Pardis Irandoost, Amir Firouzjaei, Javad Heshmati, Erfan Sadeghi, Mohammad Hossein Ayati, Nazli Namazi

“…Methods In this 8-week randomized controlled clinical trial, 90 patients with T2DM who were experiencing mild to moderate depression were included. …”
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Efficacy and safety of low-frequency repetitive transcranial magnetic stimulation for bipolar depression: a study protocol for a multicenter, double-blind, randomized, sham-control... by Takamasa Noda, Masako Nishikawa, Yuki Matsuda, Daisuke Hayashi, Shinsuke Kito

“…However, a medium or large sample, randomized, double blind, sham controlled study has not yet been performed.ObjectiveTo examine the efficacy and safety of 1-Hz rTMS to the right prefrontal cortex in patients with treatment-resistant bipolar depression. rTMS was approved by the Ministry of Health, Labor, and Welfare as a highly advanced medical technology on March 1, 2019.MethodsIn this multicenter, double-blind, randomized, sham stimulation-controlled trial for bipolar depression, patients will be individually allocated to active or sham stimulation plus usual medication and followed up for 6 months. …”
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Effect of using a hemostatic gelatin sponge versus a dense polytetrafluorethylene membrane for socket sealing following immediate implant placement: a randomized clinical study by Mahmoud Shalash, Aalaa Emara

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Effectiveness of preoperative ketamine gargle to reduce postoperative sore throat in adult patients undergoing surgery with endotracheal tube; systematic review and meta-analysis o... by Molla Amsalu Tadesse, Agmuas Asichale Alimawu, Fetene Seyoum Kebede, Eniyew Assimie Alemu, Ludwig Matrisch, Desta Oli Waktasu

“…Cochrane risk of bias tool for randomized control trials was used to assess the risk of bias of included studies. …”
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Effectiveness of acupoint hot compress on early puerperal rehabilitation of parturients after natural childbirth: study protocol for a prospective, multi-center, randomized control... by Yuhang Zhu, Aihua Zhang, Chang Liu, Nicola Robinson, Myeong Soo Lee, Xiaoyang Mio Hu, Hye Won Lee, Rong Zhang, Fan Qu

“…The aim of this study is to address this with a multi-center design and large sample size. Methods: This is a prospective, multi-center, and randomized controlled clinical trial. …”
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Platelet-rich fibrin versus acellular dermal matrix for vertical soft tissue augmentation simultaneously with dental implantation: a 3-month randomized pilot clinical trial by Farid Shiezadeh, Amir Moeintaghavi, Zahra Moslehitabar, Moein Khojaste

“…Patients were randomly assigned to the PRF (n = 10) or ADM (n = 10) groups. …”
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Task shifting to frontline community health workers for improved diabetes care in low-resource settings in India: a phase II non-randomized controlled clinical trial by Bhavya Balasubramanya, Rita Isaac, Sam Philip, H R Prashanth, Prakash Abraham, Amudha Poobalan, Nihal Thomas, L Jeyaseelan, Joy Mammen, Praveen Devarasetty, Oomen John

“… # Methods A phase II, non-randomized, controlled clinical trial was conducted in a rural block in Tamil Nadu, India. …”
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Feasibility, acceptability and effectiveness of asthma education delivered by community health workers in improving asthma control in children and adolescents: a protocol for a clu... by Rebecca Nantanda, Levicatus Mugenyi, Andrew Sentoogo Ssemata, Sarah Namusoko, Phiona Ekyaruhanga, Mary Kuteesa, Fred Matovu, Jonathan Grigg

“…The HFs will be randomly assigned to the control and intervention arms in the ratio 1:1. …”
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Optimizing Physical Fitness Before Colorectal Cancer Surgery (CANOPTIPHYS): The Effect of Preoperative Exercise on Pre- and Postoperative Physical Fitness in Older people – A Rando... by Johanna Danielsson, Julia Engström Sid, Mikael Andersson, Malin Nygren-Bonnier, Monika Egenvall, Maria Hagströmer, Laura E. Vossen, Ing-Mari Dohrn, Elisabeth Rydwik

“…While we could not demonstrate an effect of preoperative exercise on any other outcomes, these results should be interpreted with caution due to a small sample size. Trial registration: Clinicaltrials.gov, identification number: NCT04878185, URL: Study Details | Optimizing Physical Function Before Cancer Surgery in Older People at Risk | ClinicalTrials.gov.…”
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Randomized Controlled Clinical Trial to Evaluate Skeletal and Dental Treatment Effects of Rapid Maxillary Expansion in Children: Comparison Between Two-Band Expander and Bonded Pal... by Valeria Viarani, Paola Festa, Giorgia Galasso, Vincenzo D’Antò, Alessandra Putrino, Andrea Mariani, Gaia Bompiani, Angela Galeotti

“…Seventy-four subjects with palatal skeletal contraction and unilateral or bilateral posterior crossbite were treated using maxillary expander devices. The sample was made up of two different randomly assigned groups: RME (21 females, 17 males; mean age ± SD 7.7 ± 1.1 years) and SRPE (24 females, 15 males; mean age ± SD 7.6 ± 1.0 years). …”
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Prophylactic endoscopic pylorus dilatation prior to esophagectomy for esophageal cancer to prevent delayed gastric emptying, study protocol for a placebo-controlled randomized tria... by C. Mann, F. Berlth, V. J. Lozanovski, M. Passalacqua, E. Hadzijusufovic, E. Uzun, G. Capovilla, M. Valmasoni, H. Lang, P. P. Grimminger

“…After randomization, patients will either receive preoperative EPBD or a sham intervention in the routine preoperative endoscopy performed 1 day before surgery. …”
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