Multidimensional bioinformatics analysis reveals the potential carcinogenic role of acrylamide in colorectal cancer by Xiaopeng Yu, Junjie Niu, Jinyang Hu

“…Methods: Acrylamide- and CRC-associated genes were screened from the GEO and CTDbase databases, and a Venn diagram was used to identify the intersection between acrylamide target genes and CRC differentially expressed genes (DEGs). Bidirectional two-sample Mendelian randomization (MR) analysis was employed to validate the causal relationship between these genes and CRC, followed by expression validation using TCGA data. …”
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Maintenance effects of a multilevel workplace intervention to reduce sedentary time: twenty-four-month follow-up of the group randomized clinical trial ‘Stand and Move at Work’ by Krista S. Leonard, Miranda Larouche, Nathan R. Mitchell, Sarah A. Rydell, Meynard John Toledo, Sarah L. Mullane, Kristina Hasanaj, Junia N. de Brito, Matthew P. Buman, Mark A. Pereira

“…There were no significant changes in cardiometabolic risk within the total sample, while there were some significant changes in triglycerides and blood pressure for the dysglycemic participants. …”
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Feasibility and effectiveness of the mindfulness-based stress reduction programs on relieving burnout of healthcare providers during the COVID-19 pandemic: a pilot randomized contr... by Ruochen Gan, Shulin Chen, Jiang Xue

“…The roles of positive and negative emotion as well as emotion regulation strategy in the intervention effects were also investigated. Methods A sample of 112 healthcare providers in China were recruited and randomly assigned to the MBSR (n = 56) or the control condition (n = 56). …”
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Assist-linked brief intervention to reduce risky pattern of substance use in male workers employed at a tertiary care hospital in India: A randomized controlled trial by Sambhu Prasad, Debasish Basu, Surendra K. Mattoo, B. N Subodh

“…Results: The prevalence of moderate-to-high-risk use of tobacco, alcohol, and cannabis in the total sample was 28.6%, 27.5%, and 6.9%, respectively. At 3-months postintervention follow-up of the randomized sample, recipients of ALBI had significant reduction of ASSIST scores for all substances compared to the control group (p < 0.001). …”
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Testosterone Supplementation: A Potential Therapeutic Strategy for Amyotrophic Lateral Sclerosis by Wenzhi Yang, Wendi Xiao, Xiangyi Liu, Hui Li, Tao Huang, Dongsheng Fan

“…Functional enrichment found a high level of SHBG was associated with a low level of bioavailable testosterone. Two-sample MR confirmed the association of SHBG (400,210 samples), bioavailable testosterone (367,289 samples), and ALS. …”
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Effectiveness of Comprehensive Sexuality Education to Reduce Risk Sexual Behaviours Among Adolescents: A Systematic Review by Ana Rodríguez-García, Alicia Botello-Hermosa, Álvaro Borrallo-Riego, María Dolores Guerra-Martín

“…There was predominance of in-person teaching at schools with lectures and varied activities. The sample was predominantly comprised by girls aged between 14 and 16 years old. …”
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Genetically predicted interleukin 7 levels and neuroblastoma risk combined with analysis of radiation therapy timing effects by Gang Rui, Ying Cheng, Qun Gao

“…Methods We conducted two-sample Mendelian randomization analysis using GWAS summary statistics for interleukin-7 levels and neuroblastoma with three SNPs as instrumental variables. …”
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Risk of Editorial Bias: A Case Study of Factors Contributing to Review Time in a Leading Journal in Dentistry by Momen A. Atieh, Nabeel H. M. Alsabeeha

“…ABSTRACT Objectives The aim of this study was to evaluate the risk of editorial bias in the field of Dentistry by examining surrogate measures which can be readily extracted from published randomized controlled trials (RCTs) in a journal of high impact factor. …”
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Exploring the causal connection: insights into diabetic nephropathy and gut microbiota from whole-genome sequencing databases by Rui Lin, Rongping Chen

“…In this study, we employed a two-sample Mendelian randomization analysis. Our dataset encompassed 4,111 DN patients from the GWAS database, juxtaposed with 308,539 members forming a control group. …”
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Association Between Serum Apolipoprotein B and Bone Mineral Density and the Effects of Cardiovascular Disease Mediation: Results From the NHANES 2011–2016 and a Mendelian Randomiza... by Aochuan Sun, Yiduo Chen, Yang Wu, Zhuangzhuang Li, Jingchun Zhang, Zhengtang Liu

“…The primary analysis utilized the multiplicative random effects inverse variance weighted (IVW-MRE) method for the two-sample MR analysis. …”
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Analysis of shared pathogenic mechanisms and drug targets in myocardial infarction and gastric cancer based on transcriptomics and machine learning by Junyang Ma, Junyang Ma, Shufu Hou, Xinxin Gu, Peng Guo, Jiankang Zhu

“…This study aimed to identify these common factors and potential pharmacologic targets.MethodsData from the IEU Open GWAS project were used. Two-sample Mendelian randomization (MR) analysis was used to explore the causal link between MI and GC. …”
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Causal relationship and potential pathogenic mechanisms between rosacea with pharyngeal and laryngeal cancer by Zexin Zhu, Xiaoxue Wang

“…Methods: We employed a two-sample Mendelian Randomization (MR) study to assess the causality between rosacea and 17 subtypes of cancers. …”
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Causal Association Between Genetically Predicted Ankle Spacing Width and Risk of Age-Related Bone Mineral Density by Xian-Pei Xiao, Yong-Jun Dai, Hong-Xu Li, Jun-Jie Mao, Bi-Yuan Qin

“…Genome-wide associations of single nucleotides polymorphisms (SNPs) were served as instrumental variables (IVs) to infer causal effects using two-sample mendelian randomization (TSMR) and multivariable mendelian randomization (MVMR) analyses. …”
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Integrated analysis of multi-omics data for the discovery of biomarkers and therapeutic targets for juvenile idiopathic arthritis by Yi-Xin Cai, Xiao-Li Chen, Dai-Shan Zheng, Yue-Zhong Huang, Zhan-Pei Bai, Xiu-Feng Huang

“…Methods: We employed two-sample Mendelian randomization (MR) analysis to investigate the causal effects of plasma proteins on JIA. …”
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Association between the red blood cell distribution width-to-albumin ratio and risk of colorectal and gastric cancers: a cross-sectional study using NHANES 2005–2018 by Jie Luo, Peng Zhu, Shiji Zhou

“…Additionally, subgroup analyses, interaction tests, and restricted cubic splines were performed to further examine potential associations. A two-sample Mendelian randomization analysis was also conducted to investigate the causal relationship between RAR and DTT. …”
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A low-threshold intervention to increase physical activity and reduce physical inactivity in a group of healthy elderly people in Germany: Results of the randomized controlled MOVI... by Fabian Kleinke, Sabina Ulbricht, Marcus Dörr, Peter Penndorf, Wolfgang Hoffmann, Neeltje van den Berg

“…Both is likely due to selection in the convenience study sample. Thus, some ceiling effect reduced the overall intervention effect somewhat. …”
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Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment by Chaojuan Huang, Yuyang Zhang, Mingxu Li, Qiuju Gong, Siqi Yu, Zhiwei Li, Mengmeng Ren, Xia Zhou, Xiaoqun Zhu, Zhongwu Sun

“…We first conducted a bidirectional two-sample Mendelian randomization (MR) analysis to examine the susceptibility of insulin resistance on cognitive phenotypes. …”
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Exploring the Role of Inflammation and Metabolites in Bell’s Palsy and Potential Treatment Strategies by Jiaye Lu, Ziqian Yin, Youjia Qiu, Yayi Yang, Zhouqing Chen, Jiang Wu, Zhong Wang

“…<b>Methods</b>: Genetic data for Bell’s palsy were obtained from the Finnish database (version R10) and IEU OpenGWAS. A two-sample Mendelian randomization (MR) approach was applied, analyzing 4907 plasma proteins, 731 immune cell traits, 91 inflammatory proteins, and 1400 metabolites. …”
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Effect of tranexamic acid dissolved in warm, cold, and room-temperature irrigation fluid on complications during and after TURP surgery: a double-blind, randomized clinical trial by Masoomeh Salehi, Behzad Imani, Shirdel Zandi, Hamed Haghiabi, Somayeh Souri

“…Methods This prospective, double-blind clinical trial was conducted from April to November 2023 at Imam Khomeini Hospital in Alashtar, Iran. 100 patients scheduled for TURP were selected via convenience sampling and randomly assigned into four groups using a four-block and permutation design. …”
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Comparing the effects of intercostal and subcostal flank incision on post-operative pain and incisional hernia or bulge in patients undergoing open kidney surgery: A randomized cli... by Alireza Abdi, Behzad Imani, Seyed Habibollah Mousavibahar, Salman Khazaei, Shima Bahrami Jalal

“…Sixty-four patients were randomly divided into two groups of 32 patients, subcostal and intercostal, based on available sampling technique. …”
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