Do Clinical Death and Resuscitation Make an Organism Healthier? Paradox in Medical Statistics by P. P. Zolin

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Non-immunogenic staphylokinase in patients with massive intermediate-high risk pulmonary embolism: protocol of the FORPE-2 multicenter, double-blind, randomized, placebo-controlled... by S. N. Tereshchenko, E. B. Yarovaya, S. G. Leontiev, I. S. Yavelov, R. M. Shakhnovich, A. D. Erlikh, T. M. Uskach, D. V. Duplyakov, V. A. Kutsenko, O. E. Ivlev, A. G. Soplenkova, A. M. Semenov, M. P. Semenov, S. V. Ivanov, S. S. Markin

“…The study protocol provides inclusion and exclusion criteria, calculation of the required patient sample size, and the study plan. The primary efficacy endpoint will be a composite of all-cause mortality, hemodynamic collapse, and recurrent PE within 30 days of randomization. …”
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Effect of zinc supplementation on atherogenic risk indices in patients with non-alcoholic fatty liver disease: a randomized, double-blinded, placebo-controlled clinical trial by Farzaneh Mohammadi, Mohammad Ali Mohsenpour, Seyed Mohammad Amin Rezaei, Mohammad Hassan Eftekhari

“…Methods In this 8-week randomized, double-blinded, placebo-controlled clinical trial 50 overweighed or obese individuals suffering from NAFLD were randomly allocated into 2 groups of 25. …”
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Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study by Johannes-Paul Fladerer-Grollitsch, Thomas Klein, Albert Kompek, Nicole Steiner, Daniel Menzel, Christiane Schön

“…Biomarkers hsCRP and COMP showed no significant changes, likely due to sample variability. While the study did not achieve its primary endpoint, the nutritional formulation demonstrated an excellent safety profile and encouraging improvements in patient-reported symptoms and quality of life, warranting larger confirmatory trials. …”
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Impact of remote social interaction during the COVID-19 pandemic on the cognitive and psychological status of older adults with and without cognitive impairment: A randomized contr... by Ana L Vives-Rodriguez, Anna Marin, Kylie A Schiloski, Gabor P Hajos, Adolfo Di Crosta, Irene Ceccato, Pasquale La Malva, Diana C Anderson, Naheer Lahdo, Kaleigh Donnelly, Jiali Dong, Sabrina Kasha, Colleen Rooney, Judith Dayaw, Gabrielle Marton, Audrey Wack, Vanessa Hanger, Renée DeCaro, Alberto Di Domenico, Katherine W Turk, Rocco Palumbo, Andrew E Budson

“…<h4>Conclusions</h4>More work is needed to assess the utility of this intervention for the support of a heterogenous cross-cultural sample of older adults at-risk for social isolation, including individuals with cognitive impairment. …”
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Do the CONSORT and STRICTA Checklists Improve the Reporting Quality of Acupuncture and Moxibustion Randomized Controlled Trials Published in Chinese Journals? A Systematic Review a... by Bin Ma, Zhi-min Chen, Jia-ke Xu, Ya-nan Wang, Kuang-yang Chen, Fa-yong Ke, Jun-qiang Niu, Li Li, Cheng-ben Huang, Jian-xun Zheng, Jia-Hui Yang, Qian-ge Zhu, Ya-ping Wang

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Investigating Sources of Heterogeneity in Randomized Controlled Trials of the Effects of Pharmacist Interventions on Glycemic Control in Type 2 Diabetic Patients: A Systematic Revi... by Patricia Melo Aguiar, Giselle de Carvalho Brito, Tácio de Mendonça Lima, Ana Patrícia Alves Lima Santos, Divaldo Pereira Lyra, Sílvia Storpirtis

“…<h4>Methods</h4>A comprehensive literature search was performed in PubMed, Scopus, and LILACS databases for randomized controlled trials (RCTs) published up to July 2015. …”
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Intervertebral Disc Degeneration Mediates the Causal Effect of Genetically Predicted Diffuse Idiopathic Skeletal Hyperostosis on Spinal Stenosis: Evidence From a Mendelian Randomiz... by Yanzhu Shen, Yankun Jiang, Ruichen Jiang, Yanjun Huang, Sizheng Zhan, Yuming Wang, Xiangsheng Tang, Ping Yi

“…This study used Mendelian randomization (MR) to investigate the causal relationship between the two. …”
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Professional learning to support social and emotional skills in the preschool classroom: A randomized controlled trial of Sesame Street’s Building a Connected Community online cour... by Danielle Riser, Leanne Elliott, Tina Ryznar, Chanel Brown, David Cohen, Antonio Freitas, Katie Dahlke

“…The sample included 70 preschool classrooms at 20 programs across the United States. …”
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Efficacy and Safety of Murivenna Anal Infiltration Compared to Diltiazem Topical Application in Chronic Anal Fissure: Protocol for a Prospective, Randomized, Open-Label Clinical Tr... by Pratap Shankar KM, Indu Puthan Purayil, Palengara Binitha, Amit Kumar Rai, Sophia Jameela, Azeem Ahmad, Chandra Sekhara Rao Bhogavalli, Narayanam Srikanth, Rabinarayan Acharya

“…MethodsThis is an open-labeled, randomized, controlled parallel group clinical trial with a sample size of 66 participants to be randomized and allocated in a 1:1 ratio to 2 groups. …”
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The effect of simulation-based breast health education on breast cancer awareness and breast self-examination skills of Afghan refugee women: a randomized controlled trial by Nilgün Kuru Alici, Ayşe Arikan Dönmez, Okşan Aktaş, Zeybek Zeytun

“…Study design This study was a pre-test, post-test, parallel-arm randomized controlled trial. Methods The study sample consisted of 46 Afghan women, with 23 participants assigned to each of the intervention and control groups using block randomization. …”
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Comparative effect of in-person and virtual methods of eye movement desensitization and reprocessing on the fear of COVID-19 among nurses: a three-armed randomized control trial by Mohammadreza Sheikhi, Seyyed Mehdi Mousavi, Mohammad Moradi Baglooei, Mark D. Griffiths, Zainab Alimoradi

“…The present study investigated the effect of in-person and virtual methods of Eye Movement Desensitization and Reprocessing (EMDR) on the fear of COVID-19 among nurses. In a three-armed randomized control trial, the sample comprised 141 nurses working in hospitals affiliated to Qazvin University of Medical Sciences, Qazvin, Iran. …”
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A randomized control trial of a multiplex gastrointestinal PCR panel versus usual testing to assess antibiotics use for patients with infectious diarrhea in the emergency departmen... by Andrew C. Meltzer, Sophia Newton, Joel Lange, Nicole C. Hall, Nataly Montano Vargas, Yihe Huang, Seamus Moran, Yan Ma

“…Results should be interpreted with caution because of the small sample size.…”
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Sleep habits, brain functional networks, and type 2 diabetes risk: cohort studies from North American and Asian populations and mediating Mendelian randomization analyses by Faquan Hu, Qian Gong, Liyuan Xiong, Wei Zhao, Lingxiu Li, Yujiao Zheng

“…Methods We analyzed data from 20,994 U.S. adults in the National Health and Nutrition Examination Survey (NHANES) and 8,652 Chinese adults from the China Health and Aging Longitudinal Study (CHARLS), focusing on sleep habits and the incidence of T2DM. Two-sample Mendelian randomization (MR) was employed to assess the causal relationships between sleep habits, resting-state functional magnetic resonance imaging (rs-fMRI), and T2DM. …”
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Effect of a mHealth intervention on health literacy in patients completing cardiac rehabilitation: A randomized controlled trial with one- and five-year follow-up by Pernille Lunde, Hanne Søberg Finbråten, Are Hugo Pripp, Birgitta Blakstad Nilsson, Jostein Grimsmo, Asta Bye

“…Mixed model for repeated measurements and Wilcoxon signed rank test were used to analyse differences between groups, while paired sample t-test and Kendall's Tau b correlation analysed within-group changes. …”
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A Phase 2a, Randomized, Placebo-Controlled Human Challenge Trial to Evaluate the Efficacy and Safety of Molnupiravir in Healthy Participants Inoculated with Respiratory Syncytial V... by Mickie H. Cheng, Alex J. Mann, Brian M. Maas, Tian Zhao, Melissa Bevan, Andrea K. Schaeffer, Laura E. Liao, Andrew P. Catchpole, David W. Hilbert, S. Aubrey Stoch, Carisa S. De Anda

“…Results Forty participants each were randomized to prophylaxis and placebo and 36 to treatment. …”
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Carpal Tunnel Release with Ultrasound Guidance Versus Open and Mini-Open Carpal Tunnel Release: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Seper Ekhtiari, MD, MSc, Mark Phillips, PhD, Dalraj Dhillon, BSc, Ali Shahabinezhad, MD, Conner McMains, MD, Bill Dzwierzynski, MD, Mohit Bhandari, MD, PhD

“…Future RCTs with larger sample sizes are needed to corroborate these benefits and demonstrate long-term outcomes of CTR-US. …”
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Integrated Forecast of Monthly Saltwater Intrusion at Modaomen Waterway Based on Multiple Models by LU Pengyu, LIN Kairong, YANG Yugui, YUAN Fei, HE Yong

“…The results indicate that: ① RF, SVM and ENN show different extent of uncertainty on small sample sets; ② The simulation accuracy of BMA is significantly improved, with NSE of 0.67, which is 22%, 24% and 33% higher than that of RF, SVM and ENN, respectively.…”
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The effect of 3D modeling on family quality of life, surgical success, and patient outcomes in congenital heart diseases: objectives and design of a randomized controlled trial by Aylin Akça Sümengen, Abdul Veli İsmailoğlu, Pelin İsmailoğlu, Terman Gümüş, Alpay Çeliker, Deniz Namlısesli, Ezgi Poyraz, Damla Özçevik Subaşı, Ceren Zeren Erdem, Gökçe Naz Çakır

“…The study is a two-group pretest-posttest randomized controlled trial protocol. The sample size is 15 in the experimental group and 15 in the control group. …”
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White Matter Imaging Phenotypes Mediate the Negative Causality of Mitochondrial DNA Copy Number on Sleep Apnea: A Bidirectional Mendelian Randomization Study and Mediation Analysis by Ying Q, Wang M, Zhao Z, Wu Y, Sun C, Huang X, Zhang X, Guo J

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