A Comparison between the Tunnel Technique with Autogenous Grafts and Coronally Advanced Flap for Root Coverage of Multiple Gingival Recessions: A Randomized Clinical Trial by Jaber Yaghini, Mehrnegar Mahmoudzadeh, Zohreh Afshari, Amir Farmohammadi, Ahmad Mogharehabed

“…Materials and Methods: The statistical population of this randomized clinical trial consisted of 24 healthy non-smokers with Miller Class I or II gingival recession (GR) defects, equally divided into two groups of 12 to receive either a CAF or the VISTA technique. …”
Get full text

The Effect of Vitamin D Supplementation on Symptoms of Depression in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Rudi Putranto, Kuntjoro Harimurti, Siti Setiati, Eka Dian Safitri, Siti Rizny F Saldi, Imam Subekti, Martina Wiwie S Nasrun, Hamzah Shatri

Get full text

Yi-Shen-Hua-Shi regulates intestinal microbiota dysbiosis and protects against proteinuria in patients with chronic kidney disease: a randomized controlled study by Xingtong Dong, Jialing Zhang, Wen Li, Yinping Li, Linpei Jia, Zhaohui Liu, Wenjing Fu, Aihua Zhang

“…However, its efficacy in reducing proteinuria and underlying mechanisms is unknown.Objective This single-center randomized controlled trial explored whether YSHS could improve proteinuria and modulate the gut microbiota.Materials and methods 120 CKD patients were enrolled and randomized to receive the renin-angiotensin-aldosterone system (RAAS) inhibitor plus YSHS (n = 56) or RAAS inhibitor (n = 47) alone for 4 months, and 103 patients completed the study. …”
Get full text

Comparison of the Effect of Using Tranexamic Acid and Position on Cesarean Section Bleeding Rate, Surgical Team Satisfaction and Postoperative Complications, A Randomized Control T... by Elham Dehghan Naeiri, Ebrahim Nasiri Formi, Zohre Pezeshkpoor, Elmira Khodabakhsh

“…The study population consisted of patients aged 18 to 40 years who were candidates for cesarean sections under general anesthesia at Shohada Kargar Hospital in Yazd. The samples were randomly assigned to three groups each containing 33 participants: tranexamic acid, position change, and control. …”
Get full text

Randomized, Double-Blind, Crossover Study Comparing the Bioavailability of 4 Ashwagandha (Withania somnifera (L.) Dunal) Extracts in Healthy Adults Under Fasting Condition by Priyank Rathi, MD, Se-Kwon Kim, PhD

“…Participants received a single oral dose of 1 of 4 ashwagandha extracts, with varying compositions of 35% (Withania somnifera [WS]-35) or 10% (WS-10) withanolide glycosides, or 5% (WS-5) or 2.5% (WS-2.5) withanolides, each standardized to deliver 185 mg of total withanolides. Seventeen blood samples were collected over a 24-hour period after dose administration. …”
Get full text

Repetitive transcranial magnetic stimulation in children and adolescents with autism spectrum disorder: study protocol for a double-blind, sham-controlled, randomized clinical tria... by Rosa Savino, Sergio Davinelli, Anna Nunzia Polito, Giovanni Scapagnini, Aldo Scirano, Anna Valenzano, Giuseppe Cibelli

“…Methods Forty patients with ASD, aged 7–18 years and with different levels of clinical severity, will be randomized into an active treatment group (n = 20) and a sham control group (n = 20). …”
Get full text

Effectiveness of family-centered intervention programs on objectively measured physical activity in children aged under 13: a meta-analysis of randomized controlled trials by Qian Wang, Lawrence T. Lam, Heng Lin, Wenxian Yang, Fuxian Yin, Yongwei Li

“…IntroductionThis review aims to evaluate the efficacy of family-centered physical activity interventions, as assessed through randomized controlled trials (RCTs) on objectively measured moderate-to-vigorous physical activity (MVPA) and sedentary behavior (SB) in children under 13. …”
Get full text

Effects of Repetitive Transcranial Magnetic Stimulation on Upper Limb Motor Function and Serum Lipid Metabolomics in Patients With Ischemic Stroke: A Randomized Controlled Study by Meng‐Meng Li, Fei‐Yang Jia, Peng‐Cheng Liu, Hong‐Ya Liu, Gui‐Juan Zhou, Xin‐Ke Peng, Jin‐Ling Wang, Shu‐Zhi Li, Jing Liu, Jun Zhou

“…Methods A total of 102 participants were randomly assigned to receive sham rTMS, 1 Hz rTMS, and 10 Hz rTMS. …”
Get full text

Maternal concentrations of vitamin D metabolites in response to high-dose oral vitamin D during first trimester pregnancy: a randomized controlled trial by Inayah Syafitri, Rima Irwinda, Yudianto Budi Saroyo, Yuditiya Purwosunu, Noroyono Wibowo

“…Two intervention groups were randomly assigned: 5,000 IU of vitamin D3 daily or 50,000 IU weekly of vitamin D3. …”
Get full text

Inflammatory and lipemic response to red meat intake in women with and without Rheumatoid Arthritis: a single meal study within a randomized controlled trial by Torsten Sällström, Linnea Bärebring, Erik Hulander, Inger Gjertsson, Anna Winkvist, Helen M. Lindqvist

Get full text

Effect of a single-dose denosumab on mineral homeostasis in infertile men: insights from a pilot intervention study and a randomized controlled trial by Sam Kafai Yahyavi, Rune Holt, Li Juel Mortensen, Ida Marie Boisen, Lív Bech Árting, Anne Jørgensen, Anders Juul, Martin Blomberg Jensen

“…Methods Secondary data from two clinical trials designed to test the effect on semen quality were used: (1) a pilot intervention study with 12 men receiving a single-dose of 60 mg denosumab and (2) a single-center, double-blinded, randomized clinical trial, where 100 infertile men were randomized 1:1 to receive denosumab 60 mg once sc. or placebo. …”
Get full text

Impact of clinical pharmacy services on medication adherence and quality of life in pre-dialysis patients with CKDu: a randomized controlled trial from Sri Lanka by Dilmi Wickramasinghe, Catherine Lynch, Judith Coombes, Shaluka Jayamanne, Shamila De Silva

“…Mann-Whitney U test and independent samples t-test were used in analysis. Results Of 252 participants, 196 completed study (CG = 99,IG = 97). …”
Get full text

The Effectiveness of Virtual Reality–Based Mindfulness Interventions for Managing Stress, Anxiety, and Depression: Protocol for a Systematic Review and Meta-Analysis of Randomized... by Ravi Shankar, Anjali Bundele, Amartya Mukhopadhyay

“…Meta-analysis will use random effects models with inverse variance weighting, calculating standardized mean differences with 95% CIs. …”
Get full text

Similar body composition outcomes following volumetric diet and time-restricted eating in middle-aged individuals: a 12-week randomized controlled trial by Alicia Cloos, Stephan Geisler, Eduard Isenmann

“…Further studies with larger samples and a longer study duration are needed to confirm these findings. …”
Get full text

Differential effects of inulin and fructooligosaccharides on gut microbiota composition and glycemic metabolism in overweight/obese and healthy individuals: a randomized, double-bl... by Jie Li, Feitong Liu, Yuemei Luo, Anisha Wijeyesekera, Shan Wang, Xiaojiao Chen, Yamei Lv, Jing Jin, Huafang Sheng, Guopan Wang, Yuanan Wei, Zhuang Li, Muxuan Chen, Hongwei Zhou

“…In this study, we conducted a randomized, double-blind investigation to examine the impact of inulin and fructooligosaccharides (FOS) on glycemic metabolism in overweight/obese and healthy adults. …”
Get full text

GDF15 and its receptors as pathways mediating smoking related weight changeResearch in context by Alexander C. Tinworth, Andri Iona, Pang Yao, Iona Y. Millwood, Hannah Fry, Jonathan Clarke, Baihan Wang, Mohsen Mazidi, Christiana Kartsonaki, Robin G. Walters, Huaidong Du, Canqing Yu, Yiping Chen, Dianjianyi Sun, Ling Yang, Dan Valle Schmidt, Jun Lv, Daniel Avery, Liming Li, Derrick A. Bennett, Richard Peto, Robert Clarke, Fiona Bragg, Zhengming Chen, Junshi Chen, Zhengming Chen, Robert Clarke, Rory Collins, Liming Li, Jun Lv, Richard Peto, Robin Walters, Daniel Avery, Maxim Bernard, Derrick Bennett, Ruth Boxall, Ka Hung Chan, Yiping Chen, Charlotte Clarke, Jonathan Clarke, Huaidong Du, Ahmed Edris Mohamed, Hannah Fry, Simon Gilbert, Pek Kei Im, Andri Iona, Maria Kakkoura, Christiana Kartsonaki, Hubert Lam, Kuang Lin, James Liu, Mohsen Mazidi, Iona Millwood, Sam Morris, Qunhua Nie, Alfred Pozarickij, Maryam Rahmati, Paul Ryder, Dan Schmidt, Becky Stevens, Iain Turnbull, Baihan Wang, Lin Wang, Neil Wright, Ling Yang, Xiaoming Yang, Pang Yao, Xiao Han, Can Hou, Qingmei Xia, Chao Liu, Pei Pei, Dianjanyi Sun, Canqing Yu, Lang Pan, Zengchang Pang, Ruqin Gao, Shanpeng Li, Haiping Duan, Shaojie Wang, Yongmei Liu, Ranran Du, Yajing Zang, Liang Cheng, Xiaocao Tian, Hua Zhang, Yaoming Zhai, Feng Ning, Xiaohui Sun, Feifei Li, Silu Lv, Junzheng Wang, Wei Hou, Wei Sun, Shichun Yan, Xiaoming Cui, Chi Wang, Zhenyuan Wu, Yanjie Li, Quan Kang, Huiming Luo, Tingting Ou, Xiangyang Zheng, Zhendong Guo, Shukuan Wu, Yilei Li, Huimei Li, Ming Wu, Yonglin Zhou, Jinyi Zhou, Ran Tao, Jie Yang, Jian Su, Fang Liu, Jun Zhang, Yihe Hu, Yan Lu, Liangcai Ma, Aiyu Tang, Shuo Zhang, Jianrong Jin, Jiangchao Liu, Mei Lin, Zhenzhen Lu, Lifang Zhou, Changping Xie, Jian Lan, Tingping Zhu, Yun Liu, Liuping Wei, Liyuan Zhou, Ningyu Chen, Yulu Qin, Sisi Wang, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Xiaoyu Chang, Mingqiang Yuan, Xia Wu, Xiaofang Chen, Wei Jiang, Jiaqiu Liu, Qiang Sun, Faqing Chen, Xiaolan Ren, Caixia Dong, Hui Zhang, Enke Mao, Xiaoping Wang, Tao Wang, Xi Zhang, Kai Kang, Shixian Feng, Huizi Tian, Lei Fan, XiaoLin Li, Huarong Sun, Pan He, Xukui Zhang, Min Yu, Ruying Hu, Hao Wang, Xiaoyi Zhang, Yuan Cao, Kaixu Xie, Lingli Chen, Dun Shen, Xiaojun Li, Donghui Jin, Li Yin, Huilin Liu, Zhongxi Fu, Xin Xu, Hao Zhang, Jianwei Chen, Yuan Peng, Libo Zhang, Chan Qu

“…We assessed associations of individual proteins and GDF15/receptor ratios with smoking and adiposity using linear regression. In two-sample Mendelian randomization (MR) analyses, we used genetic variants for smoking intensity from publicly available GWAS as instruments to assess their causal associations with adiposity and plasma levels of proteins in East Asian and European populations. …”
Get full text

The effect of self-breast examination training provided to women between 18 and 49 years of age and practice on the belief of breast health: A randomized controlled study by Merve Yazar, Ayşenur Demir Küçükköseler, Berna Bayır

“…The universe of the research consisted of the female parents of the students studying in two schools where the research was conducted. The research sample consisted of 98 women, 45 in the intervention group and 53 in the control group, selected by simple random sampling. …”
Get full text

Heritability and causality of QRS duration and chronic heart failure risk by Zequn Zheng, Xinhan Li, Yongfei Song

“…Mendelian randomization (MR) and sensitivity analyses assessed the causality. …”
Get full text

Allantoin Serves as a Novel Risk Factor for the Progression of MASLD by Weiqiang Lv, Xueqiang Wang, Zhaode Feng, Cunxiao Sun, Hansen Wu, Mengqi Zeng, Tianlin Gao, Ke Cao, Jie Xu, Xuan Zou, Tielin Yang, Hao Li, Lei Chen, Jiankang Liu, Shanshan Dong, Zhihui Feng

“…However, Mendelian randomization analysis of over 2 million samples demonstrated causal effects of urate solely on serum triglycerides and T2D risk. …”
Get full text

GVDF-RRT*: An Improved F-RRT* Path Planning Algorithm Based on Generalized Voronoi Diagram by Yitao Zhong, Xiaojing Zhu, Jianfang Huang, Yaokun Ye, Zhaoming Wang, Yuhuai Wang

“…To address these issues, this paper proposes an improved F-RRT* algorithm based on the Generalized Voronoi Diagram (GVD), called GVDF-RRT*. First, a sparse sampling strategy based on GVD is proposed, which improves the sampling efficiency and reduces the initial sampling nodes and initial time by guiding the random tree to explore the space quickly through GVD nodes. …”
Get full text