Blood metabolites, protein regulatory networks and their roles in pan-cancer: a mendelian randomisation study by Shenglong Xia, Zhengyang Xu, Cheng Cheng, Rui An, Wenci Chen, Daopo Lin, Yuzhen Gao, Liangjing Wang, Xinyou Xie, Jun Zhang

“…However, there is a lack of studies to explore the relationship between blood metabolites, related proteins, and different types of cancer. Methods Two-sample Mendelian randomization (MR) analysis was used to assess the causal effects of genetically determined metabolites and metabolite ratios on solid cancers. we analyzed 1400 metabolites/metabolite ratios as exposures and 16 cancers from UK Biobank/FinnGen as outcomes. …”
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Thromboembolic Events in the Hemodialysis Setting: Understanding Risk Profiles and Cumulative Incidences to Inform Clinical Trial Design by Angelo Karaboyas, Junhui Zhao, Laszlo B. Tanko, Kristian Tore Joergensen, Akos F. Pap, Indranil Dasgupta, Masaomi Nangaku, Michel Jadoul, Roberto Pecoits‐Filho

“…Three‐year cumulative incidence of MAVE was 13% in the overall cohort and 18% in the ASCVD subset. The estimated sample size to be randomized in a hypothetical trial in the ASCVD population was ≈7000 patients. …”
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Exploration of shared pathogenic factors and causative genes in early-stage endometrial cancer and osteoarthritis by Yiyun Bai, Sang Luo, Ruzhen Shuai, Xiaomei Zhang, Liwei Yuan, Dan Liu

“…This study aimed to investigate the causal relationship between OA and EC and to identify causative genes common to both early-stage EC and OA. A Two-sample Mendelian randomization (MR) analysis was first performed to assess the causal relationship between OA and EC. …”
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The main mediating lipid species in cholesterol-induced colorectal cancer risk by Yuanyuan Wang, Tiantian Wang, Xinru Shen, Zhitu Zhu

“…Therefore, this study plans to search for the major lipid species that influence the risk of CRC.MethodsInitially, a two-sample Mendelian randomization analyses was employed to examine the association between 179 lipid levels and the risk of CRC. …”
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The association between the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio and delirium in ischemic stroke patients by Pangbo Wang, Pangbo Wang, Jing Huang, Liwei Xu, Rong Hu

“…We employed multivariable logistic regression and restricted cubic splines (RCS) to assess the association between the NLR, PLR, and LMR and delirium. Two-sample Mendelian randomization (MR) analysis was performed to further explore their causal relationship at the genetic level.ResultsA total of 1,436 patients with IS were included in this study, of whom 214 (14.9%) had delirium. …”
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Potential association between allergic disease and risk of Alzheimer’s disease: insight from genetic analysis by Tianyu Jin, Wei Huang, Yifan Cheng, Zheng Cao, Shunyuan Guo, Chunrong Li

“…To address this, we conducted a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the potential causal impact of allergic diseases on AD. …”
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Deciphering the causal link between gut microbiota and membranous nephropathy: insights into potential inflammatory mechanisms by Jianbo Qing, Changqun Li, Nan Jiao

“…However, direct causal relationships and therapeutic implications remain unclear.Methods We utilized a comprehensive GWAS dataset that encompasses GM, metabolites, and MN through two-sample Mendelian randomization (MR) analyses, bidirectional MR evaluations, and detailed sensitivity tests.Results We identified strong causal associations between nine specific types of GM, including class Clostridia (OR = 1.816, 95%CI: 1.021–3.236, p = .042), class Melainabacteria (OR = 0.661, 95%CI: 0.439–0.996, p = .048), order Gastranaerophilales (OR = 0.689, 95%CI: 0.480–0.996, p = .044), genus Alistipes (OR = 0.480, 95%CI: 0.223–0.998, p = .049), genus Butyricicoccus (OR = 0.464, 95%CI: 0.216–0.995, p = .048), genus Butyrivibrio (OR = 0.799, 95%CI: 0.639–0.998, p = .048), genus Ruminococcaceae UCG003 (OR = 0.563, 95%CI: 0.362–0.877, p = .011), genus Streptococcus (OR = 0.619, 95%CI: 0.393–0.973, p = .038), and genus Oscillibacter (OR = 1.90, 95%CI: 1.06–3.40, p = .031). …”
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Longitudinal Association of Changes in Metabolic Syndrome with Cognitive Function: 12-Year Follow-up of the Guangzhou Biobank Cohort Study by Yu Meng Tian, Wei Sen Zhang, Chao Qiang Jiang, Feng Zhu, Ya Li Jin, Shiu Lun Au Yeung, Jiao Wang, Kar Keung Cheng, Tai Hing Lam, Lin Xu

“…Additionally, the genome-wide association study (GWAS) of MetS was conducted and one-sample MR was performed to assess the causality between MetS and cognitive function. …”
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Role of Immune Cells in Mediating the Effect of Hypothyroidism on Idiopathic Pulmonary Fibrosis by Zhengling Liu, Chengkun Kou, Xiaobo Chen, Jing Yang, Huan Zhu, Yongning Jiao, Dongyan Zhang, Wencui Zhang, Liang Li

“…We aimed to explore the causative link between hypothyroidism and IPF, particularly focusing on immune cell phenotypes as mediating factors. Methods A two‐sample Mendelian randomization (MR) approach was utilized to investigate the influence of hypothyroidism on IPF and the role of 731 distinct immune cell phenotypes as mediators. …”
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Association between depression and asthma: insight from observational and genetic evidence by Tanao Ji, Yue Lv, Jianan Yang, Xianping Diao, Jun Gu

“…Subsequently, a linkage disequilibrium score regression (LDSC) analysis was conducted to evaluate the genetic correlation between depression and asthma. Moreover, a two-sample Mendelian randomization (MR) analysis was conducted by employing genome-wide association study (GWAS) summary statistics by means of both univariable MR (UVMR) and multivariable MR (MVMR). …”
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CDKN1A as a target of senescence in heart failure: insights from a multiomics study by Rutao Bian, Rutao Bian, Li Zhang, Li Zhang, Dongyu Li, Dongyu Li, Xuegong Xu, Xuegong Xu

“…To explore the causal relationship with HF using Mendelian Randomization (MR). Genetic variations influencing gene expression, DNA methylation, and protein expression (cis-eQTL, cis-mQTL, and cis-pQTL) were analyzed using the two-sample MR (TSMR) and summary-data-based MR (SMR). …”
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Effect of preoperative chlorhexidine, essential oil, and cetylpyridinium chloride mouthwashes on bacterial contamination during dental implant surgery: A randomized controlled clin... by Wael Yaghmoor, Montserrat Ruiz-Torruella, Yumi Ogata, Zuhair S. Natto, Matthew Finkelman, Toshi Kawai, Yong Hur

“…A statistically significant difference was observed between the groups for the pre–post and pre–end samples (p < 0.001) but not for the post–end samples (p = 0.203). …”
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Appraising non-linear association between pre-diagnostic platelet counts and cancer survival outcomes: observational and genetic analysis by Changtao Li, Junhua Chen, Deqian Han, Chi Shu, Jun Huang, Linru Wei, Haoran Luo, Qingbin Wu, Xin Chen, Yazhou He, Yanhong Zhou

“…We conducted a cohort study using the UK Biobank and a two-sample Mendelian randomization (MR) analysis. PLT levels were measured prior to cancer diagnosis. …”
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Short-term Haematological Parameters Following Surgical Removal of Mandibular Third Molars with Different Doses of Methylprednisolone Compared with Placebo. A Randomized Controlled... by Marie Kjærgaard Larsen, Thomas Kofod, Kirsten Duch, Thomas Starch-Jensen

“…Peripheral blood samples were obtained before and three days after surgery. …”
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Comparing the effects of smartphone-based and face-to-face education on the quality of life and coping skills among patients with multiple sclerosis: A randomized controlled trial by Elahe Baharian, Shahla Abolhassani, Arash Najimi, Fereshteh Ashtari

“…The training sessions were provided in the form of F2F sessions and an application installed on patients’ mobile phones in the smartphone-based education group. Independent-samples t-test, paired-samples t-test, and chi-square were employed to analyze data via Statistical Package for the Social Sciences (SPSS) software version 20. …”
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Immune Cells as Mediators of Lipidome Influence on Osteoporosis: Evidence from a Mediation Analysis by Jiheng Xiao, Wei Zhou, Jiatai He, Yanbin Zhu, Yingze Zhang, Liming Xiong

“…Genome-Wide Association Study (GWAS) summary statistics for osteoporosis and 731 immune cell immunophenotypes were sourced from the GWAS Catalog. A two-step, two-sample Mendelian randomization analysis, using inverse variance weighting (IVW), was conducted to explore the potential causal effects of lipids on osteoporosis and the mediating role of immune cells in the relationship between lipids and osteoporosis. …”
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The effects of Shenkang suppository on kidney function and gut microbiota in nondialysis patients with chronic kidney disease stages 3–4: A randomized controlled trial by Weiwei Zhang, Xin Zhang, Shuang Xu, Yousuf Abdulkarim Waheed, Yousuf Abdulkarim Waheed, Yizhou Xu, Shulin Li, Shulin Li, Dong Sun, Dong Sun, Dong Sun

“…Baseline data, clinical indicators, kidney markers, and stool samples were obtained from participants before and after treatment. …”
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Comparison of 0.9% Saline vs ringers lactate as resuscitation and maintenance fluid in critically ill children: A single blinded randomized comparative trial by Yatnesh More, Mukul Pandey, Nirmal Kumar

“…All the samples were collected at the time of admission (T0), at 12 h (T12) and 24 h (T24). …”
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Evaluation of zinc oxide nanoparticle coated elastomeric modules and it’s effect on Streptococcus mutans concentration and enamel mineralization - A randomized split mouth trial by J. Hemashree, Sridevi Padmanabhan

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A multicenter, randomized, open label, two formulation, crossover bioequivalence trial of doxorubicin hydrochloride liposomal injection in Chinese patients with metastatic breast c... by Jingshu Wang, Xiuping Lai, Herui Yao, Hui Yang, Xiaolong Cao, Xiaochen Wang, Ying Wang, Weiqi Nian, Xiaodong Zheng, Qingxiu Mai, Anding Liu, Xiaozhi Lv, Xiaoying Bi, Junyi Chen, Junyan Wu, Suiwen Ye

“…Methods To achieve these goals, the trial employed a randomized, open-label, two-formulation crossover dosing strategy among Chinese patients with metastatic breast cancer. …”
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