Succinate-Based Dietary Supplement for Menopausal Symptoms: A Pooled Analysis of Two Identical Randomized, Double-Blind, Placebo-Controlled Clinical Trials by Viktor E. Radzinsky, Yulia Uspenskaya, Lee P. Shulman, Irina V. Kuznetsova

“…To evaluate the efficacy of a succinate-based dietary supplement (SBDS; Amberen) in symptomatic menopausal women using a larger sample size derived by pooling data from two identical trials. …”
Get full text

Effects of resistant starch supplementation on renal function and inflammatory markers in patients with chronic kidney disease: a meta-analysis of randomized controlled trials by Yong Zhang, Xiang-Yang Hu, Shi-Yun Yang, Ying-Chun Hu, Kai Duan

“…Nevertheless, results should be cautiously interpreted, because of the limited sample size and different treatment dosages. Further research is necessary to corroborate the beneficial effects of RS2 supplementation in this population.…”
Get full text

Gender differences in the use of an upper-extremity exoskeleton during physically and cognitively demanding tasks- a study protocol for a randomized experimental trial by Bettina Wollesen, Bettina Wollesen, Julia Gräf, Lasse Hansen, Anna Gurevich, Shirley A. Elprama, Andreas Argubi-Wollesen, Kevin De Pauw, Kevin De Pauw, Kevin De Pauw

Get full text

Does isovaleric acid play a key role in the interaction between probiotics and antidepressants? A secondary analysis of a randomized clinical trial by Oliwia Gawlik-Kotelnicka, Marharyta Sobczak, Joanna Palma, Marta Popławska, Karolina Skonieczna-Żydecka, Maksymilian Plewka, Rafał Pawliczak, Dominik Strzelecki

“…More research with a larger sample size is needed to study SCFAs' role as a mediator of antidepressant action of both probiotics and medications. …”
Get full text

Causal impact of elevated body mass index on diabetic kidney disease: an integrated Mendelian randomization and Global Burden of Disease Study 2021 analysis by Ye-xin Chen, Dong-sen Hu, Mao-xuan Lin, Zi-heng Gao, Han-zhang Hong, Yu-xin Hu, Ling-zi Yao, Gai-wen Cui, Lin Wang

“…However, establishing a causal relationship and quantifying the resultant global health impact remain challenging.Methods A two-sample Mendelian randomization (MR) analysis was conducted using summary-level data obtained from the IEU database. …”
Get full text

Dissecting Causal Relationships Between Antihypertensive Drug, Gut Microbiota, and Type 2 Diabetes Mellitus and Its Complications: A Mendelian Randomization Study by He Zheng, Shiping Wu, Wenbin Wang, Weida Qiu, Yingqing Feng

“…Thus, we conducted a two‐sample Mendelian randomization (MR) analysis to estimate the potential impact of various antihypertensive drug target genes on T2DM and its complications. …”
Get full text

Association between Apolipoprotein B and diabetic nephropathy: insights from the National Health and Nutrition Examination Survey 2007–2016 and Mendelian randomization analysis by Hui Wang, Sensen Wu, Dikang Pan, Yachan Ning, Yanhong Fu, Chunjing Feng, Jianming Guo, Zichuan Liu, Yongquan Gu

“…Subsequently, a bidirectional two-sample Mendelian randomization study using genome-wide association study summary statistics was performed. …”
Get full text

Statistical and health economic analysis plan for a secure care hospital evaluation of manualised (interpersonal) art-psychotherapy: the SCHEMA randomized controlled trial by Jennifer Condie, Matthew Franklin, Katie Aafjes-van Doorn, Paula Foscarini-Craggs, Iain McKinnon, Toni Leigh Harrison, Arman Iranpour, Ania Zubala, Sophie Rose, Elizabeth Randell, Rachel McNamara, Muhammad Riaz, Simon Hackett

Get full text

Exploring the causal associations of the gut microbiota and plasma metabolites with ovarian cancer: an approach of mendelian randomization analysis combined with network pharmacolo... by Junfeng Guo, Chen Wang, He Li, Chenhuan Ding

“…Methods We conducted a two-sample Mendelian randomization (MR) study utilizing a large-scale genome-wide association study (GWAS) to explore the causal effects of the gut microbiota of 196/220 individuals and 1,400 plasma metabolites on OC and epithelial ovarian cancer (EOC) subtypes. …”
Get full text

The impact of physical exercise interventions on social, behavioral, and motor skills in children with autism: a systematic review and meta-analysis of randomized controlled trials by YanAn Wang, Guoping Qian, Sujie Mao, Shikun Zhang

“…Future research should focus on larger sample sizes and long-term follow-ups to confirm the sustainability and generalizability of intervention effects.…”
Get full text

Study on the safety and efficacy of Fu's subcutaneous needling for the treatment of lumbar disc herniation: a systematic review and meta analysis of randomized controlled trials by Jiao Liang, Jin Zhang, Jie Zhou, Kun Yang, Qian Xiong

“…However, due to the publication bias, the strength of the evidence is insufficient. High-quality, large-sample, multi-center randomized controlled trials are still needed for further research.Systematic review registrationThe protocol for this systematic review was registered on PROSPERO and is available in full on the website (https://www.crd.york.ac.uk/PROSPERO, CRD42024595890).…”
Get full text

Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses. by Nikhil K Khankari, Xiao-Ou Shu, Wanqing Wen, Peter Kraft, Sara Lindström, Ulrike Peters, Joellen Schildkraut, Fredrick Schumacher, Paolo Bofetta, Angela Risch, Heike Bickeböller, Christopher I Amos, Douglas Easton, Rosalind A Eeles, Rosalind A Eeles, Stephen B Gruber, Christopher A Haiman, David J Hunter, Stephen J Chanock, Brandon L Pierce, Wei Zheng, Colorectal Transdisciplinary Study (CORECT), Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE), Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE), Transdisciplinary Research in Cancer of the Lung (TRICL)

“…Our meta-analysis was limited to published studies. The sample size for the Mendelian randomization analysis of colorectal cancer was relatively small, thus affecting the precision of the point estimate.…”
Get full text

Effectiveness of prior intra-articular corticosteroid injection in elderly patients with knee osteoarthritis undergoing progressive resistance training: a randomized controlled tri... by Christine Brumini, Rita Nely Vilar Furtado, Anamaria Jones, Raphael Vilela Timóteo da Silva, Jamil Natour

“…Future studies with larger sample sizes and long-term follow-ups are needed to better assess the role of intra-articular corticosteroid injections in OA rehabilitation. …”
Get full text

Effectiveness of Virtual Simulations Versus Mannequins and Real Persons in Medical and Nursing Education: Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trial... by Nan Jiang, Yuelun Zhang, Siyu Liang, Xiaohong Lyu, Shi Chen, Xiaoming Huang, Hui Pan

“…All pooled estimates were based on random-effects models and assessed by trial sequential analyses. …”
Get full text

Therapeutic Role of Additional Mirror Therapy on the Recovery of Upper Extremity Motor Function after Stroke: A Single-Blind, Randomized Controlled Trial by Xin Wen, Li Li, Xuelian Li, Huanghong Zha, Zicai Liu, Yang Peng, Xuejin Liu, Huiyu Liu, Quan Yang, Jing Wang

“…A paired t-test was used to compare the values between pretreatment and posttreatment within an individual group. Two-sample t-test was utilized to compare the changes (baseline to postintervention) between the two groups. …”
Get full text

Short-Term Effects of Visceral Manual Therapy on Autonomic Nervous System Modulation in Individuals with Clinically Based Bruxism: A Randomized Controlled Trial by Cayetano Navarro-Rico, Hermann Fricke-Comellas, Alberto M. Heredia-Rizo, Juan Antonio Díaz-Mancha, Adolfo Rosado-Portillo, Lourdes M. Fernández-Seguín

“…<b>Methods</b>: A single-blind randomized controlled trial was conducted including 24 individuals with clinically based bruxism. …”
Get full text

Potential protective role of Bifidobacteria in myopia prevention: evidence from full-length 16S rRNA sequencing and bidirectional Mendelian randomization analysis by Guodong Tang, Yibo Han, Xiaoqi Gong, Xuejing Wang, Jing Li, Jun Zhang, Junru Wang, Jike Song, Jike Song, Hongsheng Bi, Hongsheng Bi

“…Bidirectional two-sample MR analysis was performed using genome-wide association study summary statistics comprising data on 196 GM taxa from the MiBioGen consortium and myopiaassociated data from the FinnGen database. …”
Get full text

Causal Effects of Immune Cells on Reproductive Ill-Health, Including Abnormal Spermatozoa, Polycystic Ovary Syndrome and Spontaneous Abortion: Mendelian Randomization Analyses by Chen S, Sun S, Zhou Z, Zhou Z, Zhang R, Song W, Xin H, Yang Q, Dai S, Huang K, Niu W, Shi H, Guo Y

“…However, little is known about the causal relationship between immune factors and diseases of the reproductive system.Methods: Thorough two-sample Mendelian randomization (MR) analyses were conducted to determine the causal effects of 731 immune traits on reproductive ill-health, including abnormal spermatozoa (AS), polycystic ovary syndrome (PCOS), and spontaneous abortion (SA). …”
Get full text

Impact of Kinesio Taping on Oral Feeding and Swallowing Functions: Acoustic Analysis of Swallowing Sounds in Late Preterm Infants—A Randomized Clinical Trial by Nilay Comuk Balci, Deniz Anuk Ince, Ayşe Ecevit, Balkar Erdoğan, Ilknur Ezgi Doğan, Ozden Turan, Aylin Tarcan

“…<b>Methods:</b> Seventy-four late preterm infants (mean gestational age 35.30 ± 0.81 weeks) were randomly assigned to either a Kinesio-taping group or a control group. …”
Get full text

Digital Cognitive Behavioral Therapy–Based Treatment for Insomnia, Nightmares, and Posttraumatic Stress Disorder Symptoms in Survivors of Wildfires: Pilot Randomized Feasibility Tr... by Fadia Isaac, Britt Klein, Huy Nguyen, Shaun Watson, Gerard A Kennedy

Get full text