Alcohol consumption and esophageal cancer risk: unveiling DLEU2 as a key immune modulator through Mendelian randomization and transcriptomic analysis by Kailin Qu, Jingyan Gu, Zhi Xu, Yixiang Hepeng, Qi Ning, Xu Wu

“…This study utilized Mendelian randomization analysis to establish a causal relationship between alcohol consumption and EC (OR: 4.11 [95% CI 1.83–9.23]). …”
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The impact of Hemodiafiltration with endogenous reinfusion (HFR) on micronutrient status in patients undergoing maintenance hemodialysis: study protocol of a randomized controlled... by Changhao Zhu, Lingling Ding, Naiying Lan, Fanzhou Zeng, Dan Ye, Hao Wang, Bo Yang

“…Blood samples will be collected pre- and post-treatment to measure trace elements, water-soluble vitamins, and fat-soluble vitamins. …”
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Impact of Denture Cleaning Method and Overnight Storage Condition on Denture Biofilm Mass and Composition: A Cross-Over Randomized Clinical Trial. by Joke Duyck, Katleen Vandamme, Stefanie Krausch-Hofmann, Lies Boon, Katrien De Keersmaecker, Eline Jalon, Wim Teughels

“…Each test condition was performed for 5 consecutive days, preceded by a 2-days wash-out period. Biofilm samples were taken at baseline (control) and at the end of each test period from a standardized region. …”
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Timing of unsaturated fat intake improves insulin sensitivity via the gut microbiota-bile acid axis: a randomized controlled trial by Chunbo Wei, Xiaoqing Xu, Jia Zhang, Xuanyang Wang, Tianshu Han, Yingfeng Zhang, Sijia Pan, Zhu Ming, Ran Li, Fengge Lou, Yu Cheng, Huan Xu, Xingyuan Sun, Guannan Geng, Yujun Pan, Qianmin Liu, Haitao Qi, Xuemin Yan, Keke Dang, Jiaofeng Zhou, Changhao Sun, Ying Li

“…Sixty participants with completed fecal samples were included in the final analysis (n = 15 for each group). …”
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Effects of oat β-glucan-based prebiotic blended formulas on defecation and gut microbiota in Chinese adults: a randomized clinical trial by Aiqi Li, Lei Jin, Hui Xia, Meiyuan Feng, Xirui Zhou, Yifang Chu, Feng Liu, Lanxing Jia, Ximin Chen, Dengfeng Xu, Shanjie Ma, Xiaofan Xu, Xinyu Wang, Xiaoqing Li, Guiju Sun, Liegang Liu

“…Participants completed a defecation diary and Bristol stool chart daily and digestive system questionnaires weekly. Fecal samples were collected on day 0 and day 14 to evaluate gut bacteria using 16S rDNA analysis. …”
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Psychobiotics Regulate the Anxiety Symptoms in Carriers of Allele A of IL-1β Gene: A Randomized, Placebo-Controlled Clinical Trial by P. Gualtieri, M. Marchetti, G. Cioccoloni, A. De Lorenzo, L. Romano, A. Cammarano, C. Colica, R. Condò, L. Di Renzo

“…Genotyping was performed on DNA extracted from salivary samples. Results. After 12 weeks of intervention, a significant reduction of HAM-A total score was detected in the POSG (p<0.01), compared to the PCG. …”
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Comparative Efficacy of Lidocaine, Benzocaine, and Combination Topical Therapy for Pain Reduction in Pediatric Local Anesthesia: A Randomized Clinical Trial Study by Sazgar Muhammed Sabir, Abduljaleel Samad, Shereen Najat Haji, Abdulrahman Azad Samad, Omer Mahmood Attallah

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Influence of pistachios on performance and exercise-induced inflammation, oxidative stress, immune dysfunction, and metabolite shifts in cyclists: a randomized, crossover trial. by David C Nieman, Johannes Scherr, Beibei Luo, Mary Pat Meaney, Didier Dréau, Wei Sha, Dustin A Dew, Dru A Henson, Kirk L Pappan

“…<h4>Methods</h4>Using a randomized, crossover approach, cyclists (N = 19) engaged in two 75-km time trials after 2-weeks pistachio or no pistachio supplementation, with a 2-week washout period. …”
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Effects of hyperbaric oxygen therapy on recovery after a football match in young players: a double-blind randomized controlled trial by Marko Gušić, Tomislav Stantić, Anja Lazić, Slobodan Andrašić, Bart Roelands, Bart Roelands, Špela Bogataj, Špela Bogataj

“…This study investigated if a single 1-h hyperbaric oxygen therapy (HBOT) session affects recovery and performance after a football match in elite youth players.MethodsTwenty elite youth football players (age 17.3 ± 0.5 years) were randomly assigned to a HBOT group or a control group (CON). …”
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Graded motor imagery as an adjunct to comprehensive physiotherapy in chronic rotator cuff-related pain: a single blind randomized controlled trial by Seda Sırlan, Nuray Alaca, Hacı Ahmet Yarar, Onur Başcı

“…Methods In this single-blind randomized controlled trial, 30 participants with C-RCRSP were randomized into two groups: comprehensive physiotherapy alone (CP) or combined with GMI (CP + GMI). …”
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Effect of Norepinephrine and Phenylephrine on Tissue Oxygenation During Superficial Temporal Artery-Middle Cerebral Artery Bypass: A Randomized Controlled Trial by Cheng J, Kang F, Han M, Song Y, Chang L, Huang X, Zhang Y, Li J

“…Cerebral oxygenation, muscle oxygenation, cardiac output, and urine volume were recorded at several timepoints: Before preoxygenation, After intubation, Skin cutting, Superficial temporal artery exposing, Middle cerebral artery exposing, and End of the surgery. Additionally, blood samples were collected from the superior vena cava and radial artery for blood gas analysis, to assess central venous oxygen saturation, blood lactate and calculate oxygen extraction rate. …”
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Transcranial direct current stimulation over motor cortex improves pain in end stage renal disease a randomized controlled trial by Eduarda Fonseca Mendes, Edson Silva-Filho, Joanna Brito Holanda, M. G. L. Matias, Tatiana Camila Lima, Sara Costa, Artur Quintiliano, Kevin Pacheco-Barrios, Felipe Fregni, Rodrigo Pegado

“…Thirty-four participants were randomized to receive either active or sham tDCS, with 15 sessions administered over five weeks. …”
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The impact of three months of adjuvant yoga intervention on glycemic control among adolescents with type 1 diabetes: a randomized control trial by Sonu Maurya, Suchitra Patil, Amit Singh, Indu Rani, Navneet Kaur, Sriloy Mohanty, Akshay Anand, Raghuram Nagarathna

“…Methods In this trial, 92 T1DM subjects with mean age of 13.35 ± 2.41 years were recruited and randomly allocated to either yoga or control arm with an allocation ratio of 1:1. …”
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Identification Exploring the Mechanism and Clinical Validation of Mitochondrial Dynamics-Related Genes in Membranous Nephropathy Based on Mendelian Randomization Study and Bioinfor... by Qiuyuan Shao, Nan Li, Huimin Qiu, Min Zhao, Chunming Jiang, Cheng Wan

“…RT-qPCR results corroborated a significant downregulation of all four genes in MN samples compared to controls (<i>p</i> < 0.05). <b>Conclusions:</b> These findings elucidate the molecular underpinnings of MDG-mediated mechanisms in MN, revealing novel diagnostic biomarkers and therapeutic targets. …”
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Assessment of a multi-ingredient dietary supplement on sleep quality: a randomized, double-blinded, placebo-controlled crossover clinical study by Anna Andersen, David Vollmer, Brent Vaughan, Dennis Eggett, Michael A. Grandner, Xuesheng Han

“…Participants were instructed to fill out Insomnia Severity Index (ISI) and the Leeds Sleep Evaluation Questionnaire (LSEQ) survey weekly, and keep a sleep diary daily, which were used to assess their sleep quality. Saliva samples were taken from participants before and after each 2-week treatment period to measure salivary melatonin level. …”
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Impact of Nano-Selenium supplementation on the JAK/STAT signaling pathway in major depressive disorder: a Triple-Blind, randomized controlled trial by Morvarid Noormohammadi, Farnaz Etesam, Ali Amini, Pegah Khosravian Dehkordi, Morteza Mohammadzadeh, Farzad Shidfar

“…All participants were receiving their standard treatment (sertraline 50 mg/day). Blood samples were collected at baseline and post-intervention to measure the gene expression using RT-qPCR. …”
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Effect of silver diamine fluoride and nanosilver on salivary bacterial counts in children with early childhood caries: a randomized controlled clinical trial by Nour Ammar, Magda M. El-Tekeya, Dalia M. Talat, Sara Essa, Marwa M. Essawy, Jan Kühnisch, Hams Hamed, Nouran Nabil, Samar El Achy, Maha El Tantawi

“…Followed by the application of either 38% SDF or NSF. Saliva samples were recollected after one month. The legal guardians completed a detailed questionnaire assessing their child’s dental hygiene habits, dental pain experience, and socioeconomic background. …”
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Effects of Bojungikki-Tang on immune response and clinical outcomes in NSCLC patients receiving immune checkpoint inhibitors: a randomized pilot study by Mi Mi Ko, Se Won Na, Jin-Mu Yi, Ho Jang, Chang Min Choi, Seung Hyeun Lee, Sung Yong Lee, Mi-Kyung Jeong

“…Methods Twenty-eight patients were randomized to either the BJIKT (n = 14) or placebo (n = 14) groups. …”
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Health Benefits of Montmorency Tart Cherry Juice Supplementation in Adults with Mild to Moderate Ulcerative Colitis; A Placebo Randomized Controlled Trial by Jonathan Sinclair, Graham McLaughlin, Robert Allan, Johanne Brooks-Warburton, Charlotte Lawson, Shan Goh, Terun Desai, Lindsay Bottoms

“…Materials and methods: Thirty-five patients with UC were randomly assigned to receive either placebo or Montmorency tart cherry juice, of which they drank 60 mL per day for 6 weeks. …”
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Effect of combination hepatoprotective therapy with sulfur-containing drugs on oxidative homeostasis in the blood of patients with alcoholic hepatitis: A randomized prospective stu... by I. M. Bykov, G. A. Ermakova, K. A. Popov, M. A. Popova, A. G. Zavgorodnyaya, E. S. Ustinova

“…Patients with other decompensated somatic and psychiatric disorders were excluded from the study. Via simple randomization with the use of random number tables, the patients were distributed into three groups. …”
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