A multidisciplinary pain management program for patients with chronic low back pain: a randomized, single-blind, controlled, feasibility study by Anna Dalmau-Roig, Christian Dürsteler, Mirari Ochandorena-Acha, Francisco Vilchez-Oya, Inés Martin-Villalba, Amadeu Obach, Marc Terradas-Monllor

“…Furthermore, another of the secondary objectives was to calculate the sample size for a future randomized clinical trial. …”
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Clinical benefit of physical rehabilitation after total hip and knee arthroplasty: A pragmatic, randomized, controlled trial (The DRAW1 trial) by T. Mark-Christensen, K. Thorborg, T. Kallemose, T. Bandholm

“…Objective: To compare the effectiveness of a 6-week program of physical rehabilitation (home-based telerehabilitation, or home-based rehabilitation) to no physical rehabilitation following THA and TKA. Design: 3-arm,randomized, controlled, superiority trial with blinded outcome assessments. 377 patients (210 THA/167 TKA) were screened for eligibility before the targeted sample size of 168 patients was reached. …”
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Long-term non-invasive ventilation for COPD patients following an exacerbation with acute hypercapnic respiratory failure: a randomized controlled trial by Caroline Hedsund, Kasper Linde Ankjærgaard, Tine Peick Sonne, Philip Tønnesen, Ejvind Frausing Hansen, Helle Frost Andreassen, Ronan M. G. Berg, Jens-Ulrik Stæhr Jensen, Jon Torgny Wilcke

“…LT-NIV was aimed to normalize PaCO2 using high-pressure NIV.Results The study was discontinued before full sample size due to slow recruitment. 28 patients were randomized to LT-NIV and 27 patients to standard of care. 42% of patients had a history of ≥ 2 admissions with AHRF. …”
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A single HIIT session does not alter blood sphingolipid levels in healthy young adults: The SphingoHIIT randomized controlled trial by Thomas Angst, Nadia Weber, Seraina Fischer, Joëlle Lehmann, Denis Infanger, Tony Teav, Fabian Schwendinger, Lukas Streese, Timo Hinrichs, Ilaria Croci, Christian Schmied, Hector Gallart-Ayala, Christoph Höchsmann, Karsten Koehler, Henner Hanssen, Arno Schmidt-Trucksäss, Julijana Ivanisevic, Justin Carrard

“…Thirty-six healthy young individuals (aged 20–29 years; 50 % female) were randomly assigned to a HIIT (n = 18) or control group (physical rest, n = 18). …”
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Integrating Mendelian randomization and multi-transcriptomic analyses to unveil the genetic association risk of regulatory T cell-mediated free cholesterol and gastric cancer by Fanyu Peng, Haitao Liu, Yesong Guo, Jing Wen, Yizhi Ge, Yanhong Luo

“…Methods We employed a two-sample Mendelian randomization (MR) approach to investigate the causal relationship between 233 metabolites and gastric cancer. …”
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A Mobile App–Based Intervention (Parentbot–a Digital Healthcare Assistant) for Parents: Secondary Analysis of a Randomized Controlled Trial by Joelle Yan Xin Chua, Mahesh Choolani, Cornelia Yin Ing Chee, Huso Yi, Joan Gabrielle Lalor, Yap Seng Chong, Shefaly Shorey

“…MethodsThis study is the secondary analysis of a randomized controlled trial. A convenient sample of 118 heterosexual couples (236 participants: n=118, 50% mothers and n=118, 50% fathers) from a public tertiary hospital in Singapore were recruited. …”
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Combination of Electroacupuncture and Medication for Patients With Tinnitus Associated With Idiopathic Sudden Sensorineural Hearing Loss: Protocol for a Prospective Randomized Cont... by Tuoran Wang, Lingyu Qi, Xinping Hao, Miao Zhang, Shihao Du, Biao Chen, Chang Liu, Jing Chen, Xinyue Zou, Ping Liu, Jin Huo

“…MethodsIn this double-center, assessor-blinded, randomized controlled trial, 60 patients with ISSNHL accompanied by tinnitus will be randomly allocated to either the EA group, receiving EA combined with medication, or the control group, receiving standard medication treatment, for a total treatment duration of 4 weeks. …”
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Comparative efficacy of robotic exoskeleton and conventional gait training in patients with spinal cord injury: a meta-analysis of randomized controlled trials by Shengye Liu, Fangyuan Chen, Jianqiao Yin, Guanqi Wang, Liyu Yang

“…Data synthesis Of 595 studies identified, 15 randomized controlled trials (n = 579) were included for meta-analysis. …”
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The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis by Peiye Zhu, Yunrui Jin, Jiya Sun, Xia Zhou

“…However, due to the limitations of the study, more large-sample, multi-center clinical studies are needed to verify this conclusion.…”
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Effect of early essential newborn care on breastfeeding and outcomes of mothers/newborns post-cesarean section: a randomized controlled trial in China by Min Zhou, Jin-Yi Guo, Tai-Yang Li, Chun-Hua Zhou, Xiao-Qin Zhang, Wei Wei, Jie Zhou, Sharon R. Redding, Yan-Qiong Ouyang, Hui-Jun Chen

“…This study aimed to systematically evaluate the effects of EENC during and after cesarean section. Methods A randomized controlled trial was conducted at a tertiary hospital in Wuhan, China. …”
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The impact of enteral immunonutrition on gut microbiota in colorectal cancer and gastric cancer patients in the preoperative period—preliminary results of randomized clinical trial... by Karolina Kaźmierczak-Siedlecka, Ewa Stachowska, Robert Kucharski, Robert Kucharski, Piotr Wiśniewski, Paweł Ulasiński, Michał Stańczak, Michał Stańczak, Wojciech Makarewicz, Wojciech Makarewicz, Karolina Skonieczna-Żydecka, Leszek Kalinowski, Leszek Kalinowski

“…The stool samples were collected at day 0 and after 7 days of consuming the study products. …”
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Investigating the impact of interdisciplinary training programs on self-efficacy and life satisfaction among Hemodialysis patients: a randomized controlled clinical trial by Mohadese Bahmani, Mostafa Bijani, Zhila Fereidouni, Azizallah Dehghan, Amene Modreki

“…Those who agreed to participate were randomly allocated into two groups: an intervention group (n = 50) and a control group (n = 50). …”
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The lasting influence of parenting intervention on child behavior: findings from a randomized clinical trial using care for child development guidelines by Kasra Talebi Anaraki, Nastaran Ghanbarian Alavijeh, Maryam Bemanalizadeh, Omid Yaghini, Negin Badihian, Mehri Khoshhali, Shervin Badihian, Neda Hosseini, Marziye Purpirali, Mansoore Abadian, Seyede Shahrbanoo Daniali, Roya Kelishadi

“…The comparisons between groups were done using independent two-sample t-tests, or the Mann-Whitney test and the Chi-square test. …”
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Effects and Acceptability of a 1-Week Home-Based Virtual Reality Training for Supporting the Management of Stress and Anxiety: Randomized Pilot Trial by Federica Pallavicini, Eleonora Orena, Lisa Arnoldi, Federica Achille, Stefano Stefanini, Maddalena Cassa, Alessandro Pepe, Guido Veronese, Luca Bernardelli, Francesca Sforza, Sara Fascendini, Carlo Alberto Defanti, Marco Gemma, Massimo Clerici, Giuseppe Riva, Fabrizia Mantovani

“…However, current interventions have limitations related to location (ie, therapist’s office or hospitals) and content (ie, virtual experiences only for relaxation). ObjectiveThis randomized pilot trial aims to investigate the efficacy and acceptability of a brief remote VR-based training for supporting stress and anxiety management in a sample of Italian health care workers. …”
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Spirituality-based palliative care education on quality of life, death anxiety, and resilience of heart failure patients: Randomized controlled clinical trial by Roghayeh Balaghi Inaloo, Mostafa Bijani, Leila Nikrouz, Azizallah Dehghan, Abdulhakim Alkamel, Ali Taghinezhad, Zahra Khiyali

“…Methods: This investigation employed a randomized controlled clinical trial design without blinding, incorporating both experimental and control groups. 80 patients who were randomly assigned to intervention and control groups (40 patients per group). …”
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Docosahexaenoic acid (DHA) Supplementation During Pregnancy Reduces the Risk of Preterm Birth in Threatened Preterm Labor. The Multicenter Randomized Controlled Trial by Phattharachindanuwong W, Chaiyarach S, Komwilaisak R, Saksiriwuttho P, Duangkum C, Kongwattanakul K, Kleebkaow P, Waidee T, Pongsamakthai M, Chantanavilai S, Srisataporn T

“…Wiphawi Phattharachindanuwong,1 Sukanya Chaiyarach,1 Ratana Komwilaisak,1 Piyamas Saksiriwuttho,1 Chatuporn Duangkum,1 Kiattisak Kongwattanakul,1 Pilaiwan Kleebkaow,1 Termtem Waidee,1 Manasicha Pongsamakthai,2 Sathida Chantanavilai,2 Tunyatorn Srisataporn2 1Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Department of Obstetrics and Gynecology, Khon Kaen Hospital, Khon Kaen, ThailandCorrespondence: Wiphawi Phattharachindanuwong; Sukanya Chaiyarach, Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40000, Thailand, Tel +66869077662 ; +66836760565, Email wiphawi.beer@gmail.com; sukancha@kku.ac.thBackground: Threatened preterm labor is a common reason for hospital admission, and DHA supplementation may lower the risk of preterm labor.Objective: To compare the rates of premature birth between individuals with threatened preterm labor who received DHA and those who did not.Methods: In this multi-center randomized controlled trial, the sample size was calculated to be 60 participants. …”
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Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis by Ting Zhou, Wenhui Lin, Bangyuan Yang, Yuan Liu, Wenhui Huang, Nianjin Xie, Fan Yang, Zhuoheng Lin, Ziyang Hu, Songyuan Luo, Jianfang Luo

“…However, no significant association was observed between high RC levels and the risk of either TAA or AD. Two-sample MR analyses supported a significant causal effect of RC on AAA risk (odds ratio (OR) = 2.08, 95% CI: 1.70–2.56). …”
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Association between copper exposure and renal fibrosis in patients with chronic kidney disease: evidence from Mendelian randomization and a retrospective study by Kaixiang Liu, Min Yu, Yangyang He, Ting Wang, Honghua Hu, Zhengwei Wan, Ping Shuai, Shasha Chen, Guisen Li, Li Wang, Xiang Zhong

“…This study explores the causal relationship between serum copper levels and renal fibrosis in CKD.MethodsA two-sample Mendelian Randomization (MR) analysis integrated GWAS and FinnGen data. …”
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Meditation for subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials by Jiaxin Shi, Hao Tian, Jingwen Wei, Wenhan Xu, Qin Luo, Jin Peng, Jun Xia, Wenying Huai, Ying Xiong, Yunhui Chen

“…However, given the heterogeneity and limited sample sizes, these findings should be interpreted with caution. …”
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Liposomal bupivacaine versus conventional anesthetics in adductor canal block for total knee arthroplasty: a meta-analysis of randomized controlled trials by Xiaoli Ye, Kaixi Shang, Lina Zhao, Quan Liang, Huanzhen Luo, Jing Shi

“…However, these findings should be interpreted cautiously due to the limited sample size (4 RCTs, 343 patients). Larger, well-designed RCTs are required to confirm its long-term clinical efficacy.…”
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