Genetic insights into blood urea nitrogen as a risk factor for coronary artery disease: a Mendelian randomization study in East Asians by Lijuan Shen, Qianxin Zhang, Zhouyang Zhu, Zhouqing Huang

“…Our study aimed to assess the causal effect of BUN levels on several CVDs using the two-sample Mendelian randomization (MR) method. This is the first MR study examining causal relationships between BUN and multiple cardiovascular diseases.Methods Using data from genome-wide association studies (GWAS) of East Asians, we identified single nucleotide polymorphisms (SNPs) associated with BUN levels as instrumental variables. …”
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Co-administration of AYUSH 64 as an adjunct to standard of care in mild and moderate COVID-19: A randomized, controlled, multicentric clinical trial. by Arvind Chopra, Girish Tillu, Kuldeep Chuadhary, Govind Reddy, Alok Srivastava, Muffazal Lakdawala, Dilip Gode, Himanshu Reddy, Sanjay Tamboli, Manjit Saluja, Sanjeev Sarmukaddam, Manohar Gundeti, Ashwini Kumar Raut, B C S Rao, Babita Yadav, Narayanam Srikanth, Bhushan Patwardhan

“…<h4>Methods</h4>During the first pandemic wave, 140 consenting and eligible hospitalized adult participants with mild-moderate symptomatic disease (specific standard RT-PCR assay positive) were selected as per a convenience sample, and randomized (1:1 ratio) to an open-label (assessor blind) two-arm multicentric drug trial; standard of care (SOC as per Indian guidelines) versus AYUSH 64 combined with SOC (AYUSH plus). …”
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ChatGPT-4 Performance on German Continuing Medical Education—Friend or Foe (Trick or Treat)? Protocol for a Randomized Controlled Trial by Christian Burisch, Abhav Bellary, Frank Breuckmann, Jan Ehlers, Serge C Thal, Timur Sellmann, Daniel Gödde

“…Sample size calculation was performed including guess probability (20% correct answers, SD=40%; confidence level of 1–α=.95/α=.05; test power of 1–β=.95; P<.05). …”
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The effect of Camellia sinensis ointment on perineal pain and episiotomy wound healing in primiparous women: A triple-blind randomized clinical trial. by Masoumeh Sayahi, Azam Jahangirimehr, Zahra Hatami Manesh, Faraz Mojab, Maryam Nikbina

“…Participants were randomly assigned into two groups of intervention (Camellia sinensis extract ointment) and control (placebo) with a follow-up of 14 days. …”
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Repetitive transcranial magnetic stimulation for stimulant use disorders (STIMULUS): protocol for a multi-site, double-blind, randomized controlled trial by Zahraa Atoui, Donald Egan, Manish Kumar Jha, Karen Hartwell, Russell Toll, Susan Sonne, Brenda Brunner-Jackson, Geetha Subramaniam, Jenna L. McCauley, Madhukar Trivedi, Kathleen Brady

“…Discussion Studies exploring rTMS for stimulant use disorders remain limited by small sample sizes, as well as great heterogeneity in defined study population, treatment parameters, retention in treatment, and number of sessions. …”
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Smoking and asthma mediate the protective effect of educational attainment on chronic obstructive pulmonary disease risk: a mediation Mendelian randomization analysis by Xue Bai, Lantao Chen, Fenghai Ren, Ying Zhao, Yue Zheng, Yanbo Wang, Sainan Pang, Jian Zhang, Erliang Guo, Huiyan Li

“…Methods Genome-wide association data for years of schooling, cognitive performance, intelligence, COPD, and COPD-related risk factors such as smoking and asthma were obtained from public databases. We conducted two-sample Mendelian randomization (MR) analyses to assess the causal relationships between years of schooling, cognitive performance, intelligence, and the risk of developing COPD. …”
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Impact of mobile health-based nutritional education on hemoglobin levels in anemic adolescent girls in rural Bangladesh: a randomized controlled trial by Md Jiaur Rahman, Md Moshiur Rahman, Mohammad Habibur Rahman Sarker, Ryota Matsuyama, Masayuki Kakehashi, Miwako Tsunematsu, Mohammad Ali, Ashir Ahmed, Mohammad Delwer Hossain Hawlader, Hiromi Kawasaki, Yoko Shimpuku

“…We randomly assigned one school to the intervention group and another to the control group and then performed simple random sampling to recruit 138 adolescent girls with anemia from the intervention (n = 69) and control (n = 69) groups. …”
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A randomized controlled trial comparing acarbose vs. insulin therapy for gestational diabetes in individuals with inadequate glycemic control by diet alone by J. A. Villarreal-Rodriguez, L. G. Mancillas Adame, J. Maldonado-Sanchez, A. Guzmán-López, O. R. Treviño-Montemayor, J. G. Gonzalez-Gonzalez, D. Saldívar-Rodríguez

“…Studies with a larger sample size and long-term follow-up are needed.…”
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A Prospective Randomized Pilot Study on the Efficacy of a Dietary Supplementation Regimen of Vitamin E and Selenium for the Prevention of Fluoroquinolone-Induced Tendinopathy by Oana-Maria Mișcă, Liviu-Coriolan Mișcă, Bogdan Huzum, Andreea-Adriana Neamţu, Simona Cerbu, Daniel-Raul Chioibaș, Petrișor Zorin Crăiniceanu, Andrei Gheorghe Marius Motoc

“…Although the incidence of tendinopathy was lower in the interventional group (13.3% vs. 40%), statistical significance was not reached, possibly due to the small sample size. <b>Conclusions</b>: These findings suggest that antioxidant supplementation with vitamin E and selenium may provide a protective effect against fluoroquinolone-induced tendinopathy, warranting further investigation in larger randomized clinical trials.…”
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Text Message Intervention to Facilitate Secure Storage and Disposal of Prescription Opioids to Prevent Diversion and Misuse: Protocol for a Randomized Controlled Trial by Kathleen L Egan, Melissa J Cox, Donald W Helme, J Todd Jackson, Alice R Richman

“…MethodsWe will use a 2-arm randomized controlled trial to test the intervention for feasibility and efficacy. …”
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Causal relationships between immune-related adverse events, immune cell characteristics, and plasma metabolites: insights from Mendelian randomization study by Zhiyuan Shi, Zhao Sun, Dingding Zhang, Lin Zhao

“…Initially, we conducted a two-sample bidirectional Mendelian randomization analysis to assess causal links between immune cell characteristics and immune-related adverse events. …”
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Association Between Sarcopenia Susceptibility and Cesarean Section: A Study Based on National Health and Nutrition Examination Survey (NHANES) and Mendelian Randomization by Tian F, Pan H, Wu Q, Jiang D

“…The association between sarcopenia and CS was investigated by adjusting for confounders using multivariable linear and logistic regression analysis. Two-sample bidirectional MR was employed to evaluate causal relationships. …”
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Feasibility of a family-oriented mHealth intervention for Chinese Americans with type 2 diabetes: A pilot randomized control trial. by Lu Hu, Yun Shi, Judith Wylie-Rosett, Mary Ann Sevick, Xinyi Xu, Ricki Lieu, Chan Wang, Huilin Li, Han Bao, Yulin Jiang, Ziqiang Zhu, Ming-Chin Yeh, Nadia Islam

“…<h4>Methods</h4>We conducted a pilot randomized controlled trial (RCT) with baseline, 3-, and 6-month measurements. …”
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Resilience Coaching for Adolescent Chronic Musculoskeletal Pain: Protocol for a Pilot Randomized Controlled Trial of Promoting Resilience in Stress Management (PRISM) by Sabrina Gmuca, Mackenzie McGill, Nellie Butler, Rui Xiao, Peter F Cronholm, Jami F Young, Tonya M Palermo, Pamela F Weiss, Abby R Rosenberg

“…The secondary objectives are to evaluate potential patient- and caregiver-level moderators of PRISM and identify facilitators of and barriers to engagement in PRISM. The estimated sample size is 65 patient-caregiver dyads per group, for a total of 130 dyads. …”
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The Impact of Growth Hormone Treatment on COVID-19 Susceptibility and Severity in Children with Short Stature: A Survey Study with Mendelian Randomization Analysis by Qiu W, Wang R, Liang L, Sun Y, Zhou R, Wang X, Sun W, Gu X

“…We further performed two-sample Mendelian randomization (MR) analyses to explore the causal relationship between GH levels and COVID-19 susceptibility, hospitalization, and severity using genome-wide association study summary-level data.Results: Of the 201 children, 113 (56.2%) reported COVID-19 history, and 149 (74.1%) used GH. …”
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Association Between Obstructive Sleep Apnea and Non-Alcoholic Fatty Liver Disease: Epidemiological Cross-Sectional Study and Mendelian Randomization Analysis by Yu T, Zhou Y, Wu X, Fang Z, Liu C

“…To assess causal inference and minimize observational bias, five distinct two-sample Mendelian randomization approaches were applied.Results: After excluding 9345 individuals who did not meet the study criteria, a total of 6215 participants were included. …”
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Support based on psychoeducation intervention to address quality of life and care burden among caregivers of patients with cancer: a randomized controlled trial by Seyedmohammad Mirhosseini, Fateme Imani Parsa, Hasan Moghadam-Roshtkhar, Mohammad Hasan Basirinezhad, Malihe Ameri, Hossein Ebrahimi

“…Of the 69 caregivers initially approached, one declined to participate, and two were excluded due to lack of smartphone access, leaving a final sample of 66 caregivers. Participants were assigned to either the psychoeducation intervention program or the control group using the quadruple block randomization method. …”
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Genetically predicted blood metabolites mediate the association between immune cell characteristics and urolithiasis: A Mendelian randomization study and mediation analysis by Chengcheng Wei, Jiatai He, Jun Wen, Shunyao Wang, Mengjia Shi, Juan Hu, Huanhuan Tan, Jinjun Guo, Xiaosong Li

“…We employed a two-sample Mendelian randomization analysis to examine the association between immune cell properties, blood metabolites, and urolithiasis risk. …”
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MAGNITUDE: Transcranial Magnetic Stimulation for Treatment-Resistant Obsessive–Compulsive Disorder: A Randomized Sham-Controlled Phase II Trial Protocol by Lavinia Rech, Ricardo A. Vivanco, Ana Claudia Guersoni, Gianina M. Crisóstmono Ninapaytan, Paulina Bonilla Rivera, Elisabeth J. Ramos-Orosco, Ariana Vargas-Ruiz, Martha Felipe, Sandra Carvalho

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Effect of Helicobacter pylori eradication on gastric cancer risk in patients with intestinal metaplasia or dysplasia: a meta-analysis of randomized controlled trials by Qiang Fu, Huidong Yu, Ming Liu, Liang Chen, Weiyang Chen, Ziyi Wang, Ziyi Wang, Wenya Li

“…Relative risk (RR) with its 95% confidence interval (CI) using random-effects model were employed for the effect estimate. …”
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