Transcutaneous bilirubin in newborns before, during, and after home phototherapy-Results from a secondary analysis of a randomized controlled trial. by Felicia Erlandsson Speychal, Miriam Pettersson, Mats Eriksson, Andreas Odlind, Andreas Ohlin

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The Effectiveness of High-Frequency Repetitive Transcranial Magnetic Stimulation on Patients with Neuropathic Orofacial Pain: A Systematic Review of Randomized Controlled Trials by Yingxiu Diao, Yuhua Xie, Jiaxin Pan, Manxia Liao, Hao Liu, Linrong Liao

“…High-frequency rTMS can be used as an alternative treatment for pain in individuals with NOP, but further studies will be conducted to unify treatment parameters, and the sample size will be expanded to explore its influence on psychological conditions and QOL.…”
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The effect of online training based on stroke educational program on patient’s quality of life and caregiver’s care burden: a randomized controlled trial by Amir Mohamad Nazari, Abbas Abbaszadeh, Rouzbeh Kazemi, Vahid Yousofvand, Mitra Zandi

“…Participants were selected by convenient sampling method and then randomly allocated into intervention and control groups using research randomizer software. …”
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Comparison of efficacy of mulligan's mobilization with movement with maitland mobilization along with conventional therapy in the patients with knee osteoarthritis: A randomized cl... by Aniqa Kiran, Muhammad Ijaz, Muhammad Qamar, Ayesha Basharat, Akhtar Rasul, Waqas Ahmed

“…Materials and Methods: A randomized controlled trial study was performed at the Department of Physiotherapy, Mayo Hospital, Lahore, Pakistan. …”
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Effectiveness of Calcium Hydroxide and Gingerols Mixture as a Novel Obturation Material for Infected Root in Primary Teeth: A Randomized Clinical Trial by Fathi A. Qasem, Salwa M. Awad, Rizk A. Elagamy

“…The study was conducted on 30 lower primary molars with infected pulp for children aged 4–8 years. The sample was randomly divided into two groups depending on the tested obturation material: Ginge-Cal group and the Metapex group. …”
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Randomized Controlled Trial of Gastrocnemius Muscle Analysis Using Surface Electromyography and Ultrasound in Different Striking Patterns of Young Women’s Barefoot Running by Yuwei Liu, Justin Fernandez

“…This study examines the differences in force modes and muscle morphology of the gastrocnemius calf muscle under distinct striking patterns. A randomized controlled trial was conducted with twenty young female runners, ten typically striking on their forefoot and ten on their rearfoot, all without lower limb injuries in the past six months. …”
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Low-density lipoprotein cholesterol mediates the causal association between systemic lupus erythematosus and asthma: a mediation mendelian randomization study by Hui Yin, Tongxia Wang, Lin Liu, Zhi Hu

“…This study aims to confirm the cause-and-effect relationship between SLE and asthma, and evaluate the mediation effect of lipid in European ancestry. Methods A Two-sample Mendelian randomization (MR) study was applied to analyze the causal relationships between SLE and asthma. …”
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Methodological insights from the EPISTOP trial to designing clinical trials in rare diseases-A secondary analysis of a randomized clinical trial. by Stephanie Wied, Ralf-Dieter Hilgers, Nicole Heussen, Katarzyna Kotulska, Maya Dirani, Mathieu Kuchenbuch, Sergiusz Jozwiak, Rima Nabbout

“…However, this highlights that this aspect needs to be considered in future trials, especially in rare diseases, to avoid additional biases in an already small sample size where it may be difficult to reach significance.…”
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Efficacy and safety of domperidone and metoclopramide on human milk production in postpartum mothers: a bayesian network meta-analysis of randomized controlled trials by Si Si, Ge Zhao, Guang Song, Jing Liu

“…However, this conclusion is limited due to the small sample sizes in the studies analyzed.…”
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Dextrose prolotherapy at varying concentrations ameliorates tendon injury via IGF-2R: an integrated study of Mendelian randomization and an animal model by Lina Zhou, Hui Liang, Yulin Chen, Kai Hu, Xixia Liu

“…Methods The SwissTargetPrediction database was utilized to identify potential molecular targets of dextrose. Two-sample MR analysis was performed to investigate the causal relationships between the identified targets and Achilles tendinopathy. …”
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Causal association of breast cancer with immune cells: new evidence from bi-directional Mendelian randomization using GWAS summary statistics by Zhixuan Wu, Rongrong Zhang, Xue Wu, Xinyu Meng, Haodong Wu, Xiaowu Wang, Danni Zheng, Yanyan Shen

“…Methods Bi-directional two-sample Mendelian randomization (MR) analyses were conducted to investigate the causal relationship between 731 immune cell phenotypes and breast cancer, utilizing genome-wide association study (GWAS) statistics. …”
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Process-based therapy vs. routine-CBT for difficult-to-treat mood and anxiety disorders: study protocol for a randomized controlled trial by Ulrich Stangier, Viktoria Kohl, Nora Görg, Lucie Sendig, Bettina Hufschmidt, Desiree Bonarius, Arwin Nemani, Mareike Ebert, Stefan G. Hofmann

“…Here, we examine the feasibility and effectiveness of PBT in a larger clinical sample. We have translated a training manual of PBT and modified for delivery of CBT in mental health service. …”
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Effects of Class II elastics on lower incisors during treatment with clear aligners vs. fixed appliance: a randomized clinical trial by Giuseppina Laganà, Arianna Malara, Roberta Lione, Patrizio Bollero, Paola Cozza

“…AimTo analyze the inclination of the lower incisor in patients with Class II malocclusion treated with elastics and clear aligners compared to a group wearing the same elastics and fixed appliance.Trial designProspective two-arms parallel group randomized clinical trial with a 1:1 allocation ratio.Materials and methodsA sample of 40 patients (19M and 21F), mean age 15.4 ± 1.8 years, was collected from the Department of Orthodontics at Policlinico Tor Vergata (Rome), and was randomly divided in two groups: Invisalign clear aligner group (AG), which consisted of 20 subjects (8M, 12F) and multibracket fixed appliance group (MBG), composed by 20 patients (9M, 11F). …”
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Microbiome-directed food to promote sustained recovery in children with uncomplicated acute malnutrition: protocol for a randomized controlled trial in Burkina Faso by Hermann Biénou Lanou, Jérôme Winetourefa Somé, Marie Arsène Aristide Koumbem, Seni Kouanda

“…Eligible MAM children will be randomly assigned to MDCF or RUSF and those with SAM to MDCF or RUTF. …”
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Randomized Controlled Trial: Preliminary Investigation of the Impact of High-Intensity Treadmill Gait Training on Recovery Among Persons with Traumatic Brain Injury by Tyler Shick, Courtney Perkins, Arco Paul, Melissa Martinez, Joseph Joyce, Katy Beach, Jeffrey Swahlan, Justin Weppner

“…This study suggests that HIGT may support functional recovery, and future work will involve increasing sample size.…”
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Medical thoracoscopy combined with intrapleural injection of urokinase for treatment of pleural infection-a multicenter, prospective, randomized controlled study: study protocol by Kaige Wang, Linhui Yang, Panwen Tian, Fen Tan, Dan Liu, Weimin Li

“…The estimated minimum sample size for each group is 64 cases, totaling 128 cases. …”
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Evaluation of ambulatory electrocardiographic monitoring of patients after high-risk acute coronary syndrome: the MONITOR ACS-Epic 13 randomized trial by Jose M. De La Torre Hernandez, Victor Exposito, Susana Gonzalez Enriquez, Felipe Rodriguez Entem, Adrian Margarida, Tamara García Camarero, Gabriela Veiga, Fermin Sainz Laso, Dae-Hyun Lee, Aritz Gil Ongay, Sergio Barrera, Santiago Catoya, Celia Garilleti, Rigoberto Hernandez, Cristina Obregon, Juan J. Olalla

“…A total of 150 patients (estimated sample size) were included. Baseline clinical characteristics were comparable. …”
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Investigating the non‐linear association between sleep duration and type 2 diabetes: conventional and Mendelian randomization analyses from the UK Biobank by Hiroyuki Kuroda, Shiu Lun Au Yeung, Ryosuke Fujii, Masao Iwagami, Atsushi Goto

“…Third, we performed two‐sample MR analysis. Results The results of conventional analysis of accelerometer‐derived sleep duration did not suggest a strong association between longer sleep duration and type 2 diabetes risk (hazard ratio [HR] of ≥10 h compared with 7–8 h, 1.08; 95% confidence interval [CI], 0.92–1.27). …”
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Effect of transcutaneous electrical acupoint stimulation on postoperative muscle atrophy in patients with foot and ankle fracture: A randomized controlled pilot study by Ying Xue, Xiaoqian Dai, Xueming Chen, Shiqi Guo, Chunxian Wang, Zhili Li, Rui He, Zhaoxia Liu, Yinghui Li, Baixiao Zhao

“…Because this was only a pilot trial, subsequent studies will need longer follow-ups and larger sample sizes.…”
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Efficacy and safety of a house dust mites allergoid in patients with allergic rhinitis—PROACAROS study: protocol for a randomized controlled trial by Inmaculada Buendía-Jiménez, María Matas-Ros, Teresa Garriga-Baraut, Albert Roger-Reig, Ana Tabar-Purroy, on behalf of the PROACAROS investigator group

“…The experimental group will receive 12 monthly AIT doses via subcutaneous route with a potency of 2 RC/ml per allergen. The expected sample size is 250 patients from 16 sites in Spain. …”
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