Integrating exosome wide associations study and Mendelian randomization identified causal miRNAs for type 2 diabetes mellitus and its complications by Dong-Ling Li, Xin-Yi Ding, Qiao-Ling He, Wan-Hua Zhan, Juan Long, Mei-Nan He, Jia-Lu Zhang, Qing-Xiang Zeng, Na Lu, Yong-Qian Chi, Meng-Chen Zou

“…The significant miRNAs identified between DM and its complications were further validated by integrating cis-miRNA expression quantitative trait loci (cis-miR-eQTLs) and genome-wide association study (GWAS) summary data of T2DM and peripheral arterial disease (PAD) through two-sample Mendelian randomization (MR) analysis. Results We identified several differential expressions of miRNAs between T2DM, DLEAD, and DF, such as hsa-miR-409-3p between T2DM and DLEAD, hsa-miR-543 between T2DM and DF and hsa-miR-206 between DLEAD and DF. …”
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Positive end-expiratory pressure during resuscitation at birth in very-low birth weight infants: A randomized-controlled pilot trial by Ratchada Kitsommart, Kittaya Nakornchai, Buranee Yangthara, Ratchada Jiraprasertwong, Bosco Paes

“…A further randomized, controlled clinical trial with a larger sample size is warranted to determine the utility and safety of PEEP during the resuscitation of premature infants immediately after birth. …”
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Effects of a Mobile Storytelling App (Huiyou) on Social Participation Among People With Mild Cognitive Impairment: Pilot Randomized Controlled Trial by Di Zhu, Abdullah Al Mahmud, Wei Liu

“…We measured outcomes through the Assessment of Life Habits questionnaire (77 items), particularly outdoor activities and interpersonal relationships; the Social Connectedness Scale–Revised (20 items); the General Self-Efficacy Scale (10 items), focusing on coping self-efficacy; and the Subjective Well-Being Scale (SWBS; 20 items), with a special emphasis on self-acceptance. ResultsThe sample had an average age of 69.7 (SD 3.21) years, with no significant (P=.23) baseline differences between groups in age, sex, or educational background. …”
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A comparative study of lumbar spine stabilization with 2-stage surgery and cement augmentation in osteoporosis patients: a randomized clinical trial by Parisa Hajilo, Behzad Imani, Shirdel Zandi, Ali Mehrafshan

“…Therefore, the present study was conducted with the comparative aim of stabilizing the lumbar spine with 2-stage surgery and cement augmentation in osteoporotic patients. 66 patients selected through convenience sampling and randomly assigned to two groups: CAPS and 2-stage surgery. …”
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Genetic associations of plasma metabolites with immune cells in hyperthyroidism revealed by Mendelian randomization and GWAS-sc-eQTLs xQTLbiolinks analysis by Yutong Li, Xingyu Song, Yuyang Huang, Sifan Zhou, Linkun Zhong

“…Abstract Mendelian randomization (MR) was employed to investigate the causal relationships between immune cell phenotypes, hyperthyroidism (HD), and potential metabolic mediators. …”
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Coach-Assisted eHealth With Group or Individual Support for Employees With Obesity: Randomized Controlled Trial on Weight, Body Composition, and Health Metrics by Siniriikka A Männistö, Kirsi H Pietiläinen, Joona Muotka, Laura-Unnukka Suojanen, Raimo Lappalainen, Riitta Korpela

“…ObjectiveThis study investigated whether a minimal, 3-session group or individual enhancement could provide additional benefits compared to an eHealth-only intervention when assessing weight, body composition, and laboratory metrics in a sample of occupational health patients with obesity. …”
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Comparative effects of square-stepping and strengthening exercises on cognitive and balance functions in chronic obstructive pulmonary disease: a randomized clinical trial by Alp Özel, Eylem Tütün Yümin, Suat Konuk

“…Paired sample t-tests and Wilcoxon signed-rank tests were used for within-group comparisons. …”
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The Effects of Aromatherapy With Clove and Lavender on Headache Caused by Spinal Anesthesia in Patients Undergoing Urological Surgery: A Randomized Clinical Trial Study by Mahlagha Dehghan, Atena Samareh Fekri, Niloofar Rashidipour, Naeimeh Naeimi Bafghi, Ali Maghfouri, Mohamadreza Ebadzadeh

“…Participants were selected using a convenience sampling method and randomly divided into intervention and control groups. …”
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Commentary on “Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial” by Gautret et al by Mondher Toumi, Samuel Aballea

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Improving Maternal Mental Health and Weight Control With a Mindfulness Blended Care Approach: Insights From a Randomized Controlled Trial by Kathrin Hassdenteufel, Mitho Müller, Harald Abele, Sara Yvonne Brucker, Johanna Graf, Stephan Zipfel, Armin Bauer, Peter Jakubowski, Jan Pauluschke-Fröhlich, Markus Wallwiener, Stephanie Wallwiener

“…MethodsA community-based sample of 460 pregnant women with a singleton pregnancy who screened positive for depression was enrolled in a multicenter randomized controlled trial (RCT) including the University Hospitals of Heidelberg and Tübingen as well as more than 200 gynecological practices within the state of Baden-Württemberg in Germany between February 2019 and October 2020. …”
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The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial. by Jana Foerster, Gertraud Maskarinec, Nicole Reichardt, Adrian Tett, Arjan Narbad, Michael Blaut, Heiner Boeing

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Causal Effects Between Genetically Determined Human Serum Metabolite Levels on the Risk of Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Study by Yu Shi, Shuang Chen, Zhaokai Zhou, Mengke Huang, Yue Li, Xiaogang Jing

“…Methods This research evaluated the causal relationship between serum metabolites and IPF utilizing two‐sample Mendelian randomization (MR) analysis. IVW served as the main method of analysis; concurrently, MR‐Egger, weighted median, and MR‐PRESSO acted as supplementary analyses. …”
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Comparison of Traditional and Ultrasound-Guided Techniques for Vascular Access in Patients with Difficult Venous Access in Emergency Departments: Randomized Clinical Trial Protocol by Mercedes S. Peralta-Gámez, Marina Gómez de Quero Córdoba, Silvia Reverté-Villarroya, Roser Cuesta-Martínez

“…<b>Objectives</b>: To contribute new evidence regarding the effectiveness of validated tools for identifying DIVA and to assess the clinical benefits of ultrasound-guided vascular access in emergency care, and to assess their utility in arterial puncture for arterial blood gas sampling, from now on ABG, within the ED. <b>Methods</b>: This study follows the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guidelines for protocol development and the Consolidated Standards of Reporting Trials (CONSORT) guidelines for the conduct and reporting of the randomized clinical trial (RCT). …”
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The effect of a family health nurse model on blood sugar control in middle-aged prediabetics: a randomized clinical trial (RCT) by Atefeh Afshari, Mahrokh Keshvari, Ziba Farajzadegan, Mohammad Azadmanesh

“…The participants were selected through convenience sampling on the basis of the inclusion criteria and randomly assigned to the intervention or control groups. …”
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Bidirectional Mendelian randomization analysis and systematic meta-analysis of causal relationships between hepatocellular carcinoma and non-alcoholic fatty liver disease by Tielong Zhao, Yanglieguang Lou

“…Methods We performed bidirectional two-sample Mendelian randomization using genome-wide association study data (775 HCC cases, 1,332 controls; 8,434 NAFLD cases, 770,180 controls). …”
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The effectiveness of pulsed electromagnetic field therapy in patients with shoulder impingement syndrome: A systematic review and meta-analysis of randomized controlled trials. by Hsun-Yi Wang, Yi-Jen Chen, I-Ching Huang, Chao-Ruei Lin, Ko-Long Lin, Chia-Hsin Chen

“…Our analysis included randomized controlled trials (RCTs) that evaluated the impact of PEMF therapy on pain levels and functional capacity in these patients. …”
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Photoaging smartphone app promoting poster campaign to reduce smoking prevalence in secondary schools: the Smokerface Randomized Trial: design and baseline characteristics by Michael Kreuter, Fabian N Fries, Titus J Brinker, Ute Mons, David A Groneberg, Anil Batra, Werner Seeger, Felix Herth, Julia Holzapfel, Tanja G Baudson, Katharina Sies, Lena Jakob, Hannah Maria Baumert, Marlene Heckl, Ana Cirac, Janina L Suhre, Verena Mathes, Hannah Spielmann, Nancy Rigotti, Tobias Raupach, Henning Gall, Claudia Bauer, Pat Marek, Chase H Harrison, Lava Taha, Andreas Owczarek, Felix J Hofmann, Roger Thomas

“…The prospective experimental study design includes measurements at baseline and at 6, 12 and 24 months postintervention via a questionnaire plus a random cotinine saliva sample at 24 months postintervention. …”
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Efficacy of herbal medicine (Xuanfei Baidu decoction) combined with conventional drug in treating COVID-19:A pilot randomized clinical trial by Wu-zhong Xiong, Gang Wang, Juan Du, Wang Ai

“…However, it needs to be confirmed by a large sample study. Clinical trial registration: China Clinical Trial Registry (ChiCTR2000034795).…”
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Efficacy and Safety of an Ophthalmic DMPC-Based Nanoemulsion in Patients with Dry Eye Disease: A Phase I/II Randomized Clinical Trial by Leopoldo M. Baiza-Durán, Patricia Muñoz-Villegas, Alejandra Sánchez-Ríos, Oscar Olvera-Montaño

“…Methods. This was a randomized phase I/II multicentric, prospective, double-blind clinical trial. …”
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Clinical and Radiographical Evaluation of Papilla Levels Following Two Different Techniques for Second-stage Implant Surgery: A Randomized Clinical Trial by Udayabhanu Jagannadha Raju, K. P. Ashok, Anupama Masapu, T.S.S. Manikanta, Sindhuri Yerra, Sowparnica Naidu

“…Descriptive statistics, independent sample t-test, paired t-test, Chi-square test, test of marginal uniformity, and the McNemars Chi-squared test were performed. …”
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