High mtDNA content identifies oxidative phosphorylation-driven acute myeloid leukemias and represents a therapeutic vulnerability by Diego A. Pereira-Martins, Isabel Weinhäuser, Emmanuel Griessinger, Juan L. Coelho-Silva, Douglas R. Silveira, Dominique Sternadt, Ayşegül Erdem, Bruno Kosa L. Duarte, Prodromos Chatzikyriakou, Lynn Quek, Antonio Bruno Alves-Silva, Fabiola Traina, Sara T. Olalla Saad, Jacobien R. Hilberink, Amanda Moreira-Aguiar, Maria L. Salustiano-Bandeira, Marinus M. Lima, Pedro L. Franca-Neto, Marcos A. Bezerra, Nisha K. van der Meer, Emanuele Ammatuna, Eduardo M. Rego, Gerwin Huls, Jan Jacob Schuringa, Antonio R. Lucena-Araujo

“…In this study, we identified mitochondrial DNA content (mtDNAc), measured by quantitative PCR, as a simple and precise marker to stratify the metabolic states of AML patients. …”
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Microphysiological gut-on-chip enables extended in vitro development of Cryptosporidium hominis by Samantha Gunasekera, Benjamin Thierry, Brendon King, Paul Monis, Jillian M. Carr, Abha Chopra, Mark Watson, Mark O’Dea, Edward Cheah, Ramesh Ram, Peta L. Clode, Nawal Hijjawi, Una Ryan

“…ConclusionsThese data demonstrate that bioengineered gut-on-chip models support extended C. hominis growth and can be used to interrogate responses of host cells to infection. …”
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The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts by Ilenia Masi, Flavia Ottavi, Valentina Caprara, Danila Del Rio, Martina Kunkl, Francesca Spadaro, Valerio Licursi, Loretta Tuosto, Anna Bagnato, Laura Rosano’

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Periodontitis promotes tumor growth and immune evasion via PD-1/PD-L1 by Suli Wang, Fujiao Nie, Qiuyue Yin, Haoyang Tian, Pizhang Gong, Jinhong Ju, Jiayi Liu, Pishan Yang, Chengzhe Yang

“…Methods Mouse oral or prostate cancer xenograft models were divided into control, periodontitis and periodontitis + anti-PD-1 groups. …”
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Curcumin-like Compound Inhibits Proliferation of Adenocarcinoma Cells by Inducing Cell Cycle Arrest and Senescence by Rafael Fonseca, Yasmin dos Santos Louzano, Cindy Juliet Cristancho Ortiz, Matheus de Freitas Silva, Maria Luiza Vieira Felix, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Bruno Zavan, Claudio Viegas, Marisa Ionta

“…<b>Objectives:</b> We investigated the pharmacological potential of a series of curcumin-like compounds using two lung adenocarcinoma cell lines as models. <b>Methods and Results:</b> Cell viability assay led to the identification of PQM-214 as the hit compound, and other methodologies were employed to investigate the mechanisms underlying its antitumor potential, including cell cycle analysis, mitotic index determination, assessment of clonogenic capacity, senescence-associated β-galactosidase and annexin V assays, quantitative PCR, and Western blot analyses. …”
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The Importance of the Solids Loading on Confirming the Dielectric Nanosize Dependence of BaTiO3 Powders by Slurry Method by Wei Zhou, Yi Mei Nie, Shu Jing Li, Hai Yan Liang

“…The dielectric nanosize dependence of BaTiO3 powders was investigated by the slurry method, where two series of BaTiO3 slurries with 10 vol% and 30 vol% solids loadings were prepared as model samples. Applying the Bruggeman-Hanai equation, the high-frequency limiting permittivity (εh) of the slurries was extracted from the dielectric spectra. …”
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Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies by Arantza Azpilikueta, Ignacio Melero, Sonia Guedan, Alvaro Teijeira, Lieping Chen, Maria C Ochoa, Maite Alvarez, Jose Luis Perez Gracia, Maria E Rodriguez-Ruiz, Miguel F Sanmamed, Assunta Cirella, Javier Glez-Vaz, Irene Olivera, Iñaki Eguren-Santamaria, Carlos Luri-Rey, Xinxin Nie

“…Background On the basis of efficacy in mouse tumor models, multiple CD137 (4-1BB) agonist agents are being preclinically and clinically developed. …”
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Evidence on Digital HIV Self-Testing From Accuracy to Impact: Updated Systematic Review by Ashlyn Beecroft, Olivia Vaikla, Nora Engel, Thomas Duchaine, Chen Liang, Nitika Pant Pai

“…ResultsFifty-five studies (samples ranging 120-21,035, median 1267 participants) were summarized from 19 middle- to high-income countries. …”
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On-the-fly path planning for the design of compositional gradients in high dimensions by Samuel Price, Zhaoxi Cao, Ian McCue

“…The effectiveness of this new method is quantitatively benchmarked, and it is found that it can be as much as 106 times more efficient than surrogate modeling.…”
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Nonlinear transport of Wigner solid phase surrounding the two-flux composite fermion liquid by Yu-jiang Dong, Xinghao Wang, Jianmin Zheng, Weiliang Qiao, Rui-Rui Du, Loren N. Pfeiffer, Kenneth W. West, Kirk W. Baldwin

“…According to the composite fermion (CF) model, FQH states stemming from a half-filled Landau level, specifically at fillinsg factors ν=p/(2p+1) (p=±1,±2,±3,...), can be associated with two-flux-attached CFs at the corresponding Lambda filling factor p. …”
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Effects of acute inflammation on platelet indices: An experimental study by Veysel Tahiroglu, Fatih Kara

“…This study aimed to investigate the possible effects of acute inflammation on platelet indices in plantar inflammation model in rats. Methods: A total of 10 rats, 5 in each group, were used in the study. …”
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The spiritual needs and care of children and young people with life-threatening or life-shortening conditions, and parents (SPARK): a mixed-method investigation by Bryony Beresford, Natalie Richardson, Suzanne Mukherjee, Rebecca Nye, Jan Aldridge, Karl Atkin, Mark Clayton, Faith Gibson, Julia Hackett, Richard Hain, Mohammed Arshad, Paul Nash, Bob Phillips

“…Design and research participants A mixed-method, multicomponent design was used with the quantitative and qualitative data collected. There were four work packages. …”
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Spatial pattern of Trees in the Riparian Forests (Case Study: Wildlife Refuge of Karkhe) by Shaieste Gholami

“…To describe spatial autocorrelation of a variable quantitatively, a (theoretical) variogram model can be fitted to the empirical variogram in order to obtain the model parameters nugget, sill and range. 3- Results and Discussion The variograms of Populus euphratica and Lycium shawii were spherical. …”
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The mediating role of entrepreneurial attitude with entrepreneurial education and self-efficacy on students' entrepreneurial mindset by davoud tahmasebzadeh sheikhlar, mahdiye ruhi, amin parvari

“…Structural equation modeling using the partial least squares method and SmartPLS3 software was employed to test the hypotheses. …”
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The influence of work environment and work facilities on Employee Performance With Work Motivation As an Intervening Variable by Anna Anna, Agus Sukoco

“…Design/methodology/approach: This research approach uses quantitative research, Saturated Sampling method, the population in this study is the technical team of the Health Sector of the Surabaya City Investment and One-Stop Integrated Service Office with a total of 40 people, the measurement scale in this study uses a Likert scale, The data analysis used in this study used static methods with SEM PLS modeling. …”
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Suppression of Hepatocellular Carcinoma by Deletion of SIRT2 in Hepatocytes via Elevated C/EBPβ/GADD45γSummary by Fang Wang, Claudia Rose Keating, Yingchen Xu, Wei Hou, Greg Malnassy, Kyle Boedeker, Aldeb Perera, Eugene Ham, Diya Patel, Xianzhong Ding, Wei Qiu

“…Results: Using the MET/CAT and AKT/Nras models, we found that SIRT2 is a significant mediator of liver tumorigenesis, with the knockout of SIRT2 delaying tumor growth. …”
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Effects of low pH on the coral reef cryptic invertebrate communities near CO2 vents in Papua New Guinea. by Laetitia Plaisance, Kenan Matterson, Katharina Fabricius, Sergei Drovetski, Chris Meyer, Nancy Knowlton

“…Naturally acidified habitats have been important model systems for studying these complex interactions because entire communities that are adapted to these environmental conditions can be analyzed. …”
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A novel pulse-chase SILAC strategy measures changes in protein decay and synthesis rates induced by perturbation of proteostasis with an Hsp90 inhibitor. by Ivo Fierro-Monti, Julien Racle, Celine Hernandez, Patrice Waridel, Vassily Hatzimanikatis, Manfredo Quadroni

“…Standard proteomics methods allow the relative quantitation of levels of thousands of proteins in two or more samples. …”
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Association of Circulating Phenylacetylglutamine With Multi‐Vessel Coronary Disease Severity and Outcomes in ST‐Segment–Elevation Myocardial Infarction by Peng Zhao, Nana Dong, Yan Wang, Suhong Zhao, Yanan Tian, Zhifeng Qin, Xiaofang Ban, Feiyuan Han, Li Meng, Fan Yang, Yidan Wang, Yunfei Wu, Zhongzhi Yu, Qinglu Xu, Xinyue Li, Shuo Li, Huibin Liu, Shaohong Fang, Wanqing Xie, Bo Yu, Xinxin Liu, Jinwei Tian

“…Quantitative coronary angiography analysis was performed using the QAngio XA 7.3 system. …”
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Aptasensing biosynthesized phosphatidylserine with a AuNPs nanozyme-based colorimetric aptasensor by Sai Wang, Rui Ma, Chengqiang Li, Ling Zhang, Haiyang Zhang, Xuehan Li, Xiangzhao Mao

“…Herein, phosphatidylserine (PS) was chosen as the model target, a colorimetric aptasensor was developed for the rapid quantitation in biosynthesis samples. …”
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