Liver fibrosis progression analyzed with AI predicts renal decline by Dan-Qin Sun, Jia-Qi Shen, Xiao-Fei Tong, Ya-Yun Ren, Hai-Yang Yuan, Yang-Yang Li, Xin-Lei Wang, Sui-Dan Chen, Pei-Wu Zhu, Xiao-Dong Wang, Christopher D. Byrne, Giovanni Targher, Lai Wei, Vincent W.S. Wong, Dean Tai, Arun J. Sanyal, Hong You, Ming-Hua Zheng

“…We used an automated quantitative liver fibrosis assessment (qFibrosis) technique to investigate the temporal changes in regional liver fibrosis. …”
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High-fat diet promotes gestational diabetes mellitus through modulating gut microbiota and bile acid metabolism by Lei Yao, Xuefei Zhou, Xianqi Jiang, Hao Chen, Yuanliang Li, Xiao Xiong, Yan Tang, Haogang Zhang, Pengfei Qiao

“…However, there is still a big gap in knowledge about the association between gut microbiota associated metabolism alterations and GDM development.MethodsAll the participants accomplished the validated internet-based dietary questionnaire for Chinese and serum, fecal samples were collected. HFD, control diet or colesevelam intervention was fed to GDM mice models or Fxr-/- mice models, with or without antibiotics cocktail treatment. …”
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Random Finite Element Analysis and Random Factor response Mechanism for Geocell-reinforced Soil Retaining Walls by ZHANG Bingbing, SONG Fei

“…For this reason, a finite element analysis method based on random field theory is proposed in this paper, which can more realistically reflect the non-homogeneous characteristics of the reinforced soil retaining wall system by introducing a spatial random distribution model of the soil parameters and the mechanical properties of the geocells, so as to more accurately assess the influence of the spatial variability of the material parameters on the deformation behavior and stability of the retaining wall.MethodsFirstly, in parameter random field modeling, an innovative combination of Latin Hypercube Sampling (LHS) and exponential autocorrelation function is used to construct parameter random fields. …”
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Sustainable authentication of molasses' botanical origin using infrared spectroscopy: Accuracy and greenness evaluation of spectral techniques by Macarena Rojas-Rioseco, Mecit Öztop, Cristian A. Fuentes, Martin Bravo, Ivan Smajlovic, Margarita Smajlovic, Karol Kołodziejski, Danuta Kruk, Víctor Muñoz, Rosario del P. Castillo

“…However, FT-IR scored the lowest in terms of greenness due to higher energy demands and sample handling in comparison with the other techniques. …”
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Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors by Rebecca R. J. Collins, Rebecca R. Florke Gee, Sima Tozandehjani, Tara Bayat, Maria Camila Hoyos Sanchez, Juan Sebastian Solano Gutierrez, Barbara Breznik, Anna K. Lee, Samuel T. Peters, Jon P. Connelly, Shondra M. Pruett-Miller, Martine F. Roussel, Dinesh Rakheja, Heather S. Tillman, Patrick Ryan Potts, Klementina Fon Tacer

“…We obtained formalin-fixed paraffin-embedded tumor samples of 34 patients, collected between 2008 and 2015 at the Children's Medical Center in Dallas and applied our validated reverse transcription quantitative PCR (RT-qPCR) assay to measure the expression of 23 MAGE genes. …”
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Regional and aging-specific cellular architecture of non-human primate brains by Yun-Mei Wang, Wen-Chao Wang, Yongzhang Pan, Lin Zeng, Jing Wu, Zheng-Bo Wang, Xiao-Lin Zhuang, Ming-Li Li, David N. Cooper, Sheng Wang, Yong Shao, Li-Min Wang, Ying-Yin Fan, Yonghan He, Xin-Tian Hu, Dong-Dong Wu

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Geographic origin discrimination and quantification of phenolic compounds and moisture in Artemisia argyi folium using NIRS and chemometrics by Lifei Hu, Yifan Wang, Xin Wu, Yuanyuan Shan, Fengxiao Zhu, Fan Zhang, Qiang Yang, Mingxing Liu

“…Phenolic-based analysis of adjacent-origin samples with varying storage times demonstrated that storage duration minimally affected geographical origin discrimination of AAF, and it provided a chemical basis for using cross-year samples in NIRS analysis. …”
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Climate Study of Changes of Major Water Resources in Qom Province Using Satellite Data and Remote Sensing Technologies by Nima Rohani, Taher Rajaee, Barat Mojaradi, Ehsan Jabbari, Seyed Ahmad Shafiei Darabi, Mehran Heidari Bani

“…The results of classification were controlled by the visual method and a number of ground samples. Next, the class changes were modeled and calculated. …”
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Spatial Changes in Soil Nutrients in Tea Gardens from the Perspective of South-to-North Tea Migration: A Case Study of Shangluo City by Ziqi Shang, Jichang Han, Yonghua Zhao, Ziru Niu, Tingyu Zhang

“…[Method] A total of 228 soil samples from these tea gardens were quantitatively analyzed for pH, soil organic matter (SOM), total nitrogen (TN), total phosphorus (TP), total potassium (TK), available nitrogen (AN), available phosphorus (AP), available potassium (AK), as well as clay, silt, and sand content. …”
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Driving Forces and Future Scenarios for Territorial Business Development in Iran: A Future-Oriented Study with a Spatial Planning Emphasis by Ali Hosseini, Mostafa Aryankia

“…The study utilized quantitative models to identify and analyze the factors and drivers influencing territorial businesses in Iran and develop various scenarios for their future development. …”
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m6A-methylated TAL1 exacerbates lipid accumulation in ethylene bisdithiocarbamate metabolite–induced anorectal malformations in rat fetuses via miR-205/LCOR signaling by Yifan Yao, Shuo Yang, Yuzuo Bai, Zhengwei Yuan, Zhonghua Yang

“…Western blotting and qRT-PCR were used to explore the biological functions of the indicators in HEK 293 T cells and samples from ETU-induced ARM fetal rat models. Transamniotic microinjection was performed in fetal rat models with ARM. …”
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The influence of cultural identity on achieving sustainable urban development in developing countries by Edward John Cobbina, Edward John Cobbina, Edward John Cobbina, Simon Ofori Ametepey, Simon Ofori Ametepey, Simon Ofori Ametepey, Simon Ofori Ametepey, Clinton Aigbavboa, Emmanuel Yaw Frempong-Jnr, Wellington Didibhuku Thwala, Andrew Ebekozien, Andrew Ebekozien, Hutton Addy, Hutton Addy

“…This study investigates the influence of CI and its essential elements of sustainable urban development (SUD).Design/methodology/approachA quantitative research method using closed-ended questions from a questionnaire survey was utilized to solicit responses from sampled professionals within the urban planning and development space in four urban centers in Ghana. …”
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Biobanking for discovery of novel cardiovascular biomarkers using imaging-quantified disease burden: protocol for the longitudinal, prospective, BioHEART-CT cohort study by Clara Chow, Leonard Kritharides, Sanjay Patel, Katharine A Kott, Stephen T Vernon, Thomas Hansen, Christine Yu, Kristen J Bubb, Sean Coffey, David Sullivan, Jean Yang, John O'Sullivan, James Chong, David S Celermajer, Stuart M Grieve, Gemma A Figtree

“…Outcome data will be used to build improved risk models for CAD.Ethics and dissemination The study protocol has been approved by the human research ethics committee of North Shore Local Health District in Sydney, Australia. …”
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Rheological properties of deep-sea shallow sediments in the Western Pacific mining area by Hao Liu, Zongxiang Xiu, Lejun Liu, Jie Dong, Qiuhong Xie, Mu Huang, Chenwei Luo, Yifeng Zeng, Xingsen Guo

“…The mechanism of the newly added thixotropic fluid stage was quantitatively analyzed using a modified Cross rheological model, and this stage was inferred from the perspective of mineralogy and microstructure. …”
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Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial... by Giles T. Hanley-Cook, Yuri Bastos-Moreira, Dries S. Martens, Trenton Dailey-Chwalibóg, Laeticia Celine Toe, Brenda de Kok, Lionel OIivier Ouédraogo, Alemayehu Argaw, Kokeb Tesfamariam, Patrick Kolsteren, Lieven Huybregts, Tim S. Nawrot, Sarah De Saeger, Marthe De Boevre, Carl Lachat

“…Average relative TL and mtDNAc were measured using quantitative polymerase chain reaction. Linear regression models were fitted to assess TL and mtDNAc differences across trial arms.ResultsWe found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn TL [β =-0.010 (95% CI:-0.057, 0.036); P = 0.662] or mtDNAc [β = 0.065 (95% CI:-0.203, 0.073); P = 0.354], as compared to an IFA tablet alone. …”
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Gypenosides Alleviate Hyperglycemia by Regulating Gut Microbiota Metabolites and Intestinal Permeability by Rong Wang, Xue-Feng Liu, Kuan Yang, Li-Li Yu, Shao-Jing Liu, Na-Na Wang, Yun-Mei Chen, Ya-Qi Hu, Bei Qin

“…Type 2 diabetes mellitus mouse models were established, and the mice were subsequently treated with Gps at doses of 200, 100, or 50 mg/kg for 4 weeks. …”
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Additional expression of T-cell engager in clinically tested oncolytic adeno-immunotherapy redirects tumor-infiltrated, irrelevant T cells against cancer cells to enhance antitumor... by Bora Lim, Caroline Porter, Mae Woods, Masataka Suzuki, Daisuke Morita, Amanda Rosewell Shaw, Greyson Biegert, Spyridoula Vasileiou

“…Similar to previous OAd studies, all patients primarily amplified Ad-specific T cells after treatment however, CAdVEC was still able to induce clinical responses even given at a 100-fold lower dose.Methods To address the mechanisms of CAdTrio-mediated antitumor effect in patients, we analyzed patients’ samples using Enzyme-linked immunosorbent spot (ELISpot) to measure T-cell specificity and quantitative polymerase chain reaction (qPCR) to measure CAdVEC viral genome copies at tumor sites. …”
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Identification of cerebrospinal fluid pharmacodynamic biomarkers and molecular correlates of brain activity in a Phase 2 clinical trial of the Alzheimer's disease drug candidate CT... by Valentina Di Caro, Eunah Cho, Hilary A. North, Jill Caldwell, Kiran Pandey, Duc Duong, Michael Grundman, Willem deHaan, Everard G. Vijverberg, Charlotte E. Teunissen, Anthony O. Caggiano, Nicholas T. Seyfried, Mary E. Hamby

“…CT1812 has been shown in preclinical and early clinical trials to selectively prevent and displace binding of amyloid beta oligomers from their synaptic receptors and has improved cognitive function in animal models of AD. METHODS SEQUEL (NCT04735536) is a completed Phase 2, randomized, placebo‐controlled 4‐week crossover trial in adults with mild‐to‐moderate AD that investigated the effect of CT1812 on safety, synaptic function using quantitative electroencephalography (qEEG), and biomarkers. …”
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Sensitivity analysis of the INRA 2018 feeding system for ruminants by hybrid local and global approaches: Comparing the contribution of dietary input variables to multiple response... by Seoyoung Jeon, Tristan Senga Kiessé, Sophie Lemosquet, Pierre Nozière

“…Hence, hybridizing the SA methods can help to interpret the system and facilitate a more precise evaluation thereof, especially GSA, which is amenable to nonmonotonic models such as those characterizing complex feeding systems integrating multiple nutritional and animal factors.…”
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“We Are Our Own Worst Enemies”: Workplace Bullying Among Nurses and Its Implications on Healthcare Workers and Job Performance: A Multi‐Facility Study in the Tamale Metropolis... by Abubakari Wuni, Ajara Musah, Iddrisu Mohammed Sisala, Abdul Malik Abdulai, Letitia Chanayireh, Brenda Abena Nyarko, Hannah Buasilenu, Mudasir Mohammed Ibrahim, Sulemana Musah, Dorothy Azure, Nafisah Abdulai

“…Methods Data for this study were collected from Tamale Teaching Hospital, Tamale Central Hospital, and Tamale West Hospital using a descriptive cross‐sectional multi‐facility study design with a quantitative approach to data collection. A proportionate stratified random sampling technique was used to recruit 338 nurses from the three hospitals. …”
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