Behçet syndrome: The disturbed balance between anti‐ (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions by Ali Kemal Oğuz, Çağdaş Şahap Oygür, Seda Taşır, Hilal Özdağ, Mehmet Nejat Akar

“…Validation of the microarray data was performed using quantitative reverse transcriptase polymerase chain reaction. …”
Get full text

Sigma-1 Receptor Rescues Autophagy Through AMPK/mTOR Signaling Pathway in Sepsis-Induced Acute Kidney Injury by Jiang W, Zhang J, Zhang Y, Huang Z

“…HK-2 cells induced by lipopolysaccharide (LPS) were employed as an in vitro model of sepsis-AKI. To evaluate the function of σ-1R in sepsis-AKI, siRNA and an overexpression plasmid targeting σ-1R were used. σ-1R and autophagy marker expressions were analyzed using quantitative real-time polymerase chain reaction and Western blot assays. …”
Get full text

Perceived worries in the adoption of artificial intelligence among nurses in neonatal intensive care units by Ahmad Ayed, Ahmad Batran, Ibrahim Aqtam, Malakeh Z. Malak, Moath Abu Ejheisheh, Mosaab Farajallah, Lamees Farraj, Sanaa Alkhatib

“…Methods A cross-sectional quantitative design was employed using convenience sampling. …”
Get full text

The barriers and facilitators of herpes zoster vaccination intentions of urban residents in China: a qualitative study by Beibei Yuan, Chao Long, Ming Wang, Elizabeth Maitland, Stephen Nicholas, Xianjing Qin, Weiying Zhao, Dawei Zhu, Ping He

“…Participants were recruited by purposive sampling techniques. Guided by the health belief model, thematic analysis was used to group participants’ HZ vaccine attitudes and to identify the barriers and facilitators to HZ vaccination. …”
Get full text

Validation of Reference Genes for Robust qRT-PCR Gene Expression Analysis in the Rice Blast Fungus Magnaporthe oryzae. by Sarena Che Omar, Michael A Bentley, Giulia Morieri, Gail M Preston, Sarah J Gurr

“…It also serves as a genetically-tractable model to study fungal ingress. Whilst pathogenicity determinants have been unmasked and changes in global gene expression described, we know little about Magnaporthe oryzae cell wall remodelling. …”
Get full text

NRF2 polymorphism and susceptibility to ischemic stroke in a Chinese population by Pengyu Wang, Junxiu Lu, Min Wang, Guangming Wang, Huaqiu Chen

“…However, the TC genotype of rs35652124 in the co-dominant model was significantly associated with increased IS risk. …”
Get full text

BIOFEEDBACK AS A METHOD FOR STUDENTS’ MENTAL STATE ASSESSMENT by M. Yu. Ababkova, V. L. Leontieva

“…A pilot study on the basis of biofeedback technique was conducted in order to study the influence of active learning methods on students’ mental state mastering in specialty “Advertising and Public Relations”. H. Eysenck’s PEN Model was used to form focus-groups (control and experimental); psychophysiological technique CMS (Current Mental State) was applied for results processing. …”
Get full text

Study on the Development Level, Spatial Differences and Obstacle Factors of Agricultural Modernization—Taking Cities and Counties in Hainan Province as An Example by Yiwen MA, Xiaojun XU

“…【Method】The relevant index data of Hainan Province and 17 cities and counties from 2011 to 2021 were selected as research samples, and an evaluation system with 5 dimensions and 20 indexes was constructed by comprehensive application of analytic hierarchy process (AHP), entropy method, obstacle model and other methods to quantitatively evaluate the development level, spatial differences and obstacle factors of agricultural modernization in Hainan Province.…”
Get full text

Novel Identification of CD74 as a Biomarker for Diagnosing and Prognosing Sepsis Patients by Hu K, Shi A, Shu Y, Sudesh S, Ling J, Chen Y, Hua F, Yu S, Zhang J, Yu P

“…The CD74-based diagnostic model showed better performance in the training dataset (AUC, 0.79 [95% CI, 0.75– 0.84]), was cross-validated in external datasets, and demonstrated better performances than other published diagnostic models. …”
Get full text

COVID-19 vaccine hesitancy in Addis Ababa, Ethiopia: a mixed-method study by Nebiyu Dereje, Abigel Tesfaye, Beamlak Tamene, Dina Alemeshet, Haymanot Abe, Nathnael Tesfa, Tigist Biruk, Yabets Lakew, Saron Gideon

“…Therefore, the aim of this study was to determine the level of COVID-19 vaccine hesitancy and its associated factors in Addis Ababa, Ethiopia.Design A community-based concurrent mixed-method study.Setting In a community setting.Participants Adult residents (n=422) of Akaki Kality subcity who were recruited by a two stage sampling technique and 24 adults who were selected purposively were included for the quantitative and qualitative part of the study respectively.Outcome measures Data were collected by face-to-face interview using a semistructured questionnaire. …”
Get full text

Psychometric evaluation of the Persian version of the Family Caregiver-Specific Quality of Life Scale (FAMQOL) among family caregivers of patients with chronic psychiatric disorder... by Seyedmohammad Mirhosseini, Fatemeh Moslemi, Hamid Sharif-Nia, Somaye Minaei-Moghadam, Mahboobeh Khajeh, Ali Abbasi, Hossein Ebrahimi

“…Methods This cross-sectional study was conducted in 400 family caregivers of patients with chronic psychiatric diseases in Iran in 2024 using convenience sampling. Using a forward-backward translation procedure, the face and content validity of the FAMQOL were assessed through both qualitative and quantitative methods. …”
Get full text

USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma by Shuai Chen, Kefan Wu, Yingrui Zong, Zhenzhen Hou, Zhifen Deng, Zongping Xia

“…Herein, we analyzed mRNA sequencing data of OSCC samples downloaded from the TCGA and GEO databases and found that USP44 was decreased in human OSCC tissues and was positively correlated to the survival of OSCC patients. …”
Get full text

Associations Between Polymorphisms of the CSN1S1, CSN1S2, CSN2 and CSN3 Genes and Milk Composition Traits in Holstein Cattle by Ahmet Fatih Demirel, Bahattin Çak

“…A general linear model (GLM) was applied to analyse the effect of genotypic variants on phenotypic characters. …”
Get full text

Reduced expression of uroplakin 1A is associated with the poor prognosis of gastric adenocarcinoma patients. by Yan Zheng, Dan-dan Wang, Wei Wang, Ke Pan, Chun-yu Huang, Yuan-fang Li, Qi-jing Wang, Shu-qiang Yuan, Shan-shan Jiang, Hai-bo Qiu, Yong-ming Chen, Xiao-fei Zhang, Bai-wei Zhao, Cong Mai, Jian-chuan Xia, Zhi-wei Zhou

“…<h4>Methodology/principal findings</h4>Real-time quantitative PCR (RT-qPCR), western blotting, and immunohistochemical (IHC) staining methods were used to analyze the expression of UPK1A in primary gastric adenocarcinoma tissue samples. …”
Get full text

Generative Adversarial Networks for Climate-Sensitive Urban Morphology: An Integration of Pix2Pix and the Cycle Generative Adversarial Network by Mo Wang, Ziheng Xiong, Jiayu Zhao, Shiqi Zhou, Yuankai Wang, Rana Muhammad Adnan Ikram, Lie Wang, Soon Keat Tan

“…This research focuses on eight major Chinese coastal cities, leveraging a robust dataset of 4712 samples to train the generative models. Quantitative evaluations demonstrated that the integration of CycleGAN with Pix2Pix substantially improved structural fidelity and realism in urban morphology synthesis, achieving a peak Structural Similarity Index Measure (SSIM) of 0.918 and a coefficient of determination (R²) of 0.987. …”
Get full text

Needs of health education for community residents – A survey across difference types of community in Hangzhou of China by Minzhe Yi, Qingtao Gao, Xianxiao Yang, Weiwei Chen

“…Descriptive statistics, non-parametric tests, and multivariate logistic regression models were employed to assess health education needs and analyze differences across community types. …”
Get full text

Effects of Extracellular Vesicles Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells on Cell Immunity in Nonobese Mice by Yang Ou, Yang Yang, Yan Wang, Heng Su, Yi-kun Zhou

“…In this study, we investigated whether EVs derived from human umbilical cord MSCs (HucMSC-EVs) have treatment effects on nonobese diabetic (NOD) mice as model of T1D. HucMSC-EVs were isolated from human umbilical cord MSCs and characterized. …”
Get full text

USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer by Zhiyong Wang, Cheng Yu, Gengchen Xie, Kaixiong Tao, Zhijie Yin, Qing Lv

“…Finally, a mouse xenograft model was employed to study USP14’s role in tumor growth and oxaliplatin sensitivity. …”
Get full text

Clinical and cost-effectiveness of paramedics working in general practice: a mixed-methods realist evaluation by Matthew Booker, Sarah Voss, Nicky Harris, William Hollingworth, Nouf Jeynes, Hazel Taylor, Kirsty Garfield, Helen Baxter, Jonathan Benger, Andy Gibson, Trudy Goodenough, Justin Jagosh, Kim Kirby, Cathy Liddiard, Alyesha Proctor, Sarah Purdy, Behnaz Schofield, Hannah Stott, Grace Scrimgeour, Nicola Walsh

“…A mixed-methods approach combined quantitative and qualitative data to gather comprehensive insights into the deployment of PGP models in different contexts, and to iteratively develop and test theories underpinning their successful operation (or otherwise). …”
Get full text

Establishment of nursing needs scale for elderly patients with urinary incontinence and its reliability and validity test by Xiangping Liu, Jing Pan, Silian Cai

“…However, further research with larger samples and different regions is needed to improve the scale.…”
Get full text