Diagnostic efficacy and necessity of 18F-FDG PET/CT in fever of unknown origin: insights from a retrospective cohort study by Xiaoman Yu, Shuang Wang, Na Du, Hongguang Zhao, Haiying Chen

“…The diagnostic performance for different etiologies of FUO was assessed by calculating the area under the receiver operating characteristic curve.ResultsOf the 284 enrolled patients, infectious diseases were diagnosed in 53 (18.7%), non-infectious inflammatory diseases in 76 (26.8%), malignant tumors in 66 (23.2%), and 89 (31.3%) remained undiagnosed. …”
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Host factor PLAC8 is required for pancreas infection by SARS-CoV-2 by Lesly Ibargüen-González, Sandra Heller, Darío López-García, Hanna Dietenberger, Thomas FE Barth, Patricia Gallego, Israel Fernández-Cadenas, Sayoa Alzate-Piñol, Catalina Crespí, Julieth A. Mena-Guerrero, Eugenia Cisneros-Barroso, Alejandro P. Ugalde, Gabriel Bretones, Charlotte Steenblock, Alexander Kleger, Marta L. DeDiego, Carles Barceló

“…However, the severity of pancreatic SARS-CoV-2 infection and its pathophysiology is still under debate. Here, we investigate the consequences of SARS-CoV-2 pancreatic infection and the role of the host factor Placenta-associated protein (PLAC8). …”
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Infection Dynamics of Severe Acute Respiratory Syndrome Coronavirus-2 Wild-type and Delta Variant of Concern in a Pediatric Cohort in Southern India by Asha Jyothi Penugonda, Deepayan Biswas, Murugan Thimiri Palani, Sangeetha Priya, Rajesh Kumar Subaschandrabose, Koshy Alan Valiaveetil, Belavendra Antonisamy, Rajeev Zachariah Kompithra, Leni Grace Mathew, Mahesh Moorthy

“…Materials and Methods: Between November 2020 and August 2021, we enrolled children under 16 years testing positive for SARS-CoV-2 by polymerase chain reaction (PCR). …”
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Challenges in reducing grand multiparity rates in Ethiopia: an analysis of 2019 EDHS data using a multilevel model approach by Diriba Dibaba, Tesfaye Getachow Charkos

“…Reducing grand multiparity in Ethiopia remains a challenge. Understanding the underlying factors that contribute to this issue is crucial for explaining why grand multiparity remains prevalent despite various health interventions and socio-economic progress. …”
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Differentiation value of miR-26b for major depressive disorder, schizophrenia, generalized anxiety disorder by Lingming Kong, Xiaoli Zhu, Liyi Zhang, Shengdong Chen

“…The receiver operating characteristic (ROC) curve of miR-26b in MDD patients showed that its sensitivity and specificity for diagnosis were 0.540 and 0.830, respectively, with the area under curve (AUC) being 0.728; the ROC of miR-26b for SZ and MDD differentiation showed that its sensitivity and specificity were 0.580 and 0.710, respectively, with AUC being 0.631; the ROC of miR-26b for GAD and MDD differentiation suggested that sensitivity and specificity were 0.560 and 0.750, respectively, with AUC being 0.637. …”
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Hybrid optimization of EDLP and high-low pricing strategies by Hamed Karimi

“…A significant contribution of this research is the linearization of the model under conditions where the products designated for High-Low pricing (referred to as 'Golden' products) are predetermined by the retailer. …”
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Out-of-field dose assessment for pencil beam scanning proton radiotherapy versus photon radiotherapy for breast cancer in pregnant women by Menke Weessies, Murillo Bellezzo, Britt J.P. Hupkens, Frank Verhaegen, Gloria Vilches-Freixas

“…PBS-PRT measurements showed that the total equivalent dose was below the 100 mSv threshold outlined in AAPM Task Group Report No. 36 for a 30-week pregnancy, even under a worst-case scenario, maintaining treatment goals. …”
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Mechanisms and regulatory pathways of recessive land use transition by TAN Lin, CHEN Lan

“…It is rooted in the intervention system composed of regional resource endowments, engineering and technological systems, policy and institutional environments, cultural value recognition, and socio-economic development, featuring inherent relevance and dynamic adjustability. (3) Based on the underlying logic of “comprehensive land benefits - dominant land functions - land development rights”, regulatory pathways with element-coordinated governance, classification-based management guidelines, and well-improved institutional structure are constructed, which facilitate recessive land use transition. …”
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Anemia during pregnancy and adverse maternal outcomes in Georgia-A birth registry-based cohort study. by Natia Skhvitaridze, Amiran Gamkrelidze, Tinatin Manjavidze, Tormod Brenn, Erik Eik Anda, Charlotta Rylander

“…To progress toward sustainable development goals and alleviate the public health burden of anemia, it is essential to not only identify and manage anemia during pregnancy but also address underlying factors with a multifaceted response.…”
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Effect of Walking Modes and Temperatures on the Robustness of Ventilation Systems in the Control of Walking-induced Disturbances by Jianlin Ren, Junjie He, Leihong Guo, Hongwan Li, Xiangfei Kong

“…The test results showed that the cumulative particle exposure levels under walking modes W1, W2 and W3 were 2.04 ± 0.27, 1.72 ± 0.26 and 0.87 ± 0.12 times the exposure levels without human walking. …”
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Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential by Kewalin Inthanon, Natthawut Wong-a-nan, Srisulak Dheeranupattana, Andres Garcia Guerra, Neal M. Davies, Chatchai Kesornpun, Sasithorn Sangher, Prasat Kittakoop

“…This pioneering study represents the first exploration of synthetic chromenes as potential anti-obesity agents, unveiling the underlying molecular pathways governing adipogenesis and lipolysis. …”
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Genome-wide identification and characterization of WRKYs family involved in responses to Cylindrocarpon destructans in Panax notoginseng by Manqiao Li, Xiaoli Che, Qiwen Liang, Kuixiu Li, Guisheng Xiang, Xuyan Liu, Yan Zhao, Fugang Wei, Shengchao Yang, Guanze Liu

“…These findings provide a foundation for future exploration of the mechanism underlying P. notoginseng resistance to root rot disease.…”
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A stratified two-stage tumor molecular profiling algorithm to identify clinically actionable molecular alterations in pancreatic cancer☆ by S. Hussung, D. Akhoundova, C. Pistoni, D. Lenggenhager, A. Töpfer, C. Pauli, B. Pestalozzi, C. Britschgi, M. Zoche, M. Rechsteiner, H. Moch, A. Weber, R. Fritsch

“…Moreover, the magnitude of benefit and the cost-effectiveness of comprehensive next-generation sequencing panels for PC are under debate. Materials and methods: We implemented a stratified two-stage TMP algorithm for advanced PC. …”
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Transformer-Based Person Detection in Paired RGB-T Aerial Images With VTSaR Dataset by Xiangqing Zhang, Yan Feng, Nan Wang, Guohua Lu, Shaohui Mei

“…Extensive experiments conducted on the Heridal and VTSaR datasets demonstrate the effectiveness of light-weighted VTSaRNet in achieving impressive metrics precision of 98.3%, recall of 96.78%, mAP@0.5 of 98.73%, and mAP@0.5:0.95 of 73.98% under self-built VTSaR dataset, respectively). This performance sets a new benchmark in person detection from aerial imagery.…”
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Derivation of pressure distribution models for horizontal well using source function by J.O. Oloro, E.S. Adewole

“…In this work, ten (10) models for pressure distribution for horizontal well under different boundary variation were derived following these steps for each of the models:(i) choosing a boundary condition for each axis (ii) selecting the appropriate source function for each axis and (iii)applying Newman product rule to arrive at the pressure expression. …”
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Controls on coastal saline groundwater across North America by Daniel V Kretschmer, Holly A Michael, Nils Moosdorf, Gualbert H P Oude Essink, Marc F P Bierkens, Thorsten Wagener, Robert Reinecke

“…The simulation results suggest that under a steady climate and pre-development conditions (i.e. steady 30-year mean groundwater recharge, no withdrawals nor sea level rise) saline groundwater is present in 18.6% of North America’s coastal zone, defined as up to 100 km inland and up to 100 m above mean sea level. …”
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WNT3A promotes the cementogenic differentiation of dental pulp stem cells through the FOXO1 signaling pathway by Dongmei Cheng, Yang Bao, Xue Wang, Haidong Xiang, Tianyuan Guo, Yong Du, Zhiyong Zhang, Han Guo

“…The molecular mechanisms underlying cementogenic differentiation of DPSCs remain unclear. …”
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High-resolution Cryo-EM Structure Determination of a-Synuclein—A Prototypical Amyloid Fibril by Juan Sanchez, Joshua Pierson, Collin Borcik, Chad Rienstra, Elizabeth Wright

“…The physiological role of a-synuclein (a-syn), an intrinsically disordered presynaptic neuronal protein, is believed to impact the release of neurotransmitters through interactions with the SNARE complex. However, under certain cellular conditions that are not well understood, a-syn will self-assemble into β-sheet-rich fibrils that accumulate and form insoluble neuronal inclusions. …”
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Functional analysis of heterozygous variants in the SALL1 gene in 2 children with Townes-Brocks syndrome with FSGS by Rong Liang, Bixia Zheng, Chunli Wang, Sanlong Zhao, Wei Zhou, Ying Chen, Ruochen Che

“…Abstract Background To investigate the functional characteristics of heterozygous variants in the SALL1 gene in two children with Townes-Brocks syndrome (TBS), as well as the underlying mechanisms leading to chronic kidney disease. …”
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Effect of remote ischemic preconditioning on perioperative neurocognitive disorder in elderly patients undergoing major surgery and associated genetic variant analysis: a randomize... by Feifei Xu, Tingting Liu, Huiqing Liu, Jiao Deng, Shan He, Zhihong Lu, Haopeng Zhang, Hailong Dong

“…Methods From August 2020, 250 patients scheduled for major surgeries under general anesthesia were screened and 120 patients were randomly assigned to the control group or the RIPC group. …”
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