Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways by Liang Zhu, Yanchi Bi, Ting Liang, Po Zhang, Xiao Xiao, Tengbo Yu

“…GK's anti-inflammatory and antioxidative effects were comprehensively assessed via MTT assay, western blot, cell immunofluorescence, ELISA, and transcriptome sequencing. Potential underlying mechanisms were also explored. In vivo, OA was induced in rats via anterior cruciate ligament transection (ACLT), and GK's impact on cartilage protection was further assessed via histological analysis and western blot. …”
Get full text

Nano-delivery platform with strong protection and efficient delivery: preparation of self-assembled RNA pesticide with dual RNAi targets against Apolygus lucorum by Heng Qiao, Qinhong Jiang, Jing Zhao, Liubin Xiao, Keyan Zhu-Salzman, Dejin Xu, Guangchun Xu, Jie Shen, Aiguo Gu, Dejun Hao, Shuo Yan, Yongan Tan

“…The SPc could protect the dsRNA from the degradation by midgut fluid or RNase A, thus significantly increasing the stability of dsRNA under various environmental conditions. Meanwhile, the SPc was able to improve the translocation of dsRNA across insect cuticle, and increase its plant uptake. …”
Get full text

Retention in the Bukhali trial in Soweto, South Africa: a qualitative analysis using self-determination theory by Shane A Norris, Stephen Lye, Catherine E Draper, Nosibusiso Tshetu, Nokuthula Nkosi

“…These findings have relevance for trials in under-resourced settings.…”
Get full text

Long-chain chlorinated paraffins (LCCPs) exposure induces apoptosis in primary chicken embryo hepatocytes through oxidative stress by Haochu Deng, Yezi Taishi, Guoxia Wang, Yuebing Kong, Ruoting Zhang, Xin Zheng

“…To elucidate the molecular mechanisms underlying LCCP-induced apoptosis in these cells, we assessed oxidative stress levels (ROS) and mitochondrial membrane potential, and found that the level of ROS was significantly increased, and the level of mitochondrial membrane potential was significantly decreased in primary chicken embryo hepatocytes after exposure to LCCPs. …”
Get full text

Serum adropin levels as a potential biomarker for predicting diabetic kidney disease progression by I-Wen Chen, I-Wen Chen, Cheng-Wei Lin, Cheng-Wei Lin, Cheng-Wei Lin, Chia-Ni Lin, Chia-Ni Lin, Szu-Tah Chen, Szu-Tah Chen, Szu-Tah Chen

“…Further research is needed to validate these results and explore the underlying mechanisms.…”
Get full text

Sporoderm-Removed Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway by Jingyan Liu Master degree, Tao Zeng Doctor degree

“…Tumor metastasis is a key factor of therapeutic failure in tumor patients, but the underlying molecular mechanism remains to be explored and novel effective curative strategies are urgently required. …”
Get full text

Cold War as Social Conflict, Iron Curtains and Application of Dѐtente Policy as Cold War Concept by Effiong Ekpo, Udeoji Ebele Angela

“…It dismisses the popular nation that cold war was imperialistic ruling circles which America was trying to enslave all mankind under the yoke of Wall Street. The ideological perspective to the conflict makes the difference and the primary justification to the distrust by the two superpowers and their allies that created a reality to the ordinary man in the society beyond the operative objectives. …”
Get full text

Comparison of serum ischemia modified albumin levels between preeclamptic and healthy pregnant women by Dinç Zuhal, Çakar Erbil, Kumru Pınar, Erel Özcan, Neşelioğlu Salim, Cimsit Nilüfer, Boz Gizem

“…According to the ROC analysis, the best cut-off value at which the maximum area under the curve (AUC) was obtained was found when IMA>0.98(AUC: 0.690 95% Confidence Interval (CI): 0.600-0.781 p<0.001). …”
Get full text

HISS: Snakemake-based workflows for performing SMRT-RenSeq assembly, AgRenSeq and dRenSeq for the discovery of novel plant disease resistance genes by Thomas M. Adams, Moray Smith, Yuhan Wang, Lynn H. Brown, Micha M. Bayer, Ingo Hein

“…All code is freely available and is distributed under the GNU GPL-3.0 license. Conclusions HISS provides a user-friendly, portable, and easily customised approach for identifying novel disease resistance genes in plants. …”
Get full text

Exogenous cystine increases susceptibility of drug-resistant Salmonella to gentamicin by promoting oxidation of glutathione metabolism and imbalance of intracellular redox levels by Junyuan Du, Junyuan Du, Zhiyi Wu, Zhiyi Wu, Chunyang Zhu, Chunyang Zhu, Heng Yang, Heng Yang, Feike Zhao, Feike Zhao, Binghu Fang, Binghu Fang

“…Through the application of metabolomics, the underlying metabolic mechanisms by which cystine exerts its effects on Salmonella have been elucidated, offering a novel perspective in the domain of metabolic reprogramming aimed at counteracting drug resistance. …”
Get full text

Burden of diseases attributable to excess body weight in 204 countries and territories, 1990–2019 by Saeid Safiri, Jessica A. Grieger, Amir Ghaffari Jolfayi, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Asra Fazlollahi, Mark J. M. Sullman, Nahid Karamzad, Fikrettin Sahin, Kuljit Singh, Gary S. Collins, Ali-Asghar Kolahi

“…Abstract Background To investigate the global, regional, and national burden of the diseases attributable to excess body weight (EBW) from 1990 to 2019, stratified by age, sex, underlying cause, and sociodemographic index (SDI). …”
Get full text

Assessing Mitigation Strategies to Reduce Potential Exposures to Indoor Particle Release Events by Katie Van Valkinburgh, Ali Mohammadi Nafchi, Ehsan Mousavi, Vincent Blouin, Nigel Kaye, Andrew R. Metcalf

“…An exponential particle decay rate is determined from the data and converted to a particle concentration half-life, which ranged from over 60 minutes down to under 10 minutes. We then assess how quickly the particles were removed by ventilation systems with varying conditions, including the addition of both high- and low-cost portable mitigation devices into the classroom. …”
Get full text

Integrating whole-genome re-sequencing and transcriptome data to reveal the molecular mechanism of TBX5 gene regulating feathered feet in Guangxi native chickens by Zhuliang Yang, Yongcui Liu, Jintang Luo, Cong Xiao, Hong Yuan, Wenya Du, Xiurong Yang

“…Although previous studies have mapped genomic loci associated with feathered feet, the molecular mechanisms underlying this transformation remain unclear. This study combined whole-genome re-sequencing (WGS) data, transcriptomic analysis, and cellular experiments to investigate the genetic basis of feathered feet in Guangxi native chickens. …”
Get full text

Have crops already reached peak suitability: assessing global climatic suitability decreases for crop cultivation by Vhiny-Guilley Mombo, Mathilde Duvallet, Michiel Schaeffer, Florent Baarsch

“…We applied the method to evaluate the effects of climate change under two climatic scenarios (SSP2-4.5 and SSP5-8.5), using an ensemble of five general circulation models, for nine crops (Arabica coffee, cassava, common beans, common wheat, maize, plantain, rice, sorghum and sugarcane) for four periods of time: past (1995–2014), present day (2015–2034), medium term (2040–2059), long term (2080–2099). …”
Get full text

Benefit Analysis of Precursor Emission Reduction on PM2.5: Using CMAQ-RSM to Evaluate Control Strategies in Different Seasons by Chih-Rung Chen, Hsin-Chih Lai, Min-Chuan Hsiao, Hwong-wen Ma

“…The RSM model was used to calculate the decreased concentration of PM2.5 under the reduction of primary PM2.5, NOx, SOx, and NH3 emissions, and then to estimate the impact of emission reduction on PM2.5 concentration per ton of precursor. …”
Get full text

Antimicrobial effect of silver diamine fluoride (SDF) in arresting dentine caries of permanent teeth: A Systematic review [version 1; peer review: 2 approved] by Mamata Hebbal, Albandri Mohammed Alowid, Praveen Jodalli, Shahad Saad Alkait, Ghadeer Ghalab Almutairi, Fatimah Salim Almufarji

“…Despite the promising findings, there remains a lack of comprehensive understanding regarding the precise characteristics and mechanisms underlying the antimicrobial action of SDF, particularly concerning nano-silver. …”
Get full text

Database and geospatial mapping study of those eligible for extracorporeal cardiopulmonary resuscitation in the Thames Valley Region, England by Oscar Millerchip, Jasper Eddison, Alex Rosenberg, Jon Bailey, James Raitt

“…Results: Of some 1,182 cardiac arrests attended, 188 (16%) cases were eligible under inclusion criteria for ECPR. In 2023 seven patients received ECPR, all focussed in a small area of the Thames Valley. …”
Get full text

High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis by Peng Zou, Tianjing Li, Zixuan Cao, Erwan Yang, Mingdong Bao, Haofuzi Zhang, Zhuoyuan Zhang, Dan Liu, Min Zhang, Xiangyu Gao, Junmiao Ge, Xiaofan Jiang, Zhicheng Tian, Peng Luo

“…In order to deeply investigate this scientific issue, we constructed a high-altitude hypoxic TBI model at different altitudes and used animal behavioral assessments (Modified neurological severity score, rotarod test, elevated plus maze test) as well as histopathological analyses (brain gross specimens, brain water content, Evans blue content, hypoxia inducible factor-1α, Hematoxylin-Eosin staining and ROS detection) to reveal its underlying principles and characteristics. We found that with higher altitude, TBI-induced neurological deficits were more severe and the associated histopathological changes were more significant. …”
Get full text

Analysis of antibiotic sensitivity of clinical strains of microorganisms with the Russian Mueller–Hinton broth by Irina S. Kosilova, Lyubov V. Domotenko, Mikhail V. Khramov

“…To realize the method, a production technology of Russian Mueller–Hinton broth (MHB-Obolensk) has been developed under the import substitution program. The aim. …”
Get full text

Integrating microplastic research in sustainable agriculture: Challenges and future directions for food production by Marcelo Illanes, María-Trinidad Toro, Mauricio Schoebitz, Nelson Zapata, Diego A. Moreno, María Dolores López-Belchí

“…Furthermore, machine learning algorithms can be employed to analyze complex datasets, enhancing our ability to predict the impacts of MPs on plant health and crop performance under different environmental conditions. These results are significant for agricultural practices and policy formulation. …”
Get full text