Effectiveness of supracondylar dome osteotomy in reducing lateral condylar prominence and enhancing functional outcomes in pediatric cubitus varus: a retrospective study by Yam Prakash Gurung, Sabin Pokharel, Rajan Bhusal, Tarun Rajbhandari, Ashok Kumar Banskota, Bibek Banskota

“…Methods This retrospective cohort study analyzed 65 patients under 18 who underwent dome-shaped corrective osteotomy between 2017 and 2022 at the Hospital and Rehabilitation Center for Disabled Children, Nepal. …”
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Associations of four obesity indices with diabetes mellitus in Korean middle-aged and older adults using the Korean Genome and Epidemiology Study (KoGES) by Yiseul Lee, Nam-Kyoo Lim, Hyun-Young Park

“…The integrated discrimination index (IDI) and category-free net reclassification improvement (cfNRI) and area under the curve (AUC) of the receiver operating characteristic (ROC) curve were analyzed by age group to investigate index-specific model performance. …”
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Multiclass Supervised Learning Approach for SAR-COV2 Severity and Scope Prediction: SC2SSP Framework by Shaik Khasim Saheb, B. Narayanan, T.V. Narayana Rao

“…The model may also utilize preprocessing techniques which are Gaussian smoothing for handling imbalanced data, such as oversampling or under sampling, as well as feature extraction methods such as Local Binary Pattern to identify the most relevant input features for the prediction task. …”
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3,5,6,7,8,3’,4’- Heptamethoxyflavonoid inhibits TGF-β1-induced epithelial–mesenchymal transition by regulating oxidative stress and autophagy through MEK/ERK/PI3K/AKT/mTOR signalin... by Yiting Wang, Zhiheng Ma, Weiwen Peng, Qinglian Yu, Wenjie Liang, Liu Cao, Zhuqiang Wang

“…The objective of this study was to investigate the impact of HMF on TGF-β1-induced EMT in human alveolar Type II epithelial cells (A549) and its underlying mechanism. In vitro culture of TGF-β1-induced EMT in A549 cells revealed that HMF reduced cell viability and migration, inhibited collagen deposition, decreased expression levels of mesenchymal cell markers and fibrosis markers α-SMA, MMP2, TIMP1, β-catenin, and Snail. …”
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Hip Arthroscopy for Femoroacetabular Impingement Syndrome: Preoperative Radiographic Findings and Risk Factors for Reoperation at 3–6 Years Postoperatively by Andrea H. Johnson, Laura A. Stock, Jane C. Brennan, Justin J. Turcotte, Benjamin M. Petre

“…The multivariate regression models generated area under the curve of 0.740 and 0.864 for RHA and THA, respectively, indicating acceptable to strong predictive performance. …”
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Assessing routine childhood vaccination acceptance, hesitancy and refusal in Cape Town, Western Cape, South Africa: a mixed-method study protocol by Charles Shey Wiysonge, Lindi Mathebula, Moleen Zunza, Sara Cooper

“…In South Africa, vaccination has contributed substantially to the decline in under-five childhood deaths from 89 418 in 2005 to 47 409 in 2013. …”
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Dietary and environmental factors affecting the dynamics of the gut bacteria in Tibetan Awang sheep (Ovis aries) across divergent breeding models by Yuhao Wang, Xinping Wang, Yirong Wang, Yirong Wang, Songyu Liao, Zhaxi Pubu, Jiangcuo Silang, Lixu Chai, Siyue Zhao, Siyue Zhao

“…However, knowledge regarding their gut bacterial composition remains limited.MethodsA comprehensive 16S rRNA highthroughput sequencing was performed on fecal samples from 15 Awang sheep under pure grazing, semi-captivity, and full captivity breeding models.ResultsOur results revealed that Firmicutes and Bacteroidetes were the most abundant bacterial phyla, while Christensenellaceae_R-7_group, Romboutsia, Rikenellaceae_RC9_gut_group, Ruminococcus, and Bacteroides were prevalent genera in the gut microbiota of Awang sheep. …”
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Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairment by Haiyi Zhang, Lu Zhang, Juan Lu, Jiajun Yue, Zhengzhen Yuan, Jidan Hu, Qi Yao, Yuting Fu, Guiquan Chen, Jiliang Fang, Jie Zhao

“…The underlying neuropathological mechanisms in Binswanger’s disease (BD) with mild cognitive impairment (BD-MCI) remain unclear. …”
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Diagnostic efficacy and necessity of 18F-FDG PET/CT in fever of unknown origin: insights from a retrospective cohort study by Xiaoman Yu, Shuang Wang, Na Du, Hongguang Zhao, Haiying Chen

“…The diagnostic performance for different etiologies of FUO was assessed by calculating the area under the receiver operating characteristic curve.ResultsOf the 284 enrolled patients, infectious diseases were diagnosed in 53 (18.7%), non-infectious inflammatory diseases in 76 (26.8%), malignant tumors in 66 (23.2%), and 89 (31.3%) remained undiagnosed. …”
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Host factor PLAC8 is required for pancreas infection by SARS-CoV-2 by Lesly Ibargüen-González, Sandra Heller, Darío López-García, Hanna Dietenberger, Thomas FE Barth, Patricia Gallego, Israel Fernández-Cadenas, Sayoa Alzate-Piñol, Catalina Crespí, Julieth A. Mena-Guerrero, Eugenia Cisneros-Barroso, Alejandro P. Ugalde, Gabriel Bretones, Charlotte Steenblock, Alexander Kleger, Marta L. DeDiego, Carles Barceló

“…However, the severity of pancreatic SARS-CoV-2 infection and its pathophysiology is still under debate. Here, we investigate the consequences of SARS-CoV-2 pancreatic infection and the role of the host factor Placenta-associated protein (PLAC8). …”
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Infection Dynamics of Severe Acute Respiratory Syndrome Coronavirus-2 Wild-type and Delta Variant of Concern in a Pediatric Cohort in Southern India by Asha Jyothi Penugonda, Deepayan Biswas, Murugan Thimiri Palani, Sangeetha Priya, Rajesh Kumar Subaschandrabose, Koshy Alan Valiaveetil, Belavendra Antonisamy, Rajeev Zachariah Kompithra, Leni Grace Mathew, Mahesh Moorthy

“…Materials and Methods: Between November 2020 and August 2021, we enrolled children under 16 years testing positive for SARS-CoV-2 by polymerase chain reaction (PCR). …”
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Challenges in reducing grand multiparity rates in Ethiopia: an analysis of 2019 EDHS data using a multilevel model approach by Diriba Dibaba, Tesfaye Getachow Charkos

“…Reducing grand multiparity in Ethiopia remains a challenge. Understanding the underlying factors that contribute to this issue is crucial for explaining why grand multiparity remains prevalent despite various health interventions and socio-economic progress. …”
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Out-of-field dose assessment for pencil beam scanning proton radiotherapy versus photon radiotherapy for breast cancer in pregnant women by Menke Weessies, Murillo Bellezzo, Britt J.P. Hupkens, Frank Verhaegen, Gloria Vilches-Freixas

“…PBS-PRT measurements showed that the total equivalent dose was below the 100 mSv threshold outlined in AAPM Task Group Report No. 36 for a 30-week pregnancy, even under a worst-case scenario, maintaining treatment goals. …”
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Mechanisms and regulatory pathways of recessive land use transition by TAN Lin, CHEN Lan

“…It is rooted in the intervention system composed of regional resource endowments, engineering and technological systems, policy and institutional environments, cultural value recognition, and socio-economic development, featuring inherent relevance and dynamic adjustability. (3) Based on the underlying logic of “comprehensive land benefits - dominant land functions - land development rights”, regulatory pathways with element-coordinated governance, classification-based management guidelines, and well-improved institutional structure are constructed, which facilitate recessive land use transition. …”
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Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential by Kewalin Inthanon, Natthawut Wong-a-nan, Srisulak Dheeranupattana, Andres Garcia Guerra, Neal M. Davies, Chatchai Kesornpun, Sasithorn Sangher, Prasat Kittakoop

“…This pioneering study represents the first exploration of synthetic chromenes as potential anti-obesity agents, unveiling the underlying molecular pathways governing adipogenesis and lipolysis. …”
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Genome-wide identification and characterization of WRKYs family involved in responses to Cylindrocarpon destructans in Panax notoginseng by Manqiao Li, Xiaoli Che, Qiwen Liang, Kuixiu Li, Guisheng Xiang, Xuyan Liu, Yan Zhao, Fugang Wei, Shengchao Yang, Guanze Liu

“…These findings provide a foundation for future exploration of the mechanism underlying P. notoginseng resistance to root rot disease.…”
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A stratified two-stage tumor molecular profiling algorithm to identify clinically actionable molecular alterations in pancreatic cancer☆ by S. Hussung, D. Akhoundova, C. Pistoni, D. Lenggenhager, A. Töpfer, C. Pauli, B. Pestalozzi, C. Britschgi, M. Zoche, M. Rechsteiner, H. Moch, A. Weber, R. Fritsch

“…Moreover, the magnitude of benefit and the cost-effectiveness of comprehensive next-generation sequencing panels for PC are under debate. Materials and methods: We implemented a stratified two-stage TMP algorithm for advanced PC. …”
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Transformer-Based Person Detection in Paired RGB-T Aerial Images With VTSaR Dataset by Xiangqing Zhang, Yan Feng, Nan Wang, Guohua Lu, Shaohui Mei

“…Extensive experiments conducted on the Heridal and VTSaR datasets demonstrate the effectiveness of light-weighted VTSaRNet in achieving impressive metrics precision of 98.3%, recall of 96.78%, mAP@0.5 of 98.73%, and mAP@0.5:0.95 of 73.98% under self-built VTSaR dataset, respectively). This performance sets a new benchmark in person detection from aerial imagery.…”
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Derivation of pressure distribution models for horizontal well using source function by J.O. Oloro, E.S. Adewole

“…In this work, ten (10) models for pressure distribution for horizontal well under different boundary variation were derived following these steps for each of the models:(i) choosing a boundary condition for each axis (ii) selecting the appropriate source function for each axis and (iii)applying Newman product rule to arrive at the pressure expression. …”
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WNT3A promotes the cementogenic differentiation of dental pulp stem cells through the FOXO1 signaling pathway by Dongmei Cheng, Yang Bao, Xue Wang, Haidong Xiang, Tianyuan Guo, Yong Du, Zhiyong Zhang, Han Guo

“…The molecular mechanisms underlying cementogenic differentiation of DPSCs remain unclear. …”
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