Sporoderm-Removed Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway by Jingyan Liu Master degree, Tao Zeng Doctor degree

“…Tumor metastasis is a key factor of therapeutic failure in tumor patients, but the underlying molecular mechanism remains to be explored and novel effective curative strategies are urgently required. …”
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Cold War as Social Conflict, Iron Curtains and Application of Dѐtente Policy as Cold War Concept by Effiong Ekpo, Udeoji Ebele Angela

“…It dismisses the popular nation that cold war was imperialistic ruling circles which America was trying to enslave all mankind under the yoke of Wall Street. The ideological perspective to the conflict makes the difference and the primary justification to the distrust by the two superpowers and their allies that created a reality to the ordinary man in the society beyond the operative objectives. …”
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Comparison of serum ischemia modified albumin levels between preeclamptic and healthy pregnant women by Dinç Zuhal, Çakar Erbil, Kumru Pınar, Erel Özcan, Neşelioğlu Salim, Cimsit Nilüfer, Boz Gizem

“…According to the ROC analysis, the best cut-off value at which the maximum area under the curve (AUC) was obtained was found when IMA>0.98(AUC: 0.690 95% Confidence Interval (CI): 0.600-0.781 p<0.001). …”
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HISS: Snakemake-based workflows for performing SMRT-RenSeq assembly, AgRenSeq and dRenSeq for the discovery of novel plant disease resistance genes by Thomas M. Adams, Moray Smith, Yuhan Wang, Lynn H. Brown, Micha M. Bayer, Ingo Hein

“…All code is freely available and is distributed under the GNU GPL-3.0 license. Conclusions HISS provides a user-friendly, portable, and easily customised approach for identifying novel disease resistance genes in plants. …”
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Burden of diseases attributable to excess body weight in 204 countries and territories, 1990–2019 by Saeid Safiri, Jessica A. Grieger, Amir Ghaffari Jolfayi, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Asra Fazlollahi, Mark J. M. Sullman, Nahid Karamzad, Fikrettin Sahin, Kuljit Singh, Gary S. Collins, Ali-Asghar Kolahi

“…Abstract Background To investigate the global, regional, and national burden of the diseases attributable to excess body weight (EBW) from 1990 to 2019, stratified by age, sex, underlying cause, and sociodemographic index (SDI). …”
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Integrating whole-genome re-sequencing and transcriptome data to reveal the molecular mechanism of TBX5 gene regulating feathered feet in Guangxi native chickens by Zhuliang Yang, Yongcui Liu, Jintang Luo, Cong Xiao, Hong Yuan, Wenya Du, Xiurong Yang

“…Although previous studies have mapped genomic loci associated with feathered feet, the molecular mechanisms underlying this transformation remain unclear. This study combined whole-genome re-sequencing (WGS) data, transcriptomic analysis, and cellular experiments to investigate the genetic basis of feathered feet in Guangxi native chickens. …”
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Have crops already reached peak suitability: assessing global climatic suitability decreases for crop cultivation by Vhiny-Guilley Mombo, Mathilde Duvallet, Michiel Schaeffer, Florent Baarsch

“…We applied the method to evaluate the effects of climate change under two climatic scenarios (SSP2-4.5 and SSP5-8.5), using an ensemble of five general circulation models, for nine crops (Arabica coffee, cassava, common beans, common wheat, maize, plantain, rice, sorghum and sugarcane) for four periods of time: past (1995–2014), present day (2015–2034), medium term (2040–2059), long term (2080–2099). …”
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High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis by Peng Zou, Tianjing Li, Zixuan Cao, Erwan Yang, Mingdong Bao, Haofuzi Zhang, Zhuoyuan Zhang, Dan Liu, Min Zhang, Xiangyu Gao, Junmiao Ge, Xiaofan Jiang, Zhicheng Tian, Peng Luo

“…In order to deeply investigate this scientific issue, we constructed a high-altitude hypoxic TBI model at different altitudes and used animal behavioral assessments (Modified neurological severity score, rotarod test, elevated plus maze test) as well as histopathological analyses (brain gross specimens, brain water content, Evans blue content, hypoxia inducible factor-1α, Hematoxylin-Eosin staining and ROS detection) to reveal its underlying principles and characteristics. We found that with higher altitude, TBI-induced neurological deficits were more severe and the associated histopathological changes were more significant. …”
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The influence of modification on the structure and mechanical properties of aluminum alloys by Tetiana Nosova, Stella Mamchur

“… The purpose of this work is to form the structure of an aluminum alloy for the brake housing of a wind power plant under given operating conditions. Mechanical impacts associated with the operation and transportation of products include overloads, vibrations, shocks, and acoustic loads. …”
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DEVELOPMENT OF CLIP THINKING OF HIGHER EDUCATION STUDENTS IN INFORMATION ENVIRONMENT by Sergey Bushuyev, Halyna Korchova, Yurii Krasylnyk, Mykola Rudenko, Borys Kozyr

“…It was concluded that overcoming the cognitive deficit, the dominance of the sphere of abstract and logical thinking is possible under the condition of the appropriate construction of the training organization in the direction of the logical presentation of the educational material, its compliance with practical goals, the introduction of technologies aimed at educational interaction (the use of electronic discussions (forums), electronic mail, conferences, etc.), ensuring an individual approach to the organization of educational and cognitive activities, taking into account the motives, needs and opportunities of higher education seekers, the variability of the selection of IT learning technologies and their combination. …”
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Perceptions of Cardiovascular Healthcare Professionals Regarding Clinical Trials: A Survey-Based Study from the Middle East by Zainab Atiyah Dakhil, Hasan Ali Farhan, Mohammed Dheyaa Marsool, Mohammed Saad Qasim, Michele Peters, Jose Leal

“…Background: Low-middle income countries harbor the highest burden of cardiovascular diseases globally, but there is an under-representation of these countries in cardiovascular clinical trials. …”
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Barlow Twins deep neural network for advanced 1D drug–target interaction prediction by Maximilian G. Schuh, Davide Boldini, Annkathrin I. Bohne, Stephan A. Sieber

“…The use of our hybrid approach of deep learning and gradient boosting machine as the underlying predictor ensures fast and efficient predictions without the need for substantial computational resources. …”
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Historical and projected forest cover changes in the Mount Kenya Ecosystem: Implications for sustainable forest management by Brian Rotich, Abdalrahman Ahmed, Benjamin Kinyili, Harison Kipkulei

“…LULC projections for the year 2035 under the Business as Usual (BAU) scenario suggest continued expansion of cropland (+174.70 km2), built-up areas (+0.49 km2), and open forest (+471.72 km2), with declines in closed forest (−423.53 km2) and shrubland and grassland (−357.79 km2).These results highlight the ongoing pressures on the MKE's biodiversity and ecosystem services. …”
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Sustainable PV-hydrogen-storage microgrid energy management using a hierarchical economic model predictive control framework by Xinyu Guo, Faying Gu, Hongxu Liu, Yongcheng Yu, Runjie Li, Juan Wang

“…Then a comprehensive economic cost function, including internal power demand tracking cost, system operation cost and contract deviation cost, is considered in the proposed two-level HEMPC framework in order to address challenges such as fluctuating weather conditions, dynamic market environments, and the often-overlooked dynamic synergy of microgrid components. Under the proposed framework, a mixed-integer nonlinear optimization problem is solved by the long-term EMPC in the upper level to regulate the start-up/shut-down of hydrogen devices and the state of charge in the battery, and the short-term EMPC in the lower level reoptimizes the power demand tracking cost while tracking the optimal reference signal from the long-term EMPC, thereby improving overall control system efficiency. …”
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Models for predicting risk of endometrial cancer: a systematic review by Bea Harris Forder, Anastasia Ardasheva, Karyna Atha, Hannah Nentwich, Roxanna Abhari, Christiana Kartsonaki

“…Most models had moderate (area under the receiver operating characteristic curve (AUC) 0.60–0.80) or high predictive ability (AUC > 0.80) with AUCs ranging from 0.56 to 0.92. …”
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miR-182 promoter hypermethylation predicts the better outcome of AML patients treated with AZA + VEN in a real-world setting by Yilan Xu, Danyang Li, Na Wang, Bei Ge, Chen Meng, Min Zhao, Zihan Lin, Min Li, Yigang Yuan, Yue Cai, Liuzhi Shi, Shenmeng Gao, Haige Ye

“…Moreover, the median OS and LFS were longer in AML patients with miR-182 promoter hypermethylation than AML with hypomethylation. Finally, the area under the curve (AUC) for 1-year mortality was 0.831, for 2-year was 0.788, and for 3-year was 0.800. …”
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Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1 by Guanjun Li, Ling Huang, Di Gu, Peili Wang, Letai Yi, Wenhua Kuang, Ying Zhang, Junzhe Zhang, Dandan Liu, Qiaoli Shi, Huan Tang, Jichao Sun, Guohua Zeng, Xin Peng, Jigang Wang

“…Purpose This study aimed to explore the protective effects of caffeic acid in epilepsy and elucidate its underlying mechanism. Methods In this study, we established pentylenetetrazol-induced acute and kindling models of seizures. …”
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Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome by Yu Wang, Yicong Wang, Yuning Chen, Wenhan Lu, Xiaoyu Tong, Jiajia Li, Wenhao Gao, Rui Huang, Wei Hu, Yi Feng

“…Both electroacupuncture (EA) and manual acupuncture (MA) have demonstrated therapeutic efficacy in the treatment of PCOS through improvements in hypothalamic function. However, the underlying mechanisms remain poorly understood. Gonadotropin-releasing hormone (GnRH) neurons are pivotal in regulating hypothalamic endocrine function, whereas tanycyte, a specialized glial cell type, potentially contribute to this process. …”
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The Unignorable Near-ground PM2.5, UFP, PAHs, and BC Levels around a Traffic Prohibited Night Market by Sheng-Lun Lin, Hongjie Zhang, Ming-Yeng Lin, Shih-Wei Huang

“…To better analyze the contribution of traffic sources under different sampling conditions, the mobile real-time monitoring system was used to analyze the quality of NG-PM2.5, the number of ultra-fine particles (UFP), the concentration of black carbon (BC) and total polycyclic aromatic hydrocarbons (PAH) before and after the traffic restriction. …”
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Ultra-processed food intake, genetic polymorphisms, and the risk of dyslipidemia in the adult Korean population by Minsu Cho, Heejin Lee, Jung Eun Lee

“…Design: Prospective cohort study Setting: Ultra-processed foods were identified under the NOVA classification. Participants were categorized into <5, 5 to <10, 10 to <15, 15 to <20, and ≥20%E/d of ultra-processed food intake. …”
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