MDM2 inhibition is associated with the emergence of TP53-altered clonal hematopoiesis by Vishesh Khanna, Gohar Eslami, Rochelle Reyes, Robert Diep, Sebastian Fernandez-Pol, Henning Stehr, Carlos Jose Suarez, Harlan Pinto, James M. Ford, Tian Yi Zhang, Christopher T. Chen

“…Abstract Murine double minute 2 (MDM2) inhibitors have shown promising activity in TP53-wild type tumors and are under active investigation across a spectrum of malignancies. …”
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Cinematic Orientalism: East-West Perception in Netflix's 'Swimmers' by Kemal Çelik

“…The Muslim screenwriter's distortion of Eastern historical realities under Western producers' influence represents self-orientalism. …”
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Manifesto for transparent mathematical modeling: from ecology to general science by Vyacheslav L. Kalmykov, Lev V. Kalmykov

“… Mathematical black-box models, which hide the structure and behavior of the subsystems, currently dominate science. Mechanisms under study remain hidden. Errors and paradoxes, such as the biodiversity paradox and the limiting similarity hypothesis, often arise from subjective interpretations of these hidden mechanisms. …”
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Economic Analysis of Trade-offs between Justices by Stefan Baumgärtner, Stefanie Glotzbach, Nikolai Hoberg, Klara Helene Stumpf, Martin F. Quaas

“…It can identify the “opportunity cost” of attaining one justice to a higher degree, in terms of less achievement of the other. We find that, under very general conditions, (1) efficiency in the use of instruments of justice implies that there is rivalry between the two justices and the opportunity cost of either justice is positive; (2) negative opportunity costs of achieving one justice exist if there is facilitation between the two justices, which can only happen if instruments of justice are used inefficiently; (3) opportunity costs of achieving one justice are zero if the two justices are independent of each other, which is the case in the interior of the opportunity set where instruments of justice are used inefficiently. …”
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Community Participation in Programme Planning for Universal Health Coverage in India: An exploratory study by Yogesh Chandra, Ajai Kumar Jain

“…For attaining Universal Health Coverage, community participation is important, as their active role helps in sustained efforts, collaboration, and a commitment to addressing the underlying social determinants of health, leading to equity in healthcare. …”
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Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies by Dingtian Luo, Jing Zhou, Shuiliang Ruan, Binzhong Zhang, Huali Zhu, Yangming Que, Shijie Ying, Xiaowen Li, Yuanmin Hu, Zhengwei Song

“…This review provides a comprehensive analysis of the mechanisms underlying immunotherapy resistance in GC, including the role of the tumor immune microenvironment, dynamic PD-L1 expression, compensatory activation of other immune checkpoints, and tumor genomic instability. …”
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Biology, Control and Invasive Potential of Giant Reed (Arundo donax L.) in Florida by Patrick Minogue, Seth Wright

“….), also known as giant reed, is a tall, fast-growing, bamboo-like grass that under ideal conditions can reach a height of up to 30 feet and a stem diameter up to 1.5 inches. …”
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Selective phase growth of ultra-smooth Ti2O3 and TiO2 thin films at low growth temperature controlled by the oxygen partial pressure by Jiayi Tang, Okkyun Seo, Jaemyung Kim, Ibrahima Gueye, L.S.R. Kumara, Ho Jun Oh, Wan-Gil Jung, Won-Jin Moon, Yong Tae Kim, Satoshi Yasuno, Tappei Nishihara, Akifumi Matsuda, Osami Sakata

“…Thin films are generally prepared by pulsed laser deposition under high temperatures, but it is challenging to obtain a smooth surface. …”
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Path Planning for Coal Mining Masonry Robots Combined With Trajectory Optimization by Xingyi Qian, Yan Wang

“…This study proposes a novel path planning algorithm combining an improved Rapidly-exploring Random Tree (RRT) with Particle Swarm Optimization (PSO), followed by trajectory optimization under mechanical constraints to identify the time-optimal path. …”
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Model rozwijania refl eksyjności u (przyszłych) nauczycieli edukacji wczesnoszkolnej – założenia, istota, motywy konstruowania i nadawania mu wymiaru praktycznego by Joanna Szymczak

“…The inspiration for creating (and sustaining) the model is a carried out under the direction of prof. Ewa Filipiak, Ph.D and is a research project concerning refl ection in reference to educational events taken up by early school education teachers. …”
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Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche by Jayanta Mondal, Junfeng Zhang, Feng Qing, Shunping Li, Dhiraj Kumar, Jason T. Huse, Filippo G. Giancotti

“…These findings implicate Brd7 and PBAF in triggering metastatic outgrowth in cancer, pointing to targetable underlying mechanisms involving specific immune cell compartments.…”
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Managing the health and productivity of HLB-affected groves by Tripti Vashisth

“…Growers are urgently looking for strategies to maintain fruit production in their groves under endemic HLB conditions. After years of extensive research from across the world, we still do not have a cure for HLB, however we have learned a lot about this disease, the plant’s response and the disease vector. …”
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Investigating the Coupling Effects of Momentum Wake-Buoyancy Jets in Thermohaline Stratification: A Simulation Study by Yongcheng Du, Changgeng Shuai, Feiyang Luo, Chengzhe Gao

“…In a stratified environment with a sTable positive temperature but changing positive salinity, the wake stream has “cold” characteristics at the free liquid surface, and the feature intensity has a weak positive correlation with the salinity gradient. In general, under the boundary and initial conditions studied in this paper, temperature stratification is the main factor determining the thermal characteristics of the free surface, and salinity stratification is the secondary factor. …”
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A method for testing indoxacarb residues in three vegetables and the dietary risk assessment by Ai Liu, Fengyu Li, Jiacheng Ge, Guodong Si, Xianzheng Han, Yun Gao, Wenli Wang, Li Su, Nan Zou, Wei Mu, Xiaomei Li, Xiuyu Pang

“…Overall, the study suggests that the use of indoxacarb on these three vegetables is safe for the general population, with minimal risk even under long-term exposure.…”
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Efficient chemical recycling of poly(L-lactic acid) via either alcoholysis to alkyl lactate or thermal depolymerization to L-lactide promoted by Zn(II) catalysts by Maria Gentile, Licia Gaeta, Stefano Brenna, Claudio Pellecchia

“…Here we report two very efficient chemical recycling pathways for commercial high molar mass and highly crystalline PLA samples, both ones promoted by different imidazole[1,5-a]pyrid-3-yl)phenolate Zn(II) catalysts: (i) alcoholysis was easily achieved by simply treating the polymer samples in boiling methanol in the presence of 1 % Zn(II) catalyst, resulting in up to 99 % yield and selectivity in methyl lactate; and (ii) chemical recycling to the monomer was achieved by heating the polymer samples at 180 °C under vacuum or in a nitrogen flow in the presence of 0.1 % Zn(II) catalyst and a highly boiling alcohol, resulting in up to 99 % yield of L-lactide, having high chemical and steric purity, which could be repolymerized without any further purification.…”
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Available Degrees of Spatial Multiplexing of a Uniform Linear Array With Multiple Polarizations: A Holographic Perspective by Xavier Mestre, Adrian Agustin, David Sarda

“…The high dimensionality of these systems implies that communications take place in the near-field regime, which poses some questions as to their effective performance even under simple line of sight configurations. In order to study these limitations, a uniform linear array (ULA) is considered here, the elements of which are three infinitesimal dipoles transmitting different signals in the three spatial dimensions. …”
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SUCCESSION DISPUTE OF OBAS IN ISANLU KINGDOM, KOGI STATE AND NATION BUILDING 1971-1975 by MOSES, Ayorinde Emmanuel

“…The conclusion of the study is that it is necessary to have some guidelines that would always assist the people in choosing their rulers without dispute. Peaceful dialogue in resolving succession dispute must be emphasized instead of going to war, going to court, destruction of properties and lives. …”
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Hydrological drought in the lower reaches of the Yangtze River (China): a 70-year data analysis by Hua Ge, Hua Ge, Lingling Zhu, Bing Mao, Bing Mao

“…In future scenarios, the impact of riverbed cutting on hydrological drought should be comprehensively evaluated, and the effects of future tide level changes under global climate change conditions should be measured.…”
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Inhibition of lanosterol synthase linking with MAPK/JNK signaling pathway suppresses endometrial cancer by Liangjian Ma, Wunan Huang, Xiaolei Liang, Hongli Li, Wei Yu, Lexin Liu, Yuelin Guan, Chang Liu, Xiangjun Chen, Lidan Hu

“…While abnormal cholesterol metabolism has been implicated in EC progression, the underlying mechanisms remain unclear. In this study, we identified lanosterol synthase (LSS) as a key mediator in cholesterol metabolism associated with EC. …”
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Investigation of the dose and structure effects of lipid oxidation products aldehydes on the generation of heterocyclic amines: A case study of 2-amino-1-methyl-6-phenylimidazo [4,... by Mantong Zhao, Zhongyuan Liu, Mengyin Zha, Ying Sun, Haohao Shi, Xueying Zhang, Chuan Li, Guanghua Xia

“…Therefore, aldehydes could significantly enhance the PhIP generation under processing. However, except for propanal and hexanal, the promoting effect was slightly decreased with high levels of aldehydes addition due to the strong electrophilic properties and participation of reaction with the amino group of phenylacetaldehyde, creatinine, even PhIP.…”
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