Mitochondria-targeted photothermal-chemodynamic therapy enhances checkpoint blockade immunotherapy on colon cancer by Benchao Zheng, Hongbo Wang, Shiyi Zhai, Jiangsheng Li, Kuangda Lu

“…Immunotherapy has emerged as a hotspot for cancer treatment. However, the response rate of monotherapy remains relatively low in clinical settings. …”
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Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic by Ziwei Cui, Peng Wang, Weiyue Gao

“…The oral microbiome comprises over 700 distinct species, forming complex biofilms essential for maintaining oral and systemic health. …”
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Experience of nurse-guided root cause analysis after a sentinel event: a qualitative study by Li-Li Huang, Yan-Hong Jiang, Ju-Hong Yang, Wei-Wen Hong, Hai-Fei Chen, Wei-Wei Hu

“…However, evidence on the effectiveness of nurse-guided RCA in improving compliance and corrective actions is limited. …”
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Effects of the Treatment Technology of Soybean on Volatile Flavor Compounds of Plant-based Compound Milk during Storage by Xue WANG, Youqiang YU, Xiaoyang ZHENG, Hongjiang MA, Shiwei LIU, Wenxin WANG, Fang ZHOU, Shenglin DUAN

“…The results of human and electronic senses showed that the milk, flower, fruit and cereal flavors of plant-based compound milk 1# and 2# gradually increased during storage, and the peculiar smell gradually weakened. …”
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The impact of temperature on the shear bond strength of conventional multi-step and self-adhesive orthodontic adhesive systems: an in-vitro study by Grėtė Kazlauskaitė, Rytis Vaitiekūnas, Kristina Lopatienė, Audrius Jutas, Benedikta Palesik, Dalia Smailienė

“…Results Higher mean SBS values were obtained with Transbond XT compared to GC Ortho Connect resin; however, the difference was not statistically significant (p > 0.05). …”
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Effectiveness of lateral femoral cutaneous and femoral nerve block in managing postoperative pain for hemiarthroplasty patients by Kazi Mahzabin Arin, Shofina Sultana, Ayesha Sultana, Abdul Hannan Mohammad, Chandra Shekhar Karmakar, AKM Akhtaruzzaman

“… Background: The fascia iliaca compartment block is commonly used for postoperative analgesia after hemiarthroplasty. However, the method often fails to adequately manage pain due to frequent sparing of the lateral femoral cutaneous nerve. …”
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HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis by Michio Sato, Tsuyoshi Kadomatsu, Jun Morinaga, Yuya Kinoshita, Daisuke Torigoe, Haruki Horiguchi, Sumio Ohtsuki, Shuji Yamamura, Ryoko Kusaba, Takanori Yamaguchi, Goro Yoshioka, Kimi Araki, Tomohiko Wakayama, Keishi Miyata, Koichi Node, Yuichi Oike

“…Objective: Cardiac function declines with age, impairing exercise tolerance and negatively impacting healthy aging. However, mechanisms driving age-related declines in cardiac function are not fully understood. …”
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Embodied climate impacts in urban development: a neighbourhood case study by Simon Sjökvist, Nicolas Francart, Maria Balouktsi, Harpa Birgisdottir

“…Urban planning significantly influences material flows, with a substantial portion of construction occurring in planned urban development areas (UDAs), such as 76% in Copenhagen, Denmark. However, research on UDAs is limited, with most life-cycle assessments (LCAs) focusing on individual buildings. …”
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The prevalence of malaria in the five districts of Limpopo Province, South Africa, 2015 - 2017 by M T Lamola, A Musekiwa, A de Voux, C Reddy, M Morifi, P C Mutevedzi

“…The highest malaria prevalence district was Vhembe, with 647.9 in 2015, 220.3 in 2016 and 659.4 in 2017 per 100 000 population. However, Waterberg had the highest proportion of imported malaria cases 28.5% (437/1 532). …”
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Diagnostic Accuracy of Mammography, Ultrasound, and Fine-Needle Aspiration in Detecting Breast Cancer in Patients with Painful Breast Masses:A Medical Record-Base Study by Hassan Vafapour, Sajad Borzoueisileh, Fatemeh Vafapour, Zafar Masoumi Moghaddam, Frough Nikeghbali, Yaghoub Barfar, Amir Hekmatifar

“…Diagnostic methods include physical examination, mammography, ultrasound, magnetic resonance imaging (MRI), and fine-needle aspiration (FNA). However, FNA has limitations due to its invasive nature and the need for a professional cytopathologist to interpret breast cytology results, which can pose significant challenges. …”
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Cord Blood pH and Lactate- A Step Ahead in Diagnosis of Fetal Acidaemia in Patients with Abnormal Cardiotocography by Indrani Mukhopadhyay, Sanjay Singh, Sushila Kachatti

“… OBJECTIVES: Electronic fetal monitoring (EFM) is used to identify early signs of fetal deterioration. However, caution is advised when interpreting cardiotocographic parameters. …”
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Optimal Bone Preparation for Triple-Tapered Stems: Does the Sagittal Taper Affect Optimal Femoral Sizing? by Jeff Shi, MD, Kevin Salomon, MD, Victor Shen, BS, Andrew Moore, MD, John T. Wilson, MD, Brian Palumbo, MD

“…Triple taper stems have a sagittal taper to optimize fixation in the antero-posterior (AP) plane as well; however, limited guidance exists on appropriate bone preparation. …”
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Evidence-based cancer care: assessing guideline adherence of multidisciplinary tumor board recommendations for breast and colorectal cancer in a non-academic medical center by Carl-Stephan Leonhardt, Leopold Lanzenberger, Raphael Puehringer, Ulla Klaiber, Irene Hauser, Oliver Strobel, Gerald Prager, Martin Bodingbauer

“…Conclusion Overall, guideline adherence was high for colorectal and breast cancer and comparable to results from academic medical centers. However, results need to be confirmed in other tumor entities.…”
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Re-calibrating measurements of low-cost air quality monitors using PCR-GPR air quality forecasting models. by Bing Liu, Shuting Yang, Junqi Wang

“…The PCR model can effectively extract the linear relationship between the independent and dependent variables, providing a linear part of the explanation for the calibration process. However, there are often complex nonlinear relationships between pollutant concentrations and AQM measurements. …”
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mHealth App to Promote Healthy Lifestyles for Diverse Families Living in Rural Areas: Usability Study by Alejandra Perez Ramirez, Adrian Ortega, Natalie Stephenson, Angel Muñoz Osorio, Anne Kazak, Thao-Ly Phan

“…Overall, participants found the dashboard easy to navigate and found the resources, notifications, and ability to communicate with the health care team to be especially helpful. However, all (N=4) of the Spanish-speaking participants identified challenges related to numeracy (eg, difficulty interpreting the growth chart) and literacy (eg, features not fully available in Spanish), which informed iterative refinements to make the dashboard clearer and more literacy-sensitive. …”
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Methods for identifying adverse drug reactions in primary care: A systematic review. by Vera Logan, David Hughes, Adam Turner, Neil Carter, Sue Jordan

“…Overall, results suggest that the three studies that described multidisciplinary collaborations using lists of ADRs plus prescriber reviews enhanced patient safety. However, the RCTs were unblinded and reported suboptimal retention. …”
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The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity. by Liam C Hunt, Michelle Curley, Kudzai Nyamkondiwa, Anna Stephan, Jianqin Jiao, Kanisha Kavdia, Vishwajeeth R Pagala, Junmin Peng, Fabio Demontis

“…Here, we find that E2s have diverse roles in handling a model aggregation-prone protein (huntingtin-polyQ) in the Drosophila retina: while some E2s mediate aggregate assembly, UBE2D/effete (eff) and other E2s are required for huntingtin-polyQ degradation. …”
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Behavioural Response To Self-Medication Practice Before and During Covid-19 Pandemic in Western Uganda by Samuel Sunday, Dare, Ejike, Daniel Eze, Isaac, Echoru, Ibe Michael, Usman, Fred, Ssempijja, Edmund Eriya, Bukenya, Robinson, Ssebuufu

“…This may be partly because of the absence of a recognized treatment for the disease, however, the differing prevalence and nature from country to country may influence human behavioral responses. …”
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The Effect of Banana Bacteria Wilt on The Socio-Economic Welfare of Farmers in Ruhinda Sub-County Rukungiri District . by Tayebwa, Rameka

“…The highest number of respondents mentioned source of mulch for maintaining and improving soil fertility, the lowest number of respondents mentioned that the disease has led to increased poverty among households and the study continued on possible measures to control banana bacteria wilt in Ruhinda sub-county Rukungiri district, the highest number of respondents mentioned heating garden tools such as hoes, machete, knives and slashers over a fire until the metal is too hot to touch is also effective in killing the bacteria, the lowest number of respondents talked of timely removal of male buds with a forked stick is important in where insect vector that visit the diseased flower parts carry the pathogen. …”
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Quantification of Lead and Zinc in Ground, Surface and Tap Drinking Water Sources in Kabale Municipality. by Mongusho, Ivan

“…In comparison with accepted values for safe drinking water, the outcome of the study indicates that the pollution is minimal since the obtained results are within the accepted limits. However, there is a need for further studies on water treatment, and proper management of environment as well as wastes from different sources to minimize water pollution by these metals.…”
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