Effect of nirmatrelvir/ritonavir (Paxlovid) on hospitalization among adults with COVID-19: An electronic health record-based target trial emulation from N3C. by Abhishek Bhatia, Alexander J Preiss, Xuya Xiao, M Daniel Brannock, G Caleb Alexander, Robert F Chew, Hannah Davis, Megan Fitzgerald, Elaine Hill, Elizabeth P Kelly, Hemalkumar B Mehta, Charisse Madlock-Brown, Kenneth J Wilkins, Christopher G Chute, Melissa Haendel, Richard Moffitt, Emily R Pfaff, N3C Consortium

“…We observed disparities in Paxlovid treatment, with lower rates among black and Hispanic or Latino patients, and within socially vulnerable communities. …”
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Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study by Xiao S, Ou J, Qiu W, Ye C, Li N, Chen S, Lai Y, Deng Z, Wu F, Shen Y

“…We performed sensitivity analyses stratified by the lower limit of normal definition of spirometry criteria. …”
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Transcriptomic responses of sponge holobionts to in situ, seasonal anoxia and hypoxia by Strehlow, Brian W., Schuster, Astrid, Francis, Warren R., Eckford-Soper, Lisa, Kraft, Beate, McAllen, Rob, Nielsen, Ronni, Mandrup, Susanne, Canfield, Donald E.

“…Deoxygenation can be fatal for many marine animals; however, some sponge species are tolerant of hypoxia and anoxia. …”
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Analisis Kredit Pembayaran Biaya Kuliah Dengan Pendekatan Pembelajaran Mesin by Arliyanti Nurdin, Rizqa Amelia Zunaidi, Muhammad Arkan Fauzan Wicaksono, Agi Lobita Japtara Martadinata

“…The higher the credit score, the lower the risk of default. This credit score ranges from 250 – 600. …”
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Whole genome sequencing in early onset advanced heart failure by Erik Linnér, Tomasz Czuba, Olof Gidlöf, Jakob Lundgren, Entela Bollano, Maria Hellberg, Selvi Celik, Neha Pimpalwar, Philipp Rentzsch, Molly Martorella, Anders Gummesson, Olle Melander, Sebastian Albinsson, Göran Dellgren, Jan Borén, Anders Jeppsson, R. Thomas Lumbers, Sonia Shah, Johan Nilsson, Pradeep Natarajan, Tuuli Lappalainen, Malin Levin, Hans Ehrencrona, J. Gustav Smith

“…Testing yield was highest in hypertrophic (63% LP/P carriers), dilated (40%) and arrhythmogenic right ventricular (33%) cardiomyopathy and lower in ischemic cardiomyopathy (10%). A family history was more common in LP/P variant carriers than in non-carriers but was present in less than half of carriers (44% vs 13%, P < 0.001), whereas age was similar. …”
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Long-term effects of orthognathic surgery on masticatory function in individuals with cleft lip and palate: A prospective study by Patricia Martins Bueno, Paulo Alceu Kiemle Trindade, Laís Hollara Medeiros, Leide Vilma Fidélis da Silva, Ivy Kiemle Trindade-Suedam

“…Results: In the PRE-ORTHOG phase, the BF for the CLP group (x‾ RM + LM = 285 ± 141) was significantly lower compared to the CON group (x‾ RM + LM = 524 ± 202). …”
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Efficacy and safety of glycyrrhizic acid and essential phospholipids (Phosphogliv) combination for alcoholic liver disease: results of the double-blind randomized placebo-controlle... by I. G. Bakulin, N. A. Bokhan, P. O. Bogomolov, N. I. Geyvandova, M. V. Matsiyevich, M. A. Vinnikova, V. G. Morozov, O. M. Khromtsova, G. S. Soldatova, O. Yu. Shiryayev, R. D. Ilyuk, K. V. Rybakova, A. G. Katkovskaya, S. V. Teplykh, A. A. Bagretsova, M. V. Krasnova, Ye. V. Alekseyeva, A. V. Anipchenko, Ye. V. Baskakov

“…In 24 wks in group A in comparison to the group B significantly lower mean ALT level was found: 35,2±29,4 U/l vs 48,4±36,1 U/l (р =0,044), AST level became normal in higher rate of patients: 69,4% vs 47,7% (р =0,034), that had more prominent decrease in gamma-glutamyltranspeptidase (GGT) level - 47,4±36,5% vs 25,1±63,9% (р =0,039), the rate of patients with Aktitest A2-A3 range decreased - 8,5% vs 21,4% (p…”
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Analisis Loyalitas Pelanggan Berbasis Model Recency, Frequency, dan Monetary (RFM) dan Decision Tree pada PT. Solo by Basri Basri, Windu Gata, Risnandar Risnandar

“…Cluster 1 has 860 customers resulting in moderate customer loyalty (blue), Cluster 2 has 69 customers resulting in high customer loyalty (green), and Cluster 3 has 274 customers resulting in lower customer loyalty (red). …”
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Programmed Cell Death Ligand 1 (PD-L1) and major Histocompatibility Complex Class I (MHC Class I) Expression Patterns and Their Pathologic Associations in triple-Negative Breast Ca... by Kaewkedsri P, Intarawichian P, Jessadapattarakul S, Kunprom W, Koonmee S, Thanee M, Somintara O, Wongbuddha A, Chadbunchachai P, Nawapun S, Aphivatanasiri C

“…Older FFPE blocks (2008– 2018) showed lower PD-L1 expression than newer blocks (2019– 2021). …”
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Small intestinal bacterial overgrowth syndrome and systemic inflammation in pathogenesis of hemodynamic changes at liver cirrhosis by R. V. Maslennikov, A. A. Driga, K. V. Ivashkin, M. S. Zharkova, M. V. Mayevskaya, Ch. S. Pavlov, M. G. Arslanyan, N. B. Musina, Ye. N. Berezina, V. T. Ivashkin

“…SIBO at LC plays important role in vasodilation, arterial hypotension and hyperdynamic circulation. …”
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Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight by Yu Du, Bing Han, Katharina Biere, Nathalie Abdelmalek, Xinyu Shu, Chaoyang Song, Guangyao Chen, Ning Li, Marina Tuschen, Huan Wu, Shujin Sun, Alexander Choukér, Mian Long, Dominique Moser

“…In summary, altered immune cell - endothelium interactions as quantified in partial gravity conditions show similarities to cellular behavior in microgravity. However, the different magnitudes of effects in dependence of gravitational level still need to be assessed in further investigations.…”
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Intranasal Testing and Treatment for Staphylococcus aureus With Intravenous Vancomycin and Intranasal Povidone-iodine Prior to Posterior Spinal Fusion: A Retrospective Cohort Study... by Jason Malone, DO, Alex Lee-Norris, DO, Austin Wynn, MD, Kaitlin Maher, PA-C, John Lovejoy, III, MD, Ryan Illgenfritz, MD, Margaret Baldwin, MD, Adriana Cadilla, MD, Kathryn Farrell, MSN, Emily Craver, MS

“…The PI nasal testing and treatment was $308.25 per patient and $189,580.75 over the study period. Elimination of intranasal testing and S. aureus treatment result in cost savings and eliminates an unpleasant patient experience. …”
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Comparative safety of the sodium glucose co-transporter 2 (SGLT2) inhibitors: a systematic review and meta-analysis by Kris Aubrey-Bassler, John-Michael Gamble, Jennifer R Donnan, Catherine A Grandy, Eugene Chibrikov, Carlo A Marra, Karissa Johnston, Michelle Swab, Jenna Hache, Daniel Curnew, Hai Nguyen

“…However, wide CIs for many comparisons suggest limited precision, and therefore clinically important adverse events cannot be ruled out. …”
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Association Between Fentanyl Use and Post-Intubation Mean Arterial Pressure During Rapid Sequence Intubation: Prospective Observational Study by Abdullah Bakhsh, Ahmad Bakhribah, Raghad Alshehri, Nada Alghazzawi, Jehan Alsubhi, Ebtesam Redwan, Yasmin Nour, Ahmed Nashar, Elmoiz Babekir, Mohamed Azzam

“…Introduction: The choice of medications used in rapid sequence intubation (RSI) can result in the difference between an acceptable outcome and a lethal one. When executed properly, RSI is a lifesaving intervention. Nonetheless, RSI may result in fatal complications such as peri-intubation cardiac arrest. …”
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Evaluating risk factors for Trastuzumab-Deruxtecan Pneumonitis in patients with metastatic breast cancer by Jonathan Henricks, Tyler Haddad, Omair Ahmed, Jonathan Schoenhals, Pavnesh Kumar, Ryan Wilson, Jianing Ma, Jing Gennie Wang, Michael Wert, Vincent Esguerra, Ian Bentley, Kai Johnson, Daniel Stover, Sachin R. Jhawar, Margaret Gatti-Mays, Kevin Ho

“…Patients with pneumonitis had lower baseline oxygen saturation (98% vs. 97%, p = 0.02) and were more likely to have received abemaciclib (26.1% vs. 9.6%, p = 0.03) before T-DXd. …”
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Machine Learning Diagnostic Model for Hepatocellular Carcinoma Based on Liquid–Liquid Phase Separation and Ferroptosis-Related Genes by Wenchao Chen, Ting Zhu, Xiaofan Pu, Linlin Zhao, Senhao Zhou, Xin Zhong, Suihan Wang, Tianyu Lin

“…The interplay between liquid–liquid phase separation (LLPS) and ferroptosis—a regulated form of cell death—has garnered interest in tumorigenesis. However, the precise role of LLPS and ferroptosis-related genes in HCC progression and prognosis remains obscure. …”
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Comparative transcriptomic analysis and identification of candidate genes related to Verticillium wilt resistance in Gossypium barbadense and Gossypium hirsutum by Jieyin Zhao, Xingui Hu, Yuxiang Wang, Jiaxin Lu, Wenju Gao, Xuening Su, Quanjia Chen, Yanying Qu

“…Compared with those in G. hirsutum, the expression levels and of lignin biosynthesis pathway genes and the lignin content in GbMYB14-silenced plants were lower. In conclusion, our results provide a theoretical basis for an in-depth understanding of the molecular mechanism underlying the difference in Verticillium wilt resistance between G. barbadense and G. hirsutum and provide a new genetic resource for the study of cotton resistance to Verticillium wilt.…”
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Transcriptomic and behavioral studies reveal that glutamate receptors are involved in depressive-like behavior in adult olive flounder Paralichthys olivaceus by Liangfang Liu, Tangsong Feng, Mengmeng Shi, Huafeng Zou, Weiqun Lu

“…Adult olive flounder bury themselves in the sand and present motionless behavior. However, the detail mechanism of regulating the motionless behavior is not fully understood. …”
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ALMA FACTS. II. Large Scale Variations in the 12CO(J = 2 – 1) to 12CO(J = 1 – 0) Line Ratio in Nearby Galaxies by Shinya Komugi, Tsuyoshi Sawada, Jin Koda, Fumi Egusa, Fumiya Maeda, Akihiko Hirota, Amanda M. Lee

“…We present ^12 CO( J  = 1 – 0) mapping observations over ∼1/2 of the optical disk of 12 nearby galaxies from the Fundamental CO 1–0 Transition Survey of nearby galaxies (FACTS), using the ALMA Total Power array. …”
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Enough Sulfur and Iron for Potential Life Make Enceladus’s Ocean Fully Habitable by Weiming Xu, Can Liu, Ao Zhang, Maggie Lau, H. James Cleaves, Fang Huang, Christopher R. Glein, Jihua Hao

“…The levels of bioproductivity supported by S availability are overall lower than those sustained by other nutrients, but still orders of magnitude higher than the maximum level of bioproductivity estimated from the supply of chemical energy.…”
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