The First Reported Case of a Child with Two Different Rare Metabolic Disorders: Very Long-Chain Acyl-CoA Dehydrogenase Deficiency and Encephalomyopathic Mitochondrial DNA Depletion... by Maha Alotaibi, Amal Alqasmi, Faisal Albassam, Turki Alkahtani, Muath Alqahtany, Mohammed Alkhaldi

“…A comprehensive literature review showed our patient to be the first case of MTDPS13 and VLCAD reported to date worldwide.…”
Get full text

Deciphering T-cell exhaustion in the tumor microenvironment: paving the way for innovative solid tumor therapies by Reshmi Nair, Veena Somasundaram, Anshu Kuriakose, Shiv Ram Krishn, David Raben, Rachel Salazar, Pradip Nair

“…In this review, we discuss aspects of T-cell dysfunction within the TME with a focus on T-cell exhaustion. …”
Get full text

Unveiling novel insights into Type 2 Diabetes management: a meta-analysis and statistical synthesis of nursing and physiotherapy intervention literature by Eman shokr, Rasha El-Marakby, Kamlah AL-Olimat, Rasha Alqadi, Hadeel Alsirhani, Soher Abdelaziz, Asmaa Hassan, Amira Afify

“…These findings support the recommendation for collaborative nursing-physiotherapy programs in diabetes care. …”
Get full text

Objective and Intelligent Acquisition of Two Types of Decision Data Based on Online Comment Information and Its Application in Emergency Decision-Making by Ruipu Tan, Lehua Yang, Jing Li

“…Therefore, this study developed two methods for the intelligent and objective acquisition of quantitative decision data based on machine learning and online review data and applied the methods to solve practical emergency problems. …”
Get full text

The importance of using mobile ultrasound devices in improving the quality and safety of emergency care, anesthesia and intensive care by A. A. Krishtafor, D. A. Krishtafor, O. V. Kravets, O. V. Pylypenko

“…The aim of this review is to determine the role of ultrasound visualization in improving the safety and quality of anesthesia, intensive care and emergency medical care. …”
Get full text

Preferences of patients with depression for exercises: a discrete choice experiment by Hui-qin Li, Peng Xie, Yu Hou, Weixin Jiang, Shiwei Gong, Si Jin

“…This study quantified the exercise preferences of patients with depression by a discrete choice experiment (DCE), which provided references for the development of intervention programs, so as to improve the physical activity level of patients with depression and promote the effective management of depressive symptoms. …”
Get full text

Streamlining of Simple Sequence Repeat Data Mining Methodologies and Pipelines for Crop Scanning by Subramaniam Geethanjali, Palchamy Kadirvel, Mahender Anumalla, Nithyananth Hemanth Sadhana, Anandan Annamalai, Jauhar Ali

“…This paper includes the currently available methodologies for producing SSR markers, genomic resource databases, and computational tools/pipelines for SSR data mining and primer generation. This review aims to provide a ‘one-stop shop’ of information to help each new user carefully select tools for identifying and utilizing SSRs in genetic research and breeding programs.…”
Get full text

DIAGNOSTICS OF THE INTESTINE ISCHEMIC DAMAGES IN SOME ACUTE SURGICAL DISEASES OF ABDOMINAL CAVITY by Vil M. Timerbulatov, Shamil V. Timerbulatov, Ravil B. Sagitov, Artur U. Sultanabaev, Dmitriy I. Asmanov

“…To monitor the status of bowels, the anastomoses zones it is recommended to use the technique of programmed fibrolaparoscopy through the control abdominal cavity drainage.…”
Get full text

Completion of Colonoscopy After Positive Fecal Occult Blood Test Screening at a Community Health Center by Niraj Gowda, Tatiana Rugeles Suarez, Chike Leigh, Lindsey Bierle, Michael Harring, Martin Maldonado‐Puebla, Sean M. Lee, Neeral Shah, Jillian S. Catalanotti

“…Having insurance was the strongest predictor of colonoscopy, despite available financial aid programs. Longer distances to colonoscopy sites decreased likelihood of completion.…”
Get full text

Vaccination against SARS-CoV-2 in rheumatic diseases: Safety issues by B. S. Belov, A. M. Lila, E. L. Nasonov

“…For this reason it is very important to analyze data on the above-mentioned aspects in real time, especially given that patients of the rheumatology circle were excluded from the clinical development programs of vaccines against SARS-CoV-2. This review presents the results of last year’s research on the safety of vaccination against COVID-19 in patients with RS. …”
Get full text

Therapeutic Indications of Pembrolizumab in Eight Common Cancers: Current Evidence and Future Directions by Raghed Mansour, Alghaidaq Shreba, Karam Khaddour, Michael Georgeos, Zuheir Alshehabi

“…ABSTRACT Background Pembrolizumab is a monoclonal antibody that inhibits the programmed death‐1 (PD‐1) receptor pathway, which has increasingly been implicated in cancer treatment regimens. …”
Get full text

Educación e higiene postural en el ámbito de la Educación Física. Papel del maestro en la prevención de lesiones. Revisión sistemática (Education and postural hygiene in the field... by Fátima Chacón Borrego, Jose Luis Ubago-Jimenez, Juan José La Guardia García, Rosario Padial Ruiz, Mar Cepero González

“…In fact, students are at high risk of suffering spine injuries due to inefficient postures when sitting in the classroom, improper physical activities, or overweight school backpacks, among others. This review work analyzes theory-focused documents and research, published from 2005 to the present day, that focus on education and hygiene posture, on Physical Education teachers’ vision and actions in this field, as well as on intervention programs carried out outside the school environment that might be used as a complement for physical education classes in order to achieve students’ adequate postural education. …”
Get full text

Current Context of <i>Cannabis sativa</i> Cultivation and Parameters Influencing Its Development by Andreia Saragoça, Ana Cláudia Silva, Carla M. R. Varanda, Patrick Materatski, Alfonso Ortega, Ana Isabel Cordeiro, José Telo da Gama

“…On the other hand, indoor or in vitro cultivation may serve as an excellent alternative for plant breeding programs in <i>C. sativa</i>, given the substantial inter-cultivar variability that hinders the fixation of desirable traits.…”
Get full text

Greening rice-fallow areas: integrating pulses and oilseeds for sustainable cropping in eastern India by Rakesh Kumar, Anup Das, Surajit Mondal, Pravin Kumar Upadhyay, Bhagwati Prasad Bhatt, Janki Sharan Mishra, Anil Kumar Singh, Jaipal Singh Choudhary, Sanjeev Kumar, Prem Kumar Sundaram, Ashis Kumar Biswas, Sanjay Singh Rathore, Rajiv Kumar Singh, Puspa Parameswari, Dhiraj Kumar Singh, Santosh Kumar, Akram Ahmad, Kirti Saurabh, Kumari Shubha, Ajay Kumar, Manibhushan, Pawan Jeet, Ved Prakash, Bal Krishna Jha, Sushant Kumar Naik, Santosh Sambhaji Mali, Rakesh Kumar, Surendra Kumar Ahirwal, Vinod Kumar Singh, Devendra Mandal, Manoj Kumar Roy, Arbind Kumar Choudhary, Sudhir Kumar Rajpoot, Suresh Kumar Chaudhari

“…This study critically examines the key issues affecting rice-fallow lands and provides strategic recommendations to convert these underutilized areas into the productive cropping systems during winter and spring. Additionally, it reviews Central and State Government programs related to rice-fallow management, emphasizing the need for research to align with ongoing policy initiatives for maximum impact. …”
Get full text

Research progress on masticatory function assessment tools and influencing factors in patients after mandibular reconstruction by ZHANG Yue, GU Fen, WANG Yueping, YANG Wenyu, ZHAO Xiaomei

“…Second, although individual studies have explored factors affecting postoperative masticatory function, a systematic consensus has not been veached, leading to a lack of precision and individualization in clinical interventions, which significantly prolongs the patients' rehabilitation period. This paper reviews the scope and limitations of existing assessment tools for masticatory function in patients after mandibular reconstruction and systematically analyzes the key factors affecting postoperative masticatory function, aiming to promote a shift in clinical practice from "structural reconstruction" to a "function-perception collaborative rehabilitation" approach, and to provide a theoretical framework for constructing evidence-based, personalized masticatory rehabilitation programs.…”
Get full text

Immune factors and their role in tumor aggressiveness in glioblastoma: Atypical cadherin FAT1 as a promising target for combating immune evasion by Manvi Arora, Archismita Kundu, Subrata Sinha, Kunzang Chosdol

“…The secretion of immunosuppressive molecules such as transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), the expression of checkpoint proteins such programmed death-ligand 1 (PD-L1), and the recruitment of T-regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME) leads to suppressed immune cell activity, favoring unchecked tumor growth. …”
Get full text

CANOPY-N: A Phase 2 Study of Canakinumab or Pembrolizumab, Alone or in Combination, as Neoadjuvant Therapy in Patients With Resectable, Stage IB–IIIA NSCLC by Jay M. Lee, MD, Jean-Louis Pujol, MD, PhD, Jun Zhang, MD, PhD, Oleg Leonov, MD, PhD, Masahiro Tsuboi, MD, PhD, Edward S. Kim, MD, MBA, Calvin Ng, MD, Nicolas Moreno-Mata, MD, PhD, Amy Cummings, MD, PhD, Ilhan Hacibekiroglu, MD, Abidin Sehitogullari, MD, Nirmal Veeramachaneni, MD, Cathy Spillane, PhD, Jiawei Duan, PhD, Claudia Bossen, PhD, Alexander Savchenko, MD, PhD, Chiara Lobetti-Bodoni, MD, PhD, Tony Mok, MD, Pilar Garrido, MD

“…Introduction: Canakinumab is a human monoclonal anti–interleukin-1β antibody with the potential to enhance the activity of programmed death-ligand 1 inhibitors by inhibiting protumor inflammation. …”
Get full text

Prioritising Infectious Disease Mapping. by David M Pigott, Rosalind E Howes, Antoinette Wiebe, Katherine E Battle, Nick Golding, Peter W Gething, Scott F Dowell, Tamer H Farag, Andres J Garcia, Ann M Kimball, L Kendall Krause, Craig H Smith, Simon J Brooker, Hmwe H Kyu, Theo Vos, Christopher J L Murray, Catherine L Moyes, Simon I Hay

“…The study identifies a possible future strategy for those diseases where significant knowledge gaps remain, as well as recognising those where global mapping programs have already made significant progress. For many conditions, potential shared epidemiological information has yet to be exploited.…”
Get full text

Planning for the Realization of the Demographic Dividend and Leveraging Iran\'s Demographic Dividend Window in the Health Sector by Alireza Amini, Naeim Shokri, Mohammad Mesgarpour Amiri

“…This study aims to identify strategies and solutions, and propose implementable health sector programs to realize this demographic dividend. Methods: This qualitative study employed structured interviews with 11 health experts, purposively sampled in 2021. …”
Get full text

Navigating the Parasitic Landscape: Insights into Infection Patterns and Public Health Strategies in West Africa by Patrick F. Ayeh-Kumi, Patience B. Tetteh-Quarcoo, Isabella N. A. Aryee, Peter Nii Apai Baddoo, James Teye Ocansey, Michael Kofi Otoboah

“…Parasitic infections in West Africa continue to pose significant health and economic challenges. Integrated control programs, enhanced surveillance systems, improved access to diagnostics and treatment, and targeted public health interventions are essential for reducing disease burden. …”
Get full text