Safety and efficacy of neoadjuvant therapy with tislelizumab plus chemotherapy for locally advanced head and neck squamous cell carcinoma: a single-arm, retrospective study by Haifeng Liang, Wenting Liang, Jiawang Tian, Shibei Zheng, Yangzhou Su, Piao Huang, Renhui Chen, Zhong Guan, Qian Cai

“…Inhibitors targeting the programmed death 1 (PD-1) pathway have gained widespread clinical adoption. …”
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Combining immune checkpoint inhibitors with thoracic radiotherapy enhances outcomes in advanced non-small-cell lung cancer: a real-world study by Yao Zou, Yao Zou, Yao Zou, Yichong Chen, Xiaojuan Zhou, Youling Gong, Yong Xu, Bingwen Zou, Feng Peng, Meijuan Huang, You Lu, Yongmei Liu

“…Multivariate analysis identified receipt of TRT, programmed death-ligand 1 (PD-L1) expression < 1%, PD-L1 ≥ 50%, and NLR as statistically significant independent prognostic factors for OS (P < 0.05). …”
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BEFRIENding for Depression, Anxiety and Social support in older adults living in Australian residential aged care facilities (BEFRIENDAS): randomised controlled trial protocol by Colleen Doyle, Sunil Bhar, Christina Bryant, Briony Dow, David Dunt, George Mnatzaganian, Daniel O’Connor, Julie Ratcliffe, Emily You, Anne-Marie Bagnall, Georgia Major, Robin Harper, Marcia Fearn

“…If the intervention proves effective it may be incorporated into volunteer training programs and adopted as a way of supporting older people’s mental health. …”
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Research on ways to attract foreign patients to a Korean medicine clinic: a retrospective 2024 case study from Seoul by Jeong Hyeon Kim, Serin Lee, Mijoo Kim, Seung Hwan Lee, Jeong-Su Park

“…The growing demand for internal medicine services along with long-term herbal medicine use highlights the importance of integrated and personalized TKM medical programs to enhance the global competitiveness of TKM.…”
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Presenting a model for solving lot-streaming hybrid flow shop scheduling problem by considering independent setup time and transportation time by Roja Ruhbakhsh, Esmaeil Mehdizadeh, Mohammad Amin Adibi

“…Hence, in this paper, these assumptions are discussed and the results are reviewed. In this paper, the aim is solving a multi objective mathematical model for solving hybrid flow shop scheduling problem with lot-streaming, setup time and transportation time.Methodology: At first, a multi objective mathematical programming model is presented for solving the problem. …”
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Recovery housing and on-the-ground research priorities: a scoping study through the lens of community based participatory research by Patrick F. Hibbard, Cameron W. Tice, Jodie M. Dewey, Kathryn R. Gallardo, James Tompkins, Justin S. Bell, Jasleen Sandhu, Michelle A. Cruz, Kathryn Babbitt, Amy A. Mericle, Ashli J. Sheidow

“…Given the high degree of variation between types of RH programs and between geographic locations, such consensus may not be feasible or even desirable. …”
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Post-Marketing Surveillance of Nirsevimab: Safety Profile and Adverse Event Analysis from Spain’s 2023–2024 RSV Immunisation Campaign by Pablo Estrella-Porter, Elisa Correcher-Martínez, Alejandro Orrico-Sánchez, Juan José Carreras

“…During the 2023–2024 RSV season, Spain introduced nirsevimab, a monoclonal antibody for universal RSV prophylaxis in infants. This study reviews the safety of nirsevimab through post-marketing surveillance. …”
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Development and Videographic Evaluation of a Vascular Access Simulation-Based Curriculum for Surgical and Medical Trainees by Alaska Pendleton, MD, MPH, Tiffany R. Bellomo, MD, Srihari K. Lella, MD, Kristen Jogerst, MD, Ada Stefanescu, MD, MSc, Douglas Drachman, MD, Nikolaos Zacharias, MD, Anahita Dua, MD, MBA, MSc

“…All recordings were reviewed and scored by 2 blinded, independent investigators. …”
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Real‐world first‐line treatment with pembrolizumab for non‐small cell lung carcinoma with high PD‐L1 expression: Updated analysis by Yasuyuki Ikezawa, Ryo Morita, Hidenori Mizugaki, Kazunari Tateishi, Keiki Yokoo, Toshiyuki Sumi, Hajime Kikuchi, Yasuo Kitamura, Atsushi Nakamura, Maki Kobayashi, Mari Aso, Nozomu Kimura, Fumiaki Yoshiike, Furuta Megumi, Hisashi Tanaka, Motoki Sekikawa, Tsutomu Hachiya, Keiichi Nakamura, Fumihiro Hommura, Noriaki Sukoh, Kenichiro Ito, Takashi Kikuchi, Toshihiko Agatsuma, Hiroshi Yokouchi

“…Abstract Background Selecting pembrolizumab monotherapy (MONO) or pembrolizumab plus platinum‐based chemotherapy (COMB) for patients with nonsmall cell lung cancer (NSCLC) and high programmed death‐ligand 1 (PD‐L1) expression is an important issue in clinical practice. …”
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Social Determinants of Health Including Child Opportunity Index Leading to Gaps in Care for Patients With Significant Congenital Heart Disease by Abbas H. Zaidi, Susan F. Saleeb, Michelle Gurvitz, Emily Bucholz, Kimberlee Gauvreau, Kathy J. Jenkins, Sarah D. de Ferranti

“…Hospitals should adopt formal GIC improvement programs focusing on SDOH to improve continuity of care and ultimately overall outcomes for patients with CHD.…”
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A multi-objective mathematical model for the multi-warehouse order picking system using Benders decomposition algorithm by Fatemeh Nikkhoo, Ali Hosseinzadeh Kashan, Bakhtiar Ostadi, Ehsan Nikbakhsh

“…This paper aims to provide a multi-objective mathematical programming model for integrating the decisions of batching, routing, and scheduling of selectors with the packaging problem in a multi-warehouse environment. …”
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Teaching Procedural Skills: Integrating Educational Theory Into Practice by Christopher J. Smith, Cory Rohlfsen, Jana Wardian, Khalid Sahak

“…Discussion A workshop focused on evidence-based teaching of procedural skills was well reviewed and improved participants’ attitudes and knowledge. …”
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PRESOLRE: study protocol for a primary school-based, cluster randomised controlled trial of three sun exposure risk prevention strategies on Reunion Island by Cyril Ferdynus, Léa Bruneau, Antoine Bertolotti, Charline Dugast, Adrian Fianu, Karim Boussaid, Juliette Vuichard, Floreana Duloutre, Jessica Dumez, Nathalie Sultan-Bichat

“…Results will be published in peer-reviewed journals.Trial registration number NCT05367180.…”
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Post-marketing safety concerns with Tislelizumab: a disproportionality analysis of the FDA adverse event reporting system by Chen Li, Chen Li, Yi Ding, Shanshan Cai, Bai Cheng Liu, Xiufeng Wang

“…BackgroundTislelizumab is an anti-programmed cell death protein 1(anti-PD-1) monoclonal antibody, which was approved by the Food and Drug Administration(FDA) on March 14, 2024. …”
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Why and how should we simulate platform trials? Learnings from EU-PEARL by Elias Laurin Meyer, Tobias Mielke, Marta Bofill Roig, Michaela Maria Freitag, Peter Jacko, Pavla Krotka, Peter Mesenbrink, Tom Parke, Sonja Zehetmayer, Dario Zocholl, Franz König

“…The flexibility of platform trials, however, comes with complexities when designing such trials. In the past, we reviewed existing software for simulating clinical trials and found that none of them were suitable for simulating platform trials as they do not accommodate the design features and flexibility inherent to platform trials, such as staggered entry of treatments over time. …”
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La financiación del deporte de alto rendimiento femenino en la CAPV (The financing of women’s high performance sports in the Basque Country) by Judit Martínez Abajo, María Teresa Vizcarra Morales, María Gema Lasarte Leonet, Pilar Aristizabal Llorente

“…In institutions such as the Higher Sports Council, specific programs, such as that of women and sports, are developed. …”
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Identification of Anoikis-Related Genes in Driving Immune-Inflammatory Responses in Ulcerative Colitis Based on Bioinformatics Analysis and Machine Learning by Diao W, Huang X, Huang W, Jiang J, Li W, Liu H, Yan B, Shen L

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Prevalence of Post-Traumatic Stress Disorder and Associated Factors Among Internally Displaced Persons (IDPS) In Mogadishu Cross-Sectional Study by Sh Abukar IM, Asir Rage AA, Warsame MO

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Incidence of Urinary Tract Infection Among Pregnant Women and its Risk Factors in the Municipality of Baao, Camarines Sur by Jeza Baria

“…The data collection process involved reviewing Individual Treatment Records, Laboratory Records, and Logbooks from the Rural Health Unit of Baao. …”
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PSYCHOLOGICAL INVOLVEMENT AS A BASIS FOR STIMULATING THE ACTIVITY OF STUDENTS OF DEPARTMENTAL UNIVERSITIES by Natalia E. Serebrovskaya, Maria P. Shcherbakova, Darya M. Gnezdilova

“…High engagement, however, could increase the risk of emotional burn-out, which requires an introduction of special psychological support programs on various stages of tuition. EDN: JQJVNX…”
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