Butyric Acid Modulates Gut Microbiota to Alleviate Inflammation and Secondary Bone Loss in Ankylosing Spondylitis by Ke You, Lianjun Yang, Zhihai Su, Jun Shen, Xinyang Fan, Yuanqing Guo, Zhen Yuan, Hai Lu

“…Notably, BA was associated with the downregulation of harmful inflammatory factors and the reversal of bone loss, suggesting its protective effects against AS. …”
Get full text

Circ_0000284 Is Involved in Arsenite-Induced Hepatic Insulin Resistance Through Blocking the Plasma Membrane Translocation of GLUT4 in Hepatocytes via IGF2BP2/PPAR-γ by Shiqing Xu, Zhida Hu, Yujie Wang, Qiyao Zhang, Zhi Wang, Teng Ma, Suhua Wang, Xiaohui Wang, Li Wang

“…However, a circ_0000284 inhibitor reversed arsenic exposure-induced reductions in IGF2BP2, PPAR-γ, and GLUT4 levels in the plasma membrane. …”
Get full text

Assessing Cardiomyocyte DNA Damage Using Cardiovascular Magnetic Resonance T1 Mapping by Mizuki Ichikawa, MD, Shiro Nakamori, MD, Masaki Ishida, MD, Ryuji Okamoto, MD, Rie Ito, BSc, Agr, Junko Ishiura, MD, Masaki Ishiyama, MD, Taku Omori, MD, Keishi Moriwaki, MD, Emiyo Sugiura, MD, Naoki Fujimoto, MD, Tairo Kurita, MD, Yasutaka Ichikawa, MD, Kakuya Kitagawa, MD, Kyoko Imanaka-Yoshida, MD, Hajime Sakuma, MD, Kaoru Dohi, MD

“…Background: DNA damage in cardiomyocytes is a key pathological pathway in heart failure progression. It is a reversible process that precedes apoptosis and fibrosis. …”
Get full text

Gut microbiota links to cognitive impairment in bipolar disorder via modulating synaptic plasticity by Anying Tang, Hangyuan Jiang, Jie Li, Yi Chen, Jinyu Zhang, Dandan Wang, Shaohua Hu, Jianbo Lai

“…Supplementation of gut microbiota from healthy individuals partially reversed emotional and cognitive phenotypes and neuronal plasticity in BD-CI mice. …”
Get full text

Improvements in Hemodynamics and Right Heart Remodeling Following Balloon Pulmonary Angioplasty Treatment in Patients With Chronic Thromboembolic Pulmonary Hypertension: A Retrospe... by Qi‐Le Shen, Qin‐Hua Zhao, Hui‐Ting Li, Jie Deng, Jing He, Lan Wang, Su‐Gang Gong, Jin‐Ming Liu

“…Conclusion BPA has significantly ameliorated clinical conditions, hemodynamic profiles, and initiated a continued reversal in right heart remodeling in patients with CTEPH.…”
Get full text

Dynamic skeletal muscle loss and its predictive role on 90-day mortality in patients with acute-on-chronic liver failure by Nan Geng, Ming Kong, Jiateng Zhang, Manman Xu, Huina Chen, Huina Chen, Wenyan Song, Yu Chen, Zhongping Duan

“…These findings underscore the importance of dynamic evaluation of muscle loss and emphasize the necessity of reversing muscle loss in patients with ACLF.…”
Get full text

Enterobacter-inoculation altered the C, N contents and regulated biomass allocation in Reaumuria soongorica to promote plant growth and improve salt stress tolerance by Xin-Guang Bao, Xin-Guang Bao, Pei-Fang Chong, Pei-Fang Chong, Cai He, Xue-Mei Lu, Xue-Ying Wang, Feng Zhang, Bing-Bing Tan, Jia-Li Yang, Li-Li Gao

“…We found that under NaCl stress, R. soongorica seedlings exhibit significant reductions in plant height, basal diameter, and root surface area (P<0.05). …”
Get full text

Butyrate-producing bacteria in pregnancy maintenance: mitigating dysbiosis-induced preterm birth by Azusa Uchida, Kenji Imai, Rika Miki, Tomonari Hamaguchi, Hiroshi Nishiwaki, Mikako Ito, Jun Ueyama, Satomi Hattori, Sho Tano, Kazuya Fuma, Seiko Matsuo, Takafumi Ushida, Kinji Ohno, Hiroaki Kajiyama, Tomomi Kotani

“…In human samples, significant reductions in Lachnospiraceae and Ruminococcaceae, representative butyrate-producing bacteria, were seen in PTB cases. …”
Get full text

Gpbar1-mediated SIRT1-PGC-1α axis maintains mitochondrial homeostasis and mitigates renal injury in obstructive jaundice by Mingchen Li, Kai Luo, Xu Sun, Yuting Zhao, Haiyang Chen, Courtney Quan, Caiming Xu, Guixin Zhang

“…Mitochondrial structural disorder occurred in the kidneys, with significant reductions in SOD, GSH, and ATP levels, while MDA levels were significantly increased, indicating impaired antioxidant capacity and energy metabolism dysfunction. …”
Get full text

Molecular mechanisms of the anchang group prescription in treating radiation enteritis: network pharmacology analysis and experimental evidence by Wei Liang, Bo Li, Yuehong Sun, Dapeng Jia, Tingting Hu, Rujing Huang, Zhilong Liu, Huan Yang, Baocai Chen, Xiaoming Yin, Xinying He, Yunchuan Sun

“…Although Masson staining showed no significant differences, H&E staining indicated that radiation-induced mucosal damage, including extensive ulcer formation, inflammatory cell infiltration, crypt structure destruction, and epithelial layer injury, could all be ameliorated by ACZF. Notable reductions were observed in TNF-α, IL-1β, and IL-6 levels, while IL-10 levels saw a significant rise. …”
Get full text