A modular network model of aging by Huiling Xue, Bo Xian, Dong Dong, Kai Xia, Shanshan Zhu, Zhongnan Zhang, Lei Hou, Qingpeng Zhang, Yi Zhang, Jing‐Dong J Han

“…During fly aging, another couple of modules are associated with the oxidative–reductive metabolic temporal switch. These network modules and their relationships demonstrate (1) that aging is largely associated with a small number, instead of many network modules, (2) that some modular changes might be reversible and (3) that genes connecting different modules through PPIs are more likely to affect aging/longevity, a conclusion that is experimentally validated by Caenorhabditis elegans lifespan analysis. …”
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Yeast as a model system to study metabolic impact of selenium compounds by Enrique Herrero, Ralf Erik Wellinger

“…Overall, these events result in DNA damage and dose-dependent reversible or irreversible protein oxidation, although additional oxidation of other cellular macromolecules cannot be discarded. …”
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Can changes in spending on health and social care explain the recent mortality trends in Scotland? A protocol for an observational study by Gerry McCartney, Jon Minton, Grant M A Wyper, Christina Wraw, Rory Mitchell, Clare Campbell

“…However, reductions in mortality rates have slowed down since 2012–2014 in these nations; and have reversed in some cases. …”
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Controlling impurity transport in 5D gyrokinetic simulations using a transport barrier by G. Lo-Cascio, E. Gravier, M. Lesur, T. Réveillé, Y. Sarazin, X. Garbet, K. Lim, T. Rouyer, A. Guillevic

“…Impurity transport in both turbulent and neoclassical regimes is investigated under various conditions, with and without the transport barrier, along with a reversed density profile for tungsten. The transport barrier is found to reduce outward impurity transport and enhance neoclassical thermal screening due to the steepened temperature profile. …”
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miR-468-3p suppresses osteogenic differentiation of BMSCs by targeting Runx2 and inhibits bone formation by Tao Fang, Ranxi Zhang, Feng Song, Xueru Chu, Qin Fu, Qianqian Wu

“…Distinct miR-468-3p reductions were identified during OD. MiR-468-3p also suppressed BMSC OD in gain- and loss-of-function assays, while it negatively regulated Runx2 as shown by molecular, protein, and bioinformatics approaches. …”
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C. elegans sperm and oocytes differentially transmit diet-induced adaptations to their progeny by Alexandria B. Pete, Craig P. Hunter

“…This rapidity and reversibility, which was also observed in genetically identical isogenic lines, strongly suggest a non-genetic mechanism. …”
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Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation by Sung A. Jung, Miseon Choi, Sohee Kim, Rina Yu, Taesun Park

“…Moreover, cinchonine significantly reversed HFD-induced downregulations of WNT10b and galanin-mediated signaling molecules and key adipogenic genes in the epididymal adipose tissues of mice. …”
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Antiasthmatic Effects of Hesperidin, a Potential Th2 Cytokine Antagonist, in a Mouse Model of Allergic Asthma by Seung-Hyung Kim, Bok-Kyu Kim, Young-Cheol Lee

“…The features of asthma are airway inflammation, reversible airflow obstruction, and an increased sensitivity to bronchoconstricting agents, termed airway hyperresponsiveness (AHR), excess production of Th2 cytokines, and eosinophil accumulation in the lungs. …”
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Withaferin A Attenuates Muscle Cachexia Induced by Angiotensin II Through Regulating Pathways Activated by Angiotensin II by Sham S. Kakar, Vasa Vemuri, Mariusz Z. Ratajczak

“…Ang II infusion resulted in profound muscle atrophy, evidenced by significant reductions in grip strength and in the TA, GA, and GF muscle mass. …”
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Cyclic testing of a steel-tube-enabled emulative precast column-to-column connection by Ming-Ming Ji, Ming-Ming Ji, Wei Chen, Shi Zeng, Yan Xiong, Xin-Yu Zhao

“…Nevertheless, the anchorage of the column longitudinal rebars played a critical role, as inadequate anchorages led to significant reductions in the columns’ lateral capacity. For this reason, increasing the tube thickness was shown to be insufficient as a substitute for proper anchorage detailing. …”
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Hesperidin exacerbates the therapeutic potency of cisplatin against hepatocytotoxicity of Ehrlich ascites carcinoma in mice by Nahed Saleh, Tamer Allam, Reda M. S. Korany, Abdelfattah M. Abdelfattah, Ahmed M. Omran, Mabrouk Attia Abd Eldaim, Nermeen Borai El-Borai

“…In contrast, the administration of Hesp and/or Cis to the EAC-bearing mice reversed, to varying degrees, the cytotoxic effects of EAC. …”
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Sugars in Antimicrobial Polymers – The Impact of Sugar‐Lectin Binding in Membrane Interaction of Cationic Glycopolymers by Alain M. Bapolisi, Steffen Tank, Anne‐Catherine Lehnen, Antje Stindt, Rujuta Athavale, Jan A. M. Kurki, Sany Chea, Sophia Rosencrantz, Ruben R. Rosencrantz, Katja M. Arndt, Matthias Hartlieb

“…Herein, a library of acrylamide‐based cationic glycopolymers is synthesized by a xanthate‐supported photo‐initiated Reversible Additon‐Fragmentation chain Trasnfer (XPI‐RAFT) polymerization. …”
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From Menopause to Molecular Dysregulation: Proteomic Insights into Obesity-Related Pathways—A Narrative Review by Basant E. Katamesh, Jithinraj Edakkanambeth Varayil, Nina Pillai, Ann Vincent

“…Notably, one study demonstrated that weight loss led to reductions in IL-6, IL-1 receptor antagonist, and CRP, suggesting that obesity-related inflammation may be at least partially reversible. …”
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Forecasting progress: analyzing the trajectory of under-five child mortality for Ghana, Niger, Nigeria, and Sierra Leone towards SDG3 using ARIMA time series model by Zakariya Kuupah Adama, Felix Okoe Mettle, Benedict Mbeah Baiden, Nelson Kiprono Bii

“…However, Nigeria, Niger, and Sierra Leone remain off-target, requiring significant reductions in mortality rates to meet the SDG 3 benchmark. …”
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Mixed Sweeteners Supplemented with Chromium Picolinate (CrPic) Improved Some Diabetes-Related Markers and Complications in a Type 2 Diabetic Rat Model by Ekomobong Inyang, Ifeoma Irene Ijeh, Sunday Oyedemi

“…Additionally, MSSC treatment led to notable reductions in serum triglycerides, cholesterol, malondialdehyde (MDA), and LDL cholesterol levels. …”
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Bioremediation Potential of <i>Rhodococcus qingshengii</i> PM1 in Sodium Selenite-Contaminated Soil and Its Impact on Microbial Community Assembly by Mu Peng, Guangai Deng, Chongyang Hu, Xue Hou, Zhiyong Wang

“…Sodium selenite significantly reduced microbial diversity and simplified co-occurrence networks, whereas inoculation with strain PM1 partially reversed these effects by enhancing community complexity. …”
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Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells by Megan R. Teh, Nancy Gudgeon, Joe N. Frost, Linda V. Sinclair, Alastair L. Smith, Christopher L. Millington, Barbara Kronsteiner, Jennie Roberts, Bryan P. Marzullo, Hannah Murray, Alexandra E. Preston, Victoria Stavrou, Jan Rehwinkel, Thomas A. Milne, Daniel A. Tennant, Susanna J. Dunachie, Andrew E. Armitage, Sarah Dimeloe, Hal Drakesmith

“…Glucose and glutamine metabolism in the TCA cycle is limited and partially reverses to a reductive trajectory. Previous studies identified mitochondria-derived aspartate as crucial for proliferation of transformed cells. …”
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Magnesium Hydroxide Microparticle Treatment Potently Inhibits <i>Venturia oleaginea</i> Pathogenesis on Olives by Aggeliki Andreadelli, Arthur Fau, Antiopi Tsoureki, Elisavet Papa, Katerina Pliatsika, Spyros Petrakis, Penelope Baltzopoulou, Chrysa Pagkoura, Andreas Giannopoulos, George Karagiannakis, Antonios M. Makris

“…All trees sprayed showed drastic reductions in the total fungal load and compared favorably to the commercial copper compound. …”
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Short‐term dietary methionine restriction with high fat diet counteracts metabolic dysfunction in male mice by Marissa I. McGilvrey, Bethany Fortier, Diana Cooke, Maryam A. Mahdi, Benjamin Tero, Christian M. Potts, Abigail Kaija, Larisa Ryzhova, Carolina Cora, Adam Richardson, Douglas Guzior, Ilka Pinz, Calvin Vary, Robert A. Koza, Gene Ables, Lucy Liaw

“…HFD‐MetR induced rapid weight loss and robust metabolic improvement within 10 days. Significant reductions in body weight, circulating triglycerides, glucose, insulin, adipokines and hepatokines reflected metabolic health. …”
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Impact of phenytoin and valproic acid on cytotoxicity and inflammatory mediators in human mononuclear cells: with and without lipopolysaccharide stimulation by Aminah Alesawy, Norah Alotaibi, Marwa Alalshaikh, Faisal E. Aljofi, Nada Aldossary, Nada Al-Zahrani, Omar Omar, Marwa Madi

“…This effect was enhanced under LPS exposure, although IL-1β reductions in the Val-75, Val-100, and Val-200 groups were reversed in the presence of LPS. …”
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