Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy by Kongying Hu, Wenjing Zai, Mingzhu Xu, Haiyu Wang, Xinluo Song, Chao Huang, Jiangxia Liu, Juan Chen, Qiang Deng, Zhenghong Yuan, Jieliang Chen

“…HBx-targeting siRNA (siHBx) achieved significant suppression of viral antigens and reconstitution of SMC5/6, but this effect could be reversed by the deacetylase inhibitor Belinostat. The combination of IFN with siHBx resulted in over 95% suppression of virological markers, reduction in epigenetic activation modifications (H3Ac and H4Ac) on cccDNA, and further reduced cccDNA accessibility, with the effect not reversible by Belinostat. …”
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Therapeutic management of PI3Kα inhibitor-induced hyperglycemia with a novel glucokinase activator: Advancing the Frontier of PI3Kα inhibitor therapy by Guanqin Jin, Shihuang Liu, Kewei Zheng, Xiaobo Cheng, Ranran Chai, Wei Ye, Wei Wei, Yongguo Li, Ai Huang, Guiling Li, Huan Yi, Yu Kang

“…Results: Western blot analysis demonstrated that insulin activated the AKT/INSR/mTOR pathway, reversing PI3Ki-induced p-AKT inhibition. Insulin also attenuated the anti-proliferative effects of PI3Ki. …”
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Taraxacum sinicum Kitag. (Binpu-3) root extract inhibits tumor invasion via Notch signaling in Drosophila and human breast cancer MDA-MB-231 cells by Jiawei Wu, Jianbo Zhang, Wanyu Shu, Wei Feng, Ran Meng, Lingyu Kong, Huijuan Cao, Chunhua Jiang, Sitong Wang, Fanwu Wu, Chenxi Wu, Chenxi Wu, Xiuping Wang

“…Therefore, effectively controlling or reversing tumor cell growth and metastasis is crucial for treating malignant tumors. …”
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Dosing and Safety Profile of Aficamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA‐HCM by Caroline J. Coats, Ahmad Masri, Michael E. Nassif, Roberto Barriales‐Villa, Michael Arad, Nuno Cardim, Lubna Choudhury, Brian Claggett, Hans‐Dirk Düngen, Pablo Garcia‐Pavia, Albert A. Hagège, James L. Januzzi, Matthew M. Y. Lee, Gregory D. Lewis, Chang‐Sheng Ma, Martin S. Maron, Zi Michael Miao, Michelle Michels, Iacopo Olivotto, Artur Oreziak, Anjali T. Owens, John A. Spertus, Scott D. Solomon, Jacob Tfelt‐Hansen, Marion van Sinttruije, Josef Veselka, Hugh Watkins, Daniel L. Jacoby, Polina German, Stephen B. Heitner, Stuart Kupfer, Justin D. Lutz, Fady I. Malik, Lisa Meng, Amy Wohltman, Theodore P. Abraham

“…Background Aficamten, a novel cardiac myosin inhibitor, reversibly reduces cardiac hypercontractility in obstructive hypertrophic cardiomyopathy. …”
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Flow Characteristics by Blood Speckle Imaging in Non-Stenotic Congenital Aortic Root Disease Surrounding Valve-Preserving Operations by Shihao Liu, Justin T. Tretter, Lama Dakik, Hani K. Najm, Debkalpa Goswami, Jennifer K. Ryan, Elias Sundström

“…This study demonstrates that children and young adults with non-stenotic congenital aortic root disease undergoing valve-preserving operations experience significant improvements in flow dynamics within the left ventricular outflow tract and aortic root, accompanied by a reduction in <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>O</mi><mi>S</mi><mi>I</mi></mrow></semantics></math></inline-formula>. …”
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Intratumoral administration of Hibiscus sabdariffa-derived anthocyanins exerts potent antitumor effects in murine cancer models by Miriam Ezcurra-Hualde, Miriam Ezcurra-Hualde, Juan Florencio Gómez-Leyva, Efren Juarez-Curiel, Efren Juarez-Curiel, Efren Juarez-Curiel, Yanelli Jaquelinne Regalado-Noyola, Nuria Ardaiz, Nuria Ardaiz, Noelia Casares, Noelia Casares, David Ruiz-Guillamon, David Ruiz-Guillamon, Silvia Monserrat Rodríguez-Leon, Flor Yohana Flores-Hernández, Leire Arrizabalaga, Leire Arrizabalaga, Aline Risson, Aline Risson, Román García-Fuentes, Román García-Fuentes, Celia Gomar, Celia Gomar, Virginia Belsue, Virginia Belsue, Fernando Aranda, Fernando Aranda, Pedro Berraondo, Pedro Berraondo, Pedro Berraondo, Maritza R. Garcia-Garcia, Maritza R. Garcia-Garcia, Maritza R. Garcia-Garcia

“…In vivo, intratumoral administration of anthocyanins led to a significant reduction in tumor growth. The combination of anthocyanins with doxorubicin further enhanced tumor suppression. …”
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Risk and impact of stroke across 38 countries and territories of the Americas from 1990 to 2021: a population-based trends analysis from the Global Burden of Disease Study 2021Rese... by Ramón Martinez, Paula Muñoz-Venturelli, Pedro Ordunez, Felipe Fregni, Carlos Abanto, Matias Alet, Tony Fabián Alvarez, Pablo Amaya, Sebastian Ameriso, Antonio Arauz, Miguel A. Barboza, Hernán Bayona, Antonio Bernabé-Ortiz, Juan Calleja, Vanessa Cano-Nigenda, Leonardo Augusto Carbonera, Rodrigo M. Carrillo-Larco, Angel Corredor, Ana Cláudia de Souza, Claudio Jimenez, Fernando Lanas, Sheila Martins, Victor Navia, Nelson Novarro-Escudero, Verónica Olavarría, Bruce Ovbiagele, Kevin Pacheco-Barrios, Octavio Pontes-Neto, Virginia Pujol, Alejandro Rabinstein, Julieta Rosales, Andrés Rosende, Gisele Sampaio Silva, Gustavo Saposnik, Souvik Sen, Fernando D. Testai, Victor Urrutia, Craig S. Anderson, Pablo M. Lavados

“…Interpretation: Regionally, the annual number of stroke cases and deaths significantly increased from 1990 to 2021, despite reductions in age-standardized rates. The declining pace in age-standardized stroke rates has decelerated in recent years, while trends in incidence, and ischemic stroke mortality and DALY among middle-aged adults and adults, reversed towards upward in the period 2015–2021. …”
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Upregulation of circGDI2 inhibits tumorigenesis by stabilizing the expression of RNA m6A demethylase FTO in oral squamous cell carcinoma by Yuwei Gu, Ling Sheng, Xiaoxiao Wei, Yuling Chen, Yuntao Lin, Zhangfu Li, Xiaolian Li, Huijun Yang, Yufan Wang, Hongyu Yang, Yuehong Shen

“…Dot blot analysis showed a reduction in N6-methyladenosine (m6A) modification after circGDI2 overexpression. …”
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The spice clove effectively ameliorated hyperuricemia and hyperuricemia-induced kidney injury in mice by Fang Wang, Lin Fang, Jin-Juan Zhang, Qian Wang, Ya Wang, Qiong Fu, Yan Hong, Yan-Yan Gao, Xiao-Li Guo, Jing Li, Xue-Long Yan, Guo-Bo Xu, Xing-Jiang Liao, Xiang Fang, Shang-Gao Liao

“…Transcriptomic analysis revealed that CWE reversed 38 differentially expressed key genes within the kidney induced by HUA. …”
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Changes in air pollutant emissions in China during two clean-air action periods derived from the newly developed Inversed Emission Inventory for Chinese Air Quality (CAQIEI) by L. Kong, L. Kong, X. Tang, X. Tang, Z. Wang, Z. Wang, Z. Wang, J. Zhu, J. Zhu, J. Li, H. Wu, H. Wu, Q. Wu, H. Chen, H. Chen, L. Zhu, W. Wang, B. Liu, Q. Wang, D. Chen, Y. Pan, Y. Pan, J. Li, J. Li, L. Wu, L. Wu, G. R. Carmichael

“…Thirdly, CAQIEI suggested lower emission reduction rates during 2015–2018 than previous emission inventories for most species, except for CO. …”
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Financial burden of productivity loss in severe asthma and impact of biologic therapy by Kjell Erik Julius Håkansson, Rikke Ibsen, Niels Steen Krogh, Marianne Baastrup Soendergaard, Susanne Hansen, Anne-Sofie Bjerrum, Anna von Bülow, Ole Hilberg, Anders Løkke, Barbara Bonnesen Bertelsen, Claus Rikard Johnsen, Sofie Lock Johansson, Lycely Dongo, Maria Bisgaard Borup, Roxana Vijdea, Linda Makowska Rasmussen, Johannes Martin Schmid, Charlotte Suppli Ulrik, Celeste Porsbjerg

“…Biologic therapy significantly enhances productivity, suggesting that much of the individual financial burden can be reversed.…”
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Deuterium isotope effects in mechanistic studies of biotransformations of l-tyrosine and p-hydroxyphenylpyruvic acid catalyzed by the enzyme l-phenylalanine dehydrogenase by Pałka Katarzyna, Podsadni Katarzyna, Szymańska-Majchrzak Jolanta, Winnicka Elżbieta

“…The mechanisms of the reversible oxidative deamination of l-tyrosine to p-hydroxyphenylpyruvic acid and reductive amination of phenylpyruvic acid to l-phenylalanine, both catalyzed by the enzyme l-phenylalanine dehydrogenase (PheDH, EC 1.4.1.20), were investigated using the kinetic isotope effect (KIE) and solvent isotope effect (SIE) methods. …”
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Methyl Viologen@β-Zeolite with Absorption/Fluorescence Dual-Mode and Photo/Chemical Synergistic Stimuli-Responsive Chromism by Jingxuan Han, Shaoning Li, Huihui Li, Yu Li, Jiaqiao Qin, Fuxiang Wang, Qinhe Pan

“…After the single electron transfer of the chemical reductant under UV irradiation, the cyan fluorescence of MV@β-zeolite was quenched. …”
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Musa cavendish ameliorates isoproterenol-induced renal and hepatic injury in Wistar rats by Emuesiri Kohworho Umukoro, Erhiori Akponah, Oghenekparobor Blessing Elijah, Emuesiri Goodies Moke, John O. Ohaju-Obodo, Abraham Georgewill

“…Results Results showed significant reductions in sodium, bicarbonate, and chloride levels, as well as elevations in urea and creatinine, which were reversed in the MC treatment groups. …”
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Multifunctional Au–Ag–Cr Nanocomposites: From Multiplex Sensing and Advanced Logic Computing to Scalable Information Protection by Jie Zhou, Jiao Yang Lu, Zhi Xin Xie, Dong Hua Wang, Bin Sheng He, Wei Tao Huang

“…Au–Ag–Cr NCs with Au or Ag nanoparticles anchored on Cr nanobelts were synthesized using Au–Cr nanoseeds, Ag+, ascorbic acid as the reductant, and sodium dodecylbenzenesulfonate as the stabilizer. …”
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Glutamate dehydrogenase from Pantoea ananatis: A new bacterial enzyme with dual coenzyme specificity. by Maria S Kharchenko, Victoria S Skripnikova, Julia G Rostova, Natalia P Zakataeva

“…Glutamate dehydrogenase (GDH) catalyzes the reversible conversion of α-ketoglutarate (α-KG) to L-glutamate (Glu) and plays an important role in linking nitrogen and carbon metabolism. …”
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Google search volume index and banks’ capital adequacy by Tadeo Masimengo

“…Moreover, we find that when investor concerns about economic conditions rise, as measured by the Finance Stress Index (FSI), the predictive relationship between BSVI and capital adequacy reverses, consistent with the ‘flight-to-safety’ phenomenon.…”
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ROMO1 overexpression protects the mitochondrial cysteinome from oxidations in aging by Fengli Xu, Haipeng Huang, Kun Peng, Chongshu Jian, Hao Wu, Zhiwen Jing, Shan Qiu, Ying Chen, Keke Liu, Ling Fu, Yanru Wang, Jing Yang, Xiaotao Duan, Chu Wang, Heping Cheng, Xianhua Wang

“…Importantly, ROMO1 overexpression reverses mitochondrial cysteinome oxidations in multiple organs and slows functional decline in aged male mice. …”
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Tumor microenvironment-responsive nanoplatforms for enhanced cancer immunotherapy: Advances and synergistic strategies by Jie Wu, Xiangdong Xue, Haijing Qu

“…Herein, this article systematically reviews TME-responsive design strategies based on intrinsic tumor-specific features, including acidic pH, elevated reactive oxygen species (ROS) levels, reductive conditions, hypoxia, and overexpressed enzymes. …”
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Global, Regional, and National Burden of Cardiovascular Diseases Associated with Particulate Matter Pollution: A Systematic Analysis of Deaths and Disability-Adjusted Life Years wi... by Yi He, Qiongyue Zhang, Ting Zhou, Ying Lan

“…Conclusions: This study highlights the disproportionate burden of CVDs associated with PM2.5 pollution, particularly in males and lower SDI regions, with significant regional disparities and projections indicating potential reversals in trends.…”
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