Chaihu-Shugan-San Ameliorated Osteoporosis of Mice with Depressive Behavior Caused by Chronic Unpredictable Mild Stress via Repressing Neuroinflammation and HPA Activity by He MC, Xia SH, Pan H, Zhou TT, Wang XL, Li JM, Li XM, Zhang Y

“…CUMS induced over-activity of HPA axis shown by the elevation in serum level of ACTH and corticosterone and in area percentage of zona fasciculata, intriguingly, CHSG reversed those changes in HPA system, ameliorated the reduction in mechanical strength and bone mineral density, and regulated bone metabolism factors of CUMS mice.Conclusion: The chronic stress-induced depression resulted in bone disorders developing to osteoporosis. …”
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Effects of transcatheter tricuspid valve replacement on hepatic and renal function in severe TR by Zhenzhen Li, Dawei Lin, Jiaxin Miao, Jianing Fan, Fanglin Lu, Xiaochun Zhang, Wenzhi Pan, Daxin Zhou, Junbo Ge

“…These findings underscore the reversibility of TR-induced hepatic impairment and demonstrate TTVR’s potential to improve clinical outcomes.…”
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Huashi Baidu formula alleviates lipopolysaccharide-induced inflammation and acute lung injury in mice by targeting nuclear factor κB/phosphatidylinositol 3-kinase and peroxiredoxin... by Shengnan Shen, Liwei Gu, Qiaoli Shi, Yongping Zhu, Yanqing Liu, Junzhe Zhang, Yuqing Meng, Yinkwan Wong, Wennan Luo, Mengyao Jiang, Ping Song, Jigang Wang

“…In the A549 cell line with PRDX5 knockdown (si-PRDX5), the anti-inflammation effects of HSBD, including reversing LPS-induced increase in the nitric oxide level and reduction in the hydrogen peroxide content, were attenuated. …”
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Observational study of characteristics and clinical outcomes of Dutch patients with tuberous sclerosis complex and renal angiomyolipoma treated with everolimus. by Bernard A Zonnenberg, Maureen P Neary, Mei Sheng Duh, Raluca Ionescu-Ittu, Jonathan Fortier, Francis Vekeman

“…<h4>Results</h4>Compared with non-treated patients, significantly more everolimus-treated patients experienced a reduction in the size of their largest kidney in the two years post-index date (85.2% vs. 37.9%, p < 0.01). …”
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Anticancer Effect of <i>Cycas media</i>: Molecular Basis Through Modulation of PI3K/AKT/mTOR Signaling Pathway by Jawaher Alqahtani, Esraa M. Mosalam, Hend E. Abo Mansour, Aya Ibrahim Elberri, Hanaa A. Ibrahim, Sebaey Mahgoub, Ismail A. Hussein, Mohammed F. Hawwal, Maryam Al Hmoudi, Ehssan Moglad, Rehab Ahmed, Fatma Alzahraa Mokhtar, Engy Elekhnawy, Walaa A. Negm

“…<i>C. media</i> extract reversed these parameters to a significant level and the higher dose showed a superior antitumor effect. …”
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Eurycomalactone switched hepatocellular carcinoma cells into quiescence through 5’tRFAla/DVL/β-catenin pathway inhibition by Zhipeng Zhang, Yanmei Wu, Wenqiang Liang, Zhifang Liao, Hongbo Liao, Xingxing Xing, Wenxin Yi, Zixuan Liu, Yicheng Li, Mengya Shi, Dongling Lin, Ting Gu, Biao Wu, Mingzhi Zou, Huilai Miao, Xin Wu

“…Herein, it is shown that eurycomalactone (ELT), a natural product, can reversibly switch hepatocellular carcinoma (HCC) PLC/PRF/5 and HUH7 cells into a quiescent state. …”
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Prolonged release pirfenidone restores miRNA expression and CpG island methylation in patients with HCV sustained virological response and residual liver fibrosis by Eira Cerda-Reyes, Ricardo de la Rosa-Bibiano, Ana Sandoval-Rodriguez, Rebeca Rosas-Campos, Rebeca Escutia-Gutiérrez, Ángel Vázquez-Esqueda, Stefanny Cornejo-Hernández, Alejandro Gutiérrez-Átemis, Salvador Amezquita-Pérez, Jorge Luis Poo, Gildardo Agustin Garrido-Sanchez, Juan Ramón-Aguilar, Juan Armendáriz-Borunda

“…Results: After 12 months of treatment, 28.94% of patients showed a reduction in at least 1 fibrosis stage based on liver biopsies, while 57.57% experienced fibrosis reversion according to transient elastography. …”
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Hibiscus sabdariffa calyx extract protects human keratinocyte cells from fluoranthene-induced ferroptosis via the repression of aryl hydrocarbon receptor by Mani Iyer Prasanth, Dicson Sheeja Malar, Kanika Verma, Anchalee Prasansuklab, Tewin Tencomnao

“…We found that pre-treatment of HS could restore Flu-induced reduction in cell viability through the inhibition of oxidative stress, augmenting antioxidant mechanism, modulation of aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR)/pregnane X receptor (PXR)-mediated activation of phase I and II metabolism genes. …”
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Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K–AKT signaling in rheumatoid arthritis by Tingting Liu, Chao Jin, Jing Sun, Lina Zhu, Chun Wang, Feng Xiao, Xiaochang Liu, Liying Lv, Xiaoke Yang, Wenjing Zhou, Chao Tan, Xianli Wang, Wei Wei, Xiangxiang Pan

“…This was associated with a reduction in mitochondrial membrane potential and changes in the utilization of glucose and lipids, particularly in DCs. …”
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Eleutheroside B alleviates oxidative stress and neuroinflammation by inhibiting the JAK2/STAT3 signaling pathway in a rat high altitude cerebral edema model by Yacong He, Hongying Zhang, Xiu Zhang, Yue Han, Huxinyue Duan, Wenqian Song, Qingqing Tian, Yilan Wang, Guang Li, Chunjie Wu, Zhenxing Wang, Tianzhu Zhao

“…Compared to the group treated with HACE alone, the group pre-treated with EB showed a significant reduction in levels of ROS and MDA, as well as an increase in GSH. …”
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Hypoxic cancer-associated fibroblast exosomal circSTAT3 drives triple negative breast cancer stemness via miR-671-5p/NOTCH1 signaling by Lu Yang, Siyuan Zhao, Xu Liu, Yuchen Zhang, Shaorong Zhao, Xuan Fang, Jin Zhang

“…SiRNA-mediated circSTAT3 knockdown reversed these effects. Mechanistically, circSTAT3 acted as a competitive endogenous RNA (ceRNA), sponging miR-671-5p to derepress NOTCH1. …”
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Efficacy and safety of 3D-therapy at HCV-related subcompensated liver cirrhosis (genotype 1b) by P. O. Bogomolov, M. V. Matsiyevich, A. O. Buyeverov, V. D. Beznosenko, Ye. V. Fedosova, M. Yu. Petrachenkova, S. V. Koblov, K. Yu. Kokina, O. S. Kuzmina, N. V. Voronkova

“…The assessment of liver function compensation degree in 6 months after CAT termination demonstrated 3 to 4 points reduction of the Child-Pugh Score in 21 patients (33.9 %), 1 to 2 points in 35 patients (56.5 %). …”
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Human dental follicle stem cell-derived exosomes reduce root resorption by inhibiting periodontal ligament cell pyroptosis by Xinyi Li, Xinyang Liu, Jianing Zhou, Ping Zhang, Song Chen, Ding Bai

“…Based on exosomal miRNA sequencing, miR-140-3p in Force-Exos were transferred to PDLCs, and the administration of miR-140-3p inhibitors significantly reversed the reduction in PDLC pyroptosis, M1 macrophage polarization, osteoclast number, and resorption volume caused by Force-Exos. …”
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Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel by Yui Okamura, Kei Gochi, Tatsuya Ishikawa, Takuto Hayashi, Sayaka Fuseya, Riku Suzuki, Maho Kanai, Yuri Inoue, Yuka Murakami, Shunya Sadaki, Hyojung Jeon, Mio Hayama, Hiroto Ishii, Yuki Tsunakawa, Hiroki Ochi, Shingo Sato, Michito Hamada, Chikara Abe, Hironobu Morita, Risa Okada, Dai Shiba, Masafumi Muratani, Masahiro Shinohara, Taishin Akiyama, Takashi Kudo, Satoru Takahashi

“…The present study aimed to investigate the impact of three different gravitational loadings (microgravity, 1/6 g [lunar gravity], and 1 g) on the behavior, bone, thymus, and spleen of mice housed for 25–35 days in the International Space Station. The bone density reduction under microgravity was mostly recovered by 1 g but only partially recovered by 1/6 g. …”
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Inhibition of FTO expression by thiodiphenol impairs Leydig cell maturation in pubertal male rats by Bingru Zhang, Hehua Quan, Chao Wen, Yingfen Ying, Yang Zhu, Ren-Shan Ge, Qiqi Zhu

“…Additionally, the modulation of m6A RNA methylation was explored, showing an increase in m6A levels and a reduction in FTO and ALKBH5 expression and overexpression of Fto reversed TDP-mediated suppression of testosterone and steroidogenic and antioxidative genes, suggesting a novel regulatory mechanism involving RNA modification. …”
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High-intensity eccentric training ameliorates muscle wasting in colon 26 tumor-bearing mice. by Daisuke Tatebayashi, Koichi Himori, Ryotaro Yamada, Yuki Ashida, Mitsunori Miyazaki, Takashi Yamada

“…ECC-ES increased the protein synthesis rate and the phosphorylation levels of p70S6K (Thr389) and rpS6 (Ser240/244), markers for mTORC1 signaling, and reversed an upregulation of MuRF-1 mRNA in muscles from C-26 mice. …”
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<i>SIRT5</i> Regulates Lipid Deposition in Goat Preadipocytes via PI3K-Akt and MAPK Signaling Pathways by Haiyang Li, Wenli Yao, Changheng Yang, Wenyang Zhang, Yong Wang, Yaqiu Lin, Zhanyu Du, Changhui Zhang, Lian Huang, Ming Zhang, Huaigong Fan, Jiangjiang Zhu, Hua Xiang

“…Notably, we successfully reversed the phenotypic effects observed in <i>SIRT5</i> knockdown goat precursor adipocytes by inhibiting the PI3K-Akt and MAPK signaling pathways using the AKT inhibitor LY294002 and the p38 MAPK pathway inhibitor PD169316, respectively. …”
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Effect of Remimazolam versus Propofol on Hemodynamics in Elderly Hypertensive Patients Undergoing Gastroenteroscopy: A Multicenter, Randomized Controlled Clinical Trial by Gu Q, Zeng D, Lin D, Zou J, Sun J, Wang H, Chen S, Zhang H, Xu B, Liu W, Shu J

“…Flumazenil or placebo was administered for reversal. Hemodynamics were monitored via Continuous Non-Invasive Arterial Pressure (CNAP). …”
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Combined thrombus fragmentation and catheter-directed thrombolysis in the treatment of pulmonary thromboembolism in high- and moderate-risk patients by V. Dimitrova, B. Vodenicharova, D. Dimitrov, P. Krastev

“…The overall clinical success of the procedure, defined as haemodynamic stability, reversal of hypoxia, reduction of respiratory rate and improvement of peripheral perfusion was achieved in 90.4% of patients. …”
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Hydroxychloroquine enhances efferocytosis and modulates inflammation via MerTK/Gas6 signaling in a pristane-induced lupus mouse model by Shin-Yi Liu, Shin-Yi Liu, Shin-Yi Liu, Yung-Ju Yeh, Yung-Ju Yeh, Ting-Yin Xue, Ting-Yin Xue, Fei-Hung Hsieh, Fei-Hung Hsieh, Ya-Wun Wu, Ya-Wun Wu, Meng-Zhen Wu, Meng-Zhen Wu, Wei-Jing Li, Wei-Jing Li, Jun-Chieh J. Tsay, Jun-Chieh J. Tsay, Shu-Yao Tsai, Chung-Ming Huang, Chung-Ming Huang, Hen-Hong Chang, Hen-Hong Chang, Hui-Chen Chen, Chun-Ping Lin, Gregory J. Tsay, Gregory J. Tsay, Gregory J. Tsay

“…Inhibition of MerTK signaling by UNC2025 mitigated HCQ-mediated enhancements in efferocytosis and reversed the reduction in inflammatory mediators including IL-6 and IFN-α. …”
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