Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus by Qiaolin Wang, Yutong Wu, Lianlian Ouyang, Xiaoli Min, Meiling Zheng, Lingyu Gao, Xiaoyun Chen, Zhi Hu, Shuang Yang, Wenjuan Jiang, Sujie Jia, Qianjin Lu, Ming Zhao

“…Results We observed a significant reduction in CD8αα + IELs, accompanied by a marked increase in CD8αβ + IELs in Lpr mice. …”
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Causal effects and prediction of land use systems in rural landscapes: Evidence from Henan Province by Isaac Sarfo, Jiajun Qiao, Emmanuel Yeboah, Abraham Okrah, Charafa El Rhadiouini, Benjamin Kwapong Osibo, Anita Boah, Dhekra Ben Amara

“…Land use predictions (2023–2053) show a reduction in areas covered by forests and water bodies, and a reversed trend in cultivated lands. …”
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Association Between Introduction of the 23-valent Pneumococcal Polysaccharide Vaccine (PPSV23) and Pneumonia Incidence and Mortality Among General Older Population in Japan: A Comm... by Aya Sugiyama, Masaaki Kataoka, Kentaro Tokumo, Kanon Abe, Hirohito Imada, Bunlorn Sun, Golda Ataa Akuffo, Tomoyuki Akita, Shingo Fukuma, Noboru Hattori, Junko Tanaka

“…Interrupted time series analysis indicated a 25% reduction in Sera Town’s pneumonia mortality rate post-project, reversing an annual increase of 0.23 per 1,000 population pre-project to an annual decrease of 0.04 per 1,000 population post-project. …”
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<i>Gastrodia elata</i>, <i>Polygonatum sibiricum</i>, and <i>Poria cocos</i> as a Functional Food Formula: Cognitive Enhancement via Modulation of Hippocampal Neuroinflammation and... by Yiwen Zhang, Fang Chen, Xueyan Li, Yanfei Xu, Xinmin Liu, Muhammad Qasim Barkat, Muhammad Iqbal Choudhary, Qi Chang, Ning Jiang

“…These findings suggest CGEF’s potential as a functional food for reversing cognitive impairments caused by chronic sleep restriction, primarily through its anti-inflammatory and neuroprotective effects.…”
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Estrogen receptor β activation alleviates inflammatory bowel disease by suppressing NLRP3-dependent IL-1β production in macrophages via downregulation of intracellular calcium leve... by Yanrong Zhu, Yilei Guo, Pengxiang Guo, Jing Zhang, Yue He, Yufeng Xia, Zhifeng Wei, Yue Dai

“…Combination with CaSR overexpression plasmid reversed the suppressive effect of ERβ activation on NLRP3 inflammasome assembly, and counteracting the downregulation of IL-1β secretion. …”
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SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state by Ruben Sebastian-Perez, Shoma Nakagawa, Xiaochuan Tu, Sergi Aranda, Martina Pesaresi, Pablo Aurelio Gomez-Garcia, Marc Alcoverro-Bertran, Jose Luis Gomez-Vazquez, Davide Carnevali, Eva Borràs, Eduard Sabidó, Laura Martin, Malka Nissim-Rafinia, Eran Meshorer, Maria Victoria Neguembor, Luciano Di Croce, Maria Pia Cosma

“…SMARCAD1 or TOPBP1 depletion in mouse embryos leads to developmental arrest, reduction of H3K9me3, and remodeling of heterochromatin foci. …”
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Fluoride induces hepatointestinal damage and vitamin B2 mitigation by regulating IL-17A and Bifidobacterium in ileum by Chen Liang, Cuicui Zhuang, Chenkai Cheng, Jian Bai, Yue Wu, Xiang Li, Jie Yang, Bohui Li, Weixiang Fu, Qianlong Zhu, Jiawei Lv, Yanjia Tan, Ram Kumar Manthari, Yangfei Zhao, Jundong Wang, Jianhai Zhang

“…The ileum was found to be the most sensitive to fluoride, leading to changes in ileal microbiome, particularly the reduction of Bifidobacterium. Furthermore, Bifidobacterium supplementation reversed fluoride-induced hepatointestinal injury. …”
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Unraveling the interplay between mesenchymal stem cells, gut microbiota, and systemic sclerosis: therapeutic implications by Lili Zhang, Hui Wang, Lu Zhao, Jin Zhang, Wenchang Sun, Jinjin Chu, Haobin Zhao, Chunjuan Yang, Shushan Yan, Xiaohua Chen, Donghua Xu

“…MSC treatment led to a significant reduction of conditionally pathogenic bacteria enriched in SSc, including Akkermansia muciniphila and Parasutterella excrementihominis. …”
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Up-regulation of long non-coding RNA H19 ameliorates renal tubulointerstitial fibrosis by reducing lipid deposition and inflammatory response through regulation of the microRNA-130... by Yali Jiang, Feng Ma, Jing Wang, Xiaojing Chen, Lu Xue, Xinping Chen, Jinping Hu

“…The overexpression of microRNA-130a-3p reversed the lncRNA H19-induced increases in the expression of ACSL1. …”
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Genomic and transcriptomic profiling of radioresistant prostate and head and neck cancers implicate a BAHD1-dependent modification of DNA damage at the heterochromatin by Chaw Yee Beh, Celestia Pei Xuan Yeo, Boon Hao Hong, Evelyn Mui Cheng Tan, Kah Min Tan, Dennis Jun Jie Poon, Pek Lim Chu, Dewi Susanti, Pei Ling Tai, Monica Ryu, James Proudfoot, Eugenia Li Ling Yeo, Khee Chee Soo, Melvin L. K. Chua

“…The dependency between BAHD1 and heterochromatin formation was confirmed by siRNA knockdown of BAHD1, indicating preferential reduction of H3K9me3 and H3K27me3 expression in the radioresistant cells, but not the wild-type parentals, and confirmed by clonogenic assays showing reversal of radioresistance post-siBAHD1 treatment. …”
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Baricitinib in the Treatment of Patients with COVID-19: A Review of International Data and Analysis of Clinical Results in the Russian Population by А. I. Zagrebneva, Е. А. Baryakh, Е. I. Zhelnova, N. G. Poteshkina, I. Р. Beloglazova, Z. Yu. Mutovina, I. V. Samsonova, Е. А. Kovalevskaya, V. V. Parshin, V. V. Pshenichnikova, D S. Fomina, Т. S. Kruglova, М. А. Lysenko, М. А. Dranitsyna

“…The effects of baricitinib, a selective reversible inhibitor of Janus kinase 1 and 2, in the treatment of COVID-19 are associated with different aspects of pathogenesis — inhibition of viral endocytosis, reduction of excessive inflammatory response, and mitigation of vascular and pulmonary damage, which is a strong rationale for using baricitinib to treat patients with COVID-19. …”
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Prenatal diagnosis of pulmonary atresia with intact ventricular septum: a single-center study in China by Qiong Huang, Tingting Dang, Zhenzhen Zhan, Zongjie Weng, Wen Ling, Huagu Tian, Qiumei Wu

“…Pregnancy outcomes included 41 terminations (five with pathologic dissection or vascular casting), five live births, one selective reduction, and one intrauterine death. Conclusion Fetal echocardiography is an effective tool for diagnosing PA/IVS. …”
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Micronutrient antioxidant supplementation alleviates valproic acid-induced oxidative stress and male infertility via the NRF2/HO-1 pathway by Muhammad Arif Asghar, Bing Wan, Lu Li, Jie Zhang, Shixin Tang, Hang Han, Yuanyuan Yang, Long Chu, Qian Zhang, Xiao Zhang, Qinjian Zhao

“…TUNEL assays demonstrated a reduction in apoptotic damage, and IHC confirmed an increase in HO-1 and SOD1. …”
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Aortic valve stenosis and osteoporosis: insights from a mouse model by Hannah Billig, Johanna Schmitt, Lamia Singer, Christoph Bourauel, Frank A. Schildberg, Werner Masson, Nikola Lübbering, Wenzel Vogel, Sven Perner, Marta Stei, Sven Niepmann, Miriam Silaschi, Farhad Bakhtiary, Georg Nickenig, Sebastian Zimmer

“…Results OVX induced a significant reduction in trabecular bone mineral density (TBM, 50.6%, p = 0.0025). …”
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Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD-1 agents by Mariaelena Capone, Gabriele Madonna, Ester Simeone, Paolo A Ascierto, Antonio Sorrentino, Roberta Turiello, Elva Morretta, Maria Chiara Monti, Rosa Azzaro, Silvana Morello, Pasquale Del Gaudio

“…Incubation of exosomes with CD3/28 activated T cells in the presence of AMP resulted in a significant reduction of IFN-γ release, which was reversed by the CD73 inhibitor APCP or by the selective A2A adenosine receptor antagonist ZM241385. …”
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Egg exosome miR-145-5p decreases mitochondrial ROS to protect chicken embryo hepatocytes against apoptosis through targeting MAPK10 by Fengdong Zhang, Yongchang Han, Fan Li, Boya Guo, Jian Chen, Wenchuan Zhou, Pan Xiao, Hui Ma, Yongyan Jin, Jia Feng, Yuna Min

“…Our previous study demonstrated that egg exosome-derived miRNAs may play a key role in modulating embryonic oxidation-reduction process, whereas the exact function and mechanism were still poorly understood. …”
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Bioinformatics analysis and experimental validation of potential targets and pathways in chronic kidney disease associated with renal fibrosis by Cui Huimin, Zhao Yuxin, Wang Peng, Gong Wei, Lin Hong, Li Na, Yang Jianjun

“…Additionally, this study offers a potential avenue for the development of future interventions aimed at halting or reversing the progression of CKD.…”
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Obstetrical and perinatal consequences of childbirth in women with antenatally undiagnosed fetal growth restriction by V. A. Puchkov, M. I. Pavliuchenko, O. A. Bohomolova

“…The identification of FGR during pregnancy will contribute to the reduction of both perinatal morbidity and perinatal mortality. …”
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Effects of <i>Curcuma longa</i> L. and Green Propolis Extract-Loaded Microcapsules Supplementation on Inflammation in Hemodialysis Patients: Preliminary Results of a Randomized Cli... by Isadora Britto, Heloiza Couto, Bruna Regis de Paiva, Jessyca S. de Brito, Livia Alvarenga, Ludmila F. M. F. Cardozo, Paulo Emilio Correa Leite, Andresa A. Berretta, Marcelo Ribeiro-Alves, Virgílio Pimentel Delgado, Danielle Figueiredo da Cunha, Carmen Lucia Sanz, Lia S. Nakao, Denise Mafra

“…Uremic toxins were analyzed by reversed-phase high-performance liquid chromatography. …”
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Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice by Li Kong, Xinyu Gao, Lijuan Zhu, Xing Lin, You Huang, Chunlin Huang, Wenjiang Yang, Yazhi Chen, Haoqiang Zhao, Jing Wu, Zhihang Yuan, Jin’e Yi

“…Simultaneously, BA not only reversed F-2 toxin-induced reduction of follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels in the serum, but also restrained the protein expression of the estrogen receptors α (ERα) and ERβ. …”
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