Cerebral Mask of Takotsubo Syndrome by M. A. Tyapkina, A. A. Ordyakova, E. Yu. Ponomareva, E. V. Yakovleva

“…Takotsubo Syndrome (TS) is an acutely developing and typically reversible myocardial dysfunction, predominantly affecting the left ventricle, which clinically and electrocardiographically resembles acute coronary syndrome. …”
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Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury by Liujun Tao, Jie Xu, Liangyan Jiang, Juntao Hu, Zhanhong Tang

“…Furthermore, mild hypothermia reversed the modified expression of P53, SLC7A11, and GPX4 signaling molecules. …”
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Inhibition of Aspartate β-Hydroxylase Enhances Anti-Tumor Immunity by Johari SD, Krausova K, Zucha B, Madureira Trufen CE, Polakova I, Olsen M, Smahel M

“…Therefore, this study aimed to investigate the effect of ASPH inhibition on the induction of anti-tumor immunity and to analyze the immune cells involved.Methods: In the mouse TC-1/A9 model characterized by reversible downregulation of major histocompatibility class I (MHC-I) molecules, ASPH inhibition was combined with stimulation of innate and/or adaptive immunity, and the anti-tumor response was analyzed by evaluation of tumor growth, in vivo depletion of immune cell subpopulations, and ELISPOT assay. …”
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Chlorogenic acid alleviates the intestinal barrier dysfunction and intestinal microbiota disorder induced by cisplatin by Ruiqi Tian, Yinchuan Ding, Shijie Zhang, Min Li, Yiran Wang, Qi Wu, Huanhuan Ding, Chengjie Song, Ce Shi, Min Xue

“…However, chlorogenic acid treatment especially the pretreatment reversed the reduced microbiota diversity, elevating abundance of Proteobacteria and F/B ratio.DiscussionMicrobiota diversity and all results suggest that chlorogenic acid treatment was able to mitigate these intestinal microbiota disorder and diversity reduction induced by cisplatin, effectively offer a protective effect against the inflammatory response and destruction of the mucosal barrier in the intestines caused by cisplatin.…”
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Polypharmacy with tiagabine, levetiracetam, and perampanel in status epilepticus: Insights from EEG, biochemical, and histopathological studies in rats by Sana Javaid, Faleh Alqahtani, Abida Parveen, Waseem Ashraf, Zohabia Rehman, Syed Muhammad Muneeb Anjum, Tanveer Ahmad, Imran Imran

“…However, when combinations were tested, there was an improvement in seizure presentation while TGB + PER and LEV + PER also reversed SE‐associated electrographic changes. However, the most prominent seizure attenuation was noted in rats receiving trio therapy with TGB, LEV, and PER. …”
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Finerenone attenuates downregulation of the kidney GLP-1 receptor and glucagon receptor and cardiac GIP receptor in mice with comorbid diabetes by Duc Tin Tran, Emily S. H. Yeung, Lisa Y. Q. Hong, Harmandeep Kaur, Suzanne L. Advani, Youan Liu, Madiha Zahra Syeda, Sri Nagarjun Batchu, Andrew Advani

“…Conclusions Through its anti-fibrotic actions, finerenone reverses Glp1r and Gcgr downregulation in the diabetic kidney. …”
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Antiviral Therapeutics Discovery for Enterovirus D68. by Prof Justin Jang H Chu

“…MARVAS DF01 treatment reversed this phenomenon, suggesting its mechanism of inhibition to be through the autophagy pathway. …”
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Diagnostic Challenge of Paroxysmal Nocturnal Hemoglobinuria (PNH) with Aplastic Anemia: A Case Report by Priyanshi Maurya, Anjali Bhardwaj, Rahul Singh Bisht, Arusha Desai, Thirugnanasambandam Thayumanavan, Ram Trehan

“…In this case, the patient's pancytopenia was initially attributed to various reversible causes, but the persistence of symptoms and detailed investigations ultimately led to the diagnosis of PNH. …”
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High-fat diet-induced increase in glucocorticoids contributes to adipogenesis in obese mice by Sheng-Feng Tsai, Pei-Ling Hsu, Mei-Chen Yeh, Hao-Chang Hung, Monica Meng-Chun Shih, Bon-chu Chung, Chia-Yih Wang, Chih-Jen Chang, Yu-Min Kuo

“…Results: We found that, after receiving a 12-week HFD feeding, the L/L mice show less weight gain, milder adipose expansion, and higher plasma levels of triglycerides than the wild-type mice. These changes were reversed by replenishing CORT to L/L mice. When examining the expression levels of various molecules linked to lipid uptake and de novo lipogenesis in CORT-induced adipose expansion, we observed a reduction in the expression of adipose preadipocyte factor 1 (Pref-1), a key regulator in adipogenesis. …”
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High‐Energy LiNiO2 Li Metal Batteries Enabled by Hybrid Electrolyte Consisting of Ionic Liquid and Weakly Solvating Fluorinated Ether by Qian Liu, Jiayi Xu, Wei Jiang, Jihyeon Gim, Adam P. Tornheim, Rajesh Pathak, Qijia Zhu, Peng Zuo, Zhenzhen Yang, Krzysztof Z. Pupek, Eungje Lee, Chongmin Wang, Cong Liu, Jason R. Croy, Kang Xu, Zhengcheng Zhang

“…Here, we report a hybrid electrolyte consisting of a highly fluorinated ionic liquid and a weakly solvating fluorinated ether, whose hybridization structure enables the reversible operation of a battery chemistry based on Li0 and LiNiO2 (Ni = 100%), delivering nearly theoretical capacity of the latter (up to 249 mAh g−1) for >300 cycles with retention of 78.6% and in absence of unwanted morphological changes in both electrodes. …”
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Total flavonoids of litchi seed inhibit breast cancer metastasis by regulating the PI3K/AKT/mTOR and MAPKs signaling pathways by Xin Yang, Shoushi Liu, Ying Liu, Yuanshuo Wang, Dianxin Cui, Taijin Lan, Dan Zhu, Zhiheng Su, Erwei Hao, Lilan Qin, Hongwei Guo

“…It effectively suppressed breast cancer metastasis in vitro, demonstrated by a marked reduction in cellular motility and invasiveness, alongside the reversal of EMT. …”
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The stifling burden of climate change on African public healthcare systems by Jack Ogony, Jack Ogony, Judith Mangeni, George Ayodo, Esther Amulen, Florenc Scopas, Tusubila Juma, Michael Wagaba, Amos Deogratius Mwaka, Lena Nwanja, Sambila Princewill, Ben Oyugi, Arthy Yongo, Sitraka Rakotosolofo, Alberto Francioli, Eunison Mugamu, Julia Davies, Simon Karanja, Corrie Hannah

“…It disrupts the physical environment, natural and human systems, and the functionality of healthcare systems, acting as a multiplier threat that jeopardizes and potentially reverses decades of health gains. The Sendai Framework, a roadmap for making vulnerable and marginalized communities safer and more resilient emphasizes the importance of investing in disaster risk prevention and reduction through both structural and non-structural measures, which are vital for enhancing socio-economic, health, and cultural resilience. …”
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Amelioration of biased neuronal differentiation in humanized mouse model of valproic acid‐induced autism by precisely targeted transcranial magnetic stimulation by Yilin Hou, Youyi Zhao, Dingding Yang, Tingwei Feng, Yuqian Li, Xiang Li, Zhou'an Liu, Xiao Yan, Hui Zhang, Shengxi Wu, Xufeng Liu, Yazhou Wang

“…In comparison with wild type and control chimeric mice, ASD chimeric mice (VPAhNPC mice) exhibit core syndromes of ASD, namely dramatic reduction of sociability, social interaction and social communication, and remarkable increase of stereotype repetitive behaviors and anxiety‐like behaviors. …”
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Redox regulation and dynamic control of brain-selective kinases BRSK1/2 in the AMPK family through cysteine-based mechanisms by George N Bendzunas, Dominic P Byrne, Safal Shrestha, Leonard A Daly, Sally O Oswald, Samiksha Katiyar, Aarya Venkat, Wayland Yeung, Claire E Eyers, Patrick A Eyers, Natarajan Kannan

“…In this study, we investigate redox regulation of the AMPK-related brain-selective kinases (BRSK) 1 and 2, and detail how broad catalytic activity is directly regulated through reversible oxidation and reduction of evolutionarily conserved Cys residues within the catalytic domain. …”
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Lachnospiraceae bacterium alleviates alcohol-associated liver disease by enhancing N-acetyl-glutamic acid levels and inhibiting ferroptosis through the KEAP1-NRF2 pathway by Hejiao Zhang, Qiang Hu, Yong Zhang, Lei Yang, Shanfei Tian, Xinru Zhang, Haiyuan Shen, Hang Shu, Linxi Xie, Dongqing Wu, Liangliang Zhou, Xiaoli Wei, Chen Cheng, Jiali Jiang, Hua Wang, Cailiang Shen, Derun Kong, Long Xu

“…Our results showed a significant reduction in Lachnospiraceae bacterium in the gut microbiota of ALD patients and ethanol (EtOH)-fed mice, as revealed by 16S rDNA sequencing. …”
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Association of biological aging acceleration transitions and burdens with incident cardiovascular disease: longitudinal insights from a national cohort study by Xin Zhang, Yu Yan, Yuxin Liu, Zixin Wang, Yuchen Jiang, Shuo Zhang, Tongda Xu, Ke Wang, Chu Zheng, Ping Zeng

“…Results Compared to individuals maintaining stable non-accelerated aging patterns, those transitioning to accelerated aging status showed a 29.8% (4.2–61.8%) increased CVD risk, while participants with sustained accelerated aging demonstrated a more pronounced 65.5% (35.9–101.5%) risk elevation. Reversal from accelerated to non-accelerated aging status was associated with a significant 25.6% (3.9–42.3%) risk reduction compared to persistent accelerated aging. …”
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Historical trends and controlling factors of isoprene emissions in CMIP6 Earth system models by N. T. N. Do, K. Sudo, K. Sudo, A. Ito, A. Ito, A. Ito, L. K. Emmons, V. Naik, K. Tsigaridis, K. Tsigaridis, Ø. Seland, G. A. Folberth, D. I. Kelley

“…Aside from LULCC-induced reductions, differences in CO<span class="inline-formula">₂</span> inhibition representation (strength and presence or absence of thresholds) were able to mitigate or reverse increasing trends because of rising temperatures or in combination with CO<span class="inline-formula">₂</span> fertilization. …”
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Reduced microRNA-744 expression in mast cell-derived exosomes triggers epithelial cell ferroptosis in acute respiratory distress syndrome by Xiaobin Fang, Fei Gao, Ling Zheng, Fu-Shan Xue, Tao Zhu, Xiaochun Zheng

“…Lipopolysaccharide-treated mast cell-derived exosomes reduced glutathione peroxidase 4 (GPX4) expression and increased long-chain acyl-CoA synthetase 4 (ACSL4), 15-lipoxygenase (ALOX15), and inflammatory mediator levels in HBE cells. miRNA sequencing revealed a reduction in mast cell-derived exosomal miR-744 levels, which was associated with the regulation of ACSL4, ALOX15, and GPX4 expression. …”
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Contraceptive use and decision-making in Guéra, Chad: a mixed-methods study by Vincent de Paul Allambademel, Mahamat Abdelaziz, Natalie Andrasko, Bongo Goumbo, Robert Madjigoto, Alexis Ngarmbatedjimal, Solal Noubadjim, Salomon Tamira, Theodora Varelis, Katchebe Vourbane, Sara E. Casey

“…The findings highlight the need for more diverse and tailored stigma reduction interventions in the community to promote awareness and reduce misconceptions of modern contraceptives among key groups of people, including men, couples, and religious and other community leaders. …”
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ISO-upregulated BECN1 specifically promotes LC3B-dependent autophagy and anticancer activity in invasive bladder cancer by Xiaohui Hua, Daimin Xiang, Jiheng Xu, Shouyue Zhang, Shuai Wu, Zhongxian Tian, Junlan Zhu, Chuanshu Huang

“…Downregulation of BECN1 was observed in human BCs and BBN-induced mouse invasive BC tissues, whereas co-treatment with ISO completely reversed BECN1 downregulation in BBN-induced mouse invasive BCs. …”
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