Treadmill training protects valproic acid-induced autistic features via cerebellar AMPK/PPAR-γ dependent pathway and improves mitochondrial activity in mice by Anwaar M. Shaban, Omnia Ameen, Marwa Omar, Sara A. El Derbaly, Hend R. Omara, Asmaa I. Bayomi, Asmaa A. Abdel Latif, Zainab Ibrahim Elakabawy, Suzan A. Khodir

“…Training dramatically reversed VPA-induced neurobehavioral, biochemical, and cerebellar degenerative changes. …”
Get full text

Role of phospholipase Cη1 in lateral habenula astrocytes in depressive-like behavior in mice by Sukwoon Song, Miseon Kang, Jiyoung Lee, Yong Ryoul Yang, Ho Lee, Jae-Ick Kim, Beomsue Kim, Hoon-seong Choi, Eun-bin Hong, Min-ho Nam, Pann-Ghill Suh, Jeongyeon Kim

“…In these cKO mice, we observed a reduction in cellular morphological complexity metrics, such as total process length, as well as a decrease in the passive membrane conductance of LHb astrocytes. …”
Get full text

Wireless, battery-free vagal electrical stimulation: A novel approach to inhibit cardiac hypertrophy via H3K18 lactylation mediated mitophagy by Pilong Shi, Yang Liu, Yuetong Sha, Jiaxin Wang, Jiajun Zhou, Kai Liu, Yonggang Cao, Qianhui Zhang, Xinran Wang, Hongli Sun

“…Metabolomic analysis revealed a notable reduction in lactate levels within myocardial tissue following ES. …”
Get full text

Counteractive Effects of Copper Nanoparticles and Betacellulin on Ovarian Cells by Alexander V. Sirotkin, Paula Romero-Navarro, Barbora Loncová, Zuzana Fabová, Michaela Bartušová, Abdel Halim Harrath, Francisco Alonso

“…CuNPs, prepared using a chemical reduction method, were fully characterized by different means (TEM, DLS, XRD, Z potential, XPS, and AES). …”
Get full text

Pharmacokinetics and Pharmacogenetics of Apixaban by A. V. Savinova, M. M. Petrova, N. A. Shnayder, E. N. Bochanova, R. F. Nasyrova

“…Its main mechanism of action is through reversible inhibition of factor Xa. It specifically binds and inhibits both free and bound factor Xa which ultimately results in reduction in the levels of thrombin formation. …”
Get full text

Protective effects of paederoside in rotenone-induced cellular models of Parkinson’s disease by Juan Lang, Juan Lang, Zhongkui Xiong, Zhongkui Xiong

“…Paederoside induced a dose-dependent reduction in inducible nitric oxide synthase (iNOS) activity in the rotenone-treated BV-2 cells. …”
Get full text

ELECTROKINETIC PROPERTIES, IN VITRO DISSOLUTION, AND PROSPECTIVE HEMOAND BIOCOMPATIBILITY OF TITANIUM OXIDE AND OXYNITRIDE FILMS FOR CARDIOVASCULAR STENTS by I. A. Khlusov, V. F. Pichugin, A. A. Pustovalova, M. E. Konischev, A. N. Dzyuman, M. Epple, M. Ulbricht, E. Cicinskas, V. S. Gulaya, V. V. Vikhareva

“…Modifying effect of model biological fluids on physicochemical characteristics of materials tested (roughness enhancement, a reduction or reversion of surface negative potential, sharp augmentation of surface hydrofilicity) should took into account under titanium oxide and oxynitride films formation and a forecast of their optimal biological properties as the materials for cardiovascular stents.…”
Get full text

Melatonin Receptor Agonists as the "Perioceutics" Agents for Periodontal Disease through Modulation of Porphyromonas gingivalis Virulence and Inflammatory Response. by Wei Zhou, Xuan Zhang, Cai-Lian Zhu, Zhi-Yan He, Jing-Ping Liang, Zhong-Chen Song

“…They inhibited Pg-LPS-induced IL-6 and IL-8 secretion, which was reversed by luzindole, the melatonin receptor antagonist.…”
Get full text

Cardiovascular effects of long‐duration space flight by Iqbal Hussain, Rehmat Ullah, Bharti F. N. U. Simran, Parvinder Kaur, Mahendra Kumar, Rohan Raj, Maria Faraz, Amin Mehmoodi, Jahanzeb Malik

“…Abstract Introduction Early studies exploring the physiological effects of space travel have indicated the body's capacity for reversible adaptation. However, the impact of long‐duration spaceflight, exceeding 6 months, presents more intricate challenges. …”
Get full text

Acute Dermatotoxicity of Green-Synthesized Silver Nanoparticles (AgNPs) in Zebrafish Epidermis by Grace Emily Okuthe, Busiswa Siguba

“…However, at the highest concentration, this trend reversed, with a significant decrease in goblet cell numbers and size evident between 48 and 96 h post-exposure. …”
Get full text

Drought Amplifies the Suppressive Effect of Afforestation on Net Primary Productivity in Semi-Arid Ecosystems: A Case Study of the Yellow River Basin by Futao Wang, Ziqi Zhang, Mingxuan Du, Jianzhong Lu, Xiaoling Chen

“…Drought amplified the suppressive effect of afforestation through stomatal conductance-photosynthesis coupling mechanisms, causing additional NPP losses of 7.45–31.00 gC·m⁻², yet the April–July 2008 event exhibited reversed suppression effects due to immature artificial communities during the 2000–2004 baseline period. …”
Get full text

Corticosteroids in Cardiogenic Shock: A Retrospective Analysis of the Medical Information Mart for Intensive Care-IV Database by Ghazal Haddad, MD, HBSc, GDipHR, David M. Maslove, MD, MS, FRCPC, Lawrence Mbuagbaw, MD, MPH, PhD, Emilie P. Belley-Côté, MD, PhD, FRCPC, Bram Rochwerg, MD, MSc, FRCPC

“…While corticosteroid administration in septic shock has been shown to result in faster shock reversal and lower short-term mortality, the role of corticosteroids in the management of cardiogenic shock (CS) remains unexplored. …”
Get full text

Psychodrama: implementation, study design and effectiveness: a systematic review by Jesús Maya, Miriam Pérez-Berbel, Laura Giraldo-Arroyave, Irene Hurtado

“…Generally, these interventions were based on Morenian Psychodrama. Role reversal, doubling and mirror were the techniques most used. …”
Get full text

Electrophysiological markers of preclinical diagnosis of glaucomatous optic neuropathy by M. O. Kirillova, M. V. Zueva, I. V. Tsapenko, A. N. Zhuravleva

“…A statistically significant reduction in the steady-state PERG's amplitude was found in the groups of suspected glaucoma and initial POAG. …”
Get full text

Selective serotonin reuptake inhibitors and spermatogenesis by M. N. Korshunov, E. S. Korshunova, Yu. V. Kastrikin, S. P. Darenkov

“…Using fluoxetine has a reversible negative effect on male fertility. It is important to inform the patients about the temporary side effects of SSRIs in fatherhood planning cases.…”
Get full text

Neonatal and perinatal mortality in the urban continuum: a geospatial analysis of the household survey, satellite imagery and travel time data in Tanzania by Lenka Benova, Claudia Hanson, Aliki Christou, Aline Semaan, Peter M Macharia, Jessie Pinchoff, Andrea B Pembe

“…Introduction Recent studies suggest that the urban advantage of lower neonatal mortality in urban compared with rural areas may be reversing, but methodological challenges include misclassification of neonatal deaths and stillbirths, and oversimplification of the variation in urban environments. …”
Get full text

Pain Coping in Patients With Chronic Migraine and Medication Overuse Headache by Thomas C. van denHoek, Judith A. Pijpers, Erik W. vanZwet, Irene deBoer, Gisela M. Terwindt

“…Importantly, higher PCS scores were associated with greater reduction in migraine days after treatment (OR: 1.06 [95% CI 1.01–1.11], p = 0.030). …”
Get full text

Body-mass index and risk of advanced chronic kidney disease: Prospective analyses from a primary care cohort of 1.4 million adults in England. by William G Herrington, Margaret Smith, Clare Bankhead, Kunihiro Matsushita, Sarah Stevens, Tim Holt, F D Richard Hobbs, Josef Coresh, Mark Woodward

“…Strategies to reduce weight among those who are overweight, as well as those who are obese may reduce CKD risk, with each unit reduction in BMI yielding similar relative reductions in risk.…”
Get full text

TRIM26 as a dual regulator of ferroptosis and chemoresistance in gastric cancer through HSF1 ubiquitination and exosomal miR-24-3p signaling by Nouf S. Al-Abbas

“…Functional assays including CCK-8, wound healing, colony formation, and Transwell migration, demonstrated that TRIM26 knockdown significantly enhanced GC cell proliferation, migration, and invasion, whereas TRIM26 overexpression reversed these malignant phenotypes. Mechanistically, TRIM26 induced ferroptosis via HSF1 ubiquitination and degradation, leading to reduced glutathione (GSH) levels and elevated levels of reactive oxygen species (ROS) and malondialdehyde (MDA). …”
Get full text

Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L-NAME-Induced Hypertensive Rats by Muryam Abdul Razzaq, Waqas Younis, Muhammad Nasir Hayat Malik, Tariq G. Alsahli, null Alamgeer, Shah Jahan, Roma Ehsan, Arquimedes Gasparotto Junior, Asifa Bashir

“…Concurrent treatment with pulegone for four weeks in L-NAME-treated rats caused a reduction in both systolic blood pressure and heart rate, reversed the reduced levels of serum nitric oxide (NO), and ameliorated lipid profile and oxidative stress markers. …”
Get full text