Anti-inflammatory strategies for hepatic encephalopathy: preclinical studies by Rafaela Pinto Coelho Santos, Eliana Cristina de Brito Toscano, Milene Alvarenga Rachid

“…In experimental models, anti-inflammatory strategies have demonstrated neuroprotective effects, leading to a reduction in HE-related cognitive and motor impairments. …”
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Temporal system‐level organization of the switch from glycolytic to gluconeogenic operation in yeast by Guillermo G Zampar, Anne Kümmel, Jennifer Ewald, Stefan Jol, Bastian Niebel, Paola Picotti, Ruedi Aebersold, Uwe Sauer, Nicola Zamboni, Matthias Heinemann

“…We found that the diauxic shift is accomplished by three key events that are temporally organized: (i) a reduction in the glycolytic flux and the production of storage compounds before glucose depletion, mediated by downregulation of phosphofructokinase and pyruvate kinase reactions; (ii) upon glucose exhaustion, the reversion of carbon flow through glycolysis and onset of the glyoxylate cycle operation triggered by an increased expression of the enzymes that catalyze the malate synthase and cytosolic citrate synthase reactions; and (iii) in the later stages of the adaptation, the shutting down of the pentose phosphate pathway with a change in NADPH regeneration. …”
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FBXL4 deficiency increases mitochondrial removal by autophagy by David Alsina, Oleksandr Lytovchenko, Aleksandra Schab, Ilian Atanassov, Florian A Schober, Min Jiang, Camilla Koolmeister, Anna Wedell, Robert W Taylor, Anna Wredenberg, Nils‐Göran Larsson

“…Inhibition of lysosomal function in these cells reverses the mitochondrial phenotype, whereas proteasomal inhibition has no effect. …”
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Ethyl p-methoxycinnamate inhibits tumor growth by suppressing of fatty acid synthesis and depleting ATP by Yutaro Sasaki, Niina Mizushima, Toshio Norikura, Isao Matsui-Yuasa, Akiko Kojima-Yuasa

“…The addition of exogenous palmitic acid reversed EMC-induced ATP depletion and mitigated its anti-proliferative effects. …”
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Performance analysis of vertical smart isolator based on magnetorheological elastomer by Fan Zeng, Feng Zhou, Jiangtao Li, Meng Li, Qi Wang, Ning Ma, Xufeng Dong

“…As one of the field-dependent smart materials whose stiffness and damping properties can change instantaneously and reversibly, magnetorheological elastomer (MRE) has been extensively utilized on base isolation for vibration reduction. …”
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Antioxidant protection system before and after coronary bypass surgery in coronary heart disease patients with left ventricular dysfunction by L. A. Bokeriya, V. E. Malikov, M. A. Arzumanyan, E. I. Guchua, O. V. Vladytskaya, A. I. Tedeev, G. V. Sukoyan

“…In participants with EF<35%, pseudo-normalization of SOD activity and reduction of katalase and glutathione peroxidase activity was observed: antioxidant protection system (AOP) potential was decreased (initial, reversible phase). …”
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Clinico-laboratory and immunological characteristics of patients with compensated cirrhosis of the liver in the outcome of chronic hepatitis C on the background of treatment with a... by L. L. Popova, D. Yu. Konstantinov, Ye. A. Strebkova, S. Yu. Vasiliev, Ye. A. Konstantinova, O. O. Golik, Ye. S. Kindalova, A. F. Novikova

“…There were no serious adverse events requiring treatment reversal. As a result of treatment, there was a disappearance or a significant decrease in the severity of asthenovegetative and dyspeptic syndromes, a reduction in liver size, an improvement in liver functional parameters (biochemical response), and normalization of the balance of the cellular immunity by increasing CD3 +, CD4 +, CD8 + – CD16 + lymphocyte counts. …”
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Development of Human Skin Equivalents with Inducible Ceramide Depletion for In Vitro Modeling of Lipid Impairment by Durotimi O. Dina, Miriam Maiellaro, Emanuela Camera, John T. Connelly

“…We also show that ceramide synthase 3 knockdown is reversible upon removal of doxycycline and can be used to study recovery and repair of epidermal lipids. …”
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ORM1 Mediates Ln-IgG-Induced Podocyte Damage and Autophagy via the AMPK/mTOR Signaling by Jie Chen, Libin Zou, Lu Liu, Chunfeng Wu, Mi Hu

“…Upon stimulation with IgG from LN patients, ORM1 knockdown reversed the reduction in podocyte viability, decreased the apoptosis rate, and reduced the elevated levels of autophagy, followed by an increase in AMPK phosphorylation and a decrease in mTOR phosphorylation. …”
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Integrated Management of Tomato Fusarium Wilt: Ultrastructure Insights into Zn Nanoparticles and Phytohormone Applications by Yasmin M. Heikal, Amal M. Albahi, Amal A. Alyamani, Hala M. Abdelmigid, Samia A. Haroun, Hoda M. Soliman

“…The different treatments exhibited significant effectiveness in reversing these adverse effects, leading to increased thickness of the leaf blade, mesophyll, palisade, and spongy tissues and enhanced structural integrity. …”
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TIMP2 and IGFBP-7 as Biomarkers For The Diagnosis of Acute Kidney Injury (AKI) in Post-operative Patients: An Evidence-Based Case Report by Igor Ian Wiguna, Gde Ngurah Irfan Bhaskara, Mutiara Reka Ananda Putri, Priscilla Ardianto, Widi Atmoko

“… Background: Acute kidney injury (AKI) is defined as a sudden reduction in kidney function which commonly occurs as a complication of major surgeries. …”
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Synthesis and Characterization of Quinoxaline-Fused Cyclopenta[<i>cd</i>]azulene by Tomohiro Oda, Yuina Onishi, Akihito Konishi, Makoto Yasuda

“…The ring annulation decreased the lowest excitation energy compared with that of azulene and its structural isomer <b>5</b> and led to multiple reversible reduction processes. Characterization of the molecular geometry and optoelectronic properties of <b>4</b> revealed that the embedded azulene core preserves its original aromaticity, while the fused quinoxaline acts as a nucleophilic and basic site. …”
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Innovative strategies in coagulation management for cardiothoracic surgery: a narrative review of pharmacological and nonpharmacological approaches by Aleena Ihtasham, Sahla Waqas, Muhammad Hamza, Haider Imran, Saraiba Sabar Chaudhary, Tayyaba Qayyum, Sadia Batool, Nimarta Devi, Muhammad Ali Muzammil, Malik Olatunde Oduoye

“…During cardiopulmonary bypass, factors such as hypothermia, acidosis, and fibrinolysis worsen coagulation disturbances, and protamine sulfate is administered for heparin reversal during the procedure. Point-of-care devices, including thromboelastography (TEG®) and rotational thromboelastometry (ROTEM®), provide real-time monitoring of coagulation, hence guiding clinical interventions effectively, and have demonstrated a reduction in postoperative bleeding. …”
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PIEZO1 activity promotes stemness in mesenchymal stem cells under shear stress and enhances protection of leukemia cells by Amit Sharma, Jina Bhattacharyya, Piruthivi Sukumar, Bithiah Grace Jaganathan

“…PIEZO1 activity modulates the shear-stress response in BM-MSCs, resulting in downregulation of PIEZO1 expression. Concurrently, this reduction activates Notch signaling pathway and upregulates genes associated with stemness. …”
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Adsorptive Removal of Cr(VI) from Aqueous Solution on Hydrous Cerium—Zirconium Oxide. Part I: Process Optimization by Response Surface Methodology by C.A. Rivera Corredor, M.Á. Gómez García, I. Dobrosz-Gómez

“…The Cr(VI) adsorption on hydrous Ce 0.25 Zr 0.75 O 2 was not completely reversible. The reduction of Cr(VI) to Cr(III) under acidic conditions was also responsible for Cr(VI) removal.…”
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Simulated synapse loss induces depression-like behaviors in deep reinforcement learning by Eric Chalmers, Santina Duarte, Xena Al-Hejji, Daniel Devoe, Aaron Gruber, Robert J. McDonald

“…Reversing the spine-loss effect in our computational MDD model can lead to rescue of rewarding behavior under some conditions. …”
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The Effects of Dietary Glycine on the Acetic Acid-Induced Mouse Model of Colitis by Xin Wu, Yongmin Zheng, Jie Ma, Jie Yin, Shuai Chen

“…Gly supplementation also reversed the AA-induced reduction in the abundance of bacteria such as Clostridia, Ruminococcaceae, and Clostridiales. …”
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20-HETE mediates Ang II-induced cardiac hypertrophy via ROS and Ca2+ signaling in H9c2 cells by Jingyi Han, Jiaojiao Li, Lianlian Liu, Kaiyuan Li, Chun Zhang, Yong Han

“…Inhibition of 20-HETE synthesis or blockade of its receptor, G-protein-coupled receptor 75 (GPR75), significantly reversed Ang II-induced cardiac hypertrophy. This reversal was closely associated with 20-HETE-induced ROS production, oxidative stress, and activation of the Ca2+/CaN/NFAT3 signaling pathway. …”
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Fully invertible hyperbolic neural networks for segmenting large-scale surface and sub-surface data by Bas Peters, Eldad Haber, Keegan Lensink

“…Recently developed fully reversible or fully invertible networks can mostly avoid memory limitations by recomputing the states during the backward pass through the network. …”
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Changes in Semen, Hormonal profile and Testicular Morphology of West African Dwarf Goat Bucks treated with Danazol by Lukman Oladimeji Raji, Mohammed Babashani, Ganiyu Jimoh Akorede, Aishat O Olatunji, Fatima Sanusi, Yusuf Idris, Khalid Tahlia Biobaku

“…In conclusion, danazol caused a reversed reduction in sperm cells characteristics suggesting its possible use as a contraceptive in WAD goat bucks.…”
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